| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Desheng Liu, Yuntao Gu, Wenting Wang, Wendao Che. Astragalin alleviates ischemia/reperfusion‑induced brain injury via suppression of endoplasmic reticulum stress. Molecular medicine reports. vol 22. issue 5. 2021-04-30. PMID:33000226. |
excessive apoptosis and neuronal dysfunction are pathological features of ischemic stroke. |
2021-04-30 |
2023-08-13 |
rat |
| Leonardo Lorente, María M Martín, Agustín F González-Rivero, Antonia Pérez-Cejas, Luis Ramos-Gómez, Jordi Solé-Violán, Juan J Cáceres, Jacobo J Villacampa-Jiménez, Alejandro Jiméne. Serum Levels of B-cell Lymphoma-2 Anti-Apoptotic Protein and Malignant Middle Cerebral Artery Infarction Mortality. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 30. issue 5. 2021-04-28. PMID:33690027. |
there is scarce and contradictory data on b-cell lymphoma 2 (bcl2), member of the bcl-2 antiapoptotic molecules family of intrinsic apoptosis pathway, in ischemic stroke patients. |
2021-04-28 |
2023-08-13 |
Not clear |
| Y Zhao, J Li, J Li, L Xu, W Lia. The decreased circular RNA hsa_circ_0072309 promotes cell apoptosis of ischemic stroke by sponging miR-100. European review for medical and pharmacological sciences. vol 24. issue 8. 2021-03-29. PMID:32373980. |
the decreased circular rna hsa_circ_0072309 promotes cell apoptosis of ischemic stroke by sponging mir-100. |
2021-03-29 |
2023-08-13 |
mouse |
| Yuxian Li, Ke Hu, Minghua Liang, Qing Yan, Minjiang Huang, Ling Jin, Yuefu Chen, Xirong Yang, Xiaobo L. Stilbene glycoside upregulates SIRT3/AMPK to promotes neuronal mitochondrial autophagy and inhibit apoptosis in ischemic stroke. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. vol 30. issue 2. 2021-03-18. PMID:33650328. |
stilbene glycoside upregulates sirt3/ampk to promotes neuronal mitochondrial autophagy and inhibit apoptosis in ischemic stroke. |
2021-03-18 |
2023-08-13 |
Not clear |
| Xinyu Wang, Liangshu Feng, Meiying Xin, Yulei Hao, Xu Wang, Pei Shang, Mingming Zhao, Shuai Hou, Yunhai Zhang, Yun Xiao, Di Ma, Jiachun Fen. Mechanisms underlying astrocytic connexin-43 autophagy degradation during cerebral ischemia injury and the effect on neuroinflammation and cell apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 127. 2021-03-11. PMID:32361163. |
the study has identified potentially novel therapeutic strategies against ischemic stroke and evidence of crosstalk between autophagic degradation of cx43, astrocytic apoptosis, and neuroinflammation. |
2021-03-11 |
2023-08-13 |
Not clear |
| Yanxiao Xiang, Yayun Zhang, Yanni Xia, Hua Zhao, Anchang Liu, Yuguo Che. LncRNA MEG3 targeting miR-424-5p via MAPK signaling pathway mediates neuronal apoptosis in ischemic stroke. Aging. vol 12. issue 4. 2021-02-18. PMID:32065781. |
lncrna meg3 targeting mir-424-5p via mapk signaling pathway mediates neuronal apoptosis in ischemic stroke. |
2021-02-18 |
2023-08-13 |
Not clear |
| Junna He, Xiangjian Zhan. miR-668 inhibitor attenuates mitochondrial membrane potential and protects against neuronal apoptosis in cerebral ischemic stroke. Folia neuropathologica. vol 58. issue 1. 2021-02-04. PMID:32337954. |
mir-668 inhibitor attenuates mitochondrial membrane potential and protects against neuronal apoptosis in cerebral ischemic stroke. |
2021-02-04 |
2023-08-13 |
rat |
| Hong Tang, Marcin Gamdzyk, Lei Huang, Ling Gao, Cameron Lenahan, Ruiqing Kang, Jiping Tang, Ying Xia, John H Zhan. Delayed recanalization after MCAO ameliorates ischemic stroke by inhibiting apoptosis via HGF/c-Met/STAT3/Bcl-2 pathway in rats. Experimental neurology. vol 330. 2021-02-01. PMID:32428505. |
delayed recanalization after mcao ameliorates ischemic stroke by inhibiting apoptosis via hgf/c-met/stat3/bcl-2 pathway in rats. |
2021-02-01 |
2023-08-13 |
rat |
| Han-Ze Wang, Ge Gao, Qian-Qian Yang, Xiao-Meng Hou, Bing-Qi Li, Qiang Li, Yin-Chu S. [Study on therapeutic mechanism of Rehmanniae Radix Praeparata- Corni Fructus in sequelae of ischemic stroke based on network pharmacology technology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 24. 2021-01-27. PMID:33496143. |
the results showed that in ischemic stroke sequela phase, rehmanniae radix praeparata-corni fructus drug pair could play an important role in recovering neural function, promoting the proliferation of neural stem cells, angiogenesis, preventing neural cells apoptosis and regulating inflammatory factors. |
2021-01-27 |
2023-08-13 |
Not clear |
| Cheng Qian, Dong-Fang Liu, Cong-Xiao Wang, Jie Ding, Yan-Li An, Pei-Cheng Li, Gao-Jun Ten. Targeting Early Apoptosis in Acute Ischemic Stroke with a Small-Molecule Probe. ACS biomaterials science & engineering. vol 4. issue 5. 2021-01-15. PMID:33445341. |
targeting early apoptosis in acute ischemic stroke with a small-molecule probe. |
2021-01-15 |
2023-08-13 |
Not clear |
| Cheng Qian, Dong-Fang Liu, Cong-Xiao Wang, Jie Ding, Yan-Li An, Pei-Cheng Li, Gao-Jun Ten. Targeting Early Apoptosis in Acute Ischemic Stroke with a Small-Molecule Probe. ACS biomaterials science & engineering. vol 4. issue 5. 2021-01-15. PMID:33445341. |
molecular imaging of the early apoptosis would make sense in ischemic stroke; however, few of apoptosis molecular probes could specifically target early apoptosis. |
2021-01-15 |
2023-08-13 |
Not clear |
| Shanshan Qiao, Dexin Yang, Xiaofeng Li, Weiping Li, Yuan Zhang, Wenlan Li. Silencing PAQR3 protects against oxygen-glucose deprivation/reperfusion-induced neuronal apoptosis via activation of PI3K/AKT signaling in PC12 cells. Life sciences. vol 265. 2021-01-13. PMID:33249098. |
neuronal apoptosis acts as the pivotal pathogenesis of cerebral ischemia/reperfusion (i/r) injury after ischemic stroke. |
2021-01-13 |
2023-08-13 |
Not clear |
| Jun Yang, Jingjing Zhao, Xu Liu, Ruixia Zh. LncRNAs a New Target for Post-Stroke Recovery. Current pharmaceutical design. vol 26. issue 26. 2021-01-06. PMID:32096739. |
furthermore, several lncrnas were reported to mediate ischemia cascade processes include apoptosis, bloodbrain barier breakdown, angiogenesis, microglial activation induced neuroinflammation which can cause neuron injury and influence neuron recovery after ischemic stroke. |
2021-01-06 |
2023-08-13 |
Not clear |
| Lihong Wei, Yun Fan, Lingling Wei, Xiaoxia He, Jiaqing Yang, Xianzhao Zhen. Ablation of TMEM126B protects against oxygen-glucose deprivation/reoxygenation-induced injuries of PC12 cells via maintaining mitochondrial anti-apoptotic functions. Archives of biochemistry and biophysics. vol 696. 2020-12-31. PMID:33075301. |
collectively, this study indicates that tmem126b knockdown protects against ogd/r-induced neuronal injuries through relieving oxidative stress, inflammation, apoptosis and mitochondria dysfunction, which provides a promising target for ischemic stroke treatment. |
2020-12-31 |
2023-08-13 |
Not clear |
| Jun Wang, Wentong Zhang, Bo Ma, Hongchen Zhang, Zhaoyang Fan, Mingkai Li, Xia L. A novel biscoumarin derivative dephosphorylates ERK and alleviates apoptosis induced by mitochondrial oxidative damage in ischemic stroke mice. Life sciences. vol 264. 2020-12-31. PMID:33141045. |
a novel biscoumarin derivative dephosphorylates erk and alleviates apoptosis induced by mitochondrial oxidative damage in ischemic stroke mice. |
2020-12-31 |
2023-08-13 |
mouse |
| Jun Wang, Wentong Zhang, Bo Ma, Hongchen Zhang, Zhaoyang Fan, Mingkai Li, Xia L. A novel biscoumarin derivative dephosphorylates ERK and alleviates apoptosis induced by mitochondrial oxidative damage in ischemic stroke mice. Life sciences. vol 264. 2020-12-31. PMID:33141045. |
we previously reported the protective effects of biscoumarin derivatives against oxidative stress, but effects of the derivative on mitochondrial oxidative damage induced apoptosis in ischemic stroke remains unknown. |
2020-12-31 |
2023-08-13 |
mouse |
| Shan Wang, Keng Chen, Jia Yu, Xiaojiao Wang, Qiang Li, Fei Lv, Huiyong Shen, Lei Pe. Presynaptic Caytaxin prevents apoptosis via deactivating DAPK1 in the acute phase of cerebral ischemic stroke. Experimental neurology. vol 329. 2020-12-24. PMID:32277960. |
presynaptic caytaxin prevents apoptosis via deactivating dapk1 in the acute phase of cerebral ischemic stroke. |
2020-12-24 |
2023-08-13 |
mouse |
| Shan Wang, Keng Chen, Jia Yu, Xiaojiao Wang, Qiang Li, Fei Lv, Huiyong Shen, Lei Pe. Presynaptic Caytaxin prevents apoptosis via deactivating DAPK1 in the acute phase of cerebral ischemic stroke. Experimental neurology. vol 329. 2020-12-24. PMID:32277960. |
thus, elevating presynaptic caytaxin could prevent neuronal apoptosis by inhibiting dapk1 activation in the acute stage of ischemic stroke. |
2020-12-24 |
2023-08-13 |
mouse |
| Jing Lv, Weikang Guan, Qiang You, Li Deng, Yan Zhu, Kan Guo, Xiaoqing Gao, Jiming Kong, Chaoxian Yan. RIPC provides neuroprotection against ischemic stroke by suppressing apoptosis via the mitochondrial pathway. Scientific reports. vol 10. issue 1. 2020-12-18. PMID:32210331. |
ripc provides neuroprotection against ischemic stroke by suppressing apoptosis via the mitochondrial pathway. |
2020-12-18 |
2023-08-13 |
Not clear |
| Jing Lv, Weikang Guan, Qiang You, Li Deng, Yan Zhu, Kan Guo, Xiaoqing Gao, Jiming Kong, Chaoxian Yan. RIPC provides neuroprotection against ischemic stroke by suppressing apoptosis via the mitochondrial pathway. Scientific reports. vol 10. issue 1. 2020-12-18. PMID:32210331. |
in conclusion, ripc alleviates ischemia/reperfusion injury after ischemic stroke by inhibiting apoptosis via the endogenous mitochondrial pathway. |
2020-12-18 |
2023-08-13 |
Not clear |