| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiaxin Hu, Wenchi Sha, Shuangshuang Yuan, Jiarui Wu, Yunpeng Huan. Aggregation, Transmission, and Toxicity of the Microtubule-Associated Protein Tau: A Complex Comprehension. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37834471. |
tau protein aggregates can be found in a number of devastating neurodegenerative diseases known as "tauopathies", such as alzheimer's disease (ad), frontotemporal dementia (ftd), corticobasal degeneration (cbd), etc. |
2023-10-14 |
2023-10-15 |
Not clear |
| Syed Jawad Ali Shah, Qianqian Zhang, Jingjing Guo, Hongli Liu, Huanxiang Liu, Jordi Villà-Freix. Identification of Aggregation Mechanism of Acetylated PHF6* and PHF6 Tau Peptides Based on Molecular Dynamics Simulations and Markov State Modeling. ACS chemical neuroscience. 2023-10-13. PMID:37830541. |
however, tau's dysfunction and accumulation in the human brain can lead to several neurodegenerative diseases, such as alzheimer's disease, down's syndrome, and frontotemporal dementia. |
2023-10-13 |
2023-10-15 |
human |
| Delsuz Rezaee, Fatemeh Saadatpour, Nayyereh Akbari, Anahita Zoghi, Sajad Najafi, Parisa Beiranvand, Fahimeh Zamani-Rarani, Mohammad Amin Rashidi, Saeid Bagheri-Mohammadi, Mohammad Bakhtiar. The role of microRNAs in the pathophysiology of human central nervous system: A focus on neurodegenerative diseases. Ageing research reviews. 2023-10-13. PMID:37832609. |
they are particularly known to affect the amyloid β (aβ) cleavage and accumulation, tau protein homeostasis, and expression of alpha-synuclein (α-syn), parkin, pink1, and brain-derived neurotrophic factor (bdnf) that play pivotal roles in the pathogenesis of neurodegenerative diseases. |
2023-10-13 |
2023-10-15 |
human |
| Benjamin C Creekmore, Ryohei Watanabe, Edward B Le. Neurodegenerative Disease Tauopathies. Annual review of pathology. 2023-10-13. PMID:37832941. |
tauopathies are a diverse group of progressive and fatal neurodegenerative diseases characterized by aberrant tau inclusions in the central nervous system. |
2023-10-13 |
2023-10-15 |
Not clear |
| Kyu Won Oh, Dong-Kyu Kim, Ao-Lin Hsu, Seung-Jae Le. Distinct sets of lysosomal genes define synucleinopathy and tauopathy. BMB reports. 2023-10-11. PMID:37817435. |
neurodegenerative diseases are characterized by distinct protein aggregates, such as those of α-synuclein and tau. |
2023-10-11 |
2023-10-15 |
caenorhabditis_elegans |
| Alejandra Del Carmen Alonso, Abdeslem El Idrissi, Robert Candia, Viktoriya Morozova, Frida Esther Kleima. Tau: More than a microtubule-binding protein in neurons. Cytoskeleton (Hoboken, N.J.). 2023-10-11. PMID:37819542. |
even with tau's rise to stardom as a central player in neurodegenerative disease, therapeutic efforts have largely been targeted toward cytoskeletal changes. |
2023-10-11 |
2023-10-15 |
Not clear |
| Oscar B Akide Ndunge, Henry J Shikani, Minxian Dai, Brandi D Freeman, Mahalia S Desruisseau. Effects of anti-tau immunotherapy on reactive microgliosis, cerebral endotheliopathy, and cognitive function in an experimental model of cerebral malaria. Journal of neurochemistry. 2023-10-10. PMID:37814468. |
abnormal regulation of tau, an axonal protein pathologically associated with the formation of neurofibrillary lesions in neurodegenerative diseases, has been linked to inflammation and cerebral microvascular compromise and has been reported in human and experimental cm (ecm). |
2023-10-10 |
2023-10-15 |
mouse |
| Oscar B Akide Ndunge, Henry J Shikani, Minxian Dai, Brandi D Freeman, Mahalia S Desruisseau. Effects of anti-tau immunotherapy on reactive microgliosis, cerebral endotheliopathy, and cognitive function in an experimental model of cerebral malaria. Journal of neurochemistry. 2023-10-10. PMID:37814468. |
immunotherapy with a monoclonal antibody to pathological tau (phf-1 mab) in experimental models of neurodegenerative diseases has been reported to mitigate cognitive decline. |
2023-10-10 |
2023-10-15 |
mouse |
| Ngoc-Han Thi Nguyen, Ji Hun Kim, Su-Min Lee, Byung-Kwan Cho, Yang-Hoon Kim, Jiho Mi. Inhibition of Tau Phosphorylation and Aβ Accumulation by S. cerevisiae-derived Vacuoles in LPS-Induced SH-SY5Y Cells. Journal of biotechnology. 2023-09-30. PMID:37777088. |
neurodegenerative diseases, such as alzheimer's disease (ad), are characterized by the accumulation of intracellular tau and amyloid beta (aβ) proteins, which lead to neuroinflammation and neuronal apoptosis. |
2023-09-30 |
2023-10-07 |
Not clear |
| Patrick W Cullinane, Sarah Wrigley, Teisha Y Bradshaw, Karen Shaw, Samuel Shribman, Eduardo de Pablo Fernandez, Thomas T Warner, Zane Jaunmuktan. Late Presentation of Chronic Traumatic Encephalopathy in a Former Association Football Player. Movement disorders clinical practice. vol 10. issue 9. 2023-09-29. PMID:37772307. |
chronic traumatic encephalopathy (cte) is a neurodegenerative disease characterized by widespread accumulation of hyperphosphorylated tau that typically occurs in people who have suffered repetitive head impacts. |
2023-09-29 |
2023-10-07 |
Not clear |
| Laura Vidal-Palencia, Cristina Font, Agustín Rebollada-Merino, Gabriel Santpere, Pol Andrés-Benito, Isidro Ferrer, Martí Pumarol. Primary Feline Tauopathy: Clinical, Morphological, Immunohistochemical, and Genetic Studies. Animals : an open access journal from MDPI. vol 13. issue 18. 2023-09-28. PMID:37760385. |
tauopathies are a group of neurodegenerative diseases characterized by the pathological aggregation of hyperphosphorylated tau in neurons and glia. |
2023-09-28 |
2023-10-07 |
cat |
| Giavanna Paterno, Jose Torrellas, Brach M Bell, Kimberly-Marie M Gorion, Stephan S Quintin, Gabriela P Hery, Stefan Prokop, Benoit I Giasso. Novel Conformation-Dependent Tau Antibodies Are Modulated by Adjacent Phosphorylation Sites. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37761979. |
tau proteins within the adult central nervous system (cns) are found to be abnormally aggregated into heterogeneous filaments in neurodegenerative diseases, termed tauopathies. |
2023-09-28 |
2023-10-07 |
Not clear |
| Sjors H W Scheres, Benjamin Ryskeldi-Falcon, Michel Goeder. Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids. Nature. vol 621. issue 7980. 2023-09-27. PMID:37758888. |
abnormal assembly of tau, α-synuclein, tdp-43 and amyloid-β proteins into amyloid filaments defines most human neurodegenerative diseases. |
2023-09-27 |
2023-10-07 |
human |
| Genevieve L Stein-O'Brien, Ryan Palaganas, Ernest M Meyer, Javier Redding-Ochoa, Olga Pletnikova, Haidan Guo, William R Bell, Juan C Troncoso, Richard L Huganir, Meaghan Morri. Transcriptional Signatures of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer's Disease. medRxiv : the preprint server for health sciences. 2023-09-25. PMID:37745408. |
tau pathology is common in age-related neurodegenerative diseases. |
2023-09-25 |
2023-10-07 |
Not clear |
| Naruhiko Sahara, Makoto Higuch. Diagnostic and therapeutic targeting of pathological tau proteins in neurodegenerative disorders. FEBS open bio. 2023-09-25. PMID:37746832. |
tauopathies, characterized by fibrillar tau accumulation in neurons and glial cells, constitute a major neuropathological category of neurodegenerative diseases. |
2023-09-25 |
2023-10-07 |
mouse |
| Wyatt C Powell, Ruiheng Jing, Maciej A Walcza. Chemical Synthesis of Microtubule-Associated Protein Tau. Journal of the American Chemical Society. 2023-09-22. PMID:37737824. |
deposits of the microtubule-associated protein tau (mapt) serve as a hallmark of neurodegenerative diseases known as tauopathies. |
2023-09-22 |
2023-10-07 |
Not clear |
| Pijush Chakraborty, Gwladys Rivière, Alina Hebestreit, Alain Ibáñez de Opakua, Ina M Vorberg, Loren B Andreas, Markus Zweckstette. Acetylation discriminates disease-specific tau deposition. Nature communications. vol 14. issue 1. 2023-09-22. PMID:37739953. |
the results implicate acetylation as a critical regulator that guides the selective aggregation of three-repeat tau and the development of tau isoform-specific neurodegenerative diseases. |
2023-09-22 |
2023-10-07 |
Not clear |
| Carmen Gasca-Salas, Clara Trompeta, Miguel López-Aguirre, Rafael Rodríguez Rojas, Jordi Clarimon, Oriol Dols-Icardo, Shaimaa El Bounasri, Pasqualina Guida, David Mata-Marín, Frida Hernández-Fernández, Connie Marras, Lina García-Cañamaque, Isabel Plaza de Las Heras, Ignacio Obeso, Lydia Vela, Beatriz Fernández-Rodrígue. Brain hypometabolism in non-demented microtubule-associated protein tau H1 carriers with Parkinson's disease. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2023-09-20. PMID:37726927. |
the microtubule-associated protein tau (mapt) h1 homozygosity (h1/h1 haplotype) is a genetic risk factor for neurodegenerative diseases, such as parkinson's disease (pd). |
2023-09-20 |
2023-10-07 |
Not clear |
| Maurizio Callari, Martina Sola, Claudia Magrin, Andrea Rinaldi, Marco Bolis, Paolo Paganetti, Luca Colnaghi, Stéphanie Papi. Cancer-specific association between Tau (MAPT) and cellular pathways, clinical outcome, and drug response. Scientific data. vol 10. issue 1. 2023-09-20. PMID:37730697. |
tau (mapt) is a microtubule-associated protein causing common neurodegenerative diseases or rare inherited frontotemporal lobar degenerations. |
2023-09-20 |
2023-10-07 |
Not clear |
| Lovedeep Singh, Harpreet Kaur, Girish Chandra Arya, Rajbir Bhatt. Neuroprotective potential of formononetin, a naturally occurring isoflavone phytoestrogen. Chemical biology & drug design. 2023-09-18. PMID:37722967. |
furthermore, formononetin also increases the expression of adam-10, which affects the pathology of neurodegenerative disease by lowering tau phosphorylation, maintaining synaptic plasticity, and boosting hippocampus neurogenesis. |
2023-09-18 |
2023-10-07 |
Not clear |