| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hana D'Souza, Luke Mason, Kin Y Mok, Carla M Startin, Sarah Hamburg, Rosalyn Hithersay, R Asaad Baksh, John Hardy, Andre Strydom, Michael S C Thoma. Differential Associations of Apolipoprotein E ε4 Genotype With Attentional Abilities Across the Life Span of Individuals With Down Syndrome. JAMA network open. vol 3. issue 9. 2021-01-13. PMID:32986108. |
risk of alzheimer disease (ad) is particularly high for individuals with down syndrome (ds). |
2021-01-13 |
2023-08-13 |
Not clear |
| I De Toma, M Ortega, S Catuara-Solarz, C Sierra, E Sabidó, M Diersse. Re-establishment of the epigenetic state and rescue of kinome deregulation in Ts65Dn mice upon treatment with green tea extract and environmental enrichment. Scientific reports. vol 10. issue 1. 2021-01-13. PMID:32994493. |
down syndrome (ds) is the main genetic cause of intellectual disability due to triplication of human chromosome 21 (hsa21). |
2021-01-13 |
2023-08-13 |
mouse |
| Maya Firsowicz, McKenna Boyd, Stephanie K Jack. Follicular occlusion disorders in Down syndrome patients. Pediatric dermatology. vol 37. issue 1. 2021-01-12. PMID:31626333. |
disorders involving follicular occlusion, such as hidradenitis suppurativa, folliculitis, acneiform eruptions, and pilonidal cysts, have shown an increased prevalence in the down syndrome (ds) population, but there are limited published data examining this association. |
2021-01-12 |
2023-08-13 |
Not clear |
| Sarah J Hart, Kanecia Zimmerman, Corinne M Linardic, Sheila Cannon, Anna Pastore, Vasiliki Patsiogiannis, Paolo Rossi, Stephanie L Santoro, Brian G Skotko, Amy Torres, Diletta Valentini, Kishore Vellody, Gordon Worley, Priya S Kishnan. Detection of iron deficiency in children with Down syndrome. Genetics in medicine : official journal of the American College of Medical Genetics. vol 22. issue 2. 2021-01-11. PMID:31417190. |
current american academy of pediatrics guidelines for children with down syndrome (ds) recommend a complete blood count (cbc) at birth and hemoglobin annually to screen for iron deficiency (id) and id anemia (ida) in low-risk children. |
2021-01-11 |
2023-08-13 |
Not clear |
| Mollie Romano, Ann Kaiser, Julie Lounds-Taylor, Juliann Wood. Rates of Prelinguistic Communication and Early Symbol Use in Young Children With Down Syndrome: Using a Progress-Monitoring Tool to Model Growth. American journal of speech-language pathology. vol 29. issue 1. 2021-01-11. PMID:31697567. |
purpose this study aims to provide descriptive data on rates of expressive communication skill use in young children with down syndrome (ds) across early childhood. |
2021-01-11 |
2023-08-13 |
Not clear |
| Emily D Quinn, Ann P Kaiser, Jennifer R Ledfor. Teaching Preschoolers With Down Syndrome Using Augmentative and Alternative Communication Modeling During Small Group Dialogic Reading. American journal of speech-language pathology. vol 29. issue 1. 2021-01-11. PMID:31697898. |
purpose this study evaluated the effect of aided augmentative and alternative communication modeling (aac-mod) on the communication skills of children with down syndrome (ds) during small group dialogic reading. |
2021-01-11 |
2023-08-13 |
Not clear |
| Neeltje Mth Crombag, Godelieve Cml Page-Christiaens, Brian G Skotko, Gert de Graa. Receiving the news of Down syndrome in the era of prenatal testing. American journal of medical genetics. Part A. vol 182. issue 2. 2021-01-11. PMID:31863634. |
to explore the prenatal trajectory and the experiences of mothers of a child with down syndrome (ds) at the time of receiving information or test results when participating in a nationwide prenatal screening program. |
2021-01-11 |
2023-08-13 |
Not clear |
| Sarah Grantham-Hill, Hazel J Evans, Catherine Tuffrey, Emma Sanders, Heather E Elphick, Paul Gringras, Ruth N Kingshott, Jane Martin, Janine Reynolds, Anna Joyce, Catherine M Hill, Karen Spruy. Psychometric Properties and Predictive Value of a Screening Questionnaire for Obstructive Sleep Apnea in Young Children With Down Syndrome. Frontiers in psychiatry. vol 11. 2021-01-10. PMID:32425820. |
obstructive sleep apnea (osa) is common in children with down syndrome (ds) and is associated with adverse health and cognitive outcomes. |
2021-01-10 |
2023-08-13 |
Not clear |
| Carla M Startin, Sarah Hamburg, Rosalyn Hithersay, Amy Davies, Erin Rodger, Nidhi Aggarwal, Tamara Al-Janabi, André Strydo. The LonDownS adult cognitive assessment to study cognitive abilities and decline in Down syndrome. Wellcome open research. vol 1. 2021-01-09. PMID:28018980. |
down syndrome (ds), the most common genetic cause of intellectual disability, is associated with an ultra-high risk of developing alzheimer's disease. |
2021-01-09 |
2023-08-13 |
Not clear |
| Nicholas C Firth, Carla M Startin, Rosalyn Hithersay, Sarah Hamburg, Peter A Wijeratne, Kin Y Mok, John Hardy, Daniel C Alexander, André Strydo. Aging related cognitive changes associated with Alzheimer's disease in Down syndrome. Annals of clinical and translational neurology. vol 5. issue 6. 2021-01-09. PMID:29928657. |
individuals with down syndrome (ds) have an extremely high genetic risk for alzheimer's disease (ad), however, the course of cognitive decline associated with progression to dementia is ill-defined. |
2021-01-09 |
2023-08-13 |
Not clear |
| André Strydom, Antonia Coppus, Rafael Blesa, Adrian Danek, Juan Fortea, John Hardy, Johannes Levin, Georg Nuebling, Anne-Sophie Rebillat, Craig Ritchie, Cornelia van Duijn, Shahid Zaman, Henrik Zetterber. Alzheimer's disease in Down syndrome: An overlooked population for prevention trials. Alzheimer's & dementia (New York, N. Y.). vol 4. 2021-01-09. PMID:30581976. |
the discovery that adults with down syndrome (ds) have neuropathological features identical to individuals with sporadic alzheimer's disease (ad) played a key role in the identification of the amyloid precursor protein gene on chromosome 21 and resulted in the amyloid cascade hypothesis. |
2021-01-09 |
2023-08-13 |
Not clear |
| Carla M Startin, Sarah Hamburg, Andre Strydo. Comparison of Receptive Verbal Abilities Assessed Using the KBIT-2 and BPVS3 in Adults With Down Syndrome. Frontiers in psychology. vol 9. 2021-01-09. PMID:30705655. |
down syndrome (ds) is the most common genetic cause of intellectual disability. |
2021-01-09 |
2023-08-13 |
Not clear |
| Carla M Startin, Bryony Lowe, Sarah Hamburg, Rosalyn Hithersay, Andre Strydo. Validating the Cognitive Scale for Down Syndrome (CS-DS) to Detect Longitudinal Cognitive Decline in Adults With Down Syndrome. Frontiers in psychiatry. vol 10. 2021-01-09. PMID:31057430. |
down syndrome (ds) is associated with intellectual disability and an ultra-high risk of developing dementia. |
2021-01-09 |
2023-08-13 |
Not clear |
| Carla M Startin, Bryony Lowe, Sarah Hamburg, Rosalyn Hithersay, Andre Strydo. Validating the Cognitive Scale for Down Syndrome (CS-DS) to Detect Longitudinal Cognitive Decline in Adults With Down Syndrome. Frontiers in psychiatry. vol 10. 2021-01-09. PMID:31057430. |
we previously developed the informant rated cognitive scale for down syndrome (cs-ds) to measure everyday cognitive abilities across memory, executive function, and language domains in adults with ds, finding cs-ds scores are a valid measure of general abilities, and are significantly lower for those with noticeable cognitive decline compared to those without decline. |
2021-01-09 |
2023-08-13 |
Not clear |
| Fabian Arenas, Fernanda Castro, Susana Nuñez, Gemma Gay, Carmen Garcia-Ruiz, Jose C Fernandez-Chec. STARD1 and NPC1 expression as pathological markers associated with astrogliosis in post-mortem brains from patients with Alzheimer's disease and Down syndrome. Aging. vol 12. issue 1. 2021-01-08. PMID:31902793. |
alzheimer´s disease (ad) is a progressive neurodegenerative disorder of complex etiology, while down syndrome (ds) is considered a genetically determined form of ad. |
2021-01-08 |
2023-08-13 |
Not clear |
| Wileidy Gomez, Rodrigo Morales, Vinicius Maracaja-Coutinho, Valentina Parra, Melissa Nassi. Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein. Aging. vol 12. issue 1. 2021-01-08. PMID:31918411. |
down syndrome (ds) is the leading genetic risk factor for early-onset ad, prematurely presenting the classic pathological features of the brain with ad. |
2021-01-08 |
2023-08-13 |
Not clear |
| Himanshu Champaneri, Anirban Deep Banerje. Rare Presentation: A Report of 2 Identical Cases with Thoracic Compressive Myelopathy in Down Syndrome. World neurosurgery. vol 142. 2021-01-06. PMID:32673810. |
atlantoaxial instability, a common finding in patients with down syndrome (ds), is attributed to laxity of ligamentous structures. |
2021-01-06 |
2023-08-13 |
Not clear |
| Emily Lorang, Courtney E Venker, Audra Sterlin. An investigation into maternal use of telegraphic input to children with Down syndrome. Journal of child language. vol 47. issue 1. 2021-01-05. PMID:31587679. |
maternal input influences language development in children with down syndrome (ds) and typical development (td). |
2021-01-05 |
2023-08-13 |
Not clear |
| Yuchen Gu, Gautier Moroy, Jean-Louis Paul, Anne-Sophie Rebillat, Mara Dierssen, Rafael de la Torre, Cécile Cieuta-Walti, Julien Dairou, Nathalie Jane. Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup International journal of molecular sciences. vol 21. issue 4. 2021-01-04. PMID:32092951. |
molecular rescue of dyrk1a overexpression alterations in mice with fontup epigallocatechin gallate (egcg) is an inhibitor of dyrk1a, a serine/threonine kinase considered to be a major contributor of cognitive dysfunctions in down syndrome (ds). |
2021-01-04 |
2023-08-13 |
mouse |
| Michele Salemi, Federico Ridolfo, Maria Grazia Salluzzo, Rossella Cannarrella, Mariaconcetta Giambirtone, Salvatore Caniglia, Cataldo Tirolo, Raffaele Ferri, Corrado Roman. Humanin gene expression in fibroblast of Down syndrome subjects. International journal of medical sciences. vol 17. issue 3. 2021-01-04. PMID:32132866. |
down syndrome (ds) is characterized by trisomy of chromosome 21 and peculiar phenotype. |
2021-01-04 |
2023-08-13 |
human |