| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shinji Yamamoto, Kota Yamashina, Masaki Ishikawa, Mari Gotoh, Sosuke Yagishita, Kensuke Iwasa, Kei Maruyama, Kimiko Murakami-Murofushi, Keisuke Yoshikaw. Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. Journal of neuroinflammation. vol 14. issue 1. 2018-04-19. PMID:28732510. |
multiple sclerosis is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by recurrent and progressive demyelination/remyelination cycles, neuroinflammation, oligodendrocyte loss, demyelination, and axonal degeneration. |
2018-04-19 |
2023-08-13 |
mouse |
| Ariana P Mullin, Charlene Cui, Yu Wang, Jing Wang, Erika Troy, Anthony O Caggiano, Tom J Parry, Raymond W Colburn, Elias Pavlopoulo. rHIgM22 enhances remyelination in the brain of the cuprizone mouse model of demyelination. Neurobiology of disease. vol 105. 2018-04-18. PMID:28576706. |
failure of oligodendrocyte precursor cells (opcs) to differentiate and remyelinate axons is thought to be a major cause of the limited ability of the central nervous system to repair plaques of immune-mediated demyelination in multiple sclerosis (ms). |
2018-04-18 |
2023-08-13 |
mouse |
| Massimo Santoro, Massimiliano Mirabella, Chiara De Fino, Assunta Bianco, Matteo Lucchini, Francesco Losavio, Andrea Sabino, Viviana Nocit. Sativex® effects on promoter methylation and on CNR1/CNR2 expression in peripheral blood mononuclear cells of progressive multiple sclerosis patients. Journal of the neurological sciences. vol 379. 2018-04-12. PMID:28716266. |
multiple sclerosis (ms) is a chronic demyelinating central nervous system (cns) disease that involve oligodendrocyte loss and failure to remyelinate damaged brain areas causing a progressive neurological disability. |
2018-04-12 |
2023-08-13 |
mouse |
| Carsten Tue Berg, Reza Khorooshi, Nasrin Asgari, Trevor Owen. Influence of type I IFN signaling on anti-MOG antibody-mediated demyelination. Journal of neuroinflammation. vol 14. issue 1. 2018-04-03. PMID:28646890. |
antibodies with specificity for myelin oligodendrocyte glycoprotein (mog) are implicated in multiple sclerosis and related diseases. |
2018-04-03 |
2023-08-13 |
Not clear |
| Kai Bihler, Eugenia Kress, Stefan Esser, Stella Nyamoya, Simone C Tauber, Tim Clarner, Matthias B Stope, Thomas Pufe, Lars-Ove Brandenbur. Formyl Peptide Receptor 1-Mediated Glial Cell Activation in a Mouse Model of Cuprizone-Induced Demyelination. Journal of molecular neuroscience : MN. vol 62. issue 2. 2018-03-26. PMID:28466255. |
multiple sclerosis (ms) is a chronic degenerative disease of the central nervous system that is characterized by myelin abnormalities, oligodendrocyte pathology, and concomitant glia activation. |
2018-03-26 |
2023-08-13 |
mouse |
| Maria-Eleni Androutsou, Anthi Tapeinou, Alexios Vlamis-Gardikas, Theodore Tselio. Myelin Oligodendrocyte Glycoprotein and Multiple Sclerosis. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 14. issue 2. 2018-03-05. PMID:28875859. |
myelin oligodendrocyte glycoprotein and multiple sclerosis. |
2018-03-05 |
2023-08-13 |
Not clear |
| Patrizia Ballerini, Francesca Diomede, Nicola Petragnani, Simona Cicchitti, Ilaria Merciaro, Marcos F X B Cavalcanti, Oriana Trubian. Conditioned medium from relapsing-remitting multiple sclerosis patients reduces the expression and release of inflammatory cytokines induced by LPS-gingivalis in THP-1 and MO3.13 cell lines. Cytokine. vol 96. 2018-02-27. PMID:28511117. |
the present research was aimed at evaluating the effect of the conditioned medium (cm) from human periodontal ligament stem cells (hpdlscs) obtained from healthy donors (hpdlscs-cm) and from relapsing-remitting multiple sclerosis patients (rr-ms-cm) on inflammatory response induced by porphyromonas gingivalis lipopolysaccharide (lps-g) in a monocytoid human cell line (thp-1) and human oligodendrocyte cell line (mo3.13). |
2018-02-27 |
2023-08-13 |
human |
| Y A Lomakin, A V Stepanov, D S Balabashin, N A Ponomarenko, I V Smirnov, A A Beloguro. Design of Chemical Conjugate for Targeted Therapy of Multiple Sclerosis Based of Constant Fragment of Human Antibody Heavy Chain and Peptoid Analog of Autoantigen MOG Bulletin of experimental biology and medicine. vol 162. issue 6. 2018-02-23. PMID:28429225. |
myelin oligodendrocyte glycoprotein (mog) is a significant autoantigen in multiple sclerosis. |
2018-02-23 |
2023-08-13 |
human |
| R Deschamps, A Lecler, C Lamirel, J Aboab, A Gueguen, C Bensa, C Vignal, O Gou. Etiologies of acute demyelinating optic neuritis: an observational study of 110 patients. European journal of neurology. vol 24. issue 6. 2018-02-12. PMID:28477397. |
new criteria for the diagnosis of multiple sclerosis (ms) and discovery of myelin oligodendrocyte glycoprotein (mog) or aquaporin-4 (aqp4) antibodies (abs) have changed the management of optic neuritis (on). |
2018-02-12 |
2023-08-13 |
Not clear |
| Greg J Duncan, Jason R Plemel, Peggy Assinck, Sohrab B Manesh, Fraser G W Muir, Ryan Hirata, Matan Berson, Jie Liu, Michael Wegner, Ben Emery, G R Wayne Moore, Wolfram Tetzlaf. Myelin regulatory factor drives remyelination in multiple sclerosis. Acta neuropathologica. vol 134. issue 3. 2018-02-07. PMID:28631093. |
remyelination is limited in the majority of multiple sclerosis (ms) lesions despite the presence of oligodendrocyte precursor cells (opcs) in most lesions. |
2018-02-07 |
2023-08-13 |
mouse |
| Sihan Liu, Chuanlu Ren, Xuebin Qu, Xiuxiang Wu, Fuxing Dong, Yadav Kaushal Chand, Hongbin Fan, Ruiqin Yao, Deqin Gen. miR-219 attenuates demyelination in cuprizone-induced demyelinated mice by regulating monocarboxylate transporter 1. The European journal of neuroscience. vol 45. issue 2. 2018-02-06. PMID:27873367. |
remyelination is limited in patients with multiple sclerosis (ms) due to the difficulties in recruiting proliferating oligodendrocyte precursors (opcs), the inhibition of opc differentiation and/or maturation, and/or failure in the generation of the myelin sheath. |
2018-02-06 |
2023-08-13 |
mouse |
| Mary Patricia Yannakakis, Haralambos Tzoupis, Elena Michailidou, Efthimia Mantzourani, Carmen Simal, Theodore Tselio. Molecular dynamics at the receptor level of immunodominant myelin oligodendrocyte glycoprotein 35-55 epitope implicated in multiple sclerosis. Journal of molecular graphics & modelling. vol 68. 2018-01-29. PMID:27388119. |
molecular dynamics at the receptor level of immunodominant myelin oligodendrocyte glycoprotein 35-55 epitope implicated in multiple sclerosis. |
2018-01-29 |
2023-08-13 |
human |
| Yongfeng Chen, Wei Zhen, Tony Guo, Yonggang Zhao, Ailian Liu, Justin P Rubio, David Krull, Jill C Richardson, Hongtao Lu, Ryan Wan. Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination. PloS one. vol 12. issue 12. 2018-01-08. PMID:29253893. |
agents promoting oligodendrocyte precursor cell differentiation have the potential to restore halted and/or delayed remyelination in patients with multiple sclerosis. |
2018-01-08 |
2023-08-13 |
Not clear |
| Caroline Guglielmetti, Debbie Le Blon, Eva Santermans, Angelica Salas-Perdomo, Jasmijn Daans, Nathalie De Vocht, Disha Shah, Chloé Hoornaert, Jelle Praet, Jurgen Peerlings, Firat Kara, Christian Bigot, Zhenhua Mai, Herman Goossens, Niel Hens, Sven Hendrix, Marleen Verhoye, Anna M Planas, Zwi Berneman, Annemie van der Linden, Peter Ponsaert. Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages. Glia. vol 64. issue 12. 2018-01-05. PMID:27685637. |
with this study we provide evidence that lentiviral vector-mediated expression of the immune-modulating cytokine interleukin 13 (il-13) induces an alternative activation program in both microglia and macrophages conferring protection against severe oligodendrocyte loss and demyelination in the cuprizone mouse model for multiple sclerosis (ms). |
2018-01-05 |
2023-08-13 |
mouse |
| Antonella Casamassa, Claudia La Rocca, Sophie Sokolow, Andre Herchuelz, Giuseppe Matarese, Lucio Annunziato, Francesca Bosci. Ncx3 gene ablation impairs oligodendrocyte precursor response and increases susceptibility to experimental autoimmune encephalomyelitis. Glia. vol 64. issue 7. 2018-01-02. PMID:27120265. |
here ncx3 involvement was studied in myelin oligodendrocyte glycoprotein (mog)-induced experimental autoimmune encephalomyelitis (eae), an animal model of multiple sclerosis. |
2018-01-02 |
2023-08-13 |
mouse |
| Min Su, Yujun Lin, Cheng Cui, Xiaohong Tian, Xiuling Lu, Zhixu He, Laijun La. ESC-derived thymic epithelial cells expressing MOG prevents EAE by central and peripheral tolerance mechanisms. Cellular immunology. vol 322. 2017-12-29. PMID:29074250. |
experimental autoimmune encephalomyelitis (eae) is an animal model for multiple sclerosis (ms), and is induced by immunization with disease-causative self-antigens such as myelin oligodendrocyte glycoprotein (mog). |
2017-12-29 |
2023-08-13 |
mouse |
| Kazuya Kuboyama, Naomi Tanga, Ryoko Suzuki, Akihiro Fujikawa, Masaharu Nod. Protamine neutralizes chondroitin sulfate proteoglycan-mediated inhibition of oligodendrocyte differentiation. PloS one. vol 12. issue 12. 2017-12-26. PMID:29216327. |
chondroitin sulfate proteoglycans (cspgs), which are enriched in demyelinating plaques in neurodegenerative diseases, such as multiple sclerosis (ms), impair remyelination by inhibiting the migration and differentiation of oligodendrocyte precursor cells (opcs) in the central nervous system (cns). |
2017-12-26 |
2023-08-13 |
mouse |
| Raphael Tavares, Gabriel Wajnberg, Nicole de Miranda Scherer, Bianca Alves Pauletti, Juliana S Cassoli, Carlos Gil Ferreira, Adriana Franco Paes Leme, Patricia Savio de Araujo-Souza, Daniel Martins-de-Souza, Fabio Passett. Unveiling alterative splice diversity from human oligodendrocyte proteome data. Journal of proteomics. vol 151. 2017-12-08. PMID:27222040. |
because misassembled myelin sheaths have been associated with brain disorders such as multiple sclerosis and schizophrenia, recent advances have been made towards the description of the oligodendrocyte proteome. |
2017-12-08 |
2023-08-13 |
human |
| Neil J Scolding, Marcelo Pasquini, Stephen C Reingold, Jeffrey A Cohe. Cell-based therapeutic strategies for multiple sclerosis. Brain : a journal of neurology. vol 140. issue 11. 2017-11-07. PMID:29053779. |
cell-based therapies, including immunoablation followed by autologous haematopoietic stem cell transplantation, mesenchymal and related stem cell transplantation, pharmacologic manipulation of endogenous stem cells to enhance their reparative capabilities, and transplantation of oligodendrocyte progenitor cells, have generated substantial interest as novel therapeutic strategies for immune modulation, neuroprotection, or repair of the damaged central nervous system in multiple sclerosis. |
2017-11-07 |
2023-08-13 |
Not clear |
| Diara A Santiago González, Veronica T Cheli, Norma N Zamora, Tenzing N Lama, Vilma Spreuer, Geoffrey G Murphy, Pablo M Pae. Conditional Deletion of the L-Type Calcium Channel Cav1.2 in NG2-Positive Cells Impairs Remyelination in Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 42. 2017-10-27. PMID:28899915. |
exploring the molecular mechanisms that drive the maturation of oligodendrocyte progenitor cells (opcs) during the remyelination process is essential to developing new therapeutic tools to intervene in demyelinating diseases such as multiple sclerosis. |
2017-10-27 |
2023-08-13 |
mouse |