| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruihua Liu, Linli Guo, Yanan Zhao, Dan Wu, Jiasi Yu, Ping Li. Study on multi-target effects of the novel HDAC6 inhibitor W5 on Aβ/Cu Brain research. 2024-03-05. PMID:38442843. |
study on multi-target effects of the novel hdac6 inhibitor w5 on aβ/cu histone deacetylase 6 (hdac6) is a key therapeutic target in neurodegenerative diseases such as alzheimer's disease (ad), which has been demonstrated to play an essential role in memory function and microtubule-associated tau physiology. |
2024-03-05 |
2024-03-08 |
rat |
| Shengyuan Wang, Bengang Chen, Minghao Yuan, Shu Liu, Haixia Fan, Xu Yang, Qian Zou, Yinshuang Pu, Zhiyou Ca. Enriched oxygen improves age-related cognitive impairment through enhancing autophagy. Frontiers in aging neuroscience. vol 16. 2024-03-04. PMID:38435399. |
moreover, the hyperphosphorylation of tau, a hallmark of many neurodegenerative diseases, was significantly reduced in the hbo-treated group, both |
2024-03-04 |
2024-03-06 |
mouse |
| Nadia El Mammeri, Aurelio J Dregni, Pu Duan, Mei Hon. Structures of AT8 and PHF1 phosphomimetic tau: Insights into the posttranslational modification code of tau aggregation. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 10. 2024-02-28. PMID:38408247. |
the microtubule-associated protein tau aggregates into amyloid fibrils in alzheimer's disease and other neurodegenerative diseases. |
2024-02-28 |
2024-03-01 |
Not clear |
| Abigail Alexander, Victor E Alvarez, Bertrand R Huber, Michael L Alosco, Jesse Mez, Yorghos Tripodis, Raymond Nicks, Douglas I Katz, Brigid Dwyer, Daniel H Daneshvar, Brett Martin, Joseph Palmisano, Lee E Goldstein, John F Crary, Christopher Nowinski, Robert C Cantu, Neil W Kowall, Robert A Stern, Ivana Delalle, Ann C McKee, Thor D Stei. Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE. Acta neuropathologica. vol 147. issue 1. 2024-02-26. PMID:38407651. |
chronic traumatic encephalopathy (cte) is a neurodegenerative disease caused by repetitive head impacts (rhi) and pathologically defined as neuronal phosphorylated tau aggregates around small blood vessels and concentrated at sulcal depths. |
2024-02-26 |
2024-02-28 |
human |
| Bo-Yu Kuang, Yu-Chen Zhu, Jin-Ping Liang, Shi-Feng Chu, Nai-Hong Chen, Yan-Tao Yan. [Exosome and prevention of Alzheimer's disease: based on theory of kidney storing essence]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 1. 2024-02-25. PMID:38403338. |
alzheimer's disease(ad) is one of the common neurodegenerative diseases, with the main pathological features of aβ deposition and tau phosphorylation, which activate neurotoxic reactions and eventually lead to neuronal dysfunction and cell death, severely impairing the patient's cognitive and memory functions. |
2024-02-25 |
2024-02-28 |
human |
| Ling-Ling Jiao, Hui-Lin Dong, Meng-Meng Liu, Peng-Lin Wu, Yi Cao, Yuan Zhang, Fu-Gao Gao, Huai-Yuan Zh. The potential roles of salivary biomarkers in neurodegenerative diseases. Neurobiology of disease. 2024-02-21. PMID:38382884. |
based on the available research, β-amyloid, tau protein, α-synuclein, dj-1, huntington protein in saliva profiles display reliability and validity as the biomarkers of neurodegenerative diseases. |
2024-02-21 |
2024-02-24 |
Not clear |
| Wentao Zhu, Wenqian Zhang, Jian Chen, Yichen Tong, Fang Xu, Jiyan Pan. Discovery of Effective Dual PROTAC Degraders for Neurodegenerative Disease-Associated Aggregates. Journal of medicinal chemistry. 2024-02-15. PMID:38356330. |
the aggregation of specific proteins is a histopathological hallmark in various neurodegenerative diseases (nds), among which alpha-synuclein (α-syn) and tau have received increased attention. |
2024-02-15 |
2024-02-17 |
Not clear |
| Gerard Ross. Novel Pyrrolo-pyrazol-one Ligands of Alpha-Synuclein for Diagnosis of Parkinson's Disease. ACS medicinal chemistry letters. vol 15. issue 2. 2024-02-14. PMID:38352848. |
many neurodegenerative diseases are characterized by cellular deposits such as abeta, tau, alpha-synuclein, and huntingtin. |
2024-02-14 |
2024-02-16 |
human |
| Ying-Chieh Wu, Tizibt Ashine Bogale, Jari Koistinaho, Marina Pizzi, Taisia Rolova, Arianna Bellucc. The contribution of β-amyloid, Tau and α-synuclein to blood-brain barrier damage in neurodegenerative disorders. Acta neuropathologica. vol 147. issue 1. 2024-02-12. PMID:38347288. |
central nervous system (cns) accumulation of fibrillary deposits made of amyloid β (aβ), hyperphosphorylated tau or α-synuclein (α-syn), present either alone or in the form of mixed pathology, characterizes the most common neurodegenerative diseases (ndds) as well as the aging brain. |
2024-02-12 |
2024-02-15 |
Not clear |
| Lukasz Joachimiak, Sofia Bali, Ruhar Singh, Pawel Wydorski, Aleksandra Wosztyl, Valerie Perez, Dailu Chen, Josep Riz. Ensemble-based design of tau to inhibit aggregation while preserving biological activity. Research square. 2024-02-05. PMID:38313287. |
the microtubule-associated protein tau is implicated in neurodegenerative diseases characterized by amyloid formation. |
2024-02-05 |
2024-02-07 |
Not clear |
| Michael L Alosco, Micaela White, Carter Bell, Farwa Faheem, Yorghos Tripodis, Eukyung Yhang, Zachary Baucom, Brett Martin, Joseph Palmisano, Kristen Dams-O'Connor, John F Crary, Lee E Goldstein, Douglas I Katz, Brigid Dwyer, Daniel H Daneshvar, Christopher Nowinski, Robert C Cantu, Neil W Kowall, Robert A Stern, Victor E Alvarez, Bertrand Russell Huber, Thor D Stein, Ann C McKee, Jesse Me. Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy. Molecular neurodegeneration. vol 19. issue 1. 2024-02-05. PMID:38317248. |
chronic traumatic encephalopathy (cte) is a neurodegenerative disease characterized by hyperphosphorylated tau (p-tau) accumulation. |
2024-02-05 |
2024-02-09 |
Not clear |
| Carolina Lucía Facal, Iván Fernández Bessone, Javier Andrés Muñiz, A Ezequiel Pereyra, Olivia Pedroncini, Indiana Páez-Paz, Ramiro Clerici-Delville, Cayetana Arnaiz, Leandro Urrutia, Germán Falasco, Carla Verónica Argañaraz, Trinidad Saez, Antonia Marin-Burgin, Mariano Soiza-Reilly, Tomás Falzone, María Elena Aval. Tau reduction with artificial microRNAs modulates neuronal physiology and improves tauopathy phenotypes in mice. Molecular therapy : the journal of the American Society of Gene Therapy. 2024-02-04. PMID:38310353. |
abnormal tau accumulation is the hallmark of several neurodegenerative diseases, named tauopathies. |
2024-02-04 |
2024-02-06 |
mouse |
| Maria do Socorro do Nascimento Amorim, Álefe Roger Silva França, Ralph Santos-Oliveira, Jonas Rodrigues Sanches, Thamys Marinho Melo, Bruno Araújo Serra Pinto, Leandro R S Barbosa, Luciana Magalhães Rebelo Alenca. Atomic Force Microscopy Applied to the Study of Tauopathies. ACS chemical neuroscience. 2024-02-02. PMID:38305187. |
tauopathies are neurodegenerative diseases featured by aggregation of phosphorylated tau protein inside neurons, leading to functional loss and progressive neurotoxicity. |
2024-02-02 |
2024-02-04 |
Not clear |
| Kathrin Wenger, Arthur Viode, Mukesh Kumar, Hanno Steen, Judith A Stee. Quantitative profiling of posttranslational modifications of pathological tau via sarkosyl fractionation and mass spectrometry. Nature protocols. 2024-01-30. PMID:38291250. |
it also enables the detailed molecular comparison of tau across multiple experiments, including a comparison between neurodegenerative diseases, stages of the disease, human patient heterogeneity and characterization of animal models. |
2024-01-30 |
2024-02-02 |
human |
| Courtney Lane-Donovan, Adam L Boxe. Disentangling tau: One protein, many therapeutic approaches. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-01-26. PMID:38278659. |
the tauopathies encompass over 20 adult neurodegenerative diseases and are characterized by the dysfunction and accumulation of insoluble tau protein. |
2024-01-26 |
2024-01-29 |
Not clear |
| Eduardo Pena, Rocio San Martin-Salamanca, Samia El Alam, Karen Flores, Karem Arriaz. Tau Protein Alterations Induced by Hypobaric Hypoxia Exposure. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255962. |
tauopathies are a group of neurodegenerative diseases whose central feature is dysfunction of the microtubule-associated protein tau (mapt). |
2024-01-23 |
2024-01-25 |
Not clear |
| Kacper Nijakowski, Wojciech Owecki, Jakub Jankowski, Anna Surdack. Salivary Biomarkers for Alzheimer's Disease: A Systematic Review with Meta-Analysis. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38256241. |
in conclusion, potential markers such as beta-amyloid42, tau and lactoferrin can be detected in the saliva of ad patients, which could reliably support the early diagnosis of this neurodegenerative disease. |
2024-01-23 |
2024-01-25 |
Not clear |
| Ling Wu, Stephanie Arvai, Shih-Hsiu J Wang, Andy J Liu, Bin X. Differential diagnosis of mild cognitive impairment of Alzheimer's disease by Simoa p-tau181 measurements with matching plasma and CSF. Frontiers in molecular neuroscience. vol 16. 2024-01-23. PMID:38260807. |
misfolded phosphorylated tau aggregates (p-tau) are present in multiple neurodegenerative diseases known as "tauopathies", with the most common being ad. |
2024-01-23 |
2024-01-25 |
human |
| Hui Wang, Timothy S Chang, Beth A Dombroski, Po-Liang Cheng, Vishakha Patil, Leopoldo Valiente-Banuet, Kurt Farrell, Catriona Mclean, Laura Molina-Porcel, Alex Rajput, Peter Paul De Deyn, Nathalie Le Bastard, Marla Gearing, Laura Donker Kaat, John C Van Swieten, Elise Dopper, Bernardino F Ghetti, Kathy L Newell, Claire Troakes, Justo G de Yébenes, Alberto Rábano-Gutierrez, Tina Meller, Wolfgang H Oertel, Gesine Respondek, Thomas Arzberger, Sigrun Roeber, Pau Pastor, Alexis Brice, Alexandra Durr, Isabelle Le Ber, Thomas G Beach, Geidy E Serrano, Lili-Naz Hazrati, Irene Litvan, Rosa Rademakers, Owen A Ross, Douglas Galasko, Adam L Boxer, Bruce L Miller, Willian W Seeley, Vivanna M Van Deerlin, Charles L White, Huw Morris, Rohan de Silva, John F Crary, Alison M Goate, Jeffrey S Friedman, Yuk Yee Leung, Giovanni Coppola, Adam C Naj, Li-San Wang, Dennis W Dickson, Günter U Höglinger, Gerard D Schellenberg, Daniel H Geschwind, Wan-Ping Le. Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy. medRxiv : the preprint server for health sciences. 2024-01-18. PMID:38234807. |
progressive supranuclear palsy (psp) is a neurodegenerative disease characterized by the accumulation of aggregated tau proteins in astrocytes, neurons, and oligodendrocytes. |
2024-01-18 |
2024-01-20 |
human |
| Brianne B Rogers, Ashlyn G Anderson, Shelby N Lauzon, M Natalie Davis, Rebecca M Hauser, Sydney C Roberts, Ivan Rodriguez-Nunez, Katie Trausch-Lowther, Erin A Barinaga, Paige I Hall, Matthew T Knuesel, Jared W Taylor, Mark Mackiewicz, Brian S Roberts, Sara J Cooper, Lindsay F Rizzardi, Richard M Myers, J Nicholas Cochra. Neuronal MAPT expression is mediated by long-range interactions with cis-regulatory elements. American journal of human genetics. 2024-01-17. PMID:38232730. |
tauopathies are a group of neurodegenerative diseases defined by abnormal aggregates of tau, a microtubule-associated protein encoded by mapt. |
2024-01-17 |
2024-01-20 |
human |