| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sumit Gupta, Rinku Sutradhar, Priscila Pequeno, Johann K Hitzler, Ning Liu, Paul C Natha. Risks of late mortality and morbidity among survivors of childhood acute leukemia with Down syndrome: A population-based cohort study. Cancer. 2021-11-30. PMID:34847248. |
children with leukemia and down syndrome (ds) are at higher risk of acute treatment toxicities than those without ds. |
2021-11-30 |
2023-08-13 |
Not clear |
| W Leung, J M Schuna, J Yu. Comparison of uniaxial and triaxial accelerometer outputs among individuals with and without Down syndrome. Journal of intellectual disability research : JIDR. vol 65. issue 1. 2021-11-29. PMID:33145849. |
using uniaxial accelerometry approach in measuring physical activity levels of individuals with down syndrome (ds) might underestimate their energy expenditure due to the unique mediolateral walking pattern. |
2021-11-29 |
2023-08-13 |
Not clear |
| Emmanouil Gkliatis, Alexandros Makris, Chryssoula Staiko. The impact of inhalation anesthetics on early postoperative cognitive function and recovery characteristics in Down syndrome patients: a randomized, double - blind study. BMC anesthesiology. vol 21. issue 1. 2021-11-29. PMID:34535086. |
down syndrome (ds) is associated with intellectual disability. |
2021-11-29 |
2023-08-13 |
Not clear |
| Ross Minter, Katheleen J Gardine. Trisomy of Human Chromosome 21 Orthologs Mapping to Mouse Chromosome 10 Cause Age and Sex-Specific Learning Differences: Relevance to Down Syndrome. Genes. vol 12. issue 11. 2021-11-29. PMID:34828303. |
down syndrome (ds), trisomy of human chromosome 21 (hsa21), is the most common genetic cause of intellectual disability. |
2021-11-29 |
2023-08-13 |
mouse |
| Melissa J Alldred, Sai C Penikalapati, Sang Han Lee, Adriana Heguy, Panos Roussos, Stephen D Ginsber. Profiling Basal Forebrain Cholinergic Neurons Reveals a Molecular Basis for Vulnerability Within the Ts65Dn Model of Down Syndrome and Alzheimer's Disease. Molecular neurobiology. vol 58. issue 10. 2021-11-27. PMID:34263425. |
basal forebrain cholinergic neuron (bfcn) degeneration is a hallmark of down syndrome (ds) and alzheimer's disease (ad). |
2021-11-27 |
2023-08-13 |
mouse |
| Soula Danopoulos, Gail H Deutsch, Claire Dumortier, Thomas J Mariani, Denise Al Ala. Lung disease manifestations in Down syndrome. American journal of physiology. Lung cellular and molecular physiology. vol 321. issue 5. 2021-11-26. PMID:34469245. |
down syndrome (ds) is one of the most prevalent chromosomal abnormalities worldwide, affecting 1 in 700 live births. |
2021-11-26 |
2023-08-13 |
Not clear |
| Ilario De Toma, Cesar Sierra, Mara Diersse. Meta-analysis of transcriptomic data reveals clusters of consistently deregulated gene and disease ontologies in Down syndrome. PLoS computational biology. vol 17. issue 9. 2021-11-26. PMID:34570756. |
trisomy of human chromosome 21 (hsa21) causes down syndrome (ds). |
2021-11-26 |
2023-08-13 |
mouse |
| Elizabeth A Will, Emily K Schworer, Anna J Esbense. [Formula: see text] The role of distinct executive functions on adaptive behavior in children and adolescents with Down syndrome. Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence. vol 27. issue 8. 2021-11-25. PMID:33938385. |
difficulties in executive function are a relatively well-characterized feature of the neuropsychological profile in down syndrome (ds), yet the impact of these challenges on aspects of daily functioning remain poorly understood. |
2021-11-25 |
2023-08-13 |
human |
| Lauren MacDonagh, Lisa Farrell, Ruth O'Reilly, Paul McNally, Sheila Javadpour, Des W Co. Efficacy and adherence of noninvasive ventilation treatment in children with Down syndrome. Pediatric pulmonology. vol 56. issue 6. 2021-11-24. PMID:33730448. |
children with down syndrome (ds) have an increased prevalence of obstructive sleep apnea (osa). |
2021-11-24 |
2023-08-13 |
Not clear |
| Wewika Srisraluang, Kitiwan Rojnueangni. Facial recognition accuracy in photographs of Thai neonates with Down syndrome among physicians and the Face2Gene application. American journal of medical genetics. Part A. vol 185. issue 12. 2021-11-24. PMID:34288412. |
down syndrome (ds) is typically recognizable in those who present with multiple dysmorphism, especially in regard to facial phenotypes. |
2021-11-24 |
2023-08-13 |
Not clear |
| Cesar Sierra, Ilario De Toma, Lorenzo Lo Cascio, Esteban Vegas, Mara Diersse. Social Factors Influence Behavior in the Novel Object Recognition Task in a Mouse Model of Down Syndrome. Frontiers in behavioral neuroscience. vol 15. 2021-11-23. PMID:34803627. |
the use of mouse models has revolutionized the field of down syndrome (ds), increasing our knowledge about neuropathology and helping to propose new therapies for cognitive impairment. |
2021-11-23 |
2023-08-13 |
mouse |
| Marzia Perluigi, Anna Picca, Elita Montanari, Riccardo Calvani, Federico Marini, Roberto Matassa, Antonella Tramutola, Alberto Villani, Giuseppe Familiari, Fabio Di Domenico, D Allan Butterfield, Kenneth J Oh, Emanuele Marzetti, Diletta Valentini, Eugenio Baron. Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal-derived extracellular vesicles. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-11-23. PMID:34812584. |
intellectual disability, accelerated aging, and early-onset alzheimer-like neurodegeneration are key brain pathological features of down syndrome (ds). |
2021-11-23 |
2023-08-13 |
Not clear |
| Shira Rabinowicz, Atar Lev, Yu Nee Lee, Diti Machnes-Maayan, Uriel Katz, Amir Vardi, David Mishali, Raz Somec. Immune and TRG repertoire signature of the thymus in Down syndrome patients. Pediatric research. vol 89. issue 1. 2021-11-22. PMID:32231346. |
patients with down syndrome (ds) are at increased risk for infections and autoimmune disorders. |
2021-11-22 |
2023-08-13 |
Not clear |
| Jorge R Corona-Rivera, Topacio O Andrade-Romo, Liuba M Aguirre-Salas, Lucina Bobadilla-Morales, Cristian I Aranda-Sánchez, Alfredo Corona-Rivera, René O Pérez-Ramíre. Family history of thyroid disease and risk of congenital hypothyroidism in neonates with Down síndrome. Gaceta medica de Mexico. vol 157. issue 2. 2021-11-22. PMID:34270525. |
family history of thyroid disease (fhtd) constitutes a possible risk factor for congenital hypothyroidism (ch) in the general population; however, fhtd possible relationship with ch in subjects with down syndrome (ds) has not yet been explored. |
2021-11-22 |
2023-08-13 |
human |
| Ramón Costa, Diego Real de Asúa, Alejandra Gullón, Rosa De Miguel, Azucena Bautista, Clara García, Emilia Roy, Jesús A García-Vadillo, Carmen Suárez, Fernando Moldenhauer, Santos Castañed. Volumetric BMD by 3D-DXA and Trabecular Bone Score in Adults With Down Syndrome. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry. vol 24. issue 4. 2021-11-19. PMID:33618949. |
adults with down syndrome (ds) have lower bone mineral density (bmd) than the general population. |
2021-11-19 |
2023-08-13 |
human |
| John M Starbuck, Sergi Llambrich, Rubèn Gonzàlez, Julia Albaigès, Anna Sarlé, Jens Wouters, Alejandro González, Xavier Sevillano, James Sharpe, Rafael De La Torre, Mara Dierssen, Greetje Vande Velde, Neus Martínez-Abadía. Green tea extracts containing epigallocatechin-3-gallate modulate facial development in Down syndrome. Scientific reports. vol 11. issue 1. 2021-11-19. PMID:33633179. |
trisomy of human chromosome 21 (down syndrome, ds) alters development of multiple organ systems, including the face and underlying skeleton. |
2021-11-19 |
2023-08-13 |
mouse |
| Véronique Brault, Thu Lan Nguyen, Javier Flores-Gutiérrez, Giovanni Iacono, Marie-Christine Birling, Valérie Lalanne, Hamid Meziane, Antigoni Manousopoulou, Guillaume Pavlovic, Loïc Lindner, Mohammed Selloum, Tania Sorg, Eugene Yu, Spiros D Garbis, Yann Héraul. Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome. PLoS genetics. vol 17. issue 9. 2021-11-19. PMID:34587162. |
overexpression of dyrk1a, on the other hand, has been linked with learning and memory defects observed in people with down syndrome (ds). |
2021-11-19 |
2023-08-13 |
mouse |
| Alessandra C Martini, Melissa J Alldred, Ann-Charlotte Granhol. Aging in Down Syndrome: Latest Clinical Advances and Prospects. Journal of clinical medicine. vol 10. issue 21. 2021-11-18. PMID:34768560. |
down syndrome (ds), or trisomy 21, is the most common genetic cause of intellectual disability [...]. |
2021-11-18 |
2023-08-13 |
Not clear |
| David Emes, Anke Hüls, Nicole Baumer, Mara Dierssen, Shiela Puri, Lauren Russell, Stephanie L Sherman, Andre Strydom, Stefania Bargagna, Ana Cláudia Brandão, Alberto C S Costa, Patrick T Feany, Brian Allen Chicoine, Sujay Ghosh, Anne-Sophie Rebillat, Giuseppina Sgandurra, Diletta Valentini, Tilman R Rohrer, Johannes Levin, Monica Lakhanpaul, On Behalf Of The Trisomy Research Society Covid-Initiative Study Grou. COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey. Journal of clinical medicine. vol 10. issue 21. 2021-11-18. PMID:34768645. |
adults with down syndrome (ds) are at higher risk for severe outcomes of coronavirus disease 2019 (covid-19) than the general population, but evidence is required to understand the risks for children with ds, which is necessary to inform covid-19 shielding advice and vaccination priorities. |
2021-11-18 |
2023-08-13 |
Not clear |
| Anna J Esbensen, Jeffery N Epstein, Lori B Vincent, Kelly Kamimura-Nishimura, Susan Wiley, Kathleen Angkustsiri, Leonard Abbeduto, Deborah Fidler, Tanya E Froehlic. Comparison of Attention-Deficit Hyperactivity Disorder in Typically Developing Children and Children with Down Syndrome. Journal of developmental and behavioral pediatrics : JDBP. 2021-11-17. PMID:34001744. |
this study aimed to evaluate attention-deficit hyperactivity disorder (adhd) symptom patterns among children with down syndrome (ds) with or without adhd and typically developing (td) children with adhd. |
2021-11-17 |
2023-08-13 |
Not clear |