| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philippe Huot, Susan H Fox, Adrian Newman-Tancredi, Jonathan M Brotchi. Anatomically selective serotonergic type 1A and serotonergic type 2A therapies for Parkinson's disease: an approach to reducing dyskinesia without exacerbating parkinsonism? The Journal of pharmacology and experimental therapeutics. vol 339. issue 1. 2011-11-22. PMID:21784889. |
here, we review 5-ht(1a) and 5-ht(2a) receptor function in pd and provide an anatomically based rationale as to why in some instances 5-ht(1a)- and 5-ht(2a)-modulating drugs might worsen parkinsonism, in addition to reducing dyskinesia. |
2011-11-22 |
2023-08-12 |
Not clear |
| Philippe Huot, Jonathan M Brotchi. 5-HT(1A) receptor stimulation and L-DOPA-induced dyskinesia in Parkinson's disease: bridging the gap between serotonergic and glutamatergic mechanisms. Experimental neurology. vol 231. issue 2. 2011-11-02. PMID:21819982. |
5-ht(1a) receptor stimulation and l-dopa-induced dyskinesia in parkinson's disease: bridging the gap between serotonergic and glutamatergic mechanisms. |
2011-11-02 |
2023-08-12 |
Not clear |
| Golnasim Riahi, Marc Morissette, Martin Parent, Thérèse Di Paol. Brain 5-HT(2A) receptors in MPTP monkeys and levodopa-induced dyskinesias. The European journal of neuroscience. vol 33. issue 10. 2011-09-26. PMID:21501255. |
brain 5-ht(2a) receptors in mptp monkeys and levodopa-induced dyskinesias. |
2011-09-26 |
2023-08-12 |
monkey |
| Golnasim Riahi, Marc Morissette, Martin Parent, Thérèse Di Paol. Brain 5-HT(2A) receptors in MPTP monkeys and levodopa-induced dyskinesias. The European journal of neuroscience. vol 33. issue 10. 2011-09-26. PMID:21501255. |
l-dopa treatment that induced dyskinesias increased 5-ht(2a) receptor-specific binding in the caudate nucleus and the anterior cingulate gyrus (acgg) compared with control monkeys. |
2011-09-26 |
2023-08-12 |
monkey |
| Kristin B Dupre, Corinne Y Ostock, Karen L Eskow Jaunarajs, Thomas Button, Lisa M Savage, William Wolf, Christopher Bisho. Local modulation of striatal glutamate efflux by serotonin 1A receptor stimulation in dyskinetic, hemiparkinsonian rats. Experimental neurology. vol 229. issue 2. 2011-08-05. PMID:21352823. |
given that 5-ht(1a)r stimulation reduces glutamatergic neurotransmission in the dopamine-depleted striatum, 5-ht(1a)r agonists may diminish dyskinesia in part through modulation of pro-dyskinetic striatal glutamate levels. |
2011-08-05 |
2023-08-12 |
rat |
| Philippe Huot, Tom H Johnston, Katie D Lewis, James B Koprich, M Gabriela Reyes, Susan H Fox, Matthew J Piggott, Jonathan M Brotchi. Characterization of 3,4-methylenedioxymethamphetamine (MDMA) enantiomers in vitro and in the MPTP-lesioned primate: R-MDMA reduces severity of dyskinesia, whereas S-MDMA extends duration of ON-time. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 19. 2011-07-25. PMID:21562283. |
these data suggest that racemic mdma exerts simultaneous effects, reducing dyskinesia and extending on-time, by 5-ht(2a) antagonism and sert-selective mixed monoamine uptake inhibition, which arise from its r and s enantiomers, respectively. |
2011-07-25 |
2023-08-12 |
marmoset |
| Yukihiro Ohn. Therapeutic role of 5-HT1A receptors in the treatment of schizophrenia and Parkinson's disease. CNS neuroscience & therapeutics. vol 17. issue 1. 2011-05-02. PMID:21091640. |
in the treatment of patients with parkinson's disease, 5-ht(1a) agonists are expected to improve not only affective symptoms (e.g., anxiety and depression), but also the core parkinsonian symptoms as well as antiparkinsonian agents-induced side effects (e.g., l-dopa-induced dyskinesia). |
2011-05-02 |
2023-08-12 |
Not clear |
| Marios Politis, Kit Wu, Clare Loane, Niall P Quinn, David J Brooks, Stig Rehncrona, Anders Bjorklund, Olle Lindvall, Paola Piccin. Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants. Science translational medicine. vol 2. issue 38. 2011-04-05. PMID:20592420. |
the dyskinesias were markedly attenuated by systemic administration of a serotonin [5-hydroxytryptamine (5-ht)] receptor (5-ht(1a)) agonist, which dampens transmitter release from serotonergic neurons, indicating that the dyskinesias were caused by the serotonergic hyperinnervation. |
2011-04-05 |
2023-08-12 |
Not clear |
| A Beyeler, N Kadiri, S Navailles, M Ben Boujema, F Gonon, C Le Moine, C Gross, P De Deurwaerdèr. Stimulation of serotonin2C receptors elicits abnormal oral movements by acting on pathways other than the sensorimotor one in the rat basal ganglia. Neuroscience. vol 169. issue 1. 2011-03-04. PMID:20447448. |
these results suggest that oral dyskinesia induced by 5-ht(2c) agonists are not restricted to aberrant signalling in the orofacial motor circuit and demonstrate discrete modifications in associative territories. |
2011-03-04 |
2023-08-12 |
rat |
| Yoshihiro Tani, Atsuto Ogata, Makoto Koyama, Teruyoshi Inou. Effects of piclozotan (SUN N4057), a partial serotonin 1A receptor agonist, on motor complications induced by repeated administration of levodopa in parkinsonian rats. European journal of pharmacology. vol 649. issue 1-3. 2011-03-03. PMID:20858480. |
serotonin 1a receptor agonists have attracted much interest recently as potential therapeutic agents for levodopa-induced motor complications, such as dyskinesia and motor fluctuations. |
2011-03-03 |
2023-08-12 |
rat |
| Marios Politi. Dyskinesias after neural transplantation in Parkinson's disease: what do we know and what is next? BMC medicine. vol 8. 2011-03-01. PMID:21126348. |
moreover, the dyskinesias were significantly attenuated by administration of a serotonin agonist, which activates the inhibitory serotonin autoreceptors and attenuates transmitter release from serotonergic neurons, indicating that graft-induced dyskinesias were caused by the dense serotonergic innervation engaging in false transmitter release. |
2011-03-01 |
2023-08-12 |
human |
| Bai-Yun Zeng, Mahmoud M Iravani, Michael J Jackson, Sarah Rose, André Parent, Peter Jenne. Morphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesia. Neurobiology of disease. vol 40. issue 3. 2011-01-25. PMID:20713157. |
in the present study, we used tryptophan hydroxylase (tph) immunohistochemistry to determine whether 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (mptp) treatment and the induction of dyskinesia by levodopa alter the morphology of 5-ht fibres in the striatum of common marmosets. |
2011-01-25 |
2023-08-12 |
rat |
| Bai-Yun Zeng, Mahmoud M Iravani, Michael J Jackson, Sarah Rose, André Parent, Peter Jenne. Morphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesia. Neurobiology of disease. vol 40. issue 3. 2011-01-25. PMID:20713157. |
these results confirm that striatal 5-ht hyperinnervation follows nigro-striatal pathway loss and provide the first evidence in primates that chronic levodopa treatment and the onset of dyskinesia are associated with a marked hypertrophy of striatal 5-ht axonal varicosities. |
2011-01-25 |
2023-08-12 |
rat |
| Sukju Gil, Changhwan Park, Jeongeun Lee, Hyunchul Ko. The roles of striatal serotonin and L -amino-acid decarboxylase on L-DOPA-induced Dyskinesia in a Hemiparkinsonian rat model. Cellular and molecular neurobiology. vol 30. issue 6. 2011-01-18. PMID:20232137. |
the roles of striatal serotonin and l -amino-acid decarboxylase on l-dopa-induced dyskinesia in a hemiparkinsonian rat model. |
2011-01-18 |
2023-08-12 |
rat |
| Daniella Rylander, Martin Parent, Sean S O'Sullivan, Sandra Dovero, Andrew J Lees, Erwan Bezard, Laurent Descarries, M Angela Cenc. Maladaptive plasticity of serotonin axon terminals in levodopa-induced dyskinesia. Annals of neurology. vol 68. issue 5. 2010-11-29. PMID:20882603. |
maladaptive plasticity of serotonin axon terminals in levodopa-induced dyskinesia. |
2010-11-29 |
2023-08-12 |
Not clear |
| Daniella Rylander, Martin Parent, Sean S O'Sullivan, Sandra Dovero, Andrew J Lees, Erwan Bezard, Laurent Descarries, M Angela Cenc. Maladaptive plasticity of serotonin axon terminals in levodopa-induced dyskinesia. Annals of neurology. vol 68. issue 5. 2010-11-29. PMID:20882603. |
striatal serotonin projections have been implicated in levodopa-induced dyskinesia by providing an unregulated source of dopamine release. |
2010-11-29 |
2023-08-12 |
Not clear |
| Barbara Picconi, Veronica Ghiglieri, Paolo Calabres. L-3,4-dihydroxyphenylalanine-induced sprouting of serotonin axon terminals: A useful biomarker for dyskinesias? Annals of neurology. vol 68. issue 5. 2010-11-29. PMID:21031574. |
l-3,4-dihydroxyphenylalanine-induced sprouting of serotonin axon terminals: a useful biomarker for dyskinesias? |
2010-11-29 |
2023-08-12 |
Not clear |
| Yukihiro Ohn. New insight into the therapeutic role of 5-HT1A receptors in central nervous system disorders. Central nervous system agents in medicinal chemistry. vol 10. issue 2. 2010-09-07. PMID:20518729. |
in addition, recent studies have revealed new insights into the therapeutic role of 5-ht(1a) receptors in treating various cns disorders, including not only depressive disorders (e.g., delayed onset of action and refractory symptoms), but also schizophrenia (e.g., cognitive impairment and antipsychotic-induced extrapyramidal side effects) and parkinson's disease (e.g., extrapyramidal motor symptoms and l-dopa-induced dyskinesia). |
2010-09-07 |
2023-08-12 |
Not clear |
| Jiao Mo, Hai Zhang, Lei-Ping Yu, Pei-Hua Sun, Guo-Zhang Jin, Xuechu Zhe. L-stepholidine reduced L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease. Neurobiology of aging. vol 31. issue 6. 2010-07-13. PMID:18707801. |
acute administration of l-spd to rats with established lid produced significant relief of dyskinesia; this effect was mimicked by d(2) receptor antagonist haloperidol, but blunted by 5-ht(1a) receptor antagonist way100635. |
2010-07-13 |
2023-08-12 |
rat |
| Manolo Carta, Thomas Carlsson, Ana Muñoz, Deniz Kirik, Anders Björklun. Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 25 Suppl 1. 2010-06-14. PMID:20187238. |
role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in parkinson's disease. |
2010-06-14 |
2023-08-12 |
Not clear |