| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Silvia Sacco, Charles Bouis, Jennifer Gallard, Aude Pichot, Elodie Blondiaux, Isabelle Marey, Nathalie Dorison, Franck Sturtz, Cecile Cieuta-Walti, Aimé Ravel, Clotilde Mirche. Psychomotor development in infants and young children with Down syndrome-A prospective, repeated measure, post-hoc analysis. American journal of medical genetics. Part A. 2021-12-04. PMID:34863019. |
children with down syndrome (ds) show delayed acquisition of cognitive and functional skills compared to typically developing children. |
2021-12-04 |
2023-08-13 |
Not clear |
| Elyse C Page, Susan L Heatley, Laura N Eadie, Barbara J McClure, Charles E de Bock, Sofia Omari, David T Yeung, Timothy P Hughes, Paul Q Thomas, Deborah L Whit. HMGN1 plays a significant role in CRLF2 driven Down Syndrome leukemia and provides a potential therapeutic target in this high-risk cohort. Oncogene. 2021-12-03. PMID:34857887. |
the genetic basis of the predisposition for down syndrome (ds) patients to develop cytokine receptor-like factor 2 rearranged (crlf2r) acute lymphoblastic leukemia (all) is currently unknown. |
2021-12-03 |
2023-08-13 |
Not clear |
| B Carretti, C Meneghetti, E Doerr, E Toffalini, S Lanfranch. Developmental trajectories of spatial-sequential and spatial-simultaneous working memory in Down syndrome. Journal of intellectual disability research : JIDR. 2021-12-03. PMID:34859907. |
working memory (wm) is generally considered an area of weakness in the cognitive profile associated with down syndrome (ds). |
2021-12-03 |
2023-08-13 |
Not clear |
| André Alexis Díaz-Quevedo, Hella Maomy Lucero Castillo-Quispe, Katherine Joselyn Atoche-Socola, Luis Ernesto Arriola-Guillé. Evaluation of the craniofacial and oral characteristics of individuals with Down syndrome: A review of the literature. Journal of stomatology, oral and maxillofacial surgery. vol 122. issue 6. 2021-12-01. PMID:33484855. |
the aim of this investigation was to describe the craniofacial and oral characteristics of children and/or adolescents with and without down syndrome (ds). |
2021-12-01 |
2023-08-13 |
Not clear |
| Chenin Ryan, Kishore Vellody, Leah Belazarian, Jillian F Ror. Dermatologic conditions in Down syndrome. Pediatric dermatology. vol 38 Suppl 2. 2021-12-01. PMID:34418156. |
down syndrome (ds) is the most common chromosomal condition and affects many organs including the skin. |
2021-12-01 |
2023-08-13 |
Not clear |
| Mariko Sawa, Cassia Overk, Ann Becker, Dominique Derse, Ricardo Albay, Kim Weldy, Ahmad Salehi, Thomas G Beach, Eric Doran, Elizabeth Head, Y Eugene Yu, William C Moble. Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-12-01. PMID:34757693. |
people with down syndrome (ds) are predisposed to alzheimer's disease (ad). |
2021-12-01 |
2023-08-13 |
mouse |
| Beatrice Uguagliati, Fiorenza Stagni, Marco Emili, Andrea Giacomini, Carla Russo, Sandra Guidi, Renata Bartesagh. Early appearance of dendritic alterations in neocortical pyramidal neurons of the Ts65Dn model of Down syndrome. Developmental neuroscience. 2021-12-01. PMID:34852343. |
down syndrome (ds), which is due to triplication of chromosome 21, is constantly associated with intellectual disability (id). |
2021-12-01 |
2023-08-13 |
mouse |
| b' Val\\xc3\\xa9rie C\\xc3\\xb4t\\xc3\\xa9, \\xc3\\x88ve Lalancette, Inga S Knoth, Lucie C\\xc3\\xb4t\\xc3\\xa9, Kristian Agbogba, Phetsamone Vannasing, Philippe Major, Fanny Barlaam, Jacques Michaud, Sarah Lipp\\xc3\\xa. Distinct patterns of repetition suppression in Fragile\\xc2\\xa0X\\xc2\\xa0syndrome, down syndrome, tuberous sclerosis complex and mutations in SYNGAP1. Brain research. vol 1751. 2021-11-30. PMID:33189692.' |
one hundred and five participants, aged between 3 and 30 years old, composing four clinical id groups and one control group, were recruited: fragile x syndrome (fxs; n = 14), tuberous sclerosis complex (tsc; n = 9), down syndrome (ds; n = 19), syngap1 mutations (n = 8) and neurotypical controls (nt; n = 55)). |
2021-11-30 |
2023-08-13 |
human |
| Tomer Illouz, Arya Biragyn, Milana Frenkel-Morgenstern, Orly Weissberg, Alessandro Gorohovski, Eugene Merzon, Ilan Green, Florencia Iulita, Lisi Flores-Aguilar, Mara Dierssen, Ilario De Toma, Hefziba Lifshitz, Stylianos E Antonarakis, Eugene Yu, Yann Herault, Marie-Claude Potier, Alexandra Botté, Randall Roper, Benjamin Sredni, Ronit Sarid, Jacqueline London, William Mobley, Andre Strydom, Eitan Oku. Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromolecular medicine. vol 23. issue 4. 2021-11-30. PMID:33660221. |
the current sars-cov-2 outbreak, which causes covid-19, is particularly devastating for individuals with chronic medical conditions, in particular those with down syndrome (ds) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. |
2021-11-30 |
2023-08-13 |
Not clear |
| Emilie Lalonde, Stefan Rentas, Gerald Wertheim, Kajia Cao, Lea F Surrey, Fumin Lin, Xiaonan Zhao, Amrom Obstfeld, Richard Aplenc, Minjie Luo, Marilyn M L. Clinical impact of genomic characterization of 15 patients with acute megakaryoblastic leukemia-related malignancies. Cold Spring Harbor molecular case studies. vol 7. issue 2. 2021-11-30. PMID:33832921. |
acute megakaryoblastic leukemia (amkl) is a rare subtype of acute myeloid leukemia but is approximately 500 times more likely to develop in children with down syndrome (ds) through transformation of transient abnormal myelopoiesis (tam). |
2021-11-30 |
2023-08-13 |
Not clear |
| Esther Yejin Lee, Nicole Neil, Deanna C Friese. Support needs, coping, and stress among parents and caregivers of people with Down syndrome. Research in developmental disabilities. vol 119. 2021-11-30. PMID:34678707. |
caregiving for an individual with down syndrome (ds) results in needs that can impact the stress and wellbeing of the entire family. |
2021-11-30 |
2023-08-13 |
Not clear |
| Stephanie Hargreaves, Sarah Holton, Rebecca Baxter, Kelly Burgoyn. Educational experiences of pupils with Down syndrome in the UK. Research in developmental disabilities. vol 119. 2021-11-30. PMID:34736106. |
though research has identified that increasing numbers of pupils with down syndrome (ds) in the uk are educated in mainstream schools, little detailed information about the educational experiences of pupils with ds is available. |
2021-11-30 |
2023-08-13 |
Not clear |
| E R Wallace, J P Harp, K L Van Pelt, L M Koehl, A M Caban-Holt, A J Anderson-Mooney, G A Jicha, D D Lightner, W C Robertson, E Head, F A Schmit. Identifying dementia in Down syndrome with the Severe Impairment Battery, Brief Praxis Test and Dementia Scale for People with Learning Disabilities. Journal of intellectual disability research : JIDR. vol 65. issue 12. 2021-11-30. PMID:34786786. |
individuals with down syndrome (ds) are at high risk for dementia, specifically alzheimer's disease. |
2021-11-30 |
2023-08-13 |
Not clear |
| Margaret Pulsife. Down Syndrome: Neuropsychological Phenotype across the Lifespan. Brain sciences. vol 11. issue 11. 2021-11-30. PMID:34827379. |
down syndrome (ds), caused by triplication of chromosome 21, is the most common genetic cause of intellectual disability (id), with an estimated incidence of one in 700 live births [...]. |
2021-11-30 |
2023-08-13 |
Not clear |
| Annalysa Lovos, Kenneth Bottrill, Stella Sakhon, Casandra Nyhuis, Elizabeth Egleson, Alison Luongo, Melanie Murphy, Angela John Thurman, Leonard Abbeduto, Nancy Raitano Lee, Katharine Hughes, Jamie Edgi. Circadian Sleep-Activity Rhythm across Ages in Down Syndrome. Brain sciences. vol 11. issue 11. 2021-11-30. PMID:34827402. |
across all ages, individuals with down syndrome (ds) experience high rates of sleep problems as well as cognitive impairments. |
2021-11-30 |
2023-08-13 |
human |
| Thai Duy Nguyen, Sébastien Baillieul, Michel Guinot, Stéphane Doutreleau, Véronique-Aurélie Bricou. Classification of Factors Effect on Sleep in Individuals with Down Syndrome. Brain sciences. vol 11. issue 11. 2021-11-30. PMID:34827499. |
sleep disordered breathing (sdb) is a frequent disorder with serious adverse health consequences in people with down syndrome (ds). |
2021-11-30 |
2023-08-13 |
Not clear |
| Jared R Thomas, Kourtney Sloan, Kelsey Cave, Joseph M Wallace, Randall J Rope. Skeletal Deficits in Male and Female down Syndrome Model Mice Arise Independent of Normalized Dyrk1a Expression in Osteoblasts. Genes. vol 12. issue 11. 2021-11-30. PMID:34828335. |
trisomy 21 (ts21) causes alterations in skeletal development resulting in decreased bone mass, shortened stature and weaker bones in individuals with down syndrome (ds). |
2021-11-30 |
2023-08-13 |
mouse |
| Rodolphe Dard, Manon Moreau, Estelle Parizot, Farah Ghieh, Leslie Brehier, Nadim Kassis, Valérie Serazin, Antonin Lamaziere, Chrystèle Racine, Nathalie di Clemente, François Vialard, Nathalie Jane. DYRK1A Overexpression in Mice Downregulates the Gonadotropic Axis and Disturbs Early Stages of Spermatogenesis. Genes. vol 12. issue 11. 2021-11-30. PMID:34828406. |
down syndrome (ds) is the most common chromosomal disorder. |
2021-11-30 |
2023-08-13 |
mouse |
| Erica Gastelum, Marcus Cummins, Amitoj Singh, Michael Montoya, Gino Luis Urbano, Mary Anne Tabliz. Treatment Considerations for Obstructive Sleep Apnea in Pediatric Down Syndrome. Children (Basel, Switzerland). vol 8. issue 11. 2021-11-30. PMID:34828787. |
children with down syndrome (ds) are at high risk for developing obstructive sleep apnea (osa) compared to children without ds. |
2021-11-30 |
2023-08-13 |
Not clear |
| Wenche Stensen, Ulli Rothweiler, Richard Alan Engh, Melissa R Stasko, Ilya Bederman, Alberto C S Costa, Anders Fugelli, John S Mjøen Svendse. Novel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome. Pharmaceuticals (Basel, Switzerland). vol 14. issue 11. 2021-11-30. PMID:34832952. |
down syndrome (ds) is a complex genetic disorder associated with substantial physical, cognitive, and behavioral challenges. |
2021-11-30 |
2023-08-13 |
mouse |