| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emily King, Mason Remington, Heidi Berge. Family perspectives on gaps in health care for people with Down syndrome. American journal of medical genetics. Part A. 2022-01-07. PMID:34994519. |
patients with down syndrome (ds) have significant specialized healthcare needs. |
2022-01-07 |
2023-08-13 |
Not clear |
| Hiruy S Meharena, Asaf Marco, Vishnu Dileep, Elana R Lockshin, Grace Y Akatsu, James Mullahoo, L Ashley Watson, Tak Ko, Lindsey N Guerin, Fatema Abdurrob, Shruthi Rengarajan, Malvina Papanastasiou, Jacob D Jaffe, Li-Huei Tsa. Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors. Cell stem cell. vol 29. issue 1. 2022-01-07. PMID:34995493. |
down syndrome (ds) is a genetic disorder driven by the triplication of chromosome 21 (t21) and characterized by a wide range of neurodevelopmental and physical disabilities. |
2022-01-07 |
2023-08-13 |
human |
| Renata Bartesaghi, Stefano Vicari, William C Moble. Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders. Annual review of pharmacology and toxicology. vol 62. 2022-01-06. PMID:34990205. |
those with down syndrome (ds)-trisomy for chromosome 21-are routinely impacted by cognitive dysfunction and behavioral challenges in children and adults and alzheimer's disease in older adults. |
2022-01-06 |
2023-08-13 |
human |
| Jerzy Wegiel, Michael Flory, Izabela Kuchna, Krzysztof Nowicki, Jarek Wegiel, Shuang Yong Ma, Nanbert Zhong, Teresa Wierzba Bobrowicz, Mony de Leon, Florence Lai, Wayne P Silverman, Thomas Wisniewsk. Developmental deficits and staging of dynamics of age associated Alzheimer's disease neurodegeneration and neuronal loss in subjects with Down syndrome. Acta neuropathologica communications. vol 10. issue 1. 2022-01-05. PMID:34983655. |
the increased life expectancy of individuals with down syndrome (ds) is associated with increased prevalence of trisomy 21-linked early-onset alzheimer's disease (eoad) and dementia. |
2022-01-05 |
2023-08-13 |
human |
| D J Fidler, M A Prince, K Van Deusen, A J Esbensen, A J Thurman, L Abbeduto, L Patel, C Mervis, E K Schworer, N R Lee, J O Edgin, S Hepburn, S Davis, L A Daunhaue. Latent profiles of autism symptoms in children and adolescents with Down syndrome. Journal of intellectual disability research : JIDR. 2022-01-05. PMID:34984734. |
down syndrome (ds) is associated with elevated rates of autism spectrum disorder (asd) and autism symptomatology. |
2022-01-05 |
2023-08-13 |
Not clear |
| R G K Munn, A Freeburn, D P Finn, H C Helle. Hyper-rigid phasic organisation of hippocampal activity but normal spatial properties of CA1 place cells in the Ts65Dn mouse model of Down Syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-04. PMID:34980635. |
down syndrome (ds) in humans is caused by trisomy of chromosome 21 and is marked by prominent difficulties in learning and memory. |
2022-01-04 |
2023-08-13 |
mouse |
| Alison Prahl, C Melanie Schuel. Reading and Listening Comprehension in Individuals With Down Syndrome and Word Reading-Matched Typically Developing Children. American journal of speech-language pathology. 2022-01-04. PMID:34982954. |
the purpose of this study was to explore the reading comprehension and listening comprehension performance of english-speaking children with down syndrome (ds) compared with word reading-matched typically developing (td) children. |
2022-01-04 |
2023-08-13 |
Not clear |
| Karin Windsperger, Stefanie Hoeh. Development of Down Syndrome Research Over the Last Decades-What Healthcare and Education Professionals Need to Know. Frontiers in psychiatry. vol 12. 2021-12-31. PMID:34970162. |
down syndrome (ds) is the most prevalent neurodevelopmental disorder, with a known genetic cause. |
2021-12-31 |
2023-08-13 |
Not clear |
| Giulia Solange Clas, Elmer A Fernández, Juan Carlos Guillermo Vázquez, Lucia Pertierra, Nahuel Magrath Guimet, Fernanda Tapajoz, Belén Helou, Tatiana Itzcovich, Micaela Barbieri Kennedy, Horacio Martinetto, Gustavo Sevlever, Ricardo Francisco Allegri, Ezequiel Surac. Accelerated epigenetic aging in adults with Down Syndrome in the Argentine population. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 2. 2021-12-31. PMID:34971139. |
life expectancy of individuals with down syndrome (ds) is currently 60 years. |
2021-12-31 |
2023-08-13 |
human |
| Paige Mumford, Suzanna Noy, Victor L Tybulewicz, Elizabeth Fisher, Soyon Hong, Frances K Wisema. Preclinical modelling in the mouse of altered neuroinflammation in Alzheimer's disease - Down syndrome. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 2. 2021-12-31. PMID:34971155. |
people with down syndrome (ds) develop alzheimer's disease (ad) pathology, amyloid plaques and neurofibrillary tangles, by age 40 and the majority will develop dementia, due to having three copies of the chromosome 21 (hsa21) gene app leading to raised aβ. |
2021-12-31 |
2023-08-13 |
mouse |
| Clíona Farrell, Paige Mumford, Dervis Salih, Christina Toomey, Elizabeth Fisher, Frances K Wisema. Assessing neuroinflammation and inflammasome activity in mouse models of Down syndrome. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 2. 2021-12-31. PMID:34971181. |
down syndrome (ds) is caused by trisomy of chromosome 21 (hsa21) and is a leading genetic cause of alzheimer's disease. |
2021-12-31 |
2023-08-13 |
mouse |
| Amisha Kumar, Eric Doran, Alessandra Cadete Martini, Elizabeth Head, Kate Kirb. CAA and related co-morbidities in Down syndrome and Alzheimer disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 2. 2021-12-31. PMID:34971184. |
many individuals with down syndrome (ds) develop caa due to the overexpression of the amyloid precursor protein (app) gene and the subsequent increase of beta-amyloid in the brain. |
2021-12-31 |
2023-08-13 |
Not clear |
| Toshihiko Kakiuchi, Atsuhisa Fukuta, Koichiro Yoshimaru, Yumeng Zhang, Ryo Shimoda, Muneaki Matsu. Stercoral ulcer after Hirschsprung's disease surgery. Clinical case reports. vol 9. issue 12. 2021-12-29. PMID:34963813. |
in postoperative hd associated with down syndrome (ds) with intellectual disability, vigilant follow-up is required to avoid severe constipation because ds predisposes the patients to constipation and caregivers cannot easily understand the symptoms. |
2021-12-29 |
2023-08-13 |
Not clear |
| Alison M Maxwell, Peng Yuan, Brianna M Rivera, Wilder Schaaf, Mihovil Mladinov, Vee P Prasher, Andrew C Robinson, William F DeGrado, Carlo Condell. Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer's disease pathology in Down syndrome. Acta neuropathologica communications. vol 9. issue 1. 2021-12-28. PMID:34961556. |
down syndrome (ds), as the most common genetic cause of ad, presents promising opportunities to compare such features between early and advanced ad. |
2021-12-28 |
2023-08-13 |
human |
| Francesca Antonaros, Margherita Pitocco, Domenico Abete, Beatrice Vione, Allison Piovesan, Lorenza Vitale, Pierluigi Strippoli, Maria Caracausi, Maria Chiara Peller. Structural Characterization of the Highly Restricted Down Syndrome Critical Region on 21q22.13: New Frontiers in genetics. vol 12. 2021-12-27. PMID:34956324. |
structural characterization of the highly restricted down syndrome critical region on 21q22.13: new down syndrome (ds) is caused by trisomy of chromosome 21 and it is the most common genetic cause of intellectual disability (id) in humans. |
2021-12-27 |
2023-08-13 |
human |
| Francesca Antonaros, Margherita Pitocco, Domenico Abete, Beatrice Vione, Allison Piovesan, Lorenza Vitale, Pierluigi Strippoli, Maria Caracausi, Maria Chiara Peller. Structural Characterization of the Highly Restricted Down Syndrome Critical Region on 21q22.13: New Frontiers in genetics. vol 12. 2021-12-27. PMID:34956324. |
the highly restricted down syndrome critical region (hr-dscr) is a region of hsa21 present in three copies in all individuals with pt21 and a diagnosis of ds. |
2021-12-27 |
2023-08-13 |
human |
| Alessandra Barreiro, Kristine Wolter-Warmerdam, Sandra Friedman, Francis Hickey, Susan Johnson, Juana Marmolej. Child feeding practices in children with Down Syndrome in relationship to ethnicity and BMI. Appetite. 2021-12-26. PMID:34953969. |
children with down syndrome (ds) exhibit higher overweight and obesity rates than their typically developing peers, although it is unknown whether parent feeding practices for children with ds are associated with child weight status or parental and demographic factors, especially in the hispanic and latino populations. |
2021-12-26 |
2023-08-13 |
Not clear |
| Tong Liu, Yuxi Wang, Jiaxing Wang, Changyu Ren, Hao Chen, Jifa Zhan. DYRK1A inhibitors for disease therapy: Current status and perspectives. European journal of medicinal chemistry. vol 229. 2021-12-26. PMID:34954592. |
it is located in the region q22.2 of chromosome 21, which is involved in the pathogenesis of down syndrome (ds). |
2021-12-26 |
2023-08-13 |
human |
| Alejandra Rodríguez-Ortiz, Julio César Montoya-Villegas, Felipe García-Vallejo, Yecid Mina-Pa. Spatial and Temporal Expression of High-Mobility-Group Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with Cognition in Individuals with Down Syndrome. Genes. vol 12. issue 12. 2021-12-24. PMID:34946949. |
dna methylation and histone posttranslational modifications are epigenetics processes that contribute to neurophenotype of down syndrome (ds). |
2021-12-24 |
2023-08-13 |
human |
| Erin B Stallings, Jennifer L Isenburg, Dominique Heinke, Stephanie L Sherman, Russell S Kirby, Philip J Lup. Co-occurrence of congenital anomalies by maternal race/ethnicity among infants and fetuses with Down syndrome, 2013-2017: A U.S. population-based analysis. Birth defects research. 2021-12-24. PMID:34951159. |
individuals with down syndrome (ds) have a higher prevalence of additional congenital anomalies, especially cardiovascular defects, compared to the general population. |
2021-12-24 |
2023-08-13 |
Not clear |