| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philippe Corcia, Vincent Meininge. Management of amyotrophic lateral sclerosis. Drugs. vol 68. issue 8. 2008-09-02. PMID:18484797. |
amyotrophic lateral sclerosis (als) is a neurodegenerative disease affecting the motor neurons, in both the spinal cord and medulla (lower motor neurons) and cerebral cortex (upper motor neurons). |
2008-09-02 |
2023-08-12 |
Not clear |
| Kazunori Tanaka, Yoshinori Okada, Takuya Kanno, Asako Otomo, Yoshiko Yanagisawa, Junko Shouguchi-Miyata, Etsuko Suga, Eri Kohiki, Kyuichiro Onoe, Hitoshi Osuga, Masashi Aoki, Shinji Hadano, Yasuto Itoyama, Joh-E Iked. A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice. Experimental neurology. vol 211. issue 2. 2008-07-07. PMID:18423451. |
amyotrophic lateral sclerosis (als) is a neurodegenerative disease characterized by a selective loss of motor neurons in the motor cortex, brainstem, and spinal cord. |
2008-07-07 |
2023-08-12 |
mouse |
| Andrzej W Vorbrodt, Danuta H Dobrogowska, Harry C Meeker, Richard I Car. Quantitative immunogold study of increased expression of metallothionein-I/II in the brain perivascular areas of diabetic scrapie-infected mice. Journal of molecular histology. vol 37. issue 3-4. 2008-03-03. PMID:17031522. |
these results are similar to those in alzheimer's disease reported by other authors, and suggest that neurodegenerative diseases as well as metabolic stress enhance the metallothionein expression in perivascular regions of brain cerebral cortex, predominantly in astrocytes. |
2008-03-03 |
2023-08-12 |
mouse |
| Ezia Guatteo, Irene Carunchio, Massimo Pieri, Federica Albo, Nadia Canu, Nicola B Mercuri, Cristina Zon. Altered calcium homeostasis in motor neurons following AMPA receptor but not voltage-dependent calcium channels' activation in a genetic model of amyotrophic lateral sclerosis. Neurobiology of disease. vol 28. issue 1. 2007-12-12. PMID:17706428. |
amyotrophic lateral sclerosis (als) is a late-onset progressive neurodegenerative disease characterized by a substantial loss of motor neurons in the spinal cord, brain stem and motor cortex. |
2007-12-12 |
2023-08-12 |
mouse |
| Aleksandra Mladenovic, Milka Perovic, Nikola Tanic, Suzana Petanceska, Sabera Ruzdijic, Selma Kanazi. Dietary restriction modulates alpha-synuclein expression in the aging rat cortex and hippocampus. Synapse (New York, N.Y.). vol 61. issue 9. 2007-11-29. PMID:17568432. |
the aim of this study was to assess the effects of dr on expression of alpha-synuclein, a presynaptic protein involved in pathogenesis of parkinson's and some other neurodegenerative diseases, in the cortex and hippocampus of adult, middle-aged, late middle-aged, and aged rats. |
2007-11-29 |
2023-08-12 |
rat |
| Shilpa Ramaswamy, Jodi L McBride, Christopher D Herzog, Eugene Brandon, Mehdi Gasmi, Raymond T Bartus, Jeffrey H Kordowe. Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease. Neurobiology of disease. vol 26. issue 2. 2007-06-28. PMID:17336076. |
huntington's disease (hd) is a devastating neurodegenerative disease characterized by the selective loss of neurons in the striatum and cerebral cortex. |
2007-06-28 |
2023-08-12 |
rat |
| L Van den Bosc. [The causes and mechanism of selective motor neuron death in amyotrophic lateral sclerosis]. Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie. vol 68. issue 4. 2007-01-25. PMID:17214440. |
amyotrophic lateral sclerosis is a neurodegenerative disease characterized by the selective death of motor neurons in the motor cortex, brain stem and spinal cord. |
2007-01-25 |
2023-08-12 |
mouse |
| Cristina Zona, Massimo Pieri, Irene Carunchi. Voltage-dependent sodium channels in spinal cord motor neurons display rapid recovery from fast inactivation in a mouse model of amyotrophic lateral sclerosis. Journal of neurophysiology. vol 96. issue 6. 2007-01-17. PMID:16899637. |
amyotrophic lateral sclerosis (als) is a neurodegenerative disease characterized by a substantial loss of motor neurons in the spinal cord, brain stem, and motor cortex. |
2007-01-17 |
2023-08-12 |
mouse |
| P M Gonçalves-Pereira, E Oliveira, R Insaust. [Quantitative volumetric analysis of the hippocampus, amygdala and entorhinal cortex: normative database for the adult Portuguese population]. Revista de neurologia. vol 42. issue 12. 2006-10-18. PMID:16775796. |
atrophy of the hippocampus, amygdala and entorhinal cortex can be found in neurodegenerative diseases, head trauma and epilepsy and are expressed by means of volume reductions. |
2006-10-18 |
2023-08-12 |
Not clear |
| O Bugian. Neuropathology of the dementias other than Alzheimer's. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 27 Suppl 1. 2006-07-19. PMID:16708184. |
dementia is not only the clinical hallmark of neurodegenerative diseases, most often proteinopathies, primarily involving the cerebral cortex, but also a symptom frequently associated to movement disorders, or secondary to systemic or neurological, non-degenerative diseases. |
2006-07-19 |
2023-08-12 |
Not clear |
| Michael J McConnell, Dhruv Kaushal, Amy H Yang, Marcy A Kingsbury, Stevens K Rehen, Kai Treuner, Robert Helton, Emily G Annas, Jerold Chun, Carrolee Barlo. Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in the Atm-deficient but not the Trp53-deficient adult cerebral cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 37. 2005-05-17. PMID:15371510. |
in the adult cerebral cortex of three genetic mutants, one of which is a mouse model of the human neurodegenerative disease ataxia-telangiectasia (a-t), we observed divergent levels of sex chromosome (xy) aneuploidy. |
2005-05-17 |
2023-08-12 |
mouse |
| P Hemachandra Reddy, Shannon McWeeney, Byung S Park, Maria Manczak, Ramana V Gutala, Dara Partovi, Youngsin Jung, Vincent Yau, Robert Searles, Motomi Mori, Joseph Quin. Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease. Human molecular genetics. vol 13. issue 12. 2004-12-22. PMID:15115763. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by the impairment of cognitive functions and by beta amyloid (abeta) plaques in the cerebral cortex and the hippocampus. |
2004-12-22 |
2023-08-12 |
mouse |
| A Petroni, M Cappa, M Blasevich, M Solinas, G Uzie. New findings on X-linked Adrenoleukodystrophy: 5alpha-reductase isoform 2 relative gene expression is modified in affected fibroblasts. Neuroscience letters. vol 367. issue 3. 2004-12-17. PMID:15337247. |
x-linked adrenoleukodystrophy (x-ald) is a neurodegenerative disease with an endocrinological component since, in addition to the nervous system, the adrenal cortex and the testis are mainly affected, with corresponding clinical signs. |
2004-12-17 |
2023-08-12 |
Not clear |
| Yoon Hee Chung, Soo In Kim, Kyeung Min Joo, Yang Soo Kim, Won Bok Lee, Kyu Wol Yun, Choong Ik Ch. Age-related changes in erythropoietin immunoreactivity in the cerebral cortex and hippocampus of rats. Brain research. vol 1018. issue 1. 2004-10-06. PMID:15262216. |
the first demonstration of age-related decreases in epo expression in the cerebral cortex and hippocampus may provide useful data for investigating the pathogenesis of age-related neurodegenerative diseases, suggesting that age-related decreases in epo may contribute to degenerative events following age-related decreases in brain flow and oxygen supply. |
2004-10-06 |
2023-08-12 |
rat |
| Ericka P Simpson, Albert A Yen, Stanley H Appe. Oxidative Stress: a common denominator in the pathogenesis of amyotrophic lateral sclerosis. Current opinion in rheumatology. vol 15. issue 6. 2004-02-06. PMID:14569202. |
amyotrophic lateral sclerosis, or lou gehrig disease, is a progressive neurodegenerative disease of adult onset characterized by a loss of motor neurons in the spinal cord and motor cortex. |
2004-02-06 |
2023-08-12 |
Not clear |
| Yoon Hee Chung, Eun Jung Kim, Chung Min Shin, Kyeung Min Joo, Myeung Ju Kim, Haing Won Woo, Choong Ik Ch. Age-related changes in CREB binding protein immunoreactivity in the cerebral cortex and hippocampus of rats. Brain research. vol 956. issue 2. 2003-04-22. PMID:12445700. |
the first demonstration of age-related decreases in cbp expression in the cerebral cortex and hippocampus may provide useful data for investigating the pathogenesis of age-related neurodegenerative diseases and depression. |
2003-04-22 |
2023-08-12 |
rat |
| Roberta Brambilla, Joseph T Neary, Flaminio Cattabeni, Lorenzo Cottini, Gianluca D'Ippolito, Paul C Schiller, Maria P Abbracchi. Induction of COX-2 and reactive gliosis by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signalling. Journal of neurochemistry. vol 83. issue 6. 2003-01-16. PMID:12472883. |
the present study has been aimed at characterizing the atp/p2 receptor (and transductional pathways) responsible for the morphological changes induced in vitro by alphabetamethyleneatp on rat astrocytes obtained from cerebral cortex, a brain area highly involved in neurodegenerative diseases. |
2003-01-16 |
2023-08-12 |
rat |
| Yoon Hee Chung, Chung Min Shin, Kyeung Min Joo, Myeung Ju Kim, Choong Ik Ch. Region-specific alterations in insulin-like growth factor receptor type I in the cerebral cortex and hippocampus of aged rats. Brain research. vol 946. issue 2. 2002-11-12. PMID:12137935. |
our first morphological data concerning the differential regulation of igf-i receptors in aged cerebral cortex and hippocampus may provide insights into age-related changes in trophic support as well as basic knowledge required for the study of neurodegenerative diseases such as alzheimer's disease. |
2002-11-12 |
2023-08-12 |
rat |
| H D Rosas, A K Liu, S Hersch, M Glessner, R J Ferrante, D H Salat, A van der Kouwe, B G Jenkins, A M Dale, B Fisch. Regional and progressive thinning of the cortical ribbon in Huntington's disease. Neurology. vol 58. issue 5. 2002-04-19. PMID:11889230. |
the cortex has been difficult to study in neurodegenerative diseases primarily because of its complex folding patterns and regional variability; however, an understanding of how the cortex is affected by the disease may provide important new insights into it. |
2002-04-19 |
2023-08-12 |
Not clear |
| C H Jiang, J Z Tsien, P G Schultz, Y H. The effects of aging on gene expression in the hypothalamus and cortex of mice. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11172053. |
a number of key genes involved in neuronal structure and signaling are differentially expressed in both the aged hypothalamus and cortex, including synaptotagmin i, camp-dependent protein kinase c beta, apolipoprotein e, protein phosphatase 2a, and prostaglandin d. misregulation of these proteins may contribute to age-related memory deficits and neurodegenerative diseases. |
2001-04-19 |
2023-08-12 |
mouse |