| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dale D O Martin, Shaun S Sander. Let's get fat: emergence of S-acylation as a therapeutic target in Huntington disease. Biochemical Society transactions. 2024-05-02. PMID:38695682. |
huntington disease (hd) is a devastating, fatal neurodegenerative disease characterized by motor, cognitive, and psychiatric deficits caused by a cag repeat expansion in the htt gene. |
2024-05-02 |
2024-05-04 |
Not clear |
| Javier Ojalvo-Pacheco, Sokhna M S Yakhine-Diop, José M Fuentes, Marta Paredes-Barquero, Mireia Niso-Santan. Role of TFEB in Huntington's Disease. Biology. vol 13. issue 4. 2024-04-26. PMID:38666850. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by an expansion of the cag trinucleotide repeat in exon 1 of the huntingtin (htt) gene. |
2024-04-26 |
2024-04-28 |
Not clear |
| Adam Skeens, Chathuranga Siriwardhana, Sophia E Massinople, Michelle M Wunder, Zachary L Ellis, Kaitlyn M Keith, Tyler Girman, Shelli L Frey, Justin Legleite. The polyglutamine domain is the primary driver of seeding in huntingtin aggregation. PloS one. vol 19. issue 3. 2024-03-14. PMID:38483973. |
huntington's disease (hd) is a fatal, neurodegenerative disease caused by aggregation of the huntingtin protein (htt) with an expanded polyglutamine (polyq) domain into amyloid fibrils. |
2024-03-14 |
2024-03-17 |
caenorhabditis_elegans |
| Sergio Pérez-Oliveira, Juan Castilla-Silgado, Cèlia Painous, Iban Aldecoa, Manuel Menéndez-González, Marta Blázquez-Estrada, Daniela Corte, Cristina Tomás-Zapico, Yaroslau Compta, Esteban Muñoz, Albert Lladó, Mircea Balasa, Gemma Aragonès, Pablo García-González, Maitée Rosende-Roca, Mercè Boada, Agustín Ruíz, Pau Pastor, Beatriz De la Casa-Fages, Alberto Rabano, Raquel Sánchez-Valle, Laura Molina-Porcel, Victoria Álvare. Huntingtin CAG repeats in neuropathologically confirmed tauopathies: Novel insights. Brain pathology (Zurich, Switzerland). 2024-02-28. PMID:38418081. |
previous studies have suggested a relationship between the number of cag triplet repeats in the htt gene and neurodegenerative diseases not related to huntington's disease (hd). |
2024-02-28 |
2024-03-02 |
human |
| Xuanzhuo Liu, Fang Wang, Xinman Fan, Mingyi Chen, Xiaoxin Xu, Qiuhong Xu, Huili Zhu, Anding Xu, Mahmoud A Pouladi, Xiaohong X. CHCHD2 up-regulation in Huntington disease mediates a compensatory protective response against oxidative stress. Cell death & disease. vol 15. issue 2. 2024-02-10. PMID:38341417. |
huntington disease (hd) is a neurodegenerative disease caused by the abnormal expansion of a polyglutamine tract resulting from a mutation in the htt gene. |
2024-02-10 |
2024-02-14 |
mouse |
| Francesco D'Egidio, Vanessa Castelli, Giorgia Lombardozzi, Fabrizio Ammannito, Annamaria Cimini, Michele d'Angel. Therapeutic advances in neural regeneration for Huntington's disease. Neural regeneration research. vol 19. issue 9. 2024-01-16. PMID:38227527. |
huntington's disease is a neurodegenerative disease caused by the expansion mutation of a cytosine-adenine-guanine triplet in the exon 1 of the htt gene which is responsible for the production of the huntingtin (htt) protein. |
2024-01-16 |
2024-01-18 |
Not clear |
| Sonia Podvin, Charles Mosier, William Poon, Enlin Wei, Leigh-Ana Rossotto, Vivian Hoo. Dysregulation of Human Juvenile Huntington's Disease Brain Proteomes in Cortex and Putamen Involves Mitochondrial and Neuropeptide Systems. Journal of Huntington's disease. vol 12. issue 4. 2023-12-19. PMID:38108356. |
huntington's disease (hd) is a genetic neurodegenerative disease caused by trinucleotide repeat cag expansions in the human htt gene. |
2023-12-19 |
2023-12-21 |
human |
| Huichun Tong, Tianqi Yang, Li Liu, Caijuan Li, Yize Sun, Qingqing Jia, Yiyang Qin, Laiqiang Chen, Xianxian Zhao, Gongke Zhou, Sen Yan, Xiao-Jiang Li, Shihua L. Aberrant splicing of mutant huntingtin in Huntington's disease knock-in pigs. Neurobiology of disease. 2023-09-16. PMID:37716514. |
huntington's disease (hd) is an autosomal-dominant inherited neurodegenerative disease caused by a cag repeat expansion in exon1 of the huntingtin gene (htt). |
2023-09-16 |
2023-10-07 |
mouse |
| Marta Piechota, Ewelina Latoszek, Ewa Liszewska, Hana Hansíková, Jiří Klempíř, Alžbeta Mühlbäck, Georg Bernhard Landwehrmeyer, Jacek Kuźnicki, Magdalena Czeredy. Generation of two human iPSC lines from dermal fibroblasts of adult- and juvenile-onset Huntington's disease patients and two healthy donors. Stem cell research. vol 71. 2023-08-31. PMID:37651831. |
huntington's disease (hd) is an autosomal dominant neurodegenerative disease caused by a mutation in the htt gene. |
2023-08-31 |
2023-09-07 |
human |
| Costanza Ferrari Bardile, Carola I Radulescu, Mahmoud A Poulad. Oligodendrocyte pathology in Huntington's disease: from mechanisms to therapeutics. Trends in molecular medicine. 2023-08-17. PMID:37591764. |
there is new recognition of the role of olgs in the pathogenesis of neurodegenerative diseases (ndds), including huntington's disease (hd), a prototypic ndd caused by a polyglutamine tract expansion in huntingtin (htt), which results in gain- and loss-of-function effects. |
2023-08-17 |
2023-09-07 |
Not clear |
| Alyssa R Stonebraker, Maryssa Beasley, Sophia Massinople, Michelle Wunder, Peng Li, Stephen J Valentine, Justin Legleite. Cholesterol impacts the formation of huntingtin/lipid complexes and subsequent aggregation. Protein science : a publication of the Protein Society. 2023-04-13. PMID:37052951. |
huntington's disease (hd) is a neurodegenerative disease resulting from an expansion of the polyglutamine (polyq) domain within the huntingtin protein (htt). |
2023-04-13 |
2023-08-14 |
Not clear |
| Kizito-Tshitoko Tshilenge, Carlos Galicia Aguirre, Joanna Bons, Akos A Gerencser, Nathan Basisty, Sicheng Song, Jacob Rose, Alejandro Lopez-Ramirez, Swati Naphade, Ashley Loureiro, Elena Battistoni, Mateus Milani, Cameron Wehrfritz, Anja Holtz, Claudio Hetz, Sean D Mooney, Birgit Schilling, Lisa M Ellerb. Proteomic Analysis of Huntington's Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets. Molecular & cellular proteomics : MCP. 2023-03-23. PMID:36958627. |
huntington's disease (hd) is a neurodegenerative disease caused by a cag repeat expansion in the huntingtin (htt) gene. |
2023-03-23 |
2023-08-14 |
human |
| Christiana C Christodoulou, Eleni Zamba Papanicolao. Integrated Bioinformatics Analysis of Shared Genes, miRNA, Biological Pathways and Their Potential Role as Therapeutic Targets in Huntington's Disease Stages. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36902304. |
huntington's disease (hd) is a progressive neurodegenerative disease caused by cag repeat expansion in the huntingtin gene (htt). |
2023-03-11 |
2023-08-14 |
Not clear |
| Baljit S Khakh, Steven A Goldma. Astrocytic contributions to Huntington's disease pathophysiology. Annals of the New York Academy of Sciences. 2023-03-02. PMID:36864567. |
huntington's disease (hd) is a fatal, monogenic, autosomal dominant neurodegenerative disease caused by a polyglutamine-encoding cag expansion in the huntingtin (htt) gene that results in mutant huntingtin proteins (mhtt) in cells throughout the body. |
2023-03-02 |
2023-08-14 |
mouse |
| Noria Okada, Shinsuke Nakamura, Masamitsu Shimazaw. 3-Nitropropionic Acid Enhances Ferroptotic Cell Death via NOX2-Mediated ROS Generation in STHdhQ111 Striatal Cells Carrying Mutant Huntingtin. Biological & pharmaceutical bulletin. vol 46. issue 2. 2023-02-01. PMID:36724946. |
huntington's disease (hd) is a hereditary neurodegenerative disease that involves an expansion of the cag repeats of the huntingtin (htt) gene, but the disease onset and progression do not necessarily correspond to the extent of cag repeats. |
2023-02-01 |
2023-08-14 |
mouse |
| Sirui Zhang, Yangfan Cheng, Huifang Shan. The updated development of blood-based biomarkers for Huntington's disease. Journal of neurology. 2023-01-24. PMID:36692635. |
huntington's disease is a progressive neurodegenerative disease caused by mutation of the huntingtin (htt) gene. |
2023-01-24 |
2023-08-14 |
Not clear |
| Hyuck Kim, Rocio Gomez-Pasto. HSF1 and Its Role in Huntington's Disease Pathology. Advances in experimental medicine and biology. 2022-11-17. PMID:36396925. |
this review focuses on huntington's disease (hd), a neurodegenerative disease characterized by severe protein aggregation of the huntingtin (htt) protein. |
2022-11-17 |
2023-08-14 |
Not clear |
| Ling Chen, Mingxia Bi, Zhen Zhang, Xixun Du, Xi Chen, Qian Jiao, Hong Jian. The functions of IRE1α in neurodegenerative diseases: Beyond ER stress. Ageing research reviews. 2022-11-04. PMID:36332756. |
furthermore, ire1α is a significant factor in the regulation of neurodegenerative diseases that are caused by the phosphorylation of tau protein, the accumulation of α-synuclein (α-syn) and the toxic effects of mutant htt (mhtt). |
2022-11-04 |
2023-08-14 |
Not clear |
| Yu-Ting Weng, Hui-Mei Chen, Ting Chien, Feng-Lan Chiu, Hung-Chih Kuo, Yijuang Cher. TRAX Provides Neuroprotection for Huntington's Disease Via Modulating a Novel Subset of MicroRNAs. Movement disorders : official journal of the Movement Disorder Society. 2022-08-23. PMID:35997316. |
huntington's disease (hd) is a neurodegenerative disease caused by cag-repeat expansions (>36) in exon 1 of htt, which dysregulates multiple cellular machineries. |
2022-08-23 |
2023-08-14 |
Not clear |
| Yidan Zhang, Yifan Wang, Zhan Zhao, Weixun Peng, Peng Wang, Ximing Xu, Chenyang Zha. Glutaminyl cyclases, the potential targets of cancer and neurodegenerative diseases. European journal of pharmacology. 2022-08-10. PMID:35948163. |
several substrates of sqc involving beta amyloid (aβ), huntington (htt) protein and certain inflammatory mediators such as ccl2 and cx3cl1 have been observed to associate with neurodegenerative diseases and cancers. |
2022-08-10 |
2023-08-14 |
human |