| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carlos Luis Guanín Cabrera, Arturo P Jaramillo, Maria P Vallejo, Maria G Cueva, Xavier Grandes, Mario Navarro Grijalva, Over J Hidalgo Guerrer. Navigating Prevention: A Systematic Review of Strategies for Alzheimer's Disease in High-Risk and Affected Individuals. Cureus. vol 16. issue 8. 2024-09-02. PMID:39221402. |
two key pathologies typically identify this neurodegenerative disease process: the accumulation of amyloid plaques and the formation of neurofibrillary tangles containing hyperphosphorylated tau. |
2024-09-02 |
2024-09-04 |
Not clear |
| Shuang Qi, Yuan Yuan, Wen Yang, Jing-Yang Su, Li-Ying Ha. [Calcium Dyshomeostasis and Alzheimer's Disease]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 46. issue 4. 2024-09-02. PMID:39223024. |
alzheimer's disease (ad) is a common neurodegenerative disease with the main manifestations of progressive cognitive dysfunction,behavioral disorders,and gradual decline of living ability.the etiology of ad is complex,and the pathogenesis of this disease remains controversial.calcium signaling plays an important role in regulating neuronal activities,including neurotransmitter release,synaptic plasticity,memory storage,and neuronal apoptosis.increasing studies have shown that neuronal calcium dyshomeostasis is a major pathological factor in the occurrence and development of ad.this article reviews the role and research progress in intracellular calcium dyshomeostasis in ad,including the relationship between calcium homeostasis and amyloid β,the role of calcium/calmodulin-dependent protein kinases in tau phosphorylation,calcium signaling pathways,the relationship between calcium homeostasis and mitochondrial function,autophagy,and neuroinflammation. |
2024-09-02 |
2024-09-05 |
Not clear |
| Pu Duan, Aurelio J Dregni, Hong Xu, Lakshmi Changolkar, Virginia M-Y Lee, Edward B Lee, Mei Hon. Alzheimer's Disease Seeded Tau Forms Paired Helical Filaments Yet Lacks Seeding Potential. The Journal of biological chemistry. 2024-08-30. PMID:39214304. |
alzheimer's disease (ad) and many other neurodegenerative diseases are characterized by pathological aggregation of the protein tau. |
2024-08-30 |
2024-09-04 |
Not clear |
| Ahmad M Sait, Philip J R Da. Interconnections between the Gut Microbiome and Alzheimer's Disease: Mechanisms and Therapeutic Potential. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201303. |
alzheimer's disease (ad) is a neurodegenerative disease that is known to accumulate amyloid-β (aβ) and tau protein. |
2024-08-29 |
2024-09-01 |
Not clear |
| Jonathan Benn, Shi Cheng, Sophie Keeling, Annabel E Smith, Marina J Vaysburd, Dorothea Böken, Lauren V C Miller, Taxiarchis Katsinelos, Catarina Franco, Elian Dupré, Clément Danis, Isabelle Landrieu, Luc Buée, David Klenerman, Leo C James, William A McEwa. Aggregate-selective removal of pathological tau by clustering-activated degraders. Science (New York, N.Y.). vol 385. issue 6712. 2024-08-29. PMID:39208111. |
we evaluated this approach against green fluorescent protein-tagged histone 2b (h2b-gfp) and tau, a protein that undergoes pathological aggregation in alzheimer's and other neurodegenerative diseases. |
2024-08-29 |
2024-09-04 |
Not clear |
| Clara Muñoz-Castro, Alberto Serrano-Poz. Astrocyte-Neuron Interactions in Alzheimer's Disease. Advances in neurobiology. vol 39. 2024-08-27. PMID:39190082. |
besides its two defining misfolded proteinopathies-aβ plaques and tau neurofibrillary tangles-alzheimer's disease (ad) is an exemplar of a neurodegenerative disease with prominent reactive astrogliosis, defined as the set of morphological, molecular, and functional changes that astrocytes suffer as the result of a toxic exposure. |
2024-08-27 |
2024-08-30 |
Not clear |
| Lokeswara Rao Potnuru, Austin DuBose, Mesopotamia S Nowotarski, Michael Vigers, Boqin Zhang, Chung-Ta Han, Songi Ha. Phosphoryl group wires stabilize pathological tau fibrils as revealed by multiple quantum spin counting NMR. bioRxiv : the preprint server for biology. 2024-08-26. PMID:39185239. |
hyperphosphorylation of the protein tau is one of the biomarkers of neurodegenerative diseases in the category of tauopathies. |
2024-08-26 |
2024-08-28 |
Not clear |
| Kristine Kitoka, Alons Lends, Gytis Kucinskas, Anna Lina Bula, Lukas Krasauskas, Vytautas Smirnovas, Monika Zilkova, Branislav Kovacech, Rostislav Skrabana, Jozef Hritz, Kristaps Jaudzem. dGAE(297-391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy-Like Tau Filaments. Angewandte Chemie (International ed. in English). 2024-08-26. PMID:39183704. |
the microtubule-associated protein tau forms disease-specific filamentous aggregates in several different neurodegenerative diseases. |
2024-08-26 |
2024-08-28 |
Not clear |
| Sabrina Montresor, Maria Lucia Pigazzini, Sudarson Baskaran, Mira Sleiman, Govinda Adhikari, Lukas Basilicata, Luca Secker, Natascha Jacob, Yara Ehlert, Anushree Kelkar, Gurleen Kaur Kalsi, Niraj Kulkarni, Paul Spellerberg, Janine Kirstei. HSP110 is a modulator of amyloid beta (Aβ) aggregation and proteotoxicity. Journal of neurochemistry. 2024-08-24. PMID:39180255. |
interestingly, hsp110 is vital for the hsp70/110/jdp-mediated disaggregation of amyloidogenic proteins implicated in neurodegenerative diseases (i.e., α-synuclein, htt, and tau). |
2024-08-24 |
2024-08-27 |
caenorhabditis_elegans |
| Mahaveer Singh, Haider Ali, S Renuka Jyothi, Irwanjot Kaur, Sachin Kumar, Naveen Sharma, G V Siva Prasad, Atreyi Pramanik, Waleed Hassan Almalki, Md Imra. Tau proteins and senescent Cells: Targeting aging pathways in Alzheimer's disease. Brain research. 2024-08-18. PMID:39155034. |
alzheimer's disease (ad) is a devastating neurodegenerative disease characterized by abnormal accumulation of tau proteins and amyloid-β, leading to neuronal death and cognitive impairment. |
2024-08-18 |
2024-08-21 |
Not clear |
| Hui Wang, Timothy S Chang, Beth A Dombroski, Po-Liang Cheng, Vishakha Patil, Leopoldo Valiente-Banuet, Kurt Farrell, Catriona Mclean, Laura Molina-Porcel, Alex Rajput, Peter Paul De Deyn, Nathalie Le Bastard, Marla Gearing, Laura Donker Kaat, John C Van Swieten, Elise Dopper, Bernardino F Ghetti, Kathy L Newell, Claire Troakes, Justo G de Yébenes, Alberto Rábano-Gutierrez, Tina Meller, Wolfgang H Oertel, Gesine Respondek, Maria Stamelou, Thomas Arzberger, Sigrun Roeber, Ulrich Müller, Franziska Hopfner, Pau Pastor, Alexis Brice, Alexandra Durr, Isabelle Le Ber, Thomas G Beach, Geidy E Serrano, Lili-Naz Hazrati, Irene Litvan, Rosa Rademakers, Owen A Ross, Douglas Galasko, Adam L Boxer, Bruce L Miller, Willian W Seeley, Vivanna M Van Deerlin, Edward B Lee, Charles L White, Huw Morris, Rohan de Silva, John F Crary, Alison M Goate, Jeffrey S Friedman, Yuk Yee Leung, Giovanni Coppola, Adam C Naj, Li-San Wang, Clifton Dalgard, Dennis W Dickson, Günter U Höglinger, Gerard D Schellenberg, Daniel H Geschwind, Wan-Ping Le. Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy. Molecular neurodegeneration. vol 19. issue 1. 2024-08-16. PMID:39152475. |
progressive supranuclear palsy (psp) is a rare neurodegenerative disease characterized by the accumulation of aggregated tau proteins in astrocytes, neurons, and oligodendrocytes. |
2024-08-16 |
2024-08-20 |
Not clear |
| Rosemary J Jackson, Alexandra Melloni, Dustin P Fykstra, Alberto Serrano-Pozo, Leslie Shinobu, Bradley T Hyma. Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription. Acta neuropathologica communications. vol 12. issue 1. 2024-08-14. PMID:39138580. |
progressive supranuclear palsy (psp) is a neurodegenerative disease characterized by 4r tau deposition in neurons as well as in astrocytes and oligodendrocytes. |
2024-08-14 |
2024-08-16 |
human |
| Rachel K Rowe, Philip Schulz, Ping He, Grant S Mannino, Mark R Opp, Michael R Sierk. Acute sleep deprivation in mice generates protein pathology consistent with neurodegenerative diseases. Frontiers in neuroscience. vol 18. 2024-08-08. PMID:39114483. |
key pathological features of neurodegenerative diseases include an accumulation of misfolded or misprocessed variants of amyloid beta (aβ), tau, alpha synuclein (α-syn), and tardna binding protein 43 (tdp-43). |
2024-08-08 |
2024-08-10 |
mouse |
| Xingyu Zhang, Jiangyu Wang, Zhentao Zhang, Keqiang Y. Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies. Translational neurodegeneration. vol 13. issue 1. 2024-08-07. PMID:39107835. |
tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies. |
2024-08-07 |
2024-08-09 |
Not clear |
| Xingyu Zhang, Jiangyu Wang, Zhentao Zhang, Keqiang Y. Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies. Translational neurodegeneration. vol 13. issue 1. 2024-08-07. PMID:39107835. |
the deposition of abnormal tau protein is characteristic of alzheimer's disease (ad) and a class of neurodegenerative diseases called tauopathies. |
2024-08-07 |
2024-08-09 |
Not clear |
| Shahin Ramazi, Maedeh Dadzadi, Mona Darvazi, Nasrin Seddigh, Abdollah Allahverd. Protein modification in neurodegenerative diseases. MedComm. vol 5. issue 8. 2024-08-06. PMID:39105197. |
this review elucidates the critical link between neurodegenerative diseases and specific posttranslational modifications, focusing on tau, app, α-synuclein, huntingtin protein, parkin, dj-1, and drp1. |
2024-08-06 |
2024-08-08 |
Not clear |
| Sudershana Nair, Yixiang Jiang, Isabella S Marchal, Elizabeth Chernobelsky, Huai-Wei Huang, Sarah Suh, Ruimin Pan, Xiang-Peng Kong, Hyung Don Ryoo, Einar M Sigurdsso. Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defects. Cell death & disease. vol 15. issue 7. 2024-07-30. PMID:39079958. |
tauopathies are a group of neurodegenerative diseases characterized by the presence of tau inclusions. |
2024-07-30 |
2024-08-02 |
drosophila_melanogaster |
| Samuel N Smukowski, Cassidy Danyko, Jenna Somberg, Eli J Kaufman, Meredith M Course, Nadia Postupna, Melissa Barker-Haliski, C Dirk Keene, Paul N Valdmani. mRNA and circRNA mislocalization to synapses are key features of Alzheimer's disease. PLoS genetics. vol 20. issue 7. 2024-07-29. PMID:39074152. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by accumulation of amyloid aggregates and hyperphosphorylated tau neurofibrillary tangles followed by widespread synapse loss. |
2024-07-29 |
2024-08-02 |
mouse |
| Wenqian Wang, Shan Li, Yunguo Zhu, Xianghuan Cui, Zhejin Sheng, Hongbing Wang, Zhou Chen. Antioxidant and Neuroprotective Effects of Seed Oils from Antioxidants (Basel, Switzerland). vol 13. issue 7. 2024-07-27. PMID:39061929. |
antioxidant and neuroprotective effects of seed oils from excess reactive oxygen species (ros) can accelerate amyloid β (aβ) aggregation and tau protein hyperphosphorylation in neuron cells, which further leads to neurodegenerative diseases such as alzheimer's disease (ad). |
2024-07-27 |
2024-07-29 |
Not clear |
| Joachim Strobel, Elham Yousefzadeh-Nowshahr, Katharina Deininger, Karl Peter Bohn, Christine A F von Arnim, Markus Otto, Christoph Solbach, Sarah Anderl-Straub, Dörte Polivka, Patrick Fissler, Gerhard Glatting, Matthias W Riepe, Makoto Higuchi, Ambros J Beer, Albert Ludolph, Gordon Winte. Exploratory Tau PET/CT with [11C]PBB3 in Patients with Suspected Alzheimer's Disease and Frontotemporal Lobar Degeneration: A Pilot Study on Correlation with PET Imaging and Cerebrospinal Fluid Biomarkers. Biomedicines. vol 12. issue 7. 2024-07-27. PMID:39062033. |
here, we show that [11c]pbb3 pet/ct imaging can reveal distinct tau accumulation patterns and correlate these with cognitive impairment in neurodegenerative diseases. |
2024-07-27 |
2024-07-29 |
Not clear |