| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Zhong, Bo Yin, Yingze Ye, Omar Y A T Dekhel, Xiaoxing Xiong, Zhihong Jian, Lijuan G. The bidirectional role of the JAK2/STAT3 signaling pathway and related mechanisms in cerebral ischemia-reperfusion injury. Experimental neurology. vol 341. 2021-10-04. PMID:33798563. |
the inflammatory response, apoptosis, oxidative stress and angiogenesis are the main factors involved in the pathogenesis of ischemic stroke. |
2021-10-04 |
2023-08-13 |
Not clear |
| Xiangyue Zhou, Hanmin Chen, Ling Wang, Cameron Lenahan, Lifei Lian, Yibo Ou, Yue H. Mitochondrial Dynamics: A Potential Therapeutic Target for Ischemic Stroke. Frontiers in aging neuroscience. vol 13. 2021-09-25. PMID:34557086. |
brain injury after ischemic stroke involves multiple pathophysiological mechanisms, such as oxidative stress, mitochondrial dysfunction, excitotoxicity, calcium overload, neuroinflammation, neuronal apoptosis, and blood-brain barrier (bbb) disruption. |
2021-09-25 |
2023-08-13 |
Not clear |
| Andrés da Silva-Candal, María Pérez-Mato, Manuel Rodríguez-Yáñez, Iria López-Dequidt, José M Pumar, Paulo Ávila-Gómez, Tomás Sobrino, Francisco Campos, José Castillo, Pablo Hervella, Ramón Iglesias-Re. The presence of leukoaraiosis enhances the association between sTWEAK and hemorrhagic transformation. Annals of clinical and translational neurology. vol 7. issue 11. 2021-09-24. PMID:33022893. |
to investigate whether elevated serum levels of stweak (soluble tumor necrosis factor-like inducer of apoptosis) might be involved in a higher frequency of symptomatic hemorrhagic transformation (ht) through the presence of leukoaraiosis (la) in patients with acute ischemic stroke (is) undergoing reperfusion therapies. |
2021-09-24 |
2023-08-13 |
Not clear |
| Yongli Pan, Qingzheng Jiao, Wei Wei, Tianyang Zheng, Xinyu Yang, Wenqiang Xi. Emerging Role of LncRNAs in Ischemic Stroke-Novel Insights into the Regulation of Inflammation. Journal of inflammation research. vol 14. 2021-09-16. PMID:34522116. |
the mechanisms underlying ischemic stroke include angiogenesis, autophagy, apoptosis, cell death, and neuroinflammation. |
2021-09-16 |
2023-08-13 |
Not clear |
| Wenxiang Fan, Ying Zhang, Xiaomin Li, Chi X. S-oxiracetam Facilitates Cognitive Restoration after Ischemic Stroke by Activating α7nAChR and the PI3K-Mediated Pathway. Neurochemical research. vol 46. issue 4. 2021-09-14. PMID:33481205. |
s-oxiracetam (s-orc), a nootropic drug, was used to protect against ischemic stroke by lessening the blood brain barrier dysfunction and inhibiting neuronal apoptosis. |
2021-09-14 |
2023-08-13 |
rat |
| Lei Zhao, Meng Zhang, Fang Yan, Yuxia Con. Knockdown of RMST Impedes Neuronal Apoptosis and Oxidative Stress in OGD/R-Induced Ischemic Stroke Via Depending on the miR-377/SEMA3A Signal Network. Neurochemical research. vol 46. issue 3. 2021-09-07. PMID:33409855. |
knockdown of rmst impedes neuronal apoptosis and oxidative stress in ogd/r-induced ischemic stroke via depending on the mir-377/sema3a signal network. |
2021-09-07 |
2023-08-13 |
Not clear |
| Zhimin Li, Xing Cao, Ligen Xiao, Ruijiao Zho. Aloperine protects against cerebral ischemia/reperfusion injury via activating the PI3K/AKT signaling pathway in rats. Experimental and therapeutic medicine. vol 22. issue 4. 2021-08-27. PMID:34434259. |
collectively, the aforementioned findings indicated that alo could improve cerebral i/r injury and alleviate oxidative stress, inflammation and cell apoptosis via activating the pi3k/akt signaling pathway, thus supporting the therapeutic potential of alo against cerebral i/r injury in ischemic stroke. |
2021-08-27 |
2023-08-13 |
rat |
| Kai Wang, Lu Lei, Jinyi Cao, Yi Qiao, Ruimin Liang, Jialin Duan, Zhijun Feng, Yi Ding, Yang Ma, Zhifu Yang, Enhu Zhan. Network pharmacology-based prediction of the active compounds and mechanism of Buyang Huanwu Decoction for ischemic stroke. Experimental and therapeutic medicine. vol 22. issue 4. 2021-08-27. PMID:34434264. |
furthermore, the tnf, il17, apoptosis, pi3k-akt, toll-like receptor, mapk, nf-κb and hif-1 signaling pathways were identified to be associated with ischemic stroke. |
2021-08-27 |
2023-08-13 |
Not clear |
| Xiaqing Guo, Yabo Wang, Donglin Zheng, Xiangshu Cheng, Yuhua Su. LncRNA-MIAT promotes neural cell autophagy and apoptosis in ischemic stroke by up-regulating REDD1. Brain research. vol 1763. 2021-08-25. PMID:33745924. |
lncrna-miat promotes neural cell autophagy and apoptosis in ischemic stroke by up-regulating redd1. |
2021-08-25 |
2023-08-13 |
Not clear |
| Gabriel R Linares, Yan Leng, Dragan Maric, De-Maw Chuan. Overexpression of fibroblast growth factor-21 (FGF-21) protects mesenchymal stem cells against caspase-dependent apoptosis induced by oxidative stress and inflammation. Cell biology international. vol 44. issue 10. 2021-08-10. PMID:32557962. |
on the basis of our previous findings that fibroblast growth factor 21 (fgf-21) protected neurons from glutamate excitotoxicity and that upregulation of fgf-21 in a rat model of ischemic stroke was associated with neuroprotection, we proposed that overexpression of fgf-21 protects bone marrow-derived mesenchymal stem cells (mscs) from apoptosis. |
2021-08-10 |
2023-08-13 |
rat |
| Qian Xu, Ma Guohui, Dandan Li, Fanghui Bai, Jintao Fang, Gui Zhang, Yuxin Xing, Jiawei Zhou, Yugang Guo, Yunchao Ka. lncRNA C2dat2 facilitates autophagy and apoptosis via the miR-30d-5p/DDIT4/mTOR axis in cerebral ischemia-reperfusion injury. Aging. vol 13. issue 8. 2021-08-02. PMID:33833132. |
cerebral ischemia-reperfusion injury (ciri) is an important pathophysiological process of ischemic stroke associated with various physiological and pathological processes, including autophagy and apoptosis. |
2021-08-02 |
2023-08-13 |
Not clear |
| Suiqing Weng, Sheng Wang, Jingwen Jian. Long Noncoding RNA X-Inactive Specific Transcript Regulates Neuronal Cell Apoptosis in Ischemic Stroke Through miR-98/BACH1 Axis. DNA and cell biology. vol 40. issue 7. 2021-07-30. PMID:34227845. |
long noncoding rna x-inactive specific transcript regulates neuronal cell apoptosis in ischemic stroke through mir-98/bach1 axis. |
2021-07-30 |
2023-08-13 |
mouse |
| Tianhui Yang, Ruyi He, Gongzhe Li, Jia Liang, Liang Zhao, Xing Zhao, Liyang Li, Peng Wan. Growth arrest and DNA damage-inducible protein 34 (GADD34) contributes to cerebral ischemic injury and can be detected in plasma exosomes. Neuroscience letters. vol 758. 2021-07-20. PMID:34098025. |
gadd34 has opposing effects on different stimulus-induced cell apoptosis events in many nervous system diseases, but its role in ischemic stroke is unclear. |
2021-07-20 |
2023-08-13 |
rat |
| Yuan Zhang, Xiaotian Zhang, Qiangqiang Wei, Shuo Leng, Cai Li, Bing Han, Ying Bai, Huibin Zhang, Honghong Ya. Activation of Sigma-1 Receptor Enhanced Pericyte Survival via the Interplay Between Apoptosis and Autophagy: Implications for Blood-Brain Barrier Integrity in Stroke. Translational stroke research. vol 11. issue 2. 2021-07-19. PMID:31290080. |
further studies indicated that cell apoptosis and autophagy were induced in an in vivo pmcao ischemic stroke animal model and an in vitro oxygen glucose deprivation-treatment group. |
2021-07-19 |
2023-08-13 |
mouse |
| Yiming Deng, Duanduan Chen, Feng Gao, Hong Lv, Guojun Zhang, Xuan Sun, Lian Liu, Dapeng Mo, Ning Ma, Ligang Song, Xiaochuan Huo, Tianyi Yan, Jingbo Zhang, Yun Luo, Zhongrong Mia. Silencing of Long Non-coding RNA GAS5 Suppresses Neuron Cell Apoptosis and Nerve Injury in Ischemic Stroke Through Inhibiting DNMT3B-Dependent MAP4K4 Methylation. Translational stroke research. vol 11. issue 5. 2021-07-19. PMID:31997156. |
silencing of long non-coding rna gas5 suppresses neuron cell apoptosis and nerve injury in ischemic stroke through inhibiting dnmt3b-dependent map4k4 methylation. |
2021-07-19 |
2023-08-13 |
mouse |
| Yiming Deng, Duanduan Chen, Feng Gao, Hong Lv, Guojun Zhang, Xuan Sun, Lian Liu, Dapeng Mo, Ning Ma, Ligang Song, Xiaochuan Huo, Tianyi Yan, Jingbo Zhang, Yun Luo, Zhongrong Mia. Silencing of Long Non-coding RNA GAS5 Suppresses Neuron Cell Apoptosis and Nerve Injury in Ischemic Stroke Through Inhibiting DNMT3B-Dependent MAP4K4 Methylation. Translational stroke research. vol 11. issue 5. 2021-07-19. PMID:31997156. |
ischemic stroke is associated with various physiological and pathological processes including neuronal apoptosis. |
2021-07-19 |
2023-08-13 |
mouse |
| Yiming Deng, Duanduan Chen, Feng Gao, Hong Lv, Guojun Zhang, Xuan Sun, Lian Liu, Dapeng Mo, Ning Ma, Ligang Song, Xiaochuan Huo, Tianyi Yan, Jingbo Zhang, Yun Luo, Zhongrong Mia. Silencing of Long Non-coding RNA GAS5 Suppresses Neuron Cell Apoptosis and Nerve Injury in Ischemic Stroke Through Inhibiting DNMT3B-Dependent MAP4K4 Methylation. Translational stroke research. vol 11. issue 5. 2021-07-19. PMID:31997156. |
collectively, the present study highlights that silencing gas5 may inhibit neuronal apoptosis and improve neurological function in ischemic stroke by suppressing dnmt3b-mediated map4k4 methylation, which contributes to better understanding of the pathologies of ischemic stroke and development of novel therapeutic options for this disease. |
2021-07-19 |
2023-08-13 |
mouse |
| Umadevi V Wesley, Ian C Sutton, Katelin Cunningham, Jacob W Jaeger, Allan Q Phan, James F Hatcher, Robert J Dempse. Galectin-3 protects against ischemic stroke by promoting neuro-angiogenesis via apoptosis inhibition and Akt/Caspase regulation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 41. issue 4. 2021-07-16. PMID:33736511. |
galectin-3 protects against ischemic stroke by promoting neuro-angiogenesis via apoptosis inhibition and akt/caspase regulation. |
2021-07-16 |
2023-08-13 |
rat |
| Kanika Vasudeva, Anyeasha Dutta, Anjana Munsh. Role of lncRNAs in the Development of Ischemic Stroke and Their Therapeutic Potential. Molecular neurobiology. vol 58. issue 8. 2021-07-15. PMID:33818737. |
in this review, the current knowledge of lncrnas in ischemic stroke, focusing on the mechanism by which they cause cellular apoptosis, inflammation, and microglial activation, has been summarized. |
2021-07-15 |
2023-08-13 |
human |
| Cheng Luo, Qi Chen, Bowen Liu, Shengpeng Wang, Hualin Yu, Xiaowei Guan, Yonghua Zhao, Yitao Wan. The Extracts of Oxidative medicine and cellular longevity. vol 2021. 2021-07-15. PMID:34257822. |
the extracts of the study indicates inflammation and autophagy are closely related to neural apoptosis in the pathology of ischemic stroke. |
2021-07-15 |
2023-08-13 |
Not clear |