| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manolo Carta, Thomas Carlsson, Ana Muñoz, Deniz Kirik, Anders Björklun. Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 25 Suppl 1. 2010-06-14. PMID:20187238. |
this mechanism may also play a role in the development of graft-induced dyskinesias in patients that receive fetal neuron transplants, possibly due to the inclusion of serotonin neurons in the grafted ventral midbrain tissue, which contribute to maintain dopamine receptors of the denervated striatum in a supersensitive state. |
2010-06-14 |
2023-08-12 |
Not clear |
| Karen L Eskow Jaunarajs, Kristin B Dupre, Aimee Steiniger, Anna Klioueva, Alexander Moore, Catherine Kelly, Christopher Bisho. Serotonin 1B receptor stimulation reduces D1 receptor agonist-induced dyskinesia. Neuroreport. vol 20. issue 14. 2009-10-30. PMID:19633584. |
serotonin 1b receptor stimulation reduces d1 receptor agonist-induced dyskinesia. |
2009-10-30 |
2023-08-12 |
rat |
| Susan H Fox, Rosalind Chuang, Jonathan M Brotchi. Serotonin and Parkinson's disease: On movement, mood, and madness. Movement disorders : official journal of the Movement Disorder Society. vol 24. issue 9. 2009-10-21. PMID:19412960. |
early pathological studies in pd demonstrated nonselective reductions of 5-ht in brain tissue but little correlation to comorbidities such as dyskinesia and mood disturbance. |
2009-10-21 |
2023-08-12 |
Not clear |
| Ana Muñoz, Thomas Carlsson, Elisabetta Tronci, Deniz Kirik, Anders Björklund, Manolo Cart. Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT1A and 5-HT1B receptor agonists in the rat Parkinson model. Experimental neurology. vol 219. issue 1. 2009-09-25. PMID:19500572. |
serotonin neuron-dependent and -independent reduction of dyskinesia by 5-ht1a and 5-ht1b receptor agonists in the rat parkinson model. |
2009-09-25 |
2023-08-12 |
rat |
| Laurent Grégoire, Pershia Samadi, Julie Graham, Paul J Bédard, Gerd D Bartoszyk, Thérèse Di Paol. Low doses of sarizotan reduce dyskinesias and maintain antiparkinsonian efficacy of L-Dopa in parkinsonian monkeys. Parkinsonism & related disorders. vol 15. issue 6. 2009-09-17. PMID:19196540. |
sarizotan, a 5-ht(1a) agonist with high affinity for d3 and d4 receptors was investigated on l-dopa-induced dyskinesia (lid) in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) animal model of pd. |
2009-09-17 |
2023-08-12 |
monkey |
| Emma Louise Lane, Patrik Brundin, M Angela Cenc. Amphetamine-induced abnormal movements occur independently of both transplant- and host-derived serotonin innervation following neural grafting in a rat model of Parkinson's disease. Neurobiology of disease. vol 35. issue 1. 2009-09-14. PMID:19361557. |
these data point to a major role for dopamine receptors, and to a modulatory role for 5-ht(1a) receptors, in post-grafting dyskinesias. |
2009-09-14 |
2023-08-12 |
rat |
| Emma Louise Lane, Patrik Brundin, M Angela Cenc. Amphetamine-induced abnormal movements occur independently of both transplant- and host-derived serotonin innervation following neural grafting in a rat model of Parkinson's disease. Neurobiology of disease. vol 35. issue 1. 2009-09-14. PMID:19361557. |
in the second experiment, grafted rats exhibiting amphetamine-induced dyskinesia were subjected to 5,7-dihydroxytryptamine injections into the midbrain in order to destroy the host serotonin innervation. |
2009-09-14 |
2023-08-12 |
rat |
| C Marin, E Aguilar, M C Rodríguez-Oroz, G D Bartoszyk, J A Obes. Local administration of sarizotan into the subthalamic nucleus attenuates levodopa-induced dyskinesias in 6-OHDA-lesioned rats. Psychopharmacology. vol 204. issue 2. 2009-08-05. PMID:19159919. |
it is thus conceivable that a modulation of synaptic dopamine (da) levels induced by the inhibition of serotonin (5-ht) release, as a consequence of 5-ht(1a) agonists administration, might alleviate dyskinesias. |
2009-08-05 |
2023-08-12 |
rat |
| Christopher Bishop, David M Krolewski, Karen L Eskow, Christopher J Barnum, Kristin B Dupre, Terrence Deak, Paul D Walke. Contribution of the striatum to the effects of 5-HT1A receptor stimulation in L-DOPA-treated hemiparkinsonian rats. Journal of neuroscience research. vol 87. issue 7. 2009-07-13. PMID:19115412. |
clinical and experimental studies implicate the use of serotonin (5-ht)1a receptor agonists for the reduction of l-3,4-dihydroxyphenylalanine (l-dopa)-induced dyskinesia (lid). |
2009-07-13 |
2023-08-12 |
rat |
| Kristin B Dupre, Karen L Eskow, Christopher J Barnum, Christopher Bisho. Striatal 5-HT1A receptor stimulation reduces D1 receptor-induced dyskinesia and improves movement in the hemiparkinsonian rat. Neuropharmacology. vol 55. issue 8. 2009-04-15. PMID:18824001. |
convergent evidence suggests that serotonin 5-ht1a receptor (5-ht1ar) agonists reduce l-dopa-induced dyskinesia by auto-regulating aberrant release of l-dopa-derived dopamine (da) from raphestriatal neurons. |
2009-04-15 |
2023-08-12 |
rat |
| Thomas Carlsson, Manolo Carta, Ana Muñoz, Bengt Mattsson, Christian Winkler, Deniz Kirik, Anders Björklun. Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration. Brain : a journal of neurology. vol 132. issue Pt 2. 2009-03-10. PMID:19039008. |
impact of grafted serotonin and dopamine neurons on development of l-dopa-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration. |
2009-03-10 |
2023-08-12 |
rat |
| Thomas Carlsson, Manolo Carta, Ana Muñoz, Bengt Mattsson, Christian Winkler, Deniz Kirik, Anders Björklun. Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration. Brain : a journal of neurology. vol 132. issue Pt 2. 2009-03-10. PMID:19039008. |
previous studies have shown that serotonin neurons play an important role in the induction and maintenance of l-dopa-induced dyskinesia in animals with lesion of the nigrostriatal dopamine system. |
2009-03-10 |
2023-08-12 |
rat |
| Thomas Carlsson, Manolo Carta, Ana Muñoz, Bengt Mattsson, Christian Winkler, Deniz Kirik, Anders Björklun. Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration. Brain : a journal of neurology. vol 132. issue Pt 2. 2009-03-10. PMID:19039008. |
here, we have studied the impact of grafted serotonin neurons--alone or mixed with dopamine neurons--on the development of l-dopa-induced dyskinesia in rats with a partial 6-hydroxydopamine lesion of the host nigrostriatal projection. |
2009-03-10 |
2023-08-12 |
rat |
| Thomas Carlsson, Manolo Carta, Ana Muñoz, Bengt Mattsson, Christian Winkler, Deniz Kirik, Anders Björklun. Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration. Brain : a journal of neurology. vol 132. issue Pt 2. 2009-03-10. PMID:19039008. |
in these rats, which showed only low-level dyskinesia at the time of transplantation, serotonin grafts induced a worsening in the severity of dyskinesia that developed during continued l-dopa treatment, while the dopamine-rich graft had the opposite, dampening effect. |
2009-03-10 |
2023-08-12 |
rat |
| Thomas Carlsson, Manolo Carta, Ana Muñoz, Bengt Mattsson, Christian Winkler, Deniz Kirik, Anders Björklun. Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration. Brain : a journal of neurology. vol 132. issue Pt 2. 2009-03-10. PMID:19039008. |
interestingly, rats with grafts that contained a mixture of dopamine and serotonin neurons (in approximately 2:1) showed a marked reduction in l-dopa-induced dyskinesia over time, and the appearance of severe dyskinesia induced by the removal of the residual dopamine innervation, seen in the animals with transplants of serotonin neurons alone, was blocked. |
2009-03-10 |
2023-08-12 |
rat |
| Thomas Carlsson, Manolo Carta, Ana Muñoz, Bengt Mattsson, Christian Winkler, Deniz Kirik, Anders Björklun. Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration. Brain : a journal of neurology. vol 132. issue Pt 2. 2009-03-10. PMID:19039008. |
these data indicate that as long as a sufficient portion, some 10-20%, of the dopamine innervation still remains, the increased host serotonin innervation generated by the grafted serotonin neurons will have limited effect on the development or severity of l-dopa-induced dyskinesias. |
2009-03-10 |
2023-08-12 |
rat |
| Thomas Carlsson, Manolo Carta, Ana Muñoz, Bengt Mattsson, Christian Winkler, Deniz Kirik, Anders Björklun. Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration. Brain : a journal of neurology. vol 132. issue Pt 2. 2009-03-10. PMID:19039008. |
at more advanced stages of the disease, when the dopamine innervation of the putamen is reduced below this critical threshold, grafted serotonin neurons are likely to aggravate l-dopa-induced dyskinesia in those cases where the dopamine re-innervation derived from the grafted neurons is insufficient in magnitude or do not cover the critical dyskinesia-inducing sub-regions of the grafted putamen. |
2009-03-10 |
2023-08-12 |
rat |
| Thomas Carlsson, Manolo Carta, Ana Muñoz, Bengt Mattsson, Christian Winkler, Deniz Kirik, Anders Björklun. Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration. Brain : a journal of neurology. vol 132. issue Pt 2. 2009-03-10. PMID:19039008. |
we conclude that it is not the absolute number of serotonin neurons in the grafts, but the relative densities of dopamine and serotonin innervations in the grafted striatum that is the critical factor in determining the long-term effect of foetal tissue graft, beneficial or detrimental, on dyskinesia in grafted parkinson's disease patients. |
2009-03-10 |
2023-08-12 |
rat |
| Ana Muñoz, Qin Li, Fabrizio Gardoni, Elena Marcello, Chuan Qin, Thomas Carlsson, Deniz Kirik, Monica Di Luca, Anders Björklund, Erwan Bezard, Manolo Cart. Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia. Brain : a journal of neurology. vol 131. issue Pt 12. 2009-02-02. PMID:18952677. |
we have recently demonstrated that dopamine released from serotonin neurons is responsible for l-dopa-induced dyskinesia in 6-hydroxydopamine (6-ohda)-lesioned rats, raising the possibility that blockade of serotonin neuron activity by combination of 5-ht(1a) and 5-ht(1b) agonists could reduce l-dopa-induced dyskinesia. |
2009-02-02 |
2023-08-12 |
rat |
| Ana Muñoz, Qin Li, Fabrizio Gardoni, Elena Marcello, Chuan Qin, Thomas Carlsson, Deniz Kirik, Monica Di Luca, Anders Björklund, Erwan Bezard, Manolo Cart. Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia. Brain : a journal of neurology. vol 131. issue Pt 12. 2009-02-02. PMID:18952677. |
in the present study, we have investigated the efficacy of 5-ht(1a) and 5-ht(1b) agonists to counteract l-dopa-induced dyskinesia in 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine (mptp)-treated macaques, the gold standard model of parkinson's disease. |
2009-02-02 |
2023-08-12 |
rat |