| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elisabetta Tronci, Francesco Napolitano, Ana Muñoz, Camino Fidalgo, Francesca Rossi, Anders Björklund, Alessandro Usiello, Manolo Cart. BDNF over-expression induces striatal serotonin fiber sprouting and increases the susceptibility to l-DOPA-induced dyskinesia in 6-OHDA-lesioned rats. Experimental neurology. vol 297. 2017-10-05. PMID:28757258. |
in addition to its role in neuronal survival, the brain neurotrophic factor (bdnf) has been shown to influence serotonin transmission and synaptic plasticity, events strongly implicated in the appearance of l-dopa-induced dyskinesia (lid), a motor complication occurring in parkinsonian patients after long-term treatment with the dopamine precursor. |
2017-10-05 |
2023-08-13 |
rat |
| Maria Eliza Freitas, Susan H Fo. Nondopaminergic treatments for Parkinson's disease: current and future prospects. Neurodegenerative disease management. vol 6. issue 3. 2017-09-25. PMID:27230697. |
n-methyl-d-aspartate receptor antagonists and serotonin 5ht1b receptor agonists demonstrated benefit in levodopa-induced dyskinesia. |
2017-09-25 |
2023-08-13 |
Not clear |
| Samantha M Meadows, Nicole E Chambers, Melissa M Conti, Sharon C Bossert, Crystal Tasber, Eitan Sheena, Mark Varney, Adrian Newman-Tancredi, Christopher Bisho. Characterizing the differential roles of striatal 5-HT Experimental neurology. vol 292. 2017-07-28. PMID:28342749. |
characterizing the differential roles of striatal 5-ht l-dopa remains the benchmark treatment for parkinson's disease (pd) motor symptoms, but chronic use leads to l-dopa-induced dyskinesia (lid). |
2017-07-28 |
2023-08-13 |
Not clear |
| Patrick Aldrin-Kirk, Andreas Heuer, Gang Wang, Bengt Mattsson, Martin Lundblad, Malin Parmar, Tomas Björklun. DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor. Neuron. vol 90. issue 5. 2017-06-28. PMID:27161524. |
dreadd modulation of transplanted da neurons reveals a novel parkinsonian dyskinesia mechanism mediated by the serotonin 5-ht6 receptor. |
2017-06-28 |
2023-08-13 |
Not clear |
| Giovanna Paolone, Alberto Brugnoli, Ludovico Arcuri, Daniela Mercatelli, Michele Morar. Eltoprazine prevents levodopa-induced dyskinesias by reducing striatal glutamate and direct pathway activity. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 13. 2016-10-12. PMID:26207892. |
selective serotonin (5-hydroxytryptamine; 5-ht) 5-ht1a or 5-ht1b receptor agonists, and, very recently, the mixed 5-ht1a /5-ht1b receptor agonist, eltoprazine, proved effective in inhibiting l-dopa-induced dyskinesias in experimental animals and parkinsonian patients. |
2016-10-12 |
2023-08-13 |
Not clear |
| Philippe Huot, Tom H Johnston, Susan H Fox, Adrian Newman-Tancredi, Jonathan M Brotchi. The highly-selective 5-HT(1A) agonist F15599 reduces L-DOPA-induced dyskinesia without compromising anti-parkinsonian benefits in the MPTP-lesioned macaque. Neuropharmacology. vol 97. 2016-05-24. PMID:26071982. |
the highly-selective 5-ht(1a) agonist f15599 reduces l-dopa-induced dyskinesia without compromising anti-parkinsonian benefits in the mptp-lesioned macaque. |
2016-05-24 |
2023-08-13 |
monkey |
| Michel Engeln, Philippe De Deurwaerdère, Qin Li, Erwan Bezard, Pierre-Olivier Fernagu. Widespread Monoaminergic Dysregulation of Both Motor and Non-Motor Circuits in Parkinsonism and Dyskinesia. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 9. 2016-05-06. PMID:24770706. |
a substantial increase in da levels in these regions, paralleled by a decrease in serotonin concentrations were related with dyskinesia severity, demonstrating that major changes in monoamine release also occur in nonmotor regions. |
2016-05-06 |
2023-08-13 |
monkey |
| Perdita Cheshire, Scott Ayton, Kelly L Bertram, Helen Ling, Abi Li, Catriona McLean, Glenda M Halliday, Sean S O'Sullivan, Tamas Revesz, David I Finkelstein, Elsdon Storey, David R William. Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 6. 2016-04-07. PMID:25649148. |
preclinical animal models implicate serotonin neurons in the pathophysiology of levodopa (l-dopa)-induced dyskinesias in parkinson's disease (pd), but effective treatment remains elusive. |
2016-04-07 |
2023-08-13 |
Not clear |
| Perdita Cheshire, Scott Ayton, Kelly L Bertram, Helen Ling, Abi Li, Catriona McLean, Glenda M Halliday, Sean S O'Sullivan, Tamas Revesz, David I Finkelstein, Elsdon Storey, David R William. Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 6. 2016-04-07. PMID:25649148. |
we examined the relationship between serotonin and l-dopa-induced dyskinesias in a pathologically confirmed cohort of pd patients. |
2016-04-07 |
2023-08-13 |
Not clear |
| Perdita Cheshire, Scott Ayton, Kelly L Bertram, Helen Ling, Abi Li, Catriona McLean, Glenda M Halliday, Sean S O'Sullivan, Tamas Revesz, David I Finkelstein, Elsdon Storey, David R William. Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 6. 2016-04-07. PMID:25649148. |
the absence of a correlation between striatal serotonin markers and the incidence and severity of l-dopa-induced dyskinesias suggests that an intact and functioning serotonergic system is not a risk factor for developing dyskinesias in pd. |
2016-04-07 |
2023-08-13 |
Not clear |
| C Fidalgo, W K D Ko, E Tronci, Q Li, R Stancampiano, Q Chuan, E Bezard, M Cart. Effect of serotonin transporter blockade on L-DOPA-induced dyskinesia in animal models of Parkinson's disease. Neuroscience. vol 298. 2016-03-21. PMID:25907446. |
effect of serotonin transporter blockade on l-dopa-induced dyskinesia in animal models of parkinson's disease. |
2016-03-21 |
2023-08-13 |
rat |
| C Fidalgo, W K D Ko, E Tronci, Q Li, R Stancampiano, Q Chuan, E Bezard, M Cart. Effect of serotonin transporter blockade on L-DOPA-induced dyskinesia in animal models of Parkinson's disease. Neuroscience. vol 298. 2016-03-21. PMID:25907446. |
serotonin transporter blockade with selective serotonin reuptake inhibitors (ssris) was recently shown to counteract l-dopa-induced dyskinesia in 6-hydroxydopamine (6-ohda)-lesioned rats. |
2016-03-21 |
2023-08-13 |
rat |
| Ruben Smith, Kit Wu, Thomas Hart, Clare Loane, David J Brooks, Anders Björklund, Per Odin, Paola Piccini, Marios Politi. The role of pallidal serotonergic function in Parkinson's disease dyskinesias: a positron emission tomography study. Neurobiology of aging. vol 36. issue 4. 2016-03-17. PMID:25649022. |
levels of gp serotonin transporter binding correlated positively with severity of dyskinesias. |
2016-03-17 |
2023-08-13 |
human |
| Ruben Smith, Kit Wu, Thomas Hart, Clare Loane, David J Brooks, Anders Björklund, Per Odin, Paola Piccini, Marios Politi. The role of pallidal serotonergic function in Parkinson's disease dyskinesias: a positron emission tomography study. Neurobiology of aging. vol 36. issue 4. 2016-03-17. PMID:25649022. |
this increased serotonin function may result in further dysregulation of thalamocortical signals and so promote the expression of dyskinesias. |
2016-03-17 |
2023-08-13 |
human |
| H Iderberg, A C McCreary, M A Varney, M A Cenci, A Newman-Tancred. Activity of serotonin 5-HT(1A) receptor 'biased agonists' in rat models of Parkinson's disease and L-DOPA-induced dyskinesia. Neuropharmacology. vol 93. 2016-01-01. PMID:25645393. |
activity of serotonin 5-ht(1a) receptor 'biased agonists' in rat models of parkinson's disease and l-dopa-induced dyskinesia. |
2016-01-01 |
2023-08-13 |
rat |
| H Iderberg, A C McCreary, M A Varney, M A Cenci, A Newman-Tancred. Activity of serotonin 5-HT(1A) receptor 'biased agonists' in rat models of Parkinson's disease and L-DOPA-induced dyskinesia. Neuropharmacology. vol 93. 2016-01-01. PMID:25645393. |
serotonin 5-ht1a receptor agonists reduce l-dopa-induced dyskinesia (lid) in animal models of parkinson's disease (pd). |
2016-01-01 |
2023-08-13 |
rat |
| D Lindenbach, N Palumbo, C Y Ostock, N Vilceus, M M Conti, C Bisho. Side effect profile of 5-HT treatments for Parkinson's disease and L-DOPA-induced dyskinesia in rats. British journal of pharmacology. vol 172. issue 1. 2015-09-04. PMID:25175895. |
side effect profile of 5-ht treatments for parkinson's disease and l-dopa-induced dyskinesia in rats. |
2015-09-04 |
2023-08-13 |
rat |
| D Lindenbach, N Palumbo, C Y Ostock, N Vilceus, M M Conti, C Bisho. Side effect profile of 5-HT treatments for Parkinson's disease and L-DOPA-induced dyskinesia in rats. British journal of pharmacology. vol 172. issue 1. 2015-09-04. PMID:25175895. |
dyskinesia can be reduced using compounds that act as direct or indirect agonists of the 5-ht1 a receptor, but these drugs have been reported to worsen pd features and are known to produce '5-ht syndrome', symptoms of which include tremor, myoclonus, rigidity and hyper-reflexia. |
2015-09-04 |
2023-08-13 |
rat |
| Erwan Bezard, Manolo Cart. Could the serotonin theory give rise to a treatment for levodopa-induced dyskinesia in Parkinson's disease? Brain : a journal of neurology. vol 138. issue Pt 4. 2015-05-21. PMID:25669729. |
could the serotonin theory give rise to a treatment for levodopa-induced dyskinesia in parkinson's disease? |
2015-05-21 |
2023-08-13 |
Not clear |
| Rui Zhao, Weijian Lu, Xing Fang, Lin Guo, Zhi Yang, Na Ye, Jiahao Zhao, Zhili Liu, Jia Jia, Longtai Zheng, Bin Zhao, Ao Zhang, Xuechu Zhe. (6aR)-11-amino-N-propyl-noraporphine, a new dopamine D2 and serotonin 5-HT1A dual agonist, elicits potent antiparkinsonian action and attenuates levodopa-induced dyskinesia in a 6-OHDA-lesioned rat model of Parkinson's disease. Pharmacology, biochemistry, and behavior. vol 124. 2015-05-19. PMID:24955866. |
(6ar)-11-amino-n-propyl-noraporphine, a new dopamine d2 and serotonin 5-ht1a dual agonist, elicits potent antiparkinsonian action and attenuates levodopa-induced dyskinesia in a 6-ohda-lesioned rat model of parkinson's disease. |
2015-05-19 |
2023-08-13 |
rat |