| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuxing Xia, Brach M Bell, Justin D Kim, Benoit I Giasso. Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation. Frontiers in neuroscience. vol 17. 2023-06-12. PMID:37304025. |
tauopathies are a group of neurodegenerative diseases, which include frontotemporal dementia (ftd) and alzheimer's disease (ad), broadly defined by the development of tau brain aggregates. |
2023-06-12 |
2023-08-14 |
Not clear |
| Amelia D Hines, Stephanie McGrath, Amanda S Latham, Breonna Kusick, Lisa Mulligan, McKenzie L Richards, Julie A Moren. Activated gliosis, accumulation of amyloid β, and hyperphosphorylation of tau in aging canines with and without cognitive decline. Frontiers in aging neuroscience. vol 15. 2023-06-12. PMID:37304080. |
it is well known that in neurodegenerative diseases, there is an increase in inflamed glial cells as well as an accumulation of hyperphosphorylation of tau (p-tau) and amyloid beta (aβ |
2023-06-12 |
2023-08-14 |
human |
| Marta Anglada-Huguet, Heike Endepols, Astrid Sydow, Ronja Hilgers, Bernd Neumaier, Alexander Drzezga, Senthilvelrajan Kaniyappan, Eckhard Mandelkow, Eva-Maria Mandelko. Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298211. |
the accumulation of tau is a hallmark of several neurodegenerative diseases and is associated with neuronal hypoactivity and presynaptic dysfunction. |
2023-06-11 |
2023-08-14 |
mouse |
| Monika Arbaciauskaite, Azady Pirhanov, Erik Ammermann, Yu Lei, Yong Ku Ch. Yeast biopanning against site-specific phosphorylations in tau. Protein engineering, design & selection : PEDS. 2023-06-09. PMID:37294629. |
the detection of site-specific phosphorylation in the microtubule-associated protein tau is emerging as a means to diagnose and monitor the progression of alzheimer's disease (ad) as well as other neurodegenerative diseases. |
2023-06-09 |
2023-08-14 |
Not clear |
| Houfang Long, Shuyi Zeng, Yunpeng Sun, Cong Li. Biochemical and biophysical characterization of pathological aggregation of amyloid proteins. Biophysics reports. vol 8. issue 1. 2023-06-08. PMID:37287686. |
several amyloid proteins including α-synuclein (α-syn), tau, amyloid β (aβ) protein, and tar dna-binding protein 43 kda (tdp-43) form pathological fibrils and deposit in patient brains of different neurodegenerative diseases (nds) such as parkinson's disease (pd), alzheimer's disease (ad) and amyotrophic lateral sclerosis (als). |
2023-06-08 |
2023-08-14 |
human |
| Deniz Karabag, Hannah Scheiblich, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michael T Heneka, Christina Isin. Characterizing microglial senescence: Tau as a key player. Journal of neurochemistry. 2023-06-06. PMID:37278117. |
while the contribution of senescent microglia to the development of tauopathies and other neurodegenerative diseases is a growing area of research, the effect of tau on microglial senescence remains elusive. |
2023-06-06 |
2023-08-14 |
mouse |
| Arthur Ribeiro-Dos-Santos, Leonardo Miranda de Brito, Gilderlanio Santana de Araúj. The fusiform gyrus exhibits differential gene-gene co-expression in Alzheimer's disease. Frontiers in aging neuroscience. vol 15. 2023-05-31. PMID:37255536. |
alzheimer's disease (ad) is an irreversible neurodegenerative disease clinically characterized by the presence of β-amyloid plaques and tau deposits in various regions of the brain. |
2023-05-31 |
2023-08-14 |
Not clear |
| Lei Xia, Fan Zhang, Yulu Li, Yuemi Mo, Lingqiu Zhang, Qianhua Li, Minghuang Luo, Xiaotao Hou, Zhengcai Du, Jiagang Deng, Erwei Ha. A new perspective on Alzheimer's disease: m6A modification. Frontiers in genetics. vol 14. 2023-05-31. PMID:37255714. |
as a neurodegenerative disease, alzheimer's disease (ad) is characterized by synaptic loss, extracellular plaques of amyloid accumulation, hyperphosphorylation of tau, and neuroinflammation. |
2023-05-31 |
2023-08-14 |
Not clear |
| Jingshan Chen, Xue Zhao, Wenyan Zhang, Tianxiang Zhang, Siting Wu, Jinghao Shao, Fu-Dong Sh. Reference intervals for plasma amyloid-β, total tau, and phosphorylated tau181 in healthy elderly Chinese individuals without cognitive impairment. Alzheimer's research & therapy. vol 15. issue 1. 2023-05-26. PMID:37237388. |
plasma amyloid-β (aβ) peptides and tau proteins are promising biomarkers of alzheimer's disease (ad), not only for predicting aβ and tau pathology but also for differentiating ad from other neurodegenerative diseases. |
2023-05-26 |
2023-08-14 |
Not clear |
| Siewert Hugelier, Hannah Kim, Melina Theoni Gyparaki, Charles Bond, Qing Tang, Adriana Naomi Santiago-Ruiz, Sílvia Porta, Melike Lakadamyal. ECLiPSE: A Versatile Classification Technique for Structural and Morphological Analysis of Super-Resolution Microscopy Data. bioRxiv : the preprint server for biology. 2023-05-23. PMID:37215010. |
moreover, we demonstrate the versatility of our approach by applying it to two novel biological applications: quantifying the clearance of tau protein aggregates, a critical marker for neurodegenerative diseases, and differentiating between two distinct morphological features (morphotypes) of tar dna-binding protein 43 proteinopathy, potentially associated to different tdp-43 strains, each exhibiting unique seeding and spreading properties. |
2023-05-23 |
2023-08-14 |
Not clear |
| Oskar Hansson, Kaj Blennow, Henrik Zetterberg, Jeffrey Dag. Blood biomarkers for Alzheimer's disease in clinical practice and trials. Nature aging. vol 3. issue 5. 2023-05-18. PMID:37202517. |
several assays for measuring phosphorylated tau (p-tau) in plasma exhibit high diagnostic accuracy in distinguishing ad from all other neurodegenerative diseases in patients with cognitive impairment. |
2023-05-18 |
2023-08-14 |
Not clear |
| Yuxing Xia, Brach M Bell, Benoit I Giasso. Tau Lysine Pseudomethylation Regulates Microtubule Binding and Enhances Prion-like Tau Aggregation. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175990. |
alzheimer's disease (ad) and frontotemporal dementia (ftd) can be classified as tauopathies, which are a group of neurodegenerative diseases that develop toxic tau aggregates in specific brain regions. |
2023-05-14 |
2023-08-14 |
Not clear |
| Zahra Gholami Mahmoudian, Ali Ghanbari, Iraj Rashidi, Iraj Amiri, Alireza Komak. Minocycline effects on memory and learning impairment in the beta-amyloid-induced Alzheimer's disease model in male rats using behavioral, biochemical, and histological methods. European journal of pharmacology. 2023-05-13. PMID:37179042. |
alzheimer's disease (ad), as an advanced neurodegenerative disease, is characterized by the everlasting impairment of memory, which is determined by hyperphosphorylation of intracellular tau protein and accumulation of beta-amyloid (aβ) in the extracellular space. |
2023-05-13 |
2023-08-14 |
rat |
| Chao Qi, Bert M Verheijen, Yasumasa Kokubo, Yang Shi, Stephan Tetter, Alexey G Murzin, Asa Nakahara, Satoru Morimoto, Marc Vermulst, Ryogen Sasaki, Eleonora Aronica, Yoshifumi Hirokawa, Kiyomitsu Oyanagi, Akiyoshi Kakita, Benjamin Ryskeldi-Falcon, Mari Yoshida, Masato Hasegawa, Sjors H W Scheres, Michel Goeder. Tau Filaments from Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) adopt the CTE Fold. bioRxiv : the preprint server for biology. 2023-05-10. PMID:37162924. |
the amyotrophic lateral sclerosis/parkinsonism-dementia complex (als/pdc) of the island of guam and the kii peninsula of japan is a fatal neurodegenerative disease of unknown cause that is characterised by the presence of abundant filamentous tau inclusions in brains and spinal cords. |
2023-05-10 |
2023-08-14 |
Not clear |
| S L Fowler, T S Behr, E Turkes, P Maglio Cauhy, M S Foiani, A Schaler, G Crowley, S Bez, E Ficulle, E Tsefou, D P O'Brien, R Fischer, B Geary, P Gaur, C Miller, P D'Acunzo, E Levy, K E Duff, B Ryskeldi-Falco. Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease. bioRxiv : the preprint server for biology. 2023-05-10. PMID:37163117. |
the abnormal assembly of tau protein in neurons is the pathological hallmark of multiple neurodegenerative diseases, including alzheimer's disease (ad). |
2023-05-10 |
2023-08-14 |
Not clear |
| Naruhiko Sahara, Rin Yana. Limitations of human tau-expressing mouse models and novel approaches of mouse modeling for tauopathy. Frontiers in neuroscience. vol 17. 2023-05-08. PMID:37152607. |
neurofibrillary tangles (nfts) composed of hyperphosphorylated tau protein are primarily neuropathological features of a number of neurodegenerative diseases, collectively termed tauopathy. |
2023-05-08 |
2023-08-14 |
mouse |
| Matteo Manca, Heidi G Standke, Danielle F Browne, Mikayla L Huntley, Olivia R Thomas, Christina D Orrú, Andrew G Hughson, Yongya Kim, Jing Zhang, Curtis Tatsuoka, Xiongwei Zhu, Annie Hiniker, David G Coughlin, Douglas Galasko, Allison Krau. Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases. Acta neuropathologica. 2023-05-08. PMID:37154939. |
tau seeds occur before earliest alzheimer's changes and are prevalent across neurodegenerative diseases. |
2023-05-08 |
2023-08-14 |
Not clear |
| Matteo Manca, Heidi G Standke, Danielle F Browne, Mikayla L Huntley, Olivia R Thomas, Christina D Orrú, Andrew G Hughson, Yongya Kim, Jing Zhang, Curtis Tatsuoka, Xiongwei Zhu, Annie Hiniker, David G Coughlin, Douglas Galasko, Allison Krau. Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases. Acta neuropathologica. 2023-05-08. PMID:37154939. |
furthermore, ad tau co-pathology is thought to influence features and progression of other neurodegenerative diseases including lewy body disease; yet measurements of different types of tau seeds in the setting of such diseases is an unmet need. |
2023-05-08 |
2023-08-14 |
Not clear |
| Matteo Manca, Heidi G Standke, Danielle F Browne, Mikayla L Huntley, Olivia R Thomas, Christina D Orrú, Andrew G Hughson, Yongya Kim, Jing Zhang, Curtis Tatsuoka, Xiongwei Zhu, Annie Hiniker, David G Coughlin, Douglas Galasko, Allison Krau. Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases. Acta neuropathologica. 2023-05-08. PMID:37154939. |
seed quantitation across a spectrum of neurodegenerative disease cases and controls indicated tau seeding activity can be detected well before accompanying histopathological indication of tau deposits, and even prior to the earliest evidence of alzheimer's-related tau accumulation anywhere in the brain. |
2023-05-08 |
2023-08-14 |
Not clear |
| Matteo Manca, Heidi G Standke, Danielle F Browne, Mikayla L Huntley, Olivia R Thomas, Christina D Orrú, Andrew G Hughson, Yongya Kim, Jing Zhang, Curtis Tatsuoka, Xiongwei Zhu, Annie Hiniker, David G Coughlin, Douglas Galasko, Allison Krau. Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases. Acta neuropathologica. 2023-05-08. PMID:37154939. |
this study suggests 3r/4r tau seeds are widespread even prior to the earliest stages of alzheimer's disease changes, including in normal, and even young individuals, with prevalence across multiple neurodegenerative diseases to further define disease subtypes. |
2023-05-08 |
2023-08-14 |
Not clear |