| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chiara Lanzillotta, Ilaria Zuliani, Antonella Tramutola, Eugenio Barone, Carla Blarzino, Valentina Folgiero, Matteo Caforio, Diletta Valentini, Alberto Villani, Franco Locatelli, D Allan Butterfield, Elizabeth Head, Marzia Perluigi, Jose F Abisambra, Fabio Di Domenic. Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention. Progress in neurobiology. vol 196. 2021-11-08. PMID:32795489. |
to further investigate the role of the perk pathway in neurodegenerative disorders, we focused on down syndrome (ds), in which aging confers a high risk of alzheimer disease (ad). |
2021-11-08 |
2023-08-13 |
mouse |
| M Roche, C Mircher, J Toulas, E Prioux, M Conte, A Ravel, S Falquero, A Labidi, S Stora, S Durand, A Mégarbané, C Cieuta-Walt. Efficacy and safety of methylphenidate on attention deficit hyperactivity disorder in children with Down syndrome. Journal of intellectual disability research : JIDR. vol 65. issue 8. 2021-11-08. PMID:33880800. |
attention deficit hyperactivity disorder (adhd) is a common co-morbidity that affects up to 44% of children with down syndrome (ds). |
2021-11-08 |
2023-08-13 |
Not clear |
| b' M Gimunov\\xc3\\xa1, M Bozd\\xc4\\x9bch, A Skot\\xc3\\xa1kov\\xc3\\xa1, V Gr\\xc3\\xbcn, H V\\xc3\\xa1lkov\\xc3\\xa. Comparison of forward and backward gait in males with and without intellectual disabilities. Journal of intellectual disability research : JIDR. vol 65. issue 10. 2021-11-08. PMID:34350647.' |
the aim of this study was to compare the differences between forward and backward gait in persons with nonsyndromic mild and moderate id, persons with down syndrome (ds) and a control group of healthy adults. |
2021-11-08 |
2023-08-13 |
Not clear |
| Oxana Yu Naumova, Rebecca Lipschutz, Sergey Yu Rychkov, Olga V Zhukova, Elena L Grigorenk. DNA Methylation Alterations in Blood Cells of Toddlers with Down Syndrome. Genes. vol 12. issue 8. 2021-11-08. PMID:34440289. |
recent research has provided evidence on genome-wide alterations in dna methylation patterns due to trisomy 21, which have been detected in various tissues of individuals with down syndrome (ds) across different developmental stages. |
2021-11-08 |
2023-08-13 |
Not clear |
| Yichen Li, Zhuo Xing, Tao Yu, Annie Pao, Marcel Daadi, Y Eugene Y. Coat Color-Facilitated Efficient Generation and Analysis of a Mouse Model of Down Syndrome Triplicated for All Human Chromosome 21 Orthologous Regions. Genes. vol 12. issue 8. 2021-11-05. PMID:34440389. |
down syndrome (ds) is one of the most complex genetic disorders in humans and a leading genetic cause of developmental delays and intellectual disabilities. |
2021-11-05 |
2023-08-13 |
mouse |
| Jonathan D Santoro, Dania Pagarkar, Duong T Chu, Mattia Rosso, Kelli C Paulsen, Pat Levitt, Michael S Rafi. Neurologic complications of Down syndrome: a systematic review. Journal of neurology. vol 268. issue 12. 2021-11-04. PMID:32920658. |
down syndrome (ds) is one of the most well-recognized genetic disorders. |
2021-11-04 |
2023-08-13 |
human |
| Rosemary S C Horne, Ashwini Sakthiakumaran, Ahmad Bassam, Julie Thacker, Lisa M Walter, Margot J Davey, Gillian M Nixo. Children with Down syndrome and sleep disordered breathing have altered cardiovascular control. Pediatric research. vol 90. issue 4. 2021-11-04. PMID:33230194. |
as children with down syndrome (ds) are at increased risk for sdb, we aimed to compare the cardiovascular effects of sdb in children with ds to those of td children with and without sdb. |
2021-11-04 |
2023-08-13 |
Not clear |
| Sohier Yahia, Reham El-Farahaty, Abdel-Hady El-Gilany, Rasha Shoaib, Rowayda Ramadan, Nanees Sale. Serum adiponectin, body adiposity and metabolic parameters in obese Egyptian children with Down syndrome. Journal of pediatric endocrinology & metabolism : JPEM. vol 34. issue 11. 2021-11-04. PMID:34348423. |
children with down syndrome (ds) have a higher risk for obesity. |
2021-11-04 |
2023-08-13 |
Not clear |
| Rowan Pentz, M Florencia Iulita, Adriana Ducatenzeiler, Laura Videla, Bessy Benejam, María Carmona‐Iragui, Rafael Blesa, Alberto Lleó, Juan Fortea, A Claudio Cuell. Nerve growth factor (NGF) pathway biomarkers in Down syndrome prior to and after the onset of clinical Alzheimer's disease: A paired CSF and plasma study. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 4. 2021-11-03. PMID:33226181. |
the discovery that nerve growth factor (ngf) metabolism is altered in down syndrome (ds) and alzheimer's disease (ad) brains offered a framework for the identification of novel biomarkers signalling ngf deregulation in ad pathology. |
2021-11-03 |
2023-08-13 |
Not clear |
| Rosalyn Hithersay, R Asaad Baksh, Carla M Startin, Peter Wijeratne, Sarah Hamburg, Ben Carter, Andre Strydo. Optimal age and outcome measures for Alzheimer's disease prevention trials in people with Down syndrome. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 4. 2021-11-03. PMID:33226718. |
people with down syndrome (ds) typically develop alzheimer's disease (ad) neuropathology before age 40, but a lack of outcome measures and longitudinal data have impeded their inclusion in randomized controlled trials (rcts). |
2021-11-03 |
2023-08-13 |
Not clear |
| Laszlo Pecze, Csaba Szab. Meta-analysis of gene expression patterns in Down syndrome highlights significant alterations in mitochondrial and bioenergetic pathways. Mitochondrion. vol 57. 2021-11-02. PMID:33412332. |
individuals with down syndrome (ds) have an extra copy of chromosome 21. |
2021-11-02 |
2023-08-13 |
human |
| Rahil N Khasgiwale, Beth A Smith, Julia Loope. Leg Movement Rate Pre- and Post-Kicking Intervention in Infants with Down Syndrome. Physical & occupational therapy in pediatrics. vol 41. issue 6. 2021-11-02. PMID:33792482. |
children with down syndrome (ds) have delayed development and atypical movements including kicking. |
2021-11-02 |
2023-08-13 |
Not clear |
| Martina Parrini, Shovan Naskar, Micol Alberti, Ilaria Colombi, Giovanni Morelli, Anna Rocchi, Marina Nanni, Federica Piccardi, Severine Charles, Giuseppe Ronzitti, Federico Mingozzi, Andrea Contestabile, Laura Cancedd. Restoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome. Molecular therapy : the journal of the American Society of Gene Therapy. vol 29. issue 10. 2021-11-02. PMID:34058387. |
here, we show that reducing nkcc1 expression by rna interference in the ts65dn mouse model of down syndrome (ds) restores intracellular chloride concentration, efficacy of gamma-aminobutyric acid (gaba)-mediated inhibition, and neuronal network dynamics in vitro and ex vivo. |
2021-11-02 |
2023-08-13 |
mouse |
| Yixing Wu, Heather T Whittaker, Suzanna Noy, Karen Cleverley, Veronique Brault, Yann Herault, Elizabeth M C Fisher, Frances K Wisema. The effects of Cstb duplication on APP/amyloid-β pathology and cathepsin B activity in a mouse model. PloS one. vol 16. issue 7. 2021-11-02. PMID:34292972. |
people with down syndrome (ds), caused by trisomy of chromosome 21 have a greatly increased risk of developing alzheimer's disease (ad). |
2021-11-02 |
2023-08-13 |
mouse |
| Raikan Büyükavcı, Mehmet Akif Büyükavcı, Semra Aktürk, Feyzullah Necati Arslan, Derya Doğan, Sinem Kortay Canaloğl. The relationship between motor performance and femoral cartilage thickness in children with Down syndrome. Acta neurologica Belgica. vol 121. issue 2. 2021-11-01. PMID:30838600. |
down syndrome (ds) is a genetic disorder associated with mental and motor developmental delays in childhood. |
2021-11-01 |
2023-08-13 |
Not clear |
| Raikan Büyükavcı, Mehmet Akif Büyükavcı, Semra Aktürk, Feyzullah Necati Arslan, Derya Doğan, Sinem Kortay Canaloğl. The relationship between motor performance and femoral cartilage thickness in children with Down syndrome. Acta neurologica Belgica. vol 121. issue 2. 2021-11-01. PMID:30838600. |
the aim of this study was to investigate the relationship of the femoral cartilage thickness with motor performance in children with down syndrome (ds). |
2021-11-01 |
2023-08-13 |
Not clear |
| Clare Harrop, Aaron R Dallman, Luc Lecavalier, James W Bodfish, Brian A Boy. Behavioral Inflexibility Across Two Neurogenetic Conditions: Down Syndrome and Fragile X Syndrome. American journal on intellectual and developmental disabilities. vol 126. issue 5. 2021-11-01. PMID:34428269. |
this study characterized bi in two common neurogenetic conditions: fragile x syndrome (fxs) and down syndrome (ds). |
2021-11-01 |
2023-08-13 |
Not clear |
| Mario Fernando Jojoa-Acosta, Sara Signo-Miguel, Maria Begoña Garcia-Zapirain, Mercè Gimeno-Santos, Amaia Méndez-Zorrilla, Chandan J Vaidya, Marta Molins-Sauri, Myriam Guerra-Balic, Olga Bruna-Rabass. Executive Functioning in Adults with Down Syndrome: Machine-Learning-Based Prediction of Inhibitory Capacity. International journal of environmental research and public health. vol 18. issue 20. 2021-11-01. PMID:34682531. |
the study of executive function decline in adults with down syndrome (ds) is important, because it supports independent functioning in real-world settings. |
2021-11-01 |
2023-08-13 |
Not clear |
| Elizabeth A Will, Jane E Robert. Motor Influences on Communication: Comparisons Between Down Syndrome and Fragile X Syndrome. American journal on intellectual and developmental disabilities. vol 126. issue 6. 2021-11-01. PMID:34700347. |
motor skills, an important foundation for language and communication, are considerably delayed in children with down syndrome (ds) and fragile x syndrome (fxs). |
2021-11-01 |
2023-08-13 |
human |
| R B Cejas, M Tamaño-Blanco, J G Blanc. Analysis of the intracellular traffic of IgG in the context of Down syndrome (trisomy 21). Scientific reports. vol 11. issue 1. 2021-10-29. PMID:34040082. |
persons with down syndrome (ds, trisomy 21) have widespread cellular protein trafficking defects. |
2021-10-29 |
2023-08-13 |
human |