| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Muñoz, Qin Li, Fabrizio Gardoni, Elena Marcello, Chuan Qin, Thomas Carlsson, Deniz Kirik, Monica Di Luca, Anders Björklund, Erwan Bezard, Manolo Cart. Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia. Brain : a journal of neurology. vol 131. issue Pt 12. 2009-02-02. PMID:18952677. |
the results demonstrate the existence of a potent synergistic effect between 5-ht(1a) and 5-ht(1b) agonists in their ability to dampen l-dopa-induced dyskinesia in the mptp-treated macaques. |
2009-02-02 |
2023-08-12 |
rat |
| Manolo Carta, Thomas Carlsson, Ana Muñoz, Deniz Kirik, Anders Björklun. Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias. Progress in brain research. vol 172. 2009-01-15. PMID:18772046. |
an increasing body of evidence points to dopamine released as a false neurotransmitter from the striatal serotonin terminals as the main pre-synaptic determinant of l-dopa-induced dyskinesia. |
2009-01-15 |
2023-08-12 |
human |
| Manolo Carta, Thomas Carlsson, Ana Muñoz, Deniz Kirik, Anders Björklun. Involvement of the serotonin system in L-dopa-induced dyskinesias. Parkinsonism & related disorders. vol 14 Suppl 2. 2008-12-12. PMID:18579429. |
indeed, an increasing body of evidence points to dopamine released as a false neurotransmitter from the serotonin terminals as the main pre-synaptic determinant of l-dopa-induced dyskinesias in animal models of parkinson's disease. |
2008-12-12 |
2023-08-12 |
Not clear |
| Kristin B Dupre, Karen L Eskow, Aimee Steiniger, Anna Klioueva, Giselle E Negron, Lydia Lormand, John Y Park, Christopher Bisho. Effects of coincident 5-HT1A receptor stimulation and NMDA receptor antagonism on L-DOPA-induced dyskinesia and rotational behaviors in the hemi-parkinsonian rat. Psychopharmacology. vol 199. issue 1. 2008-12-03. PMID:18545986. |
serotonin 1a receptor (5-ht1ar) agonists reduce l-dopa-induced dyskinesia and enhance motor function in experimental and clinical investigations of parkinson's disease (pd). |
2008-12-03 |
2023-08-12 |
rat |
| Trond Kvernmo, John Houben, Ingebrigt Sylt. Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Current topics in medicinal chemistry. vol 8. issue 12. 2008-10-27. PMID:18691132. |
5-ht(1a)-receptor agonism and alpha(2) adrenergic antagonism may contribute to prevention of dyskinesia. |
2008-10-27 |
2023-08-12 |
Not clear |
| Trond Kvernmo, John Houben, Ingebrigt Sylt. Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Current topics in medicinal chemistry. vol 8. issue 12. 2008-10-27. PMID:18691132. |
5-ht(1a)-receptor agonism (prevention of dyskinesia), 5-ht(2b) antagonism or no 5-ht(2b)-receptor activity also seems beneficial. |
2008-10-27 |
2023-08-12 |
Not clear |
| Wei-Li Kuan, Jing-Wei Zhao, Roger A Barke. The role of anxiety in the development of levodopa-induced dyskinesias in an animal model of Parkinson's disease, and the effect of chronic treatment with the selective serotonin reuptake inhibitor citalopram. Psychopharmacology. vol 197. issue 2. 2008-09-03. PMID:18157704. |
the role of anxiety in the development of levodopa-induced dyskinesias in an animal model of parkinson's disease, and the effect of chronic treatment with the selective serotonin reuptake inhibitor citalopram. |
2008-09-03 |
2023-08-12 |
rat |
| Stephen J Kish, Junchao Tong, Oleh Hornykiewicz, Ali Rajput, Li-Jan Chang, Mark Guttman, Yoshiaki Furukaw. Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease. Brain : a journal of neurology. vol 131. issue Pt 1. 2008-03-06. PMID:17956909. |
striatal serotonin concentration was similar in the subset of patients reported to have had dyskinesias versus those not reported to have had this drug complication. |
2008-03-06 |
2023-08-12 |
Not clear |
| Karen L Eskow, Vikas Gupta, Salmahn Alam, John Y Park, Christopher Bisho. The partial 5-HT(1A) agonist buspirone reduces the expression and development of l-DOPA-induced dyskinesia in rats and improves l-DOPA efficacy. Pharmacology, biochemistry, and behavior. vol 87. issue 3. 2007-10-12. PMID:17553556. |
the partial 5-ht(1a) agonist buspirone reduces the expression and development of l-dopa-induced dyskinesia in rats and improves l-dopa efficacy. |
2007-10-12 |
2023-08-12 |
rat |
| Thomas Carlsson, Manolo Carta, Christian Winkler, Anders Björklund, Deniz Kiri. Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 30. 2007-08-20. PMID:17652591. |
here, we have evaluated the effect of transplants containing serotonin neurons, or a mixture of dopamine and serotonin neurons, on l-dopa-induced dyskinesias in 6-hydroxydopamine-lesioned animals. |
2007-08-20 |
2023-08-12 |
rat |
| Thomas Carlsson, Manolo Carta, Christian Winkler, Anders Björklund, Deniz Kiri. Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 30. 2007-08-20. PMID:17652591. |
we conclude that serotonin neurons in the grafts are likely to have a detrimental effect on l-dopa-induced dyskinesias in cases in which the grafts contain no or few dopamine neurons. |
2007-08-20 |
2023-08-12 |
rat |
| Manolo Carta, Thomas Carlsson, Deniz Kirik, Anders Björklun. Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats. Brain : a journal of neurology. vol 130. issue Pt 7. 2007-07-24. PMID:17452372. |
dopamine released from 5-ht terminals is the cause of l-dopa-induced dyskinesia in parkinsonian rats. |
2007-07-24 |
2023-08-12 |
rat |
| Manolo Carta, Thomas Carlsson, Deniz Kirik, Anders Björklun. Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats. Brain : a journal of neurology. vol 130. issue Pt 7. 2007-07-24. PMID:17452372. |
removal of the serotonin afferents, or dampening of serotonin neuron activity by 5-ht1a and 5-ht1b agonist drugs, resulted in a near-complete block of the l-dopa-induced dyskinesias, suggesting that dysregulated dopamine release from serotonin terminals is the prime trigger of dyskinesia in the rat parkinson's disease model. |
2007-07-24 |
2023-08-12 |
rat |
| P Nowak, G Szczerbak, I Biedka, M Drosik, R M Kostrzewa, R Bru. Effect of ketanserin and amphetamine on nigrostriatal neurotransmission and reactive oxygen species in Parkinsonian rats. In vivo microdialysis study. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 57. issue 4. 2007-02-06. PMID:17229983. |
moreover, previously we established that 5-ht(2a/2c) antagonist attenuate da d(1) agonist mediated vacuous chewing movements (vcms) which are considered as an animal representation of human dyskinesia. |
2007-02-06 |
2023-08-12 |
human |
| P Nowak, G Szczerbak, I Biedka, M Drosik, R M Kostrzewa, R Bru. Effect of ketanserin and amphetamine on nigrostriatal neurotransmission and reactive oxygen species in Parkinsonian rats. In vivo microdialysis study. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 57. issue 4. 2007-02-06. PMID:17229983. |
these findings implicate 5-ht neuronal phenotypes in basal ganglia pathology, and promote 5-ht(2) antagonists as a rational treatment approach for dyskinesia that is prominent in most instances of pd replacement therapy. |
2007-02-06 |
2023-08-12 |
human |
| P Nowak, G Szczerbak, I Biedka, M Drosik, R M Kostrzewa, R Bru. Effect of ketanserin and amphetamine on nigrostriatal neurotransmission and reactive oxygen species in Parkinsonian rats. In vivo microdialysis study. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 57. issue 4. 2007-02-06. PMID:17229983. |
as 5-ht(2a/2c) receptor-mediated transmission might prove usefulness not only in addressing motor complications of pd patients (dyskinesia) but also in addressing non-motor problems such depression and/or l-dopa evoked psychosis, the findings from the current study showed that the use of 5-ht(2a/2c) receptor antagonists in parkinson's disease does not impend the neostriatal neuropil to be damaged by these drugs. |
2007-02-06 |
2023-08-12 |
human |
| Mahmoud M Iravani, Kayhan Tayarani-Binazir, Wing B Chu, Michael J Jackson, Peter Jenne. In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates, the selective 5-hydroxytryptamine 1a agonist (R)-(+)-8-OHDPAT inhibits levodopa-induced dyskinesia but only with\ increased motor disability. The Journal of pharmacology and experimental therapeutics. vol 319. issue 3. 2007-01-09. PMID:16959959. |
in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates, the selective 5-hydroxytryptamine 1a agonist (r)-(+)-8-ohdpat inhibits levodopa-induced dyskinesia but only with\ increased motor disability. |
2007-01-09 |
2023-08-12 |
Not clear |
| Mahmoud M Iravani, Kayhan Tayarani-Binazir, Wing B Chu, Michael J Jackson, Peter Jenne. In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates, the selective 5-hydroxytryptamine 1a agonist (R)-(+)-8-OHDPAT inhibits levodopa-induced dyskinesia but only with\ increased motor disability. The Journal of pharmacology and experimental therapeutics. vol 319. issue 3. 2007-01-09. PMID:16959959. |
5-hydroxytryptamine 1a (5-ht(1a)) receptor agonists, such as sarizotan and tandospirone, are reported to reduce levodopa-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated macaques and in parkinson's disease without worsening motor disability. |
2007-01-09 |
2023-08-12 |
Not clear |
| Mahmoud M Iravani, Kayhan Tayarani-Binazir, Wing B Chu, Michael J Jackson, Peter Jenne. In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates, the selective 5-hydroxytryptamine 1a agonist (R)-(+)-8-OHDPAT inhibits levodopa-induced dyskinesia but only with\ increased motor disability. The Journal of pharmacology and experimental therapeutics. vol 319. issue 3. 2007-01-09. PMID:16959959. |
we now report on the effects of (2r)-(+)-8-hydroxy-2-(di-n-propylamino)tetralin [(r)-(+)-8-ohdpat], a selective 5-ht(1a) agonist lacking dopaminergic activity, on motor disability and dyskinesia (chorea and dystonia) in levodopa-primed mptp-treated common marmosets. |
2007-01-09 |
2023-08-12 |
Not clear |
| Roberto Scatena, Giuseppe E Martorana, Patrizia Bottoni, Giorgia Botta, Paola Pastore, Bruno Giardin. An update on pharmacological approaches to neurodegenerative diseases. Expert opinion on investigational drugs. vol 16. issue 1. 2007-01-08. PMID:17155854. |
there are also many other drugs involved, including astrocyte-modulating agents, 5-ht(1a) agonists and alpha(2)-adrenergic receptor antagonists, which are targeted at preventing or ameliorating parkinson's disease-related or l-dopa-induced dyskinesias. |
2007-01-08 |
2023-08-12 |
Not clear |