| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Silvia Lanfranchi, Chiara Meneghetti, Enrico Toffalini, Barbara Carrett. Individuals with Down Syndrome: Editorial. Brain sciences. vol 12. issue 3. 2022-03-25. PMID:35326354. |
down syndrome (ds) is the most common syndromic cause of intellectual disability, so it has long been of interest to researchers [...]. |
2022-03-25 |
2023-08-13 |
Not clear |
| Ahhyeon Kim, Hyung-Ju Cho, Eun Kyoung Choi, Yoon Jeong Cho. Improvement of obstructive sleep apnea in a child with Down syndrome with rapid palatal expansion. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. 2022-03-25. PMID:35332867. |
children with down syndrome (ds) have distinct orofacial structures that predispose them to sleep-disordered breathing. |
2022-03-25 |
2023-08-13 |
Not clear |
| Nicole T Baumer, Mara L Becker, George T Capone, Kathleen Egan, Juan Fortea, Benjamin L Handen, Elizabeth Head, James E Hendrix, Ruth Y Litovsky, Andre Strydom, Ignacio E Tapia, Michael S Rafi. Conducting clinical trials in persons with Down syndrome: summary from the NIH INCLUDE Down syndrome clinical trials readiness working group. Journal of neurodevelopmental disorders. vol 14. issue 1. 2022-03-24. PMID:35321660. |
the recent national institute of health (nih) include (investigation of co-occurring conditions across the lifespan to understand down syndrome) initiative has bolstered capacity for the current increase in clinical trials involving individuals with down syndrome (ds). |
2022-03-24 |
2023-08-13 |
human |
| Dani Stanbouly, Barry Steinberg, Sung-Kiang Chuan. What are the Soft Tissue Risk Factors for Obstructive Sleep Apnea in Patients with Down's Syndrome? The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. 2022-03-21. PMID:35306875. |
to determine the risk factors and their respective magnitudes for developing obstructive sleep apnea (osa) in down syndrome (ds) patients. |
2022-03-21 |
2023-08-13 |
Not clear |
| Md Mahiuddin Ahmed, Athena Ching-Jung Wang, Mihret Elos, Heidi J Chial, Stefan Sillau, D Adriana Solano, Christina Coughlan, Leila Aghili, Paige Anton, Neil Markham, Vanesa Adame, Katheleen J Gardiner, Timothy D Boyd, Huntington Potte. The innate immune system stimulating cytokine GM-CSF improves learning/memory and interneuron and astrocyte brain pathology in Dp16 down syndrome mice and improves learning/memory in wild-type mice. Neurobiology of disease. 2022-03-21. PMID:35307513. |
down syndrome (ds) is characterized by chronic neuroinflammation, peripheral inflammation, astrogliosis, imbalanced excitatory/inhibitory neuronal function, and cognitive deficits in both humans and mouse models. |
2022-03-21 |
2023-08-13 |
mouse |
| Jordan T Jones, Jacqueline Kitchen, Nasreen Tali. Down Syndrome-Associated Arthritis (DA): Diagnostic and Management Challenges. Pediatric health, medicine and therapeutics. vol 13. 2022-03-21. PMID:35311022. |
down syndrome (ds) is one of the most common birth defects in the united states, the most common genomic disorder of intellectual disability, and results from trisomy 21. |
2022-03-21 |
2023-08-13 |
Not clear |
| Shojiro Ichimata, Koji Yoshida, Naomi P Visanji, Anthony E Lang, Naoki Nishida, Gabor G Kovac. Patterns of Mixed Pathologies in Down Syndrome. Journal of Alzheimer's disease : JAD. 2022-03-21. PMID:35311708. |
down syndrome (ds) is frequently associated with alzheimer's disease (ad)-related neuropathological changes. |
2022-03-21 |
2023-08-13 |
Not clear |
| Jacob J Junco, Barry Zorman, Vincent U Gant, Jaime Muñoz, H Daniel Lacorazza, Pavel Sumazin, Karen R Rabi. CRLF2 overexpression results in reduced B cell differentiation and upregulated E2F signaling in the Dp16 mouse model of Down syndrome. Experimental hematology. 2022-03-20. PMID:35306048. |
children with down syndrome (ds) are 10-fold more likely to develop b-cell acute lymphoblastic leukemia (b-all), with a higher frequency of rearrangements resulting in overexpression of cytokine receptor-like factor 2 (crlf2). |
2022-03-20 |
2023-08-13 |
mouse |
| Lei Xu, Hai-Qin Huo, Kai-Qin Lu, Xiao-Yan Tang, Yuan Hong, Xiao Han, Zi-Xing Fu, Kai-Heng Fang, Min Xu, Xing Guo, Yan Li. Abnormal mitochondria in Down syndrome iPSC-derived GABAergic interneurons and organoids. Biochimica et biophysica acta. Molecular basis of disease. 2022-03-18. PMID:35301086. |
down syndrome (ds) is caused by trisomy 21, and it is characterized by developmental brain disorders and neurological dysfunction. |
2022-03-18 |
2023-08-13 |
Not clear |
| Lucía Morán, Laura E Gómez, Giulia Balboni, Asunción Monsalve, Miguel Ángel Verdugo, Mar Rodrígue. Predictors of individual quality of life in young people with Down syndrome. Rehabilitation psychology. 2022-03-17. PMID:35298204. |
although the concept of quality of life (qol) has become a reference framework for the provision of support and services to people with intellectual disability (id), its conceptualization and application for persons with down syndrome (ds) have received little attention. |
2022-03-17 |
2023-08-13 |
Not clear |
| Guilherme Prado Mattar, Ricardo R Uchida, Glenda G Haddad, Pedro Shiozawa, Maria de Fátima Rebouças da Silva, Marcelo Q Hoexter, Geraldo F Busatto, Cassio M de Campos Bottino, Luciana M Fonseca, Orestes V Forlenz. Screening for Dementia and Cognitive Decline in Adults With Down Syndrome: A Novel Approach Using the Informant Questionnaire on Cognitive Decline in the Elderly. Alzheimer disease and associated disorders. 2022-03-16. PMID:35293379. |
the aim was to examine the psychometric properties of the informant questionnaire on cognitive decline in the elderly (iqcode) as a diagnostic tool to screen for dementia in aging individuals with down syndrome (ds). |
2022-03-16 |
2023-08-13 |
Not clear |
| Ravenna Araújo Santos, Lellis Henrique Costa, Rebeca Coêlho Linhares, Márcia Pradella-Hallinan, Fernando Morgadinho Santos Coelho, Giuliano da Paz Oliveir. Sleep disorders in Down syndrome: a systematic review. Arquivos de neuro-psiquiatria. 2022-03-16. PMID:35293557. |
sleep disorders are commonly observed in children with down syndrome (ds) and can lead to significant behavioral and cognitive morbidities in these individuals. |
2022-03-16 |
2023-08-13 |
Not clear |
| Savannah Tallino, Wendy Winslow, Samantha K Bartholomew, Ramon Velazque. Temporal and brain region-specific elevations of soluble Amyloid-β Aging cell. 2022-03-15. PMID:35290711. |
temporal and brain region-specific elevations of soluble amyloid-β down syndrome (ds) is a leading cause of intellectual disability that also results in hallmark alzheimer's disease (ad) pathologies such as amyloid beta (aβ) plaques and hyperphosphorylated tau. |
2022-03-15 |
2023-08-13 |
mouse |
| Emily K Farran, Kerry D Hudson, Amelia Bennett, Aan Ameen, Iliana Misheva, Badri Bechlem, Mark Blades, Yannick Courboi. Anxiety and Spatial Navigation in Williams Syndrome and Down Syndrome. Developmental neuropsychology. 2022-03-14. PMID:35282728. |
individuals with down syndrome (ds) and individuals with williams syndrome (ws) present with poor navigation and elevated anxiety. |
2022-03-14 |
2023-08-13 |
Not clear |
| Sara Pagnotta, Antonella Tramutola, Eugenio Barone, Fabio Di Domenico, Valeria Pittalà, Loredana Salerno, Valentina Folgiero, Matteo Caforio, Franco Locatelli, Stefania Petrini, D Allan Butterfield, Marzia Perluig. CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down Syndrome. Free radical biology & medicine. 2022-03-14. PMID:35283228. |
among these, down syndrome (ds) is a complex genetic disorder characterized by bach1 gene triplication that likely results in the impairment of nrf2 causing increased os. |
2022-03-14 |
2023-08-13 |
mouse |
| Barbara Cisterna, Pietro Bontempi, Anatoly Petrovich Sobolev, Manuela Costanzo, Manuela Malatesta, Carlo Zancanar. Quantitative magnetic resonance characterization of the effect of physical training on skeletal muscle of the Ts65Dn mice, a model of Down syndrome. Quantitative imaging in medicine and surgery. vol 12. issue 3. 2022-03-14. PMID:35284271. |
down syndrome (ds) is characterized by muscle hypotonia and low muscle strength associated with motor dysfunction. |
2022-03-14 |
2023-08-13 |
mouse |
| Hoda M Abd El-Ghany, Iman Ehsan Abdel Meguid, Rabab El Hawary, Safa Meshaal, Iman Taha Lafy Shimila, Eman Roshdy Radwa. Potential Role of Neutrophil-Platelet Interaction in Increased Susceptibility to Infection of Patients with Down Syndrome. Laboratory medicine. 2022-03-14. PMID:35285899. |
recurrent infection in down syndrome (ds) has been previously documented; the potential role of platelets and neutrophil-platelet interaction has not been addressed in previous studies. |
2022-03-14 |
2023-08-13 |
Not clear |
| Rebecca A Saberi, Gareth P Gilna, Blaire V Slavin, Carlos T Huerta, Walter A Ramsey, Christopher F O'Neil, Eduardo A Perez, Juan E Sola, Chad M Thorso. Hirschsprung Disease in Down Syndrome: An Opportunity for Improvement. Journal of pediatric surgery. 2022-03-13. PMID:35279286. |
down syndrome (ds) is the most common abnormality associated with hirschsprung disease (hd). |
2022-03-13 |
2023-08-13 |
Not clear |
| Heng Liu, Shuai Chen, Qian Sun, Qingquan Sha, Yu Tang, Wenming Jia, Long Chen, Juan Zhao, Tan Wang, Xiulian Su. Let-7c increases BACE2 expression by RNAa and decreases Aβ production. American journal of translational research. vol 14. issue 2. 2022-03-11. PMID:35273693. |
in order to further understand the potential roles of mirnas in the pathogenesis of ad, we analyzed down syndrome (ds), a special model of ad, by using a taqman microrna array and found that mirna let-7c was up-regulated in both ds and ad. |
2022-03-11 |
2023-08-13 |
mouse |
| Harshit Doshi, Samarth Shukla, Shalinkumar Patel, Parth Bhatt, Neel Bhatt, Comfort Anim-Koranteng, Akosua Ameley, Bernice Biney, Fredrick Dapaah-Siakwan, Keyur Dond. Gastrostomy Tube Placement and Resource Use in Neonatal Hospitalizations With Down Syndrome. Hospital pediatrics. 2022-03-10. PMID:35265996. |
to determine the trends in gastrostomy tube (gt) placement and resource utilization in neonates ≥35 weeks' gestational age with down syndrome (ds) in the united states from 2006 to 2017. |
2022-03-10 |
2023-08-13 |
Not clear |