| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joseph B Rayma. Focusing on oligomeric tau as a therapeutic target in Alzheimer's disease and other tauopathies. Expert opinion on therapeutic targets. 2023-05-04. PMID:37140480. |
tau has commanded much attention as a potential therapeutic target in neurodegenerative diseases. |
2023-05-04 |
2023-08-14 |
Not clear |
| Kumarappan Chidambara. Identification of BACE-1 Inhibitors against Alzheimer's Disease through E-Pharmacophore-Based Virtual Screening and Molecular Dynamics Simulation Studies: An Insilco Approach. Life (Basel, Switzerland). vol 13. issue 4. 2023-04-28. PMID:37109481. |
alzheimer is a severe memory and cognitive impairment neurodegenerative disease that is the most common cause of dementia worldwide and characterized by the pathological accumulation of tau protein and amyloid-beta peptides. |
2023-04-28 |
2023-08-14 |
Not clear |
| Nadia El Mammeri, Olivia Gampp, Pu Duan, Mei Hon. Membrane-induced tau amyloid fibrils. Communications biology. vol 6. issue 1. 2023-04-28. PMID:37117483. |
the intrinsically disordered protein tau aggregates into β-sheet amyloid fibrils that spread in human brains afflicted with alzheimer's disease and other neurodegenerative diseases. |
2023-04-28 |
2023-08-14 |
human |
| Brianne B Rogers, Ashlyn G Anderson, Shelby N Lauzon, M Natalie Davis, Rebecca M Hauser, Sydney C Roberts, Ivan Rodriguez-Nunez, Katie Trausch-Lowther, Erin A Barinaga, Jared W Taylor, Mark Mackiewicz, Brian S Roberts, Sara J Cooper, Lindsay F Rizzardi, Richard M Myers, J Nicholas Cochra. bioRxiv : the preprint server for biology. 2023-04-24. PMID:37090552. |
tauopathies are a group of neurodegenerative diseases driven by abnormal aggregates of tau, a microtubule associated protein encoded by the |
2023-04-24 |
2023-08-14 |
Not clear |
| Lydia Reinhardt, Fabrizio Musacchio, Maria Bichmann, Annika Behrendt, Ebru Ercan-Herbst, Juliane Stein, Isabelle Becher, Per Haberkant, Julia Mader, David C Schöndorf, Melanie Schmitt, Jürgen Korffmann, Peter Reinhardt, Christian Pohl, Mikhail Savitski, Corinna Klein, Laura Gasparini, Martin Fuhrmann, Dagmar E Ehrnhoefe. Dual truncation of tau by caspase-2 accelerates its CHIP-mediated degradation. Neurobiology of disease. 2023-04-22. PMID:37086756. |
intraneuronal aggregates of the microtubule binding protein tau are a hallmark of different neurodegenerative diseases including alzheimer's disease (ad). |
2023-04-22 |
2023-08-14 |
mouse |
| Christopher Daniel Morrone, Radha Raghuraman, S Abid Hussaini, Wai Haung Y. Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer's disease. Molecular neurodegeneration. vol 18. issue 1. 2023-04-21. PMID:37085942. |
this phenomenon extends beyond β-amyloid and tau, with interactions of sleep impairment with the homeostasis of tdp-43, α-synuclein, fus, and huntingtin proteins, implicating sleep loss as an important consideration in an array of neurodegenerative diseases and in cases of mixed neuropathology. |
2023-04-21 |
2023-08-14 |
Not clear |
| Tony S Eteläinen, M Catarina Silva, Johanna K Uhari-Väänänen, Francesca De Lorenzo, Maria H Jäntti, Hengjing Cui, Marta Chavero-Pieres, Tommi Kilpeläinen, Christina Mechtler, Reinis Svarcbahs, Erin Seppälä, Juha R Savinainen, Elena Puris, Gert Fricker, Mikko Gynther, Ulrika H Julku, Henri J Huttunen, Stephen J Haggarty, Timo T Myöhäne. A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy. Science translational medicine. vol 15. issue 691. 2023-04-12. PMID:37043557. |
tauopathies are neurodegenerative diseases that are characterized by accumulation of hyperphosphorylated tau protein, higher-order aggregates, and tau filaments. |
2023-04-12 |
2023-08-14 |
mouse |
| Haiyang Zhong, Hongli Liu, Huanxiang Li. Molecular Mechanism of Tau Misfolding and Aggregation: Insights from Molecular Dynamics Simulation. Current medicinal chemistry. 2023-04-09. PMID:37031392. |
tau dysfunction has a close association with many neurodegenerative diseases, which are collectively referred to as tauopathies. |
2023-04-09 |
2023-08-14 |
Not clear |
| Rebecca L Kow, Aristide H Black, Brandon P Henderson, Brian C Kraeme. Sut-6/NIPP1 modulates tau toxicity. Human molecular genetics. 2023-03-31. PMID:37000013. |
neurodegenerative diseases exhibiting the pathological accumulation of tau such as alzheimer's disease and related disorders still have no disease-modifying treatments and the molecular mechanisms of neurodegeneration remain unclear. |
2023-03-31 |
2023-08-14 |
human |
| Bote Qi, Jingwang Tan, Yunxiang Sun, Meng Cao, Jinghan Lin, Qingwen Zhang, Yu Zo. Mechanistic Insights into the Binding of Different Positron Emission Tomography Tracers to Chronic Traumatic Encephalopathy Tau Protofibrils. ACS chemical neuroscience. 2023-03-31. PMID:37000128. |
chronic traumatic encephalopathy (cte) is a neurodegenerative disease associated with exposure to repetitive head impacts, and it is neuropathologically defined as the accumulation of abnormally hyperphosphorylated tau (p-tau). |
2023-03-31 |
2023-08-14 |
Not clear |
| Bote Qi, Jingwang Tan, Yunxiang Sun, Meng Cao, Jinghan Lin, Qingwen Zhang, Yu Zo. Mechanistic Insights into the Binding of Different Positron Emission Tomography Tracers to Chronic Traumatic Encephalopathy Tau Protofibrils. ACS chemical neuroscience. 2023-03-31. PMID:37000128. |
previous experimental studies reported that positron emission tomography (pet) technique using several tau tracers are available for imaging certain neurodegenerative diseases. |
2023-03-31 |
2023-08-14 |
Not clear |
| Letizia Clementi, Samantha Sabetta, Veronica Zelli, Chiara Compagnoni, Alessandra Tessitore, Vincenzo Mattei, Adriano Angelucc. Mitotic phosphorylation of Tau/MAPT modulates cell cycle progression in prostate cancer cells. Journal of cancer research and clinical oncology. 2023-03-31. PMID:37000265. |
tau/mapt (microtubule associated protein tau) protein is actively studied for the pathologic consequences of its aberrant proteostasis in central nervous system leading to neurodegenerative diseases. |
2023-03-31 |
2023-08-14 |
Not clear |
| Aamir S Mukadam, Lauren V C Miller, Annabel E Smith, Marina Vaysburd, Siri A Sakya, Sophie Sanford, Sophie Keeling, Benjamin J Tuck, Taxiarchis Katsinelos, Chris Green, Lise Skov, Sanne S Kaalund, Stian Foss, Keith Mayes, Kevin O'Connell, Mark Wing, Claire Knox, Jessica Banbury, Edward Avezov, James B Rowe, Michel Goedert, Jan Terje Andersen, Leo C James, William A McEwa. Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models. Science (New York, N.Y.). vol 379. issue 6639. 2023-03-30. PMID:36996217. |
aggregates of the protein tau are proposed to drive pathogenesis in neurodegenerative diseases. |
2023-03-30 |
2023-08-14 |
mouse |
| Lauren H Fairley, Imane Lejri, Amandine Grimm, Anne Ecker. Spermidine Rescues Bioenergetic and Mitophagy Deficits Induced by Disease-Associated Tau Protein. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982371. |
abnormal tau build-up is a hallmark of alzheimer's disease (ad) and more than 20 other serious neurodegenerative diseases. |
2023-03-29 |
2023-08-14 |
human |
| Prechiel A Barredo, Mannix P Balana. Recent Advances in Molecular Dynamics Simulations of Tau Fibrils and Oligomers. Membranes. vol 13. issue 3. 2023-03-29. PMID:36984665. |
the study of tau protein aggregation and interactions with other molecules or solvents using molecular dynamics simulations (mds) is of interest to many researchers to propose new mechanism-based therapeutics for neurodegenerative diseases such as alzheimer's disease, pick's disease, chronic traumatic encephalopathy, and other tauopathies. |
2023-03-29 |
2023-08-14 |
Not clear |
| Haruaki Sato, Kensaku Kasuga, Noriko Isoo, Toshihiro Hayashi, Takeshi Ikeuchi, Yukiko Hori, Taisuke Tomit. Soluble form of the APP fragment, sAPPβ, positively regulates tau secretion. Neuroscience research. 2023-03-26. PMID:36967088. |
extracellular tau has been highlighted in the pathogenesis of alzheimer disease (ad), which is the most common neurodegenerative disease. |
2023-03-26 |
2023-08-14 |
mouse |
| Dailu Chen, Sofia Bali, Ruhar Singh, Aleksandra Wosztyl, Vishruth Mullapudi, Jaime Vaquer-Alicea, Parvathy Jayan, Shamiram Melhem, Harro Seelaar, John C van Swieten, Marc I Diamond, Lukasz A Joachimia. FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation. Nature communications. vol 14. issue 1. 2023-03-24. PMID:36959205. |
amyloid deposition of the microtubule-associated protein tau is associated with neurodegenerative diseases. |
2023-03-24 |
2023-08-14 |
Not clear |
| Carlo Condello, Jacob I Ayers, Clifton L Dalgard, M Madhy Garcia Garcia, Brianna M Rivera, William W Seeley, Daniel P Perl, Stanley B Prusine. Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 13. 2023-03-23. PMID:36952379. |
the amyotrophic lateral sclerosis-parkinsonism dementia complex (als-pdc) of guam is an endemic neurodegenerative disease that features widespread tau tangles, occasional α-synuclein lewy bodies, and sparse β-amyloid (aβ) plaques distributed in the central nervous system. |
2023-03-23 |
2023-08-14 |
Not clear |
| Jingjing Liu, Xin Zhang, Hui Wan. The cGAS-STING-mediated NLRP3 inflammasome is involved in the neurotoxicity induced by manganese exposure. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 154. 2023-03-21. PMID:36942606. |
inflammation and tau hyperphosphorylation are prominent hallmarks of neurodegenerative diseases induced by mn exposure. |
2023-03-21 |
2023-08-14 |
Not clear |
| Yu-Qing Liu, Chu-Qiao Liang, Zhi-Wei Chen, Jun Hu, Jin-Jian Hu, Yun-Yi Luo, Yong-Xiang Chen, Yan-Mei L. 14-3-3ζ Participates in the Phase Separation of Phosphorylated and Glycated Tau and Modulates the Physiological and Pathological Functions of Tau. ACS chemical neuroscience. 2023-03-20. PMID:36939323. |
tau plays a major role in alzheimer's disease (ad) and several other neurodegenerative diseases. |
2023-03-20 |
2023-08-14 |
Not clear |