| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aisling Mary Smith, Philip T Levy, Orla Franklin, Eleanor Molloy, Afif El-Khuffas. Pulmonary hypertension and myocardial function in infants and children with Down syndrome. Archives of disease in childhood. vol 105. issue 11. 2020-12-16. PMID:32160992. |
down syndrome (ds) is the most common chromosomal abnormality of live born babies. |
2020-12-16 |
2023-08-13 |
Not clear |
| Nancy Raitano Lee, Amritha Nayak, M Okan Irfanoglu, Neda Sadeghi, Catherine J Stoodley, Elizabeth Adeyemi, Liv S Clasen, Carlo Pierpaol. Hypoplasia of cerebellar afferent networks in Down syndrome revealed by DTI-driven tensor based morphometry. Scientific reports. vol 10. issue 1. 2020-12-16. PMID:32214129. |
quantitative magnetic resonance imaging (mri) investigations of brain anatomy in children and young adults with down syndrome (ds) are limited, with no diffusion tensor imaging (dti) studies covering that age range. |
2020-12-16 |
2023-08-13 |
human |
| Elisângela Santos Dias, Laura Cruz-Mamani, Alessandro Antônio Pereira, Felipe Fornias Sperandio, Kellen Cristina Gasque, Marina Lara de Carli, João Adolfo Haneman. Pyogenic granuloma in the tongue of a patient with Down syndrome. General dentistry. vol 68. issue 4. 2020-12-16. PMID:32597780. |
down syndrome (ds), a genetic disorder caused by chromosome 21 trisomy, is characterized by intellectual disability, congenital malformations, craniofacial alterations, and dentofacial anomalies. |
2020-12-16 |
2023-08-13 |
Not clear |
| b' Noem\\xc3\\xad Rueda, Ver\\xc3\\xb3nica Vidal, Susana Garc\\xc3\\xada-Cerro, Alba Puente, V\\xc3\\xadctor Campa, Sara Lantigua, Oriol Narc\\xc3\\xads, Renata Bartesaghi, Carmen Mart\\xc3\\xadnez-Cu\\xc3\\xa. Prenatal, but not Postnatal, Curcumin Administration Rescues Neuromorphological and Cognitive Alterations in Ts65Dn Down Syndrome Mice. The Journal of nutrition. vol 150. issue 9. 2020-12-16. PMID:32729926.' |
the cognitive dysfunction in down syndrome (ds) is partially caused by deficient neurogenesis during fetal stages. |
2020-12-16 |
2023-08-13 |
mouse |
| David de Gonzalo-Calvo, Isabel Barroeta, Madalina Nicoleta Nan, José Rives, Diana Garzón, María Carmona-Iragui, Bessy Benejam, Laura Videla, Susana Fernández, Miren Altuna, Sílvia Valldeneu, Rafael Blesa, Alberto Lleó, Francisco Blanco-Vaca, Juan Fortea, Mireia Tond. Evaluation of biochemical and hematological parameters in adults with Down syndrome. Scientific reports. vol 10. issue 1. 2020-12-16. PMID:32792619. |
down syndrome (ds) is the most common worldwide cause of intellectual disability of genetic origin and the most common chromosomal disorder affecting live-born infants. |
2020-12-16 |
2023-08-13 |
human |
| Yekaterina Galat, Mariana Perepitchka, Irina Elcheva, Stephen Iannaccone, Philip M Iannaccone, Vasiliy Gala. iPSC-derived progenitor stromal cells provide new insights into aberrant musculoskeletal development and resistance to cancer in down syndrome. Scientific reports. vol 10. issue 1. 2020-12-15. PMID:32764607. |
down syndrome (ds) is a congenital disorder caused by trisomy 21 (t21). |
2020-12-15 |
2023-08-13 |
Not clear |
| Megan Flores, Katy Mitchell, Christina Bickley, Carolyn P Da Silv. Psychometric Properties of Segmental Assessment of Trunk Control in Infants and Toddlers With Down Syndrome. Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association. vol 32. issue 3. 2020-12-14. PMID:32516220. |
this study investigated infants and toddlers with down syndrome (ds) to determine: reliability of the segmental assessment of trunk control (satco), concurrent validity of the satco with the gross motor function measure (gmfm), and whether age and satco score predict gmfm score. |
2020-12-14 |
2023-08-13 |
Not clear |
| Emanuele Rocco Villani, Angelo Carfì, Antonella Di Paola, Luigi Palmieri, Chiara Donfrancesco, Cinzia Lo Noce, Domenica Taruscio, Paola Meli, Paolo Salerno, Yllka Kodra, Flavia Pricci, Manuela Tamburo de Bella, Marco Floridia, Graziano Onde. Clinical characteristics of individuals with Down syndrome deceased with CoVID-19 in Italy-A case series. American journal of medical genetics. Part A. vol 182. issue 12. 2020-12-14. PMID:32918520. |
persons with down syndrome (ds) are presumed to be at high risk of severe covid-19, due to immune dysregulation and often compromised cardiopulmonary function. |
2020-12-14 |
2023-08-13 |
Not clear |
| Luigi Tarani, Valentina Carito, Giampiero Ferraguti, Carla Petrella, Antonio Greco, Massimo Ralli, Marisa Patrizia Messina, Debora Rasio, Enrica De Luca, Carolina Putotto, Paolo Versacci, Mauro Ceccanti, Marco Fior. Neuroinflammatory Markers in the Serum of Prepubertal Children with Down Syndrome. Journal of immunology research. vol 2020. 2020-12-11. PMID:32280719. |
down syndrome (ds) is the most common chromosomal disorder. |
2020-12-11 |
2023-08-13 |
Not clear |
| Julie-Anne Little, Aman-Deep S Mahil, Patrick Richardson, J Margaret Woodhouse, Valldeflors Vinuela-Navarro, Kathryn J Saunder. In-vivo anterior segment OCT imaging provides unique insight into cerulean blue-dot opacities and cataracts in Down syndrome. Scientific reports. vol 10. issue 1. 2020-12-10. PMID:32572106. |
down syndrome (ds) is frequently associated with cataract, but there remains scant information about ds cataract morphology. |
2020-12-10 |
2023-08-13 |
human |
| Charles R Goodlett, Megan Stringer, Jonathan LaCombe, Roshni Patel, Joseph M Wallace, Randall J Rope. Evaluation of the therapeutic potential of Epigallocatechin-3-gallate (EGCG) via oral gavage in young adult Down syndrome mice. Scientific reports. vol 10. issue 1. 2020-12-10. PMID:32591597. |
epigallocatechin-3-gallate (egcg) is a candidate therapeutic for down syndrome (ds) phenotypes based on in vitro inhibition of dyrk1a, a triplicated gene product of trisomy 21 (ts21). |
2020-12-10 |
2023-08-13 |
mouse |
| Faycal Guedj, Ashley E Siegel, Jeroen L A Pennings, Fatimah Alsebaa, Lauren J Massingham, Umadevi Tantravahi, Diana W Bianch. Apigenin as a Candidate Prenatal Treatment for Trisomy 21: Effects in Human Amniocytes and the Ts1Cje Mouse Model. American journal of human genetics. vol 107. issue 5. 2020-12-09. PMID:33098770. |
we hypothesize that by analyzing and integrating dysregulated gene expression and pathways common to humans with down syndrome (ds) and mouse models we can discover novel targets for prenatal therapy. |
2020-12-09 |
2023-08-13 |
mouse |
| Juliana C S Chaves, Felippe T Machado, Michael F Almeida, Tatiana B Bacovsky, Merari F R Ferrar. microRNAs expression correlates with levels of APP, DYRK1A, hyperphosphorylated Tau and BDNF in the hippocampus of a mouse model for Down syndrome during ageing. Neuroscience letters. vol 714. 2020-12-07. PMID:31605772. |
down syndrome (ds) patients are more susceptible to alzheimer's disease (ad) due to the presence of three copies of genes on chromosome 21 such as dyrk1a, which encodes a broad acting kinase, and app (amyloid precursor protein), leading to formation of amyloid beta (aβ) peptide and hyperphosphorylation of tau. |
2020-12-07 |
2023-08-13 |
mouse |
| Francesca Antonaros, Veronica Ghini, Francesca Pulina, Giuseppe Ramacieri, Elena Cicchini, Elisa Mannini, Anna Martelli, Agnese Feliciello, Silvia Lanfranchi, Sara Onnivello, Renzo Vianello, Chiara Locatelli, Guido Cocchi, Maria Chiara Pelleri, Lorenza Vitale, Pierluigi Strippoli, Claudio Luchinat, Paola Turano, Allison Piovesan, Maria Caracaus. Plasma metabolome and cognitive skills in Down syndrome. Scientific reports. vol 10. issue 1. 2020-12-07. PMID:32591596. |
trisomy 21 (down syndrome, ds) is the main human genetic cause of intellectual disability (id). |
2020-12-07 |
2023-08-13 |
human |
| Kathryn D Tuttle, Katherine A Waugh, Paula Araya, Ross Minter, David J Orlicky, Michael Ludwig, Zdenek Andrysik, Matthew A Burchill, Beth A J Tamburini, Colin Sempeck, Keith Smith, Ross Granrath, Dayna Tracy, Jessica Baxter, Joaquin M Espinosa, Kelly D Sulliva. JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome. Cell reports. vol 33. issue 7. 2020-12-07. PMID:33207208. |
individuals with down syndrome (ds; trisomy 21) display hyperactivation of interferon (ifn) signaling and chronic inflammation, which could potentially be explained by the extra copy of four ifn receptor (ifnr) genes encoded on chromosome 21. |
2020-12-07 |
2023-08-13 |
mouse |
| Mahasweta Chatterjee, Tanusree Saha, Subhamita Maitra, Swagata Sinha, Kanchan Mukhopadhya. Folate System Gene Variant rs1801394 66A>G may have a Causal Role in Down Syndrome in the Eastern Indian Population. International journal of molecular and cellular medicine. vol 9. issue 3. 2020-12-07. PMID:33274184. |
down syndrome (ds) is associated with trisomy of the 21 |
2020-12-07 |
2023-08-13 |
Not clear |
| Karol Dowjat, Tatyana Adayev, Urszula Wojda, Katarzyna Brzozowska, Anna Barczak, Tomasz Gabryelewicz, Yu-Wen Hwan. Abnormalities of DYRK1A-Cytoskeleton Complexes in the Blood Cells as Potential Biomarkers of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 72. issue 4. 2020-12-04. PMID:31683476. |
dyrk1a is implicated in mental retardation and alzheimer's disease (ad) dementia of down syndrome (ds) individuals. |
2020-12-04 |
2023-08-13 |
Not clear |
| Tushar Arora, Pablo Caviedes, Shiv Kumar Sharm. Effects of a Tripeptide on Mitogen-Activated Protein Kinase and Glycogen Synthase Kinase Activation in a Cell Line Derived from the Foetal Hippocampus of a Trisomy 16 Mouse: an Animal Model of Down Syndrome. Neurotoxicity research. vol 37. issue 3. 2020-12-04. PMID:31802378. |
down syndrome (ds) is a developmental disorder that results from the trisomy of chromosome 21. |
2020-12-04 |
2023-08-13 |
mouse |
| Rebecca Deering Brose, Alena Savonenko, Benjamin Devenney, Kirby D Smith, Roger H Reeve. Hydroxyurea Improves Spatial Memory and Cognitive Plasticity in Mice and Has a Mild Effect on These Parameters in a Down Syndrome Mouse Model. Frontiers in aging neuroscience. vol 11. 2020-12-01. PMID:31139073. |
down syndrome (ds), a genetic disorder caused by partial or complete triplication of chromosome 21, is the most common genetic cause of intellectual disability. |
2020-12-01 |
2023-08-13 |
mouse |
| b' Marie-Odile Rethor\\xc3\\xa9, Jacques Rou\\xc3\\xabss\\xc3\\xa9, Daniel Satg\\xc3\\xa. Cancer screening in adults with down syndrome, a proposal. European journal of medical genetics. vol 63. issue 4. 2020-12-01. PMID:31605815.' |
the specific distribution of cancers in down syndrome (ds) calls into question the validity of screening policies for cancer surveillance as implemented for the general population. |
2020-12-01 |
2023-08-13 |
Not clear |