| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masumi Sugiyama, Kenneth S Kosik, Eleni Panagioto. Mathematical topology and geometry-based classification of tauopathies. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555402. |
while it is known that different morphologies of tau filaments characterize different neurodegenerative diseases, there are few metrics of global and local structure complexity that enable to quantify their structural diversity rigorously. |
2024-03-30 |
2024-04-02 |
Not clear |
| Masumi Sugiyama, Kenneth S Kosik, Eleni Panagioto. Mathematical topology and geometry-based classification of tauopathies. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555402. |
in this manuscript, we employ for the first time mathematical topology and geometry to classify neurodegenerative diseases by using cryo-electron microscopy structures of tau filaments that are available in the protein data bank. |
2024-03-30 |
2024-04-02 |
Not clear |
| Takuya Oshima, Mandy S J Kater, Christiaan F M Huffels, Evelyn M Wesseling, Jinte Middeldorp, Elly M Hol, Mark H G Verheijen, August B Smit, Erik W G M Boddeke, Bart J L Egge. Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice. Journal of neuroscience research. vol 102. issue 3. 2024-03-22. PMID:38515329. |
alzheimer's disease (ad) is a progressive neurodegenerative disease and the most common cause of dementia, characterized by deposition of extracellular amyloid-beta (aβ) aggregates and intraneuronal hyperphosphorylated tau. |
2024-03-22 |
2024-03-24 |
mouse |
| Tabassum Khair Barbhuiya, Dulari K Jayarathna, Raechelle Gilmour, Caroline Smet-Nocca, Neha S Gandh. Characterization of Posttranslationally Modified PHF-1 Tau Peptides Using Gaussian Accelerated Molecular Dynamics Simulation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512658. |
the microtubule-associated protein, tau, is an intrinsically disordered protein that plays a crucial role in neurodegenerative diseases like alzheimer's disease. |
2024-03-21 |
2024-03-24 |
Not clear |
| Yanyan Zhao, Anna Mikes, Gergely Tóth, Franklin Aigbirhi. Detection of Small-Molecule Interactions with Fibrillar Tau Protein Aggregates Using Microscale Thermophoresis. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512669. |
aggregated fibrillar tau protein is a pathological hallmark of several neurodegenerative diseases. |
2024-03-21 |
2024-03-24 |
Not clear |
| Yanxian Li. Preparation of Tau Condensates by Liquid-Liquid Phase Separation to Study Tau Amyloid Aggregation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512667. |
amyloid aggregation of tau is a hallmark of alzheimer's disease and other neurodegenerative diseases. |
2024-03-21 |
2024-03-24 |
Not clear |
| Parissa Fereydouni-Forouzandeh, Geoffrey Canet, Sofia Diego-Diàz, Emma Rocaboy, Serena Petry, Robert A Whittington, Emmanuel Plane. Western Blot of Tau Protein from Mouse Brains Extracts: How to Avoid Signal Artifacts. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512673. |
in alzheimer's disease and other neurodegenerative diseases known as tauopathies, tau undergoes several abnormal post-translational modifications including hyperphosphorylation, conformational changes, oligomerization, and aggregation. |
2024-03-21 |
2024-03-24 |
mouse |
| Léa El Hajjar, Clarisse Bridot, Marine Nguyen, François-Xavier Cantrelle, Isabelle Landrieu, Caroline Smet-Nocc. Phosphorylation of Tau Protein by CDK2/cyclin A and GSK3β Recombinant Kinases: Analysis of Phosphorylation Patterns by Nuclear Magnetic Resonance Spectroscopy. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512672. |
under its aggregated form, tau is a hallmark of alzheimer's disease and other neurodegenerative diseases named tauopathies involving tau dysfunction and/or mutations. |
2024-03-21 |
2024-03-24 |
Not clear |
| Geoffrey Canet, Emma Rocaboy, Sofia Diego-Diàz, Robert A Whittington, Carl Julien, Emmanuel Plane. Methods for Biochemical Isolation of Insoluble Tau in Rodent Models of Tauopathies. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512674. |
the intracellular accumulation of microtubule-associated protein tau is a characteristic feature of tauopathies, a group of neurodegenerative diseases including alzheimer's disease. |
2024-03-21 |
2024-03-24 |
mouse |
| Kristen E Fun. Measuring Antibody-Mediated Tau Fibril Uptake in Microglia by Flow Cytometry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512680. |
microtubule-associated protein tau is an intracellular protein that self-aggregates into neurofibrillary tangles in alzheimer's disease and many other neurodegenerative diseases. |
2024-03-21 |
2024-03-24 |
Not clear |
| Sarah Buchholz, Michael Bell-Simons, Cagla Cakmak, Jennifer Klimek, Li Gan, Hans Zempe. Cultivation, Differentiation, and Lentiviral Transduction of Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Glutamatergic Neurons for Studying Human Tau. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512688. |
tau pathology is a major hallmark of many neurodegenerative diseases summarized under the term tauopathies. |
2024-03-21 |
2024-03-24 |
human |
| Felix Langerscheidt, Michael Bell-Simons, Hans Zempe. Differentiating SH-SY5Y Cells into Polarized Human Neurons for Studying Endogenous and Exogenous Tau Trafficking: Four Protocols to Obtain Neurons with Noradrenergic, Dopaminergic, and Cholinergic Properties. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512687. |
pathological alterations of the neuronal tau protein are characteristic for many neurodegenerative diseases, called tauopathies. |
2024-03-21 |
2024-03-24 |
human |
| Fangjia Yang, Paula Beltran-Lobo, Katherine Sung, Caoimhe Goldrick, Cara L Croft, Agnes Nishimura, Erin Hedges, Farah Mahiddine, Claire Troakes, Todd E Golde, Beatriz G Perez-Nievas, Diane P Hanger, Wendy Noble, Maria Jimenez-Sanche. Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection. Science advances. vol 10. issue 12. 2024-03-20. PMID:38507480. |
molecular chaperones are protective in neurodegenerative diseases by preventing protein misfolding and aggregation, such as extracellular amyloid plaques and intracellular tau neurofibrillary tangles in alzheimer's disease (ad). |
2024-03-20 |
2024-03-23 |
human |
| Yongna Yuan, Xuqi Mao, Xiaohang Pan, Ruisheng Zhang, Wei S. Kinetic Ensemble of Tau Protein through the Markov State Model and Deep Learning Analysis. Journal of chemical theory and computation. 2024-03-19. PMID:38501645. |
the ordered assembly of tau protein into filaments characterizes alzheimer's and other neurodegenerative diseases, and thus, stabilization of tau protein is a promising avenue for tauopathies therapy. |
2024-03-19 |
2024-03-21 |
Not clear |
| Zerui Wang, Ling Wu, Maria Gerasimenko, Tricia Gilliland, Steven A Gunzler, Vincenzo Donadio, Rocco Liguori, Bin Xu, Wen-Quan Zo. Seeding Activity of Skin Misfolded Tau as a Biomarker for Tauopathies. Research square. 2024-03-18. PMID:38496453. |
background tauopathies are a group of age-related neurodegenerative diseases characterized by the accumulation of pathologically phosphorylated tau protein in the brain, leading to prion-like propagation and aggregation. |
2024-03-18 |
2024-03-20 |
Not clear |
| Goonho Park, Angela Galdamez, Keon-Hyoung Song, Masako Le, Kyle Kim, Jonathan H Li. Ethnic variation and structure-function analysis of tauopathy-associated medRxiv : the preprint server for health sciences. 2024-03-18. PMID:38496636. |
in addition to its central position in intracellular stress regulation, human gwas identify eif2ak3 as a risk factor in tauopathies, neurodegenerative diseases caused by aberrant tau protein accumulation. |
2024-03-18 |
2024-03-20 |
human |
| Zhentao Zhan. Q&A with Zhentao Zhang. Cell reports. vol 43. issue 3. 2024-03-14. PMID:38483901. |
in this interview with zhentao zhang, we discuss his research focusing on the molecular mechanisms underlying the aggregation of prion-like proteins in neurodegenerative diseases and spotlight his recent work in cell reports that shows that a yeast prion protein interacts with tau and facilitates its aggregation. |
2024-03-14 |
2024-03-17 |
Not clear |
| Hong Xu, Qi Qiu, Peng Hu, Kevt'her Hoxha, Elliot Jang, Mia O'Reilly, Christopher Kim, Zhuohao He, Nicholas Marotta, Lakshmi Changolkar, Bin Zhang, Hao Wu, Gerard D Schellenberg, Brian Kraemer, Kelvin C Luk, Edward B Lee, John Q Trojanowski, Kurt R Brunden, Virginia M-Y Le. MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons. Acta neuropathologica. vol 147. issue 1. 2024-03-13. PMID:38472475. |
inclusions comprised of microtubule-associated protein tau (tau) are implicated in a group of neurodegenerative diseases, collectively known as tauopathies, that include alzheimer's disease (ad). |
2024-03-13 |
2024-03-15 |
mouse |
| Marina Han, Aleen Saxton, Heather Currey, Sarah M Waldherr, Nicole F Liachko, Brian C Kraeme. Transgenic Dendra2::tau expression allows in vivo monitoring of tau proteostasis in C. elegans. Disease models & mechanisms. 2024-03-12. PMID:38469687. |
protein homeostasis is perturbed in aging-related neurodegenerative diseases called tauopathies, which are pathologically characterized by aggregation of the microtubule-associated protein tau. |
2024-03-12 |
2024-03-14 |
caenorhabditis_elegans |
| Suzuko Ochi, Kumiko Yamada, Takashi Saito, Takaomi C Saido, Mitsuo Iinuma, Kagaku Azuma, Kin-Ya Kub. Effects of early tooth loss on chronic stress and progression of neuropathogenesis of Alzheimer's disease in adult Alzheimer's model Frontiers in aging neuroscience. vol 16. 2024-03-12. PMID:38469162. |
effects of early tooth loss on chronic stress and progression of neuropathogenesis of alzheimer's disease in adult alzheimer's model alzheimer's disease (ad), the most common neurodegenerative disease, is characterized by accumulated amyloid-β (aβ) plaques, aggregated phosphorylated tau protein, gliosis-associated neuroinflammation, synaptic dysfunction, and cognitive impairment. |
2024-03-12 |
2024-03-14 |
Not clear |