| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yueyong Li, Yingjun Zhang, Huangde Fu, Huadong Huang, Qifeng Lu, Houji Qin, Yingning Wu, Huatuo Huang, Guizhen Mao, Zhongheng Wei, Pinhu Lia. Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/eIF2α/ATF4/CHOP Signaling Pathway. Neuroscience bulletin. vol 36. issue 2. 2020-12-17. PMID:31309426. |
hes1 knockdown exacerbates ischemic stroke following tmcao by increasing er stress-dependent apoptosis via the perk/eif2α/atf4/chop signaling pathway. |
2020-12-17 |
2023-08-13 |
mouse |
| Yueyong Li, Yingjun Zhang, Huangde Fu, Huadong Huang, Qifeng Lu, Houji Qin, Yingning Wu, Huatuo Huang, Guizhen Mao, Zhongheng Wei, Pinhu Lia. Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/eIF2α/ATF4/CHOP Signaling Pathway. Neuroscience bulletin. vol 36. issue 2. 2020-12-17. PMID:31309426. |
apoptosis induced by endoplasmic reticulum (er) stress plays a crucial role in mediating brain damage after ischemic stroke. |
2020-12-17 |
2023-08-13 |
mouse |
| Yueyong Li, Yingjun Zhang, Huangde Fu, Huadong Huang, Qifeng Lu, Houji Qin, Yingning Wu, Huatuo Huang, Guizhen Mao, Zhongheng Wei, Pinhu Lia. Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/eIF2α/ATF4/CHOP Signaling Pathway. Neuroscience bulletin. vol 36. issue 2. 2020-12-17. PMID:31309426. |
furthermore, inhibition of perk with the specific inhibitor gsk2606414 markedly attenuated the hes1 knockdown-induced apoptosis and the increased cerebral infarction as well as the worsened neurological outcome following tmcao, implying that the protection of hes1 against ischemic stroke is associated with the amelioration of er stress via modulating the perk/eif2α/atf4/chop signaling pathway. |
2020-12-17 |
2023-08-13 |
mouse |
| Yueyong Li, Yingjun Zhang, Huangde Fu, Huadong Huang, Qifeng Lu, Houji Qin, Yingning Wu, Huatuo Huang, Guizhen Mao, Zhongheng Wei, Pinhu Lia. Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/eIF2α/ATF4/CHOP Signaling Pathway. Neuroscience bulletin. vol 36. issue 2. 2020-12-17. PMID:31309426. |
taken together, these results unveil the detrimental role of hes1 knockdown after ischemic stroke and further relate it to the regulation of er stress-induced apoptosis, thus highlighting the importance of targeting er stress in the treatment of ischemic stroke. |
2020-12-17 |
2023-08-13 |
mouse |
| Yun-An Chen, Yi-Chieh Tsai, Yi-Dao Chen, Der-Zen Liu, Tai-Horng Young, Li-Kai Tsa. Intraventricular Medium B Treatment Benefits an Ischemic Stroke Rodent Model via Enhancement of Neurogenesis and Anti-apoptosis. Scientific reports. vol 10. issue 1. 2020-11-26. PMID:32313130. |
in summary, medium b treatment results in less neuronal death and better functional outcome in both cellular and rodent models of ischemic stroke, probably via promotion of neurogenesis and reduction of apoptosis. |
2020-11-26 |
2023-08-13 |
rat |
| Yan Wang, Xi-Xi Gu, Hua-Tuo Huang, Chun-Hong Liu, Ye-Sheng We. A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke. Lipids in health and disease. vol 19. issue 1. 2020-11-23. PMID:32238151. |
particularly in ischemic stroke (is), the abnormal expression of malat1 played important roles including promotion of angiogenesis, inhibition of apoptosis and inflammation and regulation of autophagy. |
2020-11-23 |
2023-08-13 |
Not clear |
| Xianghui Zhang, Guan'en Zho. MiR-199a-5p inhibition protects cognitive function of ischemic stroke rats by AKT signaling pathway. American journal of translational research. vol 12. issue 10. 2020-11-17. PMID:33194051. |
in conclusion, silencing mir-199a-5p can effectively improve cognitive function in ischemic stroke rats and decrease neuronal apoptosis in hippocampus by activating the akt signaling pathway. |
2020-11-17 |
2023-08-13 |
rat |
| A V Lugovaya, V S Emanuel, N M Kalinina, A M Ivanov, A V Artemov. [Apoptosis and autophagy in the pathogenesis of acute ischemic stroke (review of literature).] Klinicheskaia laboratornaia diagnostika. vol 65. issue 7. 2020-11-02. PMID:32762181. |
[apoptosis and autophagy in the pathogenesis of acute ischemic stroke (review of literature).] |
2020-11-02 |
2023-08-13 |
Not clear |
| Qingqing Dai, Song Han, Ting Liu, Jiayin Zheng, Cui Liu, Junfa Li, Shujuan L. IL-17A Neutralization Improves the Neurological Outcome of Mice With Ischemic Stroke and Inhibits Caspase-12-Dependent Apoptosis. Frontiers in aging neuroscience. vol 12. 2020-10-28. PMID:33101005. |
il-17a neutralization improves the neurological outcome of mice with ischemic stroke and inhibits caspase-12-dependent apoptosis. |
2020-10-28 |
2023-08-13 |
mouse |
| Qingqing Dai, Song Han, Ting Liu, Jiayin Zheng, Cui Liu, Junfa Li, Shujuan L. IL-17A Neutralization Improves the Neurological Outcome of Mice With Ischemic Stroke and Inhibits Caspase-12-Dependent Apoptosis. Frontiers in aging neuroscience. vol 12. 2020-10-28. PMID:33101005. |
the il-17a neutralization could also significantly inhibit the increase of pro-caspase-3 cleavage through caspase-12-dependent cell apoptosis, as well as preventing the decrease of antiapoptotic factor b-cell lymphoma 2 (bcl-2) and the increase of proapoptotic bcl-2-associated x protein (bax) in the peri-infarct region of mice following ischemic stroke. |
2020-10-28 |
2023-08-13 |
mouse |
| Qingqing Dai, Song Han, Ting Liu, Jiayin Zheng, Cui Liu, Junfa Li, Shujuan L. IL-17A Neutralization Improves the Neurological Outcome of Mice With Ischemic Stroke and Inhibits Caspase-12-Dependent Apoptosis. Frontiers in aging neuroscience. vol 12. 2020-10-28. PMID:33101005. |
these results suggest that il-17a neutralization could improve the neurological outcome of mice with ischemic stroke through inhibiting caspase-12-dependent neuronal apoptosis. |
2020-10-28 |
2023-08-13 |
mouse |
| Mahdieh Khoshnazar, Siavash Parvardeh, Mohammad Reza Bigdel. Alpha-pinene exerts neuroprotective effects via anti-inflammatory and anti-apoptotic mechanisms in a rat model of focal cerebral ischemia-reperfusion. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 29. issue 8. 2020-10-23. PMID:32689608. |
neuro-inflammation and apoptosis play an essential role in the pathogenesis of neuronal death during ischemic stroke. |
2020-10-23 |
2023-08-13 |
rat |
| Qiang He, Hui Liu, Shuwen Deng, Xiqian Chen, Dong Li, Xuan Jiang, Wenbo Zeng, Wei L. The Golgi Apparatus May Be a Potential Therapeutic Target for Apoptosis-Related Neurological Diseases. Frontiers in cell and developmental biology. vol 8. 2020-10-06. PMID:33015040. |
golgi-related apoptosis is associated with a variety of neurological diseases including glioma, alzheimer's disease (ad), parkinson's disease (pd), and ischemic stroke. |
2020-10-06 |
2023-08-13 |
Not clear |
| Shouye Hu, Qingwen Cao, Peng Xu, Wenchen Ji, Gang Wang, Yuelin Zhan. Rolipram stimulates angiogenesis and attenuates neuronal apoptosis through the cAMP/cAMP-responsive element binding protein pathway following ischemic stroke in rats. Experimental and therapeutic medicine. vol 11. issue 3. 2020-10-01. PMID:26998028. |
rolipram stimulates angiogenesis and attenuates neuronal apoptosis through the camp/camp-responsive element binding protein pathway following ischemic stroke in rats. |
2020-10-01 |
2023-08-13 |
rat |
| Jing Sun, Da-Dui Ren, Jin-Yi Wan, Chen Chen, Dong Chen, Huan Yang, Chun-Lai Feng, Jing Ga. Desensitizing Mitochondrial Permeability Transition by ERK-Cyclophilin D Axis Contributes to the Neuroprotective Effect of Gallic Acid against Cerebral Ischemia/Reperfusion Injury. Frontiers in pharmacology. vol 8. 2020-10-01. PMID:28428752. |
much evidence confirms that opening of the mitochondrial permeability transition pore (mptp) is related with mitochondrial dysfunction to apoptosis in ischemic stroke, thus elucidating its signaling mechanism and screening novel mptp inhibitor is therefore of paramount importance. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jing Sun, Da-Dui Ren, Jin-Yi Wan, Chen Chen, Dong Chen, Huan Yang, Chun-Lai Feng, Jing Ga. Desensitizing Mitochondrial Permeability Transition by ERK-Cyclophilin D Axis Contributes to the Neuroprotective Effect of Gallic Acid against Cerebral Ischemia/Reperfusion Injury. Frontiers in pharmacology. vol 8. 2020-10-01. PMID:28428752. |
our study firstly identifies erk-cypd axis is one of the cornerstones of the cell death pathways following ischemic stroke, and confirms ga is a novel inhibitor of mptp, which inhibits apoptosis depending on regulating the erk-cypd axis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Dongmei Liu, Man Zhang, Xianfang Rong, Jiang Li, Xiaoliang Wan. Potassium 2-(1-hydroxypentyl)-benzoate attenuates neuronal apoptosis in neuron-astrocyte co-culture system through neurotrophy and neuroinflammation pathway. Acta pharmaceutica Sinica. B. vol 7. issue 5. 2020-10-01. PMID:28924549. |
potassium 2-(1-hydroxypentyl)-benzoate (d,l-phpb), a new drug candidate for ischemic stroke at the phase ii clinic trial, has been shown to protect neurons by inhibiting oxidative injury and reducing neuron apoptosis in previous studies. |
2020-10-01 |
2023-08-13 |
Not clear |
| Rajeev Gupta, Subhendu Ghos. Putative roles of mitochondrial Voltage-Dependent Anion Channel, Bcl-2 family proteins and c-Jun N-terminal Kinases in ischemic stroke associated apoptosis. Biochimie open. vol 4. 2020-10-01. PMID:29450141. |
putative roles of mitochondrial voltage-dependent anion channel, bcl-2 family proteins and c-jun n-terminal kinases in ischemic stroke associated apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Gaby Enzmann, Soghra Kargaran, Britta Engelhard. Ischemia-reperfusion injury in stroke: impact of the brain barriers and brain immune privilege on neutrophil function. Therapeutic advances in neurological disorders. vol 11. 2020-10-01. PMID:30181779. |
reperfusion injury following ischemic stroke is a complex pathophysiological process involving numerous mechanisms ranging from the release of excitatory amino acids and ion disequilibrium to the induction of apoptosis and necrosis, to oxidative stress and inflammation. |
2020-10-01 |
2023-08-13 |
human |
| Olena Y Glushakova, Andriy A Glushakov, Dayanjan S Wijesinghe, Alex B Valadka, Ronald L Hayes, Alexander V Glushako. Prospective clinical biomarkers of caspase-mediated apoptosis associated with neuronal and neurovascular damage following stroke and other severe brain injuries: Implications for chronic neurodegeneration. Brain circulation. vol 3. issue 2. 2020-10-01. PMID:30276309. |
over the past two decades, several clinical biomarkers of apoptosis have been identified in cerebrospinal fluid and peripheral blood following ischemic stroke, intracerebral and subarachnoid hemorrhage, and tbi. |
2020-10-01 |
2023-08-13 |
Not clear |