| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meredith D Hartley, Tania Banerji, Ian J Tagge, Lisa L Kirkemo, Priya Chaudhary, Evan Calkins, Danielle Galipeau, Mitra D Shokat, Margaret J DeBell, Shelby Van Leuven, Hannah Miller, Gail Marracci, Edvinas Pocius, Tapasree Banerji, Skylar J Ferrara, J Matthew Meinig, Ben Emery, Dennis Bourdette, Thomas S Scanla. Myelin repair stimulated by CNS-selective thyroid hormone action. JCI insight. vol 4. issue 8. 2020-06-19. PMID:30996143. |
oligodendrocyte processes wrap axons to form neuroprotective myelin sheaths, and damage to myelin in disorders, such as multiple sclerosis (ms), leads to neurodegeneration and disability. |
2020-06-19 |
2023-08-13 |
mouse |
| Jinma Ren, Marisa Ascencio, Tommaso Raimondi, Edward C Rainville, Reuben M Valenzuela, Carl V Asch. Association Between Exposure of Ipratropium and Salmeterol and Diagnosis of Multiple Sclerosis: A Matched Case-control Study. Clinical therapeutics. vol 41. issue 8. 2020-05-20. PMID:31128979. |
ipratropium and salmeterol were found to stimulate oligodendrocyte differentiation in a high-throughput drug screening assay; thus, they may play a role in the risk reduction of multiple sclerosis (ms). |
2020-05-20 |
2023-08-13 |
Not clear |
| Wonjin Yun, Wonjun Hong, Daryeon Son, Hui-Wen Liu, Seung-Soo Kim, Minji Park, In Yong Kim, Dae-Sung Kim, Gwonhwa Song, Seungkwon Yo. Generation of Anterior Hindbrain-Specific, Glial-Restricted Progenitor-Like Cells from Human Pluripotent Stem Cells. Stem cells and development. vol 28. issue 10. 2020-04-30. PMID:30880587. |
engraftment of oligodendrocyte progenitor cells (opcs), which form myelinating oligodendrocytes, has the potential to treat demyelinating diseases such as multiple sclerosis. |
2020-04-30 |
2023-08-13 |
mouse |
| Tianci Chu, Yi Ping Zhang, Zhisen Tian, Chuyuan Ye, Mingming Zhu, Lisa B E Shields, Maiying Kong, Gregory N Barnes, Christopher B Shields, Jun Ca. Dynamic response of microglia/macrophage polarization following demyelination in mice. Journal of neuroinflammation. vol 16. issue 1. 2020-03-30. PMID:31623610. |
the glial response in multiple sclerosis (ms), especially for recruitment and differentiation of oligodendrocyte progenitor cells (opcs), predicts the success of remyelination of ms plaques and return of function. |
2020-03-30 |
2023-08-13 |
mouse |
| Fei Wang, Feng Me. Kappa opioid receptor and oligodendrocyte remyelination. Vitamins and hormones. vol 111. 2020-03-26. PMID:31421704. |
adult oligodendrocyte precursor cells (opcs) maintain the abilities to differentiate and myelinate denuded axons in demyelinating diseases, such as multiple sclerosis (ms), albert often inefficiently. |
2020-03-26 |
2023-08-13 |
Not clear |
| Alexandra M Nicaise, Laura J Wagstaff, Cory M Willis, Carolyn Paisie, Harshpreet Chandok, Paul Robson, Valentina Fossati, Anna Williams, Stephen J Crocke. Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 18. 2020-03-25. PMID:30910981. |
we had previously determined that neural progenitor cells (npcs) derived from induced pluripotent stem cell (ipsc) lines from patients with primary progressive multiple sclerosis (ppms) failed to promote oligodendrocyte progenitor cell (opc) maturation, whereas npcs from age-matched control cell lines did so efficiently. |
2020-03-25 |
2023-08-13 |
human |
| Markus Reindl, Patrick Water. Myelin oligodendrocyte glycoprotein antibodies in neurological disease. Nature reviews. Neurology. vol 15. issue 2. 2020-01-29. PMID:30559466. |
anti-myelin oligodendrocyte glycoprotein (mog) antibodies (mog-abs) were first detected by immunoblot and enzyme-linked immunosorbent assay nearly 30 years ago, but their association with multiple sclerosis (ms) was not specific. |
2020-01-29 |
2023-08-13 |
Not clear |
| Dharmaraja Allimuthu, Zita Hubler, Fadi J Najm, Hong Tang, Ilya Bederman, William Seibel, Paul J Tesar, Drew J Adam. Diverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP. Cell chemical biology. vol 26. issue 4. 2020-01-27. PMID:30773481. |
small molecules that promote oligodendrocyte formation have been identified in "drug repurposing" screens to nominate candidate therapeutics for diseases in which myelin is lost, including multiple sclerosis. |
2020-01-27 |
2023-08-13 |
Not clear |
| Jing Wang, Ruo-Xuan Sui, Qiang Miao, Qing Wang, Li-Juan Song, Jie-Zhong Yu, Yan-Hua Li, Bao-Guo Xiao, Cun-Gen M. Hydroxyfasudil alleviates demyelination through the inhibition of MOG antibody and microglia activation in cuprizone mouse model. Clinical immunology (Orlando, Fla.). vol 201. 2020-01-21. PMID:30660624. |
multiple sclerosis (ms) is an immune-mediated demyelinating disease of the central nervous system characterized by oligodendrocyte loss and progressive neurodegeneration. |
2020-01-21 |
2023-08-13 |
mouse |
| A Bellinvia, L Pastò, L Razzolini, R Fratangelo, E Prestipino, M Fonderico, L Tudisco, M P Amat. The clinical spectrum of anti-MOG associated acquired demyelinating disorders: Three case-reports. Multiple sclerosis and related disorders. vol 33. 2020-01-13. PMID:31152967. |
there is now growing evidence that supports anti-myelin oligodendrocyte antibodies associated demyelination as a distinct disease entity, with some clinical characteristics that somehow overlap those of multiple sclerosis (ms) and anti-aqp4+ neuromyelitis optica spectrum disorders (aqp4+nmosd) but different pathogenesis and treatment strategies. |
2020-01-13 |
2023-08-13 |
Not clear |
| Jae-Won Hyun, So-Young Huh, Hyun-June Shin, Mark Woodhall, Su-Hyun Kim, Sarosh R Irani, Sang Hyun Lee, Patrick Waters, Ho Jin Ki. Evaluation of brain lesion distribution criteria at disease onset in differentiating MS from NMOSD and MOG-IgG-associated encephalomyelitis. Multiple sclerosis (Houndmills, Basingstoke, England). vol 25. issue 4. 2020-01-09. PMID:29512413. |
we aimed to evaluate the utility of the recently described brain lesion distribution criteria to differentiate multiple sclerosis (ms) from aquaporin-4 immunoglobulin g-positive neuromyelitis optica spectrum disorder (nmosd) and myelin oligodendrocyte glycoprotein immunoglobulin g-associated encephalomyelitis (mog-em) at disease onset in an asian cohort. |
2020-01-09 |
2023-08-13 |
Not clear |
| Marilou Caron-Cantin, Dean M Cestari, Elizabeth Forti. Clinical and radiologic approach to 'typical' versus antibody-related optic neuritis. Current opinion in ophthalmology. vol 30. issue 6. 2019-12-20. PMID:31503075. |
optic neuritis is an autoimmune optic neuropathy that has been associated with multiple sclerosis (ms), neuromyelitis optica spectrum disorder (nmosd), and more recently antimyelin oligodendrocyte glycoprotein (anti-mog)-positive disorder. |
2019-12-20 |
2023-08-13 |
Not clear |
| Jing Zhang, Zheng Gang Zhang, Mei Lu, Yi Zhang, Xia Shang, Michael Chop. MiR-146a promotes oligodendrocyte progenitor cell differentiation and enhances remyelination in a model of experimental autoimmune encephalomyelitis. Neurobiology of disease. vol 125. 2019-12-16. PMID:30707940. |
remyelination requires the differentiation of oligodendrocyte progenitor cells (opcs) into myelinating ols, which in the cns with neurodegenerative diseases such as multiple sclerosis (ms), is often inhibited. |
2019-12-16 |
2023-08-13 |
mouse |
| Esther M Tantsis, Kristina Prelog, Gulay Alper, Leslie Benson, Mark Gorman, Ming Lim, Shekeeb S Mohammad, Sudarshini Ramanathan, Fabienne Brilot, Russell C Dal. Magnetic resonance imaging in enterovirus-71, myelin oligodendrocyte glycoprotein antibody, aquaporin-4 antibody, and multiple sclerosis-associated myelitis in children. Developmental medicine and child neurology. vol 61. issue 9. 2019-12-06. PMID:30537075. |
we used magnetic resonance imaging (mri) to compare the neuroimaging of children with their first episode of clinical enterovirus 71-associated transverse myelitis (ev71-tm), myelin oligodendrocyte glycoprotein antibody positive transverse myelitis (mog-tm), aquaporin-4 antibody positive transverse myelitis (aqp4-tm), transverse myelitis in multiple sclerosis (ms-tm), and unclassified transverse myelitis (unc-tm). |
2019-12-06 |
2023-08-13 |
Not clear |
| Francesco Girolamo, Mariella Errede, Giovanna Longo, Tiziana Annese, Carlotta Alias, Giovanni Ferrara, Sara Morando, Maria Trojano, Nicole Kerlero de Rosbo, Antonio Uccelli, Daniela Virgintin. Defining the role of NG2-expressing cells in experimental models of multiple sclerosis. A biofunctional analysis of the neurovascular unit in wild type and NG2 null mice. PloS one. vol 14. issue 3. 2019-12-03. PMID:30870435. |
during experimental autoimmune encephalomyelitis (eae), a model for multiple sclerosis associated with blood-brain barrier (bbb) disruption, oligodendrocyte precursor cells (opcs) overexpress proteoglycan nerve/glial antigen 2 (ng2), proliferate, and make contacts with the microvessel wall. |
2019-12-03 |
2023-08-13 |
mouse |
| Mitrovic, Parkinson, Merril. An in Vitro Model of Oligodendrocyte Destruction by Nitric Oxide and Its Relevance to Multiple Sclerosis Methods (San Diego, Calif.). vol 10. issue 3. 2019-11-20. PMID:8954860. |
an in vitro model of oligodendrocyte destruction by nitric oxide and its relevance to multiple sclerosis there is mounting evidence that nitric oxide (no) is produced in the brains of patients with multiple sclerosis (ms) and in the experimental model of ms, experimental autoimmune encephalomyelitis, after the induction of type ii nitric oxide synthase (inos). |
2019-11-20 |
2023-08-12 |
Not clear |
| Arun Thiruvalluvan, Marcin Czepiel, Yolanda A Kap, Ietje Mantingh-Otter, Ilia Vainchtein, Jeroen Kuipers, Marjolein Bijlard, Wia Baron, Ben Giepmans, Wolfgang Brück, Bert A 't Hart, Erik Boddeke, Sjef Copra. Survival and Functionality of Human Induced Pluripotent Stem Cell-Derived Oligodendrocytes in a Nonhuman Primate Model for Multiple Sclerosis. Stem cells translational medicine. vol 5. issue 11. 2019-11-20. PMID:27400790. |
: fast remyelination by endogenous oligodendrocyte precursor cells (opcs) is essential to prevent axonal and subsequent retrograde neuronal degeneration in demyelinating lesions in multiple sclerosis (ms). |
2019-11-20 |
2023-08-13 |
mouse |
| Maggie S Y Yeung, Mehdi Djelloul, Embla Steiner, Samuel Bernard, Mehran Salehpour, Göran Possnert, Lou Brundin, Jonas Frisé. Publisher Correction: Dynamics of oligodendrocyte generation in multiple sclerosis. Nature. vol 566. issue 7744. 2019-11-20. PMID:30723267. |
publisher correction: dynamics of oligodendrocyte generation in multiple sclerosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Yana Zorina, Jason Stricker, Anthony O Caggiano, Donald C Butto. Human IgM antibody rHIgM22 promotes phagocytic clearance of myelin debris by microglia. Scientific reports. vol 8. issue 1. 2019-10-10. PMID:29925848. |
in multiple sclerosis (ms), demyelinated cns lesions fail to sufficiently remyelinate, despite the presence of oligodendrocyte precursor cells (opcs) capable of differentiating into mature oligodendrocytes. |
2019-10-10 |
2023-08-13 |
mouse |
| Charlotte G H M de Jong, Mirjana Stancic, Tineke H Pinxterhuis, Jack van Horssen, Anne-Marie van Dam, Hans-Joachim Gabius, Wia Baro. Galectin-4, a Negative Regulator of Oligodendrocyte Differentiation, Is Persistently Present in Axons and Microglia/Macrophages in Multiple Sclerosis Lesions. Journal of neuropathology and experimental neurology. vol 77. issue 11. 2019-10-07. PMID:30252090. |
galectin-4, a negative regulator of oligodendrocyte differentiation, is persistently present in axons and microglia/macrophages in multiple sclerosis lesions. |
2019-10-07 |
2023-08-13 |
Not clear |