| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Megumi Asada-Utsugi, Makoto Urushitan. Tau beyond Tangles: DNA Damage Response and Cytoskeletal Protein Crosstalk on Neurodegeneration. International journal of molecular sciences. vol 25. issue 14. 2024-07-27. PMID:39063148. |
our research has centered on the microtubule-associated protein tau (mapt), a crucial pathological protein implicated in neurodegenerative diseases, and its interplay with neurons' dna damage response (ddr). |
2024-07-27 |
2024-07-29 |
Not clear |
| Manish Kumar Singh, Tae Hoon Ryu, Minh Nguyet Nguyen, Kweon Y. Inhibition of high-fat diet-induced miRNA ameliorates tau toxicity in Drosophila. Biochemical and biophysical research communications. vol 733. 2024-07-27. PMID:39067249. |
alzheimer's disease (ad), caused by amyloid beta (aβ) plaques and tau tangles, is a neurodegenerative disease characterized by progressive memory impairment and cognitive dysfunction. |
2024-07-27 |
2024-08-02 |
drosophila_melanogaster |
| Hannah Scheiblich, Frederik Eikens, Lena Wischhof, Sabine Opitz, Kay Jüngling, Csaba Cserép, Susanne V Schmidt, Jessica Lambertz, Tracy Bellande, Balázs Pósfai, Charlotte Geck, Jasper Spitzer, Alexandru Odainic, Sergio Castro-Gomez, Stephanie Schwartz, Ibrahim Boussaad, Rejko Krüger, Enrico Glaab, Donato A Di Monte, Daniele Bano, Ádám Dénes, Eike Latz, Ronald Melki, Hans-Christian Pape, Michael T Henek. Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes. Neuron. 2024-07-26. PMID:39059388. |
in neurodegenerative diseases like parkinson's and alzheimer's disease, toxic aggregates of alpha-synuclein (α-syn) and tau accumulate within neurons. |
2024-07-26 |
2024-07-29 |
Not clear |
| Yoshiyuki Soeda, Emi Hayashi, Naoko Nakatani, Shinsuke Ishigaki, Yuta Takaichi, Taro Tachibana, Yuichi Riku, James K Chambers, Riki Koike, Moniruzzaman Mohammad, Akihiko Takashim. A novel monoclonal antibody generated by immunization with granular tau oligomers binds to tau aggregates at 423-430 amino acid sequence. Scientific reports. vol 14. issue 1. 2024-07-26. PMID:39060263. |
prior to the formation of amyloid fibrils, the pathological hallmark in tau-related neurodegenerative disease, tau monomers aggregate into a diverse range of oligomers. |
2024-07-26 |
2024-07-29 |
mouse |
| Lei Xia, Junjie Li, Yayan Pang, Mingliang Xu, Yehong Du, Mulan Chen, Boqing Xu, Yiqiong Qiu, Zhifang Don. Dihydroartemisinin promotes tau O-GlcNAcylation and improves cognitive function in hTau transgenic mice. Progress in neuro-psychopharmacology & biological psychiatry. 2024-07-25. PMID:39053763. |
tauopathy is a collective term for several neurodegenerative diseases characterized by the intracellular accumulation of hyperphosphorylated microtubule-associated protein tau (p-tau). |
2024-07-25 |
2024-07-28 |
mouse |
| Ankit Kolay, Neelam Singh, Puneet Gupta, Ayaz Mukarram Shaikh, Radha Goel, Dheeraj Nagpal, Havagiray Chitm. Immunotherapies: A Treasure Trove of Alzheimer's Disease. Current pharmaceutical biotechnology. 2024-07-23. PMID:39039684. |
alzheimer's disease (ad) is a progressive neurodegenerative disease that falls under the umbrella of dementia and is characterized by the presence of enormously neurotoxic amyloid-beta (aβ) plaques and neurofibrillary tangles (nfts) of tau protein inside the brain. |
2024-07-23 |
2024-07-25 |
Not clear |
| Yoshiyuki Soeda, Hideaki Yoshimura, Hiroko Bannai, Riki Koike, Isshin Shiiba, Akihiko Takashim. Intracellular tau fragment droplets serve as seeds for tau fibrils. Structure (London, England : 1993). 2024-07-20. PMID:39032487. |
these results suggest that tau droplet formation and n-terminal cleavage are necessary for neurofibrillary tangles formation in neurodegenerative diseases. |
2024-07-20 |
2024-07-24 |
Not clear |
| Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmal. Tau protein profiling in tauopathies: a human brain study. Molecular neurodegeneration. vol 19. issue 1. 2024-07-19. PMID:39026372. |
abnormal accumulation of misfolded and hyperphosphorylated tau protein in brain is the defining feature of several neurodegenerative diseases called tauopathies, including alzheimer's disease (ad). |
2024-07-19 |
2024-07-21 |
human |
| Celeste Parra Bravo, Sarah A Naguib, Li Ga. Cellular and pathological functions of tau. Nature reviews. Molecular cell biology. 2024-07-16. PMID:39014245. |
tauopathies are neurodegenerative diseases marked by the abnormal accumulation of tau protein aggregates in neurons, as seen, for example, in conditions such as frontotemporal dementia and alzheimer disease. |
2024-07-16 |
2024-07-19 |
human |
| Celeste Parra Bravo, Sarah A Naguib, Li Ga. Cellular and pathological functions of tau. Nature reviews. Molecular cell biology. 2024-07-16. PMID:39014245. |
pathological tau is strongly implicated in the progression of neurodegenerative diseases, and the propagation of tau aggregates is associated with disease severity. |
2024-07-16 |
2024-07-19 |
human |
| Jiechao Zhou, Yang 'an Chuang, Javier Redding-Ochoa, Rongzhen Zhang, Alexander J Platero, Alexander H Barrett, Juan C Troncoso, Paul F Worley, Wenchi Zhan. The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation. Nature cell biology. 2024-07-15. PMID:39009640. |
multiple neurodegenerative diseases are characterized by aberrant proteinaceous accumulations of tau. |
2024-07-15 |
2024-07-18 |
mouse |
| Harman Sharma, Sushma Koirala, Yee Lian Chew, Anna Konopk. DNA Damage and Chromatin Rearrangement Work Together to Promote Neurodegeneration. Molecular neurobiology. 2024-07-08. PMID:38977621. |
this review focused on hallmark proteins involved in various neurodegenerative diseases, such as the microtubule-associated protein tau, tar dna/rna binding protein 43 (tdp-43), superoxide dismutase 1 (sod1), fused in sarcoma (fus), huntingtin (htt), α-synuclein, and β-amyloid precursor protein (app). |
2024-07-08 |
2024-07-12 |
Not clear |
| Yiyang Zhu, Wade K Self, David M Holtzma. An emerging role for the gut microbiome in tauopathy. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-07-04. PMID:38964948. |
tauopathies constitute a group of neurodegenerative diseases characterized by abnormal aggregation of the protein tau, progressive neuronal and synaptic loss, and eventual cognitive and motor impairment. |
2024-07-04 |
2024-07-11 |
human |
| Subashchandrabose Chinnathambi, Smita Eknath Desal. The crosstalk between extracellular matrix proteins and Tau. Advances in protein chemistry and structural biology. vol 141. 2024-07-03. PMID:38960482. |
alzheimer's disease is progressive neurodegenerative disease characterize by the presence of extracellular accumulation of amyloid-β plaques and intracellular deposits of neurofibrillary tangles of tau. |
2024-07-03 |
2024-07-10 |
Not clear |
| Jens Sobek, Junhao Li, Benjamin F Combes, Juan A Gerez, Martin T Henrich, Fanni F Geibl, Peter R Nilsson, Kuangyu Shi, Axel Rominger, Wolfgang H Oertel, Roger M Nitsch, Agneta Nordberg, Hans Ågren, Ruiqing N. Efficient characterization of multiple binding sites of small molecule imaging ligands on amyloid-beta, tau and alpha-synuclein. European journal of nuclear medicine and molecular imaging. 2024-07-02. PMID:38953933. |
there is an unmet need for compounds to detect fibrillar forms of alpha-synuclein (αsyn) and 4-repeat tau, which are critical in many neurodegenerative diseases. |
2024-07-02 |
2024-07-06 |
Not clear |
| Jing-Fen Su, Yue Xiao, Lin-Yu Wei, Hui-Yang Lei, Fei Sun, Wei-Xia Wang, Shi-Hong Li, Xiao-Chuan Wang, Jie Zheng, Jian-Zhi Wan. A new tau dephosphorylation-targeting chimera for the treatment of tauopathies. Acta pharmacologica Sinica. 2024-07-02. PMID:38956416. |
abnormal accumulation of hyperphosphorylated tau protein plays a pivotal role in a collection of neurodegenerative diseases named tauopathies, including alzheimer's disease (ad). |
2024-07-02 |
2024-07-06 |
mouse |
| Jiakai Yang, Weijia Zhi, Lifeng Wan. Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review. Molecules (Basel, Switzerland). vol 29. issue 12. 2024-06-27. PMID:38930877. |
role of tau protein in neurodegenerative diseases and development of its targeted drugs: a literature review. |
2024-06-27 |
2024-06-29 |
Not clear |
| Jiakai Yang, Weijia Zhi, Lifeng Wan. Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review. Molecules (Basel, Switzerland). vol 29. issue 12. 2024-06-27. PMID:38930877. |
tau protein aggregates abnormally and forms neurofibrillary tangles in neurodegenerative diseases, disrupting the structure and function of neurons and leading to neuronal death, which triggers the initiation and progression of neurological disorders. |
2024-06-27 |
2024-06-29 |
Not clear |
| Jiakai Yang, Weijia Zhi, Lifeng Wan. Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review. Molecules (Basel, Switzerland). vol 29. issue 12. 2024-06-27. PMID:38930877. |
the aggregation of tau protein in neurodegenerative diseases is associated with post-translational modifications, which may affect the hydrophilicity, spatial conformation, and stability of tau protein, promoting tau protein aggregation and the formation of neurofibrillary tangles. |
2024-06-27 |
2024-06-29 |
Not clear |
| Jiakai Yang, Weijia Zhi, Lifeng Wan. Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review. Molecules (Basel, Switzerland). vol 29. issue 12. 2024-06-27. PMID:38930877. |
therefore, studying the role of tau protein in neurodegenerative diseases and the mechanism of aberrant aggregation is important for understanding the mechanism of neurodegenerative diseases and finding therapeutic approaches. |
2024-06-27 |
2024-06-29 |
Not clear |