| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anatoly B Uzdensk. Apoptosis regulation in the penumbra after ischemic stroke: expression of pro- and antiapoptotic proteins. Apoptosis : an international journal on programmed cell death. vol 24. issue 9-10. 2020-07-02. PMID:31256300. |
apoptosis regulation in the penumbra after ischemic stroke: expression of pro- and antiapoptotic proteins. |
2020-07-02 |
2023-08-13 |
human |
| Jing Zhao, Chao Lv, Qiuling Wu, Huawu Zeng, Xin Guo, Jian Yang, Saisai Tian, Weidong Zhan. Computational systems pharmacology reveals an antiplatelet and neuroprotective mechanism of Deng-Zhan-Xi-Xin injection in the treatment of ischemic stroke. Pharmacological research. vol 147. 2020-06-17. PMID:31348992. |
these target genes were further found to be associated with pathways involved in neuronal apoptosis in ischemic stroke, such as nf-κb signaling, tnf signaling, and pi3k-akt signaling. |
2020-06-17 |
2023-08-13 |
human |
| Zheyi Zhou, Changjun Lu, Shuhui Meng, Linglu Dun, Nannan Yin, Hongwei An, Hong Xu, Guocheng Liu, Yefeng Ca. Silencing of PTGS2 exerts promoting effects on angiogenesis endothelial progenitor cells in mice with ischemic stroke via repression of the NF-κB signaling pathway. Journal of cellular physiology. vol 234. issue 12. 2020-06-08. PMID:31222746. |
the objective of the current study is to investigate the effect of ptgs2 on proliferation, migration, angiogenesis and apoptosis of endothelial progenitor cells (epcs) in mice with ischemic stroke through the nf-κb signaling pathway. |
2020-06-08 |
2023-08-13 |
mouse |
| Zheyi Zhou, Changjun Lu, Shuhui Meng, Linglu Dun, Nannan Yin, Hongwei An, Hong Xu, Guocheng Liu, Yefeng Ca. Silencing of PTGS2 exerts promoting effects on angiogenesis endothelial progenitor cells in mice with ischemic stroke via repression of the NF-κB signaling pathway. Journal of cellular physiology. vol 234. issue 12. 2020-06-08. PMID:31222746. |
taken together, we conclude that the specific knockdown of ptgs2 expression could repress the nf-κb signaling pathway, thereby inhibits apoptosis and promotes proliferation, migration and angiogenesis of epcs, providing protective effect on mice with ischemic stroke. |
2020-06-08 |
2023-08-13 |
mouse |
| Qiong Cheng, Fang Tong, Yuntian Shen, Chunjiao He, Caiping Wang, Fei Din. Achyranthes bidentata polypeptide k improves long-term neurological outcomes through reducing downstream microvascular thrombosis in experimental ischemic stroke. Brain research. vol 1706. 2020-05-29. PMID:30414726. |
we previously demonstrated that abppk has potent neuroprotective effects against neuronal apoptosis both in vitro and in vivo, but the roles and mechanisms of abppk on long-term functional recovery after ischemic stroke remain unknown. |
2020-05-29 |
2023-08-13 |
rat |
| Aixiang Zhang, Yuanjie Qian, Jian Qia. MicroRNA-152-3p protects neurons from oxygen-glucose-deprivation/reoxygenation-induced injury through upregulation of Nrf2/ARE antioxidant signaling by targeting PSD-93. Biochemical and biophysical research communications. vol 517. issue 1. 2020-05-26. PMID:31326116. |
overall, these results demonstrated that mir-152-3p protected neurons from ogd/r-induced apoptosis and ros production by reinforcing nrf2/are antioxidant signaling through targeting and inhibiting psd-93, findings that suggest mir-152-3p is a potential target for neuroprotection during ischemic stroke. |
2020-05-26 |
2023-08-13 |
Not clear |
| Xiaorong Gao, Haijun Li, Zhiyan Dong, Pengxuan Zhang, Rui Liu, Yidong Xue, Ning Sh. Relationship between Erk1/2 signal pathway and nerve cell apoptosis rats with ischemic stroke. Cellular and molecular biology (Noisy-le-Grand, France). vol 65. issue 7. 2020-05-18. PMID:31880530. |
relationship between erk1/2 signal pathway and nerve cell apoptosis rats with ischemic stroke. |
2020-05-18 |
2023-08-13 |
rat |
| Xiaorong Gao, Haijun Li, Zhiyan Dong, Pengxuan Zhang, Rui Liu, Yidong Xue, Ning Sh. Relationship between Erk1/2 signal pathway and nerve cell apoptosis rats with ischemic stroke. Cellular and molecular biology (Noisy-le-Grand, France). vol 65. issue 7. 2020-05-18. PMID:31880530. |
to investigate the relationship between the erk1/2 signal pathway and neuronal apoptosis in ischemic stroke rats. |
2020-05-18 |
2023-08-13 |
rat |
| Xiaorong Gao, Haijun Li, Zhiyan Dong, Pengxuan Zhang, Rui Liu, Yidong Xue, Ning Sh. Relationship between Erk1/2 signal pathway and nerve cell apoptosis rats with ischemic stroke. Cellular and molecular biology (Noisy-le-Grand, France). vol 65. issue 7. 2020-05-18. PMID:31880530. |
the activation of erk1/2 signal pathway during ischemic stroke promotes apoptosis of nerve cells. |
2020-05-18 |
2023-08-13 |
rat |
| Fangfang Li, Haiping Zhao, Ziping Han, Rongliang Wang, Zhen Tao, Zhibin Fan, Sijia Zhang, Guangwen Li, Zhigang Chen, Yumin Lu. Xuesaitong May Protect Against Ischemic Stroke by Modulating Microglial Phenotypes and Inhibiting Neuronal Cell Apoptosis via the STAT3 Signaling Pathway. CNS & neurological disorders drug targets. vol 18. issue 2. 2020-05-13. PMID:30426907. |
xuesaitong may protect against ischemic stroke by modulating microglial phenotypes and inhibiting neuronal cell apoptosis via the stat3 signaling pathway. |
2020-05-13 |
2023-08-13 |
Not clear |
| Faheem Hyder Pottoo, Shrestha Sharma, Md Noushad Javed, Md Abul Barkat, Harshita, Md Sabir Alam, Mohd Javed Naim, Ozair Alam, Mohammad Azam Ansari, George E Barreto, Ghulam Md Ashra. Lipid-based nanoformulations in the treatment of neurological disorders. Drug metabolism reviews. vol 52. issue 1. 2020-04-14. PMID:32116044. |
in recent years, advances in nanomedicine have led to therapies that target central nervous system (cns) pathobiology via altering signaling mechanisms such as activation of pi3k/akt pathway in ischemic stroke arrests apoptosis, interruption of α-synuclein aggregation prevents neuronal degeneration in parkinson's. |
2020-04-14 |
2023-08-13 |
Not clear |
| Fang Han, Xiaoming Guan, Wei Guo, Bai L. Therapeutic potential of a TrkB agonistic antibody for ischemic brain injury. Neurobiology of disease. vol 127. 2020-01-09. PMID:30981830. |
together, our study revealed necroptosis in human stroke brain, and demonstrated a bdnf-based strategy targeting both apoptosis and necroptosis for ischemic stroke treatment. |
2020-01-09 |
2023-08-13 |
mouse |
| Qian Xia, Xing Li, Huijuan Zhou, Lu Zheng, Jing Sh. S100A11 protects against neuronal cell apoptosis induced by cerebral ischemia via inhibiting the nuclear translocation of annexin A1. Cell death & disease. vol 9. issue 6. 2019-12-10. PMID:29844306. |
this study provides a novel mechanism whereby s100a11 protects against neuronal cells apoptosis, suggesting the potential for a previously unidentified treatment strategy in minimizing apoptosis after ischemic stroke. |
2019-12-10 |
2023-08-13 |
Not clear |
| Nami Kim, Dongmei Chen, Xiao Zhen Zhou, Tae Ho Le. Death-Associated Protein Kinase 1 Phosphorylation in Neuronal Cell Death and Neurodegenerative Disease. International journal of molecular sciences. vol 20. issue 13. 2019-12-06. PMID:31248062. |
however, the deregulation of neuronal apoptosis by various factors leads to neurodegenerative diseases such as ischemic stroke and alzheimer's disease (ad). |
2019-12-06 |
2023-08-13 |
Not clear |
| Yan Wang, Guoce Li, Li Zhao, Jianping L. Long noncoding RNA HOTTIP alleviates oxygen-glucose deprivation-induced neuronal injury via modulating miR-143/hexokinase 2 pathway. Journal of cellular biochemistry. vol 119. issue 12. 2019-11-25. PMID:30129112. |
we used gain-of function and loss-of function approaches in vitro to investigate the effect and mechanism of hottip on ischemic stroke by evaluating cell viability, apoptosis, and glycolytic metabolism of neurons exposed to ogd. |
2019-11-25 |
2023-08-13 |
mouse |
| Saibin Wang, Qian Ye, Junwei T. Evaluation of retinal injury in a rat model of transient ischemic stroke. Histology and histopathology. vol 34. issue 5. 2019-11-22. PMID:30411312. |
moreover, when compared to non-stroke rats, tunel staining revealed signs of apoptosis in the retina after transient ischemic stroke was induced (p<0.001). |
2019-11-22 |
2023-08-13 |
rat |
| Kai Zhang, Mengjiao Tu, Wei Gao, Xiaojun Cai, Fahuan Song, Zheng Chen, Qian Zhang, Jing Wang, Chentao Jin, Jingjing Shi, Xiang Yang, Yuankai Zhu, Weizhong Gu, Bing Hu, Yuanyi Zheng, Hong Zhang, Mei Tia. Hollow Prussian Blue Nanozymes Drive Neuroprotection against Ischemic Stroke via Attenuating Oxidative Stress, Counteracting Inflammation, and Suppressing Cell Apoptosis. Nano letters. vol 19. issue 5. 2019-11-21. PMID:30908916. |
hollow prussian blue nanozymes drive neuroprotection against ischemic stroke via attenuating oxidative stress, counteracting inflammation, and suppressing cell apoptosis. |
2019-11-21 |
2023-08-13 |
Not clear |
| Yilei Xiao, Fengyang Geng, Guifang Wang, Xueyuan Li, Jianxin Zhu, Weijie Zh. Bone marrow-derived mesenchymal stem cells-derived exosomes prevent oligodendrocyte apoptosis through exosomal miR-134 by targeting caspase-8. Journal of cellular biochemistry. 2019-11-20. PMID:30191592. |
taken together, these results demonstrated that bmscs-derived exosomes suppressed ols apoptosis through exosomal mir-134 by negatively regulating the caspase-8-dependent apoptosis pathway and may, therefore, be a novel potential therapeutic target for ischemic stroke treatment. |
2019-11-20 |
2023-08-13 |
rat |
| Qingqing Dai, Shujuan Li, Ting Liu, Jiayin Zheng, Song Han, Aijuan Qu, Junfa L. Interleukin-17A-mediated alleviation of cortical astrocyte ischemic injuries affected the neurological outcome of mice with ischemic stroke. Journal of cellular biochemistry. 2019-11-20. PMID:30746745. |
these results suggested that il-17a-mediated alleviation of cortical astrocyte ischemic injuries could affect the neurological outcome of mice with ischemic stroke, which might be mainly dependent on the cell apoptosis pathway through inhibiting the downregulation of il-17ra and -17rc membrane translocations. |
2019-11-20 |
2023-08-13 |
mouse |
| Nathanael Matei, Justin Camara, Devin McBride, Richard Camara, Ningbo Xu, Jiping Tang, John H Zhan. Intranasal wnt3a Attenuates Neuronal Apoptosis through Frz1/PIWIL1a/FOXM1 Pathway in MCAO Rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 30. 2019-10-28. PMID:29954850. |
after ischemic stroke, apoptosis of neurons is a primary factor in determining outcome. |
2019-10-28 |
2023-08-13 |
rat |