| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fernando Gonzalez-Ortiz, Przemysław R Kac, Wagner S Brum, Henrik Zetterberg, Kaj Blennow, Thomas K Karikar. Plasma phospho-tau in Alzheimer's disease: towards diagnostic and therapeutic trial applications. Molecular neurodegeneration. vol 18. issue 1. 2023-03-17. PMID:36927491. |
one such promising biomarker is plasma phosphorylated tau (p-tau), which has demonstrated specificity to ad versus non-ad neurodegenerative diseases, and will be extremely important to inform on clinical diagnosis and eligibility for therapies that have recently been approved. |
2023-03-17 |
2023-08-14 |
human |
| Suying Duan, Jing Yang, Zheqing Cui, Jiaqi Li, Honglin Zheng, Taiqi Zhao, Yanpeng Yuan, Yutao Liu, Lu Zhao, Yangyang Wang, Haiyang Luo, Yuming X. Seed amplification assay of nasal swab extracts for accurate and non-invasive molecular diagnosis of neurodegenerative diseases. Translational neurodegeneration. vol 12. issue 1. 2023-03-16. PMID:36922862. |
in neurodegenerative diseases, nasal swab tests are currently being explored using seed amplification assay (saa) of pathogenic misfolded proteins, such as prion, α-synuclein, and tau. |
2023-03-16 |
2023-08-14 |
Not clear |
| Ryusei Kaneko, Ako Matsui, Mahiro Watanabe, Yoshihiro Harada, Mitsuhiro Kanamori, Natsumi Awata, Mio Kawazoe, Tomoaki Takao, Yutaro Kobayashi, Chie Kikutake, Mikita Suyama, Takashi Saito, Takaomi C Saido, Minako It. Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer's disease. Inflammation and regeneration. vol 43. issue 1. 2023-03-16. PMID:36922861. |
alzheimer's disease (ad) is one of the neurodegenerative diseases and characterized by the appearance and accumulation of amyloid-β (aβ) aggregates and phosphorylated tau with aging. |
2023-03-16 |
2023-08-14 |
mouse |
| Ha-Lim Song, Na-Young Kim, Jaewan Park, Meong Il Kim, Yu-Na Jeon, Se-Jong Lee, Kwangmin Cho, Young-Lim Shim, Kyoung-Hye Lee, Yeon-Seon Mun, Jung-A Song, Min-Seok Kim, Chan-Gi Pack, Minkyo Jung, Hyemin Jang, Duk L Na, Minsun Hong, Dong-Hou Kim, Seung-Yong Yoo. Monoclonal antibody Y01 prevents tauopathy progression induced by lysine280-acetylated tau in cell and mouse models. The Journal of clinical investigation. 2023-03-14. PMID:36917188. |
however, the mechanism that links tau acetylated on lysine 280 (tau-ack280) to subsequent progression to neurodegenerative disease remains unclear. |
2023-03-14 |
2023-08-14 |
mouse |
| Erika Cecon, Atsuro Oishi, Marine Luka, Delphine Ndiaye-Lobry, Arnaud François, Mathias Lescuyer, Fany Panayi, Julie Dam, Patricia Machado, Ralf Jocker. Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells. eLife. vol 12. 2023-03-14. PMID:36917493. |
aggregates of the tau protein are a well-known hallmark of several neurodegenerative diseases, collectively referred to as tauopathies, including frontal temporal dementia and alzheimer's disease (ad). |
2023-03-14 |
2023-08-14 |
Not clear |
| Evan Lester, Roy Parke. Tau, RNA, and RNA-Binding Proteins: Complex Interactions in Health and Neurodegenerative Diseases. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2023-03-09. PMID:36892034. |
tau, rna, and rna-binding proteins: complex interactions in health and neurodegenerative diseases. |
2023-03-09 |
2023-08-14 |
Not clear |
| Evan Lester, Roy Parke. Tau, RNA, and RNA-Binding Proteins: Complex Interactions in Health and Neurodegenerative Diseases. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2023-03-09. PMID:36892034. |
the tau protein is a key contributor to multiple neurodegenerative diseases. |
2023-03-09 |
2023-08-14 |
Not clear |
| Masaomi Miyamoto, Chio Okuyama, Shinya Kagawa, Kuninori Kusano, Masaaki Takahashi, Keisuke Takahata, Ming-Kuei Jang, Hiroshi Yamauch. Radiation dosimetry and pharmacokinetics of the tau PET tracer florzolotau (18F) in healthy Japanese subjects. Annals of nuclear medicine. 2023-03-08. PMID:36890399. |
abnormal aggregation of tau in the brain is a major contributing factor in various neurodegenerative diseases. |
2023-03-08 |
2023-08-14 |
human |
| Lizanne Arnoldy, Sarah Gauci, Lauren M Young, Wolfgang Marx, Helen Macpherson, Andrew Pipingas, Oren Civier, David J Whit. The association of dietary and nutrient patterns on neurocognitive decline: a systematic review of MRI and PET studies. Ageing research reviews. 2023-03-06. PMID:36878405. |
the inclusion criteria for the articles comprised studies reporting on the association between dietary patterns and neuroimaging outcomes, which includes both specific pathological hallmarks of neurodegenerative diseases such as aβ and tau and nonspecific markers such as structural mri and glucose metabolism. |
2023-03-06 |
2023-08-14 |
Not clear |
| b' Daniel Alcolea, Michal Schnaider Beeri, Julio C Rojas, Raquel C Gardner, Alberto Lle\\xc3\\xb. Blood Biomarkers in Neurodegenerative Diseases: Implications for the Clinical Neurologist. Neurology. 2023-03-06. PMID:36878698.' |
currently, research studies have reported robust assays of blood markers for the detection of amyloid and tau pathologies specific to alzheimer's disease (aß peptides, p-tau), as well as non-specific blood markers of neuronal (neurofilament light, ß-synuclein, ubiquitin-c-terminal-hydrolase-l1) and glial degeneration (glial fibrillary acidic protein) that can measure key pathophysiological processes in several neurodegenerative diseases. |
2023-03-06 |
2023-08-14 |
Not clear |
| Narendran Annadurai, Jiří Hrubý, Agáta Kubíčková, Lukáš Malina, Marián Hajdúch, Viswanath Da. Time- and dose-dependent seeding tendency of exogenous tau R2 and R3 aggregates in cells. Biochemical and biophysical research communications. vol 653. 2023-03-02. PMID:36863211. |
tauopathies are a group of neurodegenerative diseases categorised into three types, 3r, 4r, or 3r+4r (mixed) tauopathies, based on the tau isoforms that make up the aberrant filaments. |
2023-03-02 |
2023-08-14 |
Not clear |
| Petra Hnilicova, Ema Kantorova, Stanislav Sutovsky, Milan Grofik, Kamil Zelenak, Egon Kurca, Norbert Zilka, Petra Parvanovova, Martin Kolise. Imaging Methods Applicable in the Diagnostics of Alzheimer's Disease, Considering the Involvement of Insulin Resistance. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834741. |
alzheimer's disease (ad) is an incurable neurodegenerative disease and the most frequently diagnosed type of dementia, characterized by (1) perturbed cerebral perfusion, vasculature, and cortical metabolism; (2) induced proinflammatory processes; and (3) the aggregation of amyloid beta and hyperphosphorylated tau proteins. |
2023-02-25 |
2023-08-14 |
Not clear |
| Abhishek Dahal, Karthivashan Govindarajan, Satyabrata Ka. Administration of kainic acid differentially alters astrocyte markers and transiently enhanced phospho-tau level in adult rat hippocampus. Neuroscience. 2023-02-22. PMID:36805001. |
additionally, a role for microtubule associated tau protein, involved in various neurodegenerative diseases including alzheimer's disease, has also been suggested in the development of seizure and/or neurodegeneration in tle pathogenesis. |
2023-02-22 |
2023-08-14 |
human |
| Daniela Jimenez-Harrison, Carol J Huseby, Claire N Hoffman, Steven Sher, Dalton Snyder, Brayden Seal, Chunhua Yuan, Hongjun Fu, Vicki Wysocki, Flaviano Giorgini, Jeff Kure. DJ-1 Molecular Chaperone Activity Depresses Tau Aggregation Propensity through Interaction with Monomers. Biochemistry. 2023-02-22. PMID:36813261. |
tau aggregate-bearing lesions are pathological markers and potential mediators of tauopathic neurodegenerative diseases, including alzheimer's disease. |
2023-02-22 |
2023-08-14 |
Not clear |
| Kariem Ezzat, Andrea Sturchio, Alberto J Espa. The shift to a proteinopenia paradigm in neurodegeneration. Handbook of clinical neurology. vol 193. 2023-02-21. PMID:36803814. |
we therefore advocate for a paradigm shift from proteinopathy (gof) to proteinopenia (lof) based on the universal depletion of soluble functional proteins in neurodegenerative diseases (low amyloid-β 42 in alzheimer's disease, low α-synuclein in parkinson's disease, and low tau in progressive supranuclear palsy) and supported by the confluence of biologic, thermodynamic, and evolutionary principles with proteins having evolved to perform a function, not to become toxic, and where protein depletion is consequential. |
2023-02-21 |
2023-08-14 |
Not clear |
| Eloise Masquelier, Esther Taxon, Sheng-Ping Liang, Yahya Al Sabeh, Lior Sepunaru, Michael J Gordon, Daniel E Mors. A new electrochemical method that mimics phosphorylation of the core tau peptide K18 enables kinetic and structural analysis of intermediates and assembly. The Journal of biological chemistry. 2023-02-13. PMID:36781124. |
tau protein's reversible assembly and binding of microtubules in brain neurons are regulated by charge-neutralizing phosphorylation, while its hyperphosphorylation drives the irreversible formation of cytotoxic filaments associated with neurodegenerative diseases. |
2023-02-13 |
2023-08-14 |
Not clear |
| Tim Altendorf, Ian Gering, Beatrix Santiago-Schübel, Selma Aghabashlou Saisan, Gültekin Tamgüney, Markus Tusche, Dominik Honold, Sarah Schemmert, Wolfgang Hoyer, Jeannine Mohrlüder, Dieter Willbol. Stabilization of Monomeric Tau Protein by All D-Enantiomeric Peptide Ligands as Therapeutic Strategy for Alzheimer's Disease and Other Tauopathies. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768484. |
the tau protein is involved in a multitude of different neurodegenerative diseases. |
2023-02-11 |
2023-08-14 |
Not clear |
| Anuradha Sharma, Poonam Piplan. Acridine: A Scaffold for the development of drugs for Alzheimer's disease. Current topics in medicinal chemistry. 2023-02-06. PMID:36740790. |
it is a most common age-related multifactorial neurodegenerative disease and characterized by two histopathological hallmarks; the formation of senile plaques composed of the amyloid-β (aβ) peptide and neurofibrillary tangles composed of hyperphosphorylated tau protein. |
2023-02-06 |
2023-08-14 |
Not clear |
| Kun Li, Ziqiang Wan. lncRNA NEAT1: key player in neurodegenerative diseases. Ageing research reviews. 2023-02-04. PMID:36738893. |
this review summarizes our current knowledge of the role of neat1 in neurodegenerative diseases and its association with the characteristic aggregation of misfolded proteins: amyloid-β and tau in ad, α-synuclein in pd, mutant huntingtin in hd, and tar dna-binding protein-43 fused in sarcoma/translocated in liposarcoma in als. |
2023-02-04 |
2023-08-14 |
Not clear |
| Anne-Marie Jacobsen, Nico C van de Merbel, Dorte K Ditlevsen, Ketil Tvermosegaard, Frank Schalk, Wietske Lambert, Christoffer Bundgaard, Jan T Pedersen, Nina Rosenqvis. A Quantitative LC-MS/MS Method for Distinguishing the Tau Protein Forms Phosphorylated and Nonphosphorylated at Serine-396. Journal of the American Society for Mass Spectrometry. 2023-01-31. PMID:36719168. |
hyperphosphorylated tau protein is well-known to be involved in the formation of neurofibrillary tangles and the progression of age-related neurodegenerative diseases (tauopathies), including alzheimer's disease (ad). |
2023-01-31 |
2023-08-14 |
mouse |