| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher Bishop, Jennifer L Taylor, Donald M Kuhn, Karen L Eskow, John Y Park, Paul D Walke. MDMA and fenfluramine reduce L-DOPA-induced dyskinesia via indirect 5-HT1A receptor stimulation. The European journal of neuroscience. vol 23. issue 10. 2006-08-04. PMID:16817869. |
clinical and experimental studies indicate that indirect serotonin agonists can suppress dyskinesia without affecting the efficacy of l-dopa. |
2006-08-04 |
2023-08-12 |
rat |
| William Bara-Jimenez, Francesco Bibbiani, Michael J Morris, Tzvetelina Dimitrova, Abdullah Sherzai, Maral M Mouradian, Thomas N Chas. Effects of serotonin 5-HT1A agonist in advanced Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 20. issue 8. 2005-10-19. PMID:15791634. |
if 5-ht1a autoreceptors regulate dopamine as well as serotonin release, in parkinsonian patients inhibition of striatal serotonergic neuron firing might help maintain more physiological intrasynaptic dopamine concentrations and thus ameliorate motor fluctuations and dyskinesias. |
2005-10-19 |
2023-08-12 |
Not clear |
| Michael J Jackson, Ghassan Al-Barghouthy, Ronald K B Pearce, Lance Smith, James J Hagan, Peter Jenne. Effect of 5-HT1B/D receptor agonist and antagonist administration on motor function in haloperidol and MPTP-treated common marmosets. Pharmacology, biochemistry, and behavior. vol 79. issue 3. 2005-05-12. PMID:15582011. |
this study assessed the effects of treatment with a non-selective 5-ht(1b/d) receptor agonist and a selective 5-ht(1b) receptor antagonist on akinesia induced in marmosets by long-term treatment with haloperidol and on motor disability and l-3, 4-dihydroxyphenylalanine (l-dopa)-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated marmosets. |
2005-05-12 |
2023-08-12 |
Not clear |
| Mahmoud M Iravani, Michael J Jackson, Mikko Kuoppamäki, Lance A Smith, Peter Jenne. 3,4-methylenedioxymethamphetamine (ecstasy) inhibits dyskinesia expression and normalizes motor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 27. 2003-11-04. PMID:14534244. |
the ability of mdma to inhibit dyskinesia results from its broad spectrum of action on 5-ht systems. |
2003-11-04 |
2023-08-12 |
Not clear |
| P De Deurwaèrdere, M F Chessele. Nigrostriatal lesions alter oral dyskinesia and c-Fos expression induced by the serotonin agonist 1-(m-chlorophenyl)piperazine in adult rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 13. 2000-07-26. PMID:10864974. |
nigrostriatal lesions alter oral dyskinesia and c-fos expression induced by the serotonin agonist 1-(m-chlorophenyl)piperazine in adult rats. |
2000-07-26 |
2023-08-12 |
rat |
| P De Deurwaèrdere, M F Chessele. Nigrostriatal lesions alter oral dyskinesia and c-Fos expression induced by the serotonin agonist 1-(m-chlorophenyl)piperazine in adult rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 13. 2000-07-26. PMID:10864974. |
specifically, the effects of unilateral lesions of nigrostriatal da neurons on oral dyskinesia and fos protein expression induced by the non-selective 5-ht(2c) agonist 1-(m-chlorophenyl)piperazine (m-cpp) were examined. |
2000-07-26 |
2023-08-12 |
rat |
| B Henry, A R Crossman, J M Brotchi. Characterization of enhanced behavioral responses to L-DOPA following repeated administration in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease. Experimental neurology. vol 151. issue 2. 1998-07-09. PMID:9628768. |
once established, the enhanced behavioral response to repeated l-dopa-administration (6.5 mg/kg, twice daily) can, like l-dopa-induced dyskinesia in man and mptp-treated monkeys, be selectively reduced by coadministration of l-dopa with the alpha2-adrenergic receptor antagonist yohimbine (10 mg/kg, -95%), the 5-ht uptake inhibitor 5-mdot (2 mg/kg, -90%), or the beta-adrenergic receptor antagonist propranalol (10 mg/kg, -35%). |
1998-07-09 |
2023-08-12 |
rat |
| R P Iacono, S M Kuniyoshi, J R Ahlman, G J Zimmerman, G Maeda, R D Pearlstei. Concentrations of indoleamine metabolic intermediates in the ventricular cerebrospinal fluid of advanced Parkinson's patients with severe postural instability and gait disorders. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 4-5. 1997-11-21. PMID:9295177. |
we have measured the concentrations of serotonin, 5-hydroxytryptophan (5-htp), 5-hydroxy-3-indoleacetic acid (5-hiaa), and homovanillic acid (hva) in samples of ventricular cerebrospinal fluid from ten pd patients with severe disability from pigd and from ten pd patients with tremor and levodopa induced dyskinesia as their predominant motor dysfunction. |
1997-11-21 |
2023-08-12 |
Not clear |
| H Tanii, A Okayama, A Yamatodani, M Hayashi, K Hashimot. Alterations in the metabolism of serotonin and dopamine in the mouse brain following a single administration of allylnitrile, which induces long-term dyskinesia. Toxicology letters. vol 58. issue 3. 1991-12-30. PMID:1720266. |
alterations in the metabolism of serotonin and dopamine in the mouse brain following a single administration of allylnitrile, which induces long-term dyskinesia. |
1991-12-30 |
2023-08-11 |
mouse |
| H Tanii, A Okayama, A Yamatodani, M Hayashi, K Hashimot. Alterations in the metabolism of serotonin and dopamine in the mouse brain following a single administration of allylnitrile, which induces long-term dyskinesia. Toxicology letters. vol 58. issue 3. 1991-12-30. PMID:1720266. |
the effects of allylnitrile (aln), which induces a long-term dyskinesia in mice, on the metabolism of serotonin (5-ht) and dopamine (da) were studied after a single administration. |
1991-12-30 |
2023-08-11 |
mouse |
| S Przedborski, M Wright, S Fahn, J L Cade. Quantitative autoradiographic changes in 5-[3H]HT-labeled 5-HT1 serotonin receptors in discrete regions of brain in the rat model of persistent dyskinesias induced by iminodipropionitrile (IDPN). Neuroscience letters. vol 116. issue 1-2. 1991-01-28. PMID:2259456. |
quantitative autoradiographic changes in 5-[3h]ht-labeled 5-ht1 serotonin receptors in discrete regions of brain in the rat model of persistent dyskinesias induced by iminodipropionitrile (idpn). |
1991-01-28 |
2023-08-11 |
rat |
| H Tanii, M Hayashi, K Hashimot. Alterations in the metabolism of serotonin and dopamine in the central nervous system of mice displaying a persistent dyskinesia due to crotononitrile or 2-pentenenitrile. Archives of toxicology. vol 64. issue 3. 1990-08-23. PMID:2372234. |
alterations in the metabolism of serotonin and dopamine in the central nervous system of mice displaying a persistent dyskinesia due to crotononitrile or 2-pentenenitrile. |
1990-08-23 |
2023-08-11 |
mouse |
| T Nishikawa, S Yamada, A Tsuda, M Tanaka, I Koga, Y Uchid. Chronic treatment with talipexole dihydrochloride on abnormal involuntary movement in humans. Clinical neuropharmacology. vol 13. issue 3. 1990-07-27. PMID:1694103. |
two cases of severe dystonia and dyskinesia were treated with talipexole, a dopamine autoreceptor agonist, and the metabolites of dopamine, norepinephrine, and serotonin in cerebrospinal fluid (csf) were determined. |
1990-07-27 |
2023-08-11 |
Not clear |
| N Ogawa, K Mizukawa, K Haba, H Sat. Neurotransmitter and receptor alterations in the rat persistent dyskinesia model induced by iminodipropionitrile. European neurology. vol 30 Suppl 1. 1990-04-16. PMID:1968833. |
conventionally, this idpn-induced dyskinesia has been considered to be due to abnormalities in the serotonin neuronal system. |
1990-04-16 |
2023-08-11 |
rat |
| S Przedborski, M Wright, S Fahn, J L Cade. Regional changes in brain 5-HT1A serotonin receptors in the rat model of persistent spasmodic dyskinesias induced by iminodipropionitrile. Brain research. vol 504. issue 2. 1990-02-06. PMID:2532054. |
regional changes in brain 5-ht1a serotonin receptors in the rat model of persistent spasmodic dyskinesias induced by iminodipropionitrile. |
1990-02-06 |
2023-08-11 |
rat |
| J M Liebman, S C Gerhardt, R Gerbe. Effects of 5-HT1A agonists and 5-HT2 antagonists on haloperidol-induced dyskinesias in squirrel monkeys: no evidence for reciprocal 5-HT-dopamine interaction. Psychopharmacology. vol 97. issue 4. 1989-06-27. PMID:2524857. |
tonic inhibition of brain extrapyramidal dopamine systems by serotonin systems does not appear to characterize neuroleptic-related dyskinesias in squirrel monkeys. |
1989-06-27 |
2023-08-11 |
monkey |
| J L Cadet, V Jackson-Lewis, S Fah. The iminodipropionitrile (IDPN) model of persistent spasmodic dyskinesias: regional serotonin metabolism in rat brain. Brain research. vol 456. issue 2. 1989-02-21. PMID:2463039. |
the iminodipropionitrile (idpn) model of persistent spasmodic dyskinesias: regional serotonin metabolism in rat brain. |
1989-02-21 |
2023-08-11 |
rat |
| J L Cadet, B Kuyatt, S Fahn, E B De Souz. Differential changes in 125I-LSD-labeled 5-HT-2 serotonin receptors in discrete regions of brain in the rat model of persistent dyskinesias induced by iminodipropionitrile (IDPN): evidence from autoradiographic studies. Brain research. vol 437. issue 2. 1988-03-25. PMID:3435844. |
differential changes in 125i-lsd-labeled 5-ht-2 serotonin receptors in discrete regions of brain in the rat model of persistent dyskinesias induced by iminodipropionitrile (idpn): evidence from autoradiographic studies. |
1988-03-25 |
2023-08-11 |
rat |
| B Sundén-Kuronen, P Pohto, E Alane. Oral dyskinesias induced and inhibited by 5-hydroxytryptamine injections into different parts of the rat brain. Proceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran toimituksia. vol 80. issue 2. 1984-09-05. PMID:6463038. |
oral dyskinesias induced and inhibited by 5-hydroxytryptamine injections into different parts of the rat brain. |
1984-09-05 |
2023-08-12 |
rat |
| A Dra. Serotonin in the basal ganglia: functions and interactions with other neuronal pathways. Journal de physiologie. vol 77. issue 2-3. 1981-12-22. PMID:7026771. |
different types of serotonin receptors in basal ganglia suggest that altered serotonin neurotransmission might be involved in the catalepsy or dyskinesias produced by neuroleptic therapy. |
1981-12-22 |
2023-08-12 |
Not clear |