| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mais Musleh, Qossay Alhusei. A rare presentation and treatment challenges for multiple myeloma in down syndrome: A case report and literature review. Clinical case reports. vol 12. issue 7. 2024-07-04. PMID:38962468. |
down syndrome (ds), characterized by trisomy 21, significantly increases susceptibility to leukemia, although the occurrence of multiple myeloma (mm) in ds is exceedingly rare. |
2024-07-04 |
2024-07-10 |
Not clear |
| Yannick Courbois, Mark Blades, Kerry D Hudson, Pascal Sockeel, Emily K Farra. Spatial exploration and navigation in Down syndrome and Williams syndrome. Cortex; a journal devoted to the study of the nervous system and behavior. vol 178. 2024-07-04. PMID:38964151. |
in this cross-syndrome study, individuals with down syndrome (ds), individuals with williams syndrome (ws) and typically developing children (td; aged 5-11 years) explored virtual environments with the goal of learning where everything was within the environment (experiment 1) or to find six stars (experiment 2). |
2024-07-04 |
2024-07-11 |
human |
| Arlene Mannion, Nicole Neil, Theresa Fiani, Lindsay Athamanah, James Lyons, Kelly McDonagh, Erin Boland, Róisín Cooney, Meagan Lynch, Merna Youssef, Geraldine Leade. An investigation of sleep problems, gastrointestinal symptoms, comorbid psychopathology and challenging behavior in children and adolescents with Down Syndrome. Research in developmental disabilities. vol 151. 2024-07-04. PMID:38964213. |
down syndrome (ds) is one of the most common chromosomal abnormalities, and children with ds have increased risks of receiving diagnoses of specific comorbidities. |
2024-07-04 |
2024-07-11 |
Not clear |
| Muzhen Qiao, Qianwen Huang, Xin Wang, Jiahuai Ha. ZBTB21 suppresses CRE-mediated transcription to impair synaptic function in Down syndrome. Science advances. vol 10. issue 27. 2024-07-03. PMID:38959316. |
down syndrome (ds) is the most common chromosomal disorder and a major cause of intellectual disability. |
2024-07-03 |
2024-07-10 |
Not clear |
| Matthew Merckling, Sima Vazquez, Bridget Nolan, Galadu Subah, Michael Fortunato, Alan Stein, Harsdadkumar Patel, David Asprinio, John Wainwright, Merritt Kinon, Chirag Gandhi, Fawaz Al-Muft. Atlantoaxial subluxation and Down syndrome: A cross-sectional analysis. Journal of craniovertebral junction & spine. vol 15. issue 2. 2024-07-03. PMID:38957770. |
a higher prevalence of aas within the down syndrome (ds) population has been well-established. |
2024-07-03 |
2024-07-06 |
Not clear |
| Angela L Rachubinski, Elizabeth Wallace, Emily Gurnee, Belinda A Enriquez Estrada, Kayleigh R Worek, Keith P Smith, Paula Araya, Katherine A Waugh, Ross E Granrath, Eleanor Britton, Hannah R Lyford, Micah G Donovan, Neetha Paul Eduthan, Amanda A Hill, Barry Martin, Kelly D Sullivan, Lina Patel, Deborah J Fidler, Matthew D Galbraith, Cory A Dunnick, David A Norris, Joaquin M Espinos. JAK inhibition decreases the autoimmune burden in Down syndrome. medRxiv : the preprint server for health sciences. 2024-07-01. PMID:38946973. |
individuals with down syndrome (ds), the genetic condition caused by trisomy 21 (t21), display clear signs of immune dysregulation, including high rates of autoimmune disorders and severe complications from infections. |
2024-07-01 |
2024-07-03 |
human |
| Sophia Krasny, Cynthia Yan, Sigan L Hartley, Ben L Handen, Julie K Wisch, Anna H Boehrwinkle, Beau M Ances, Michael S Rafi. Assessing amyloid PET positivity and cognitive function in Down syndrome to guide clinical trials targeting amyloid. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-06-28. PMID:38940611. |
trisomy 21, or down syndrome (ds), predisposes individuals to early-onset alzheimer's disease (ad). |
2024-06-28 |
2024-06-30 |
Not clear |
| Sebastiano Giallongo, Jessica Ferrigno, Rosario Caltabiano, Giuseppe Broggi, Amer M Alanazi, Alfio Distefano, Emanuela Tropea, Antonella Tramutola, Marzia Perluigi, Giovanni Li Volti, Eugenio Barone, Ignazio Alberto Barbagall. Aging exacerbates oxidative stress and liver fibrosis in an animal model of Down Syndrome. Aging. vol 16. 2024-06-28. PMID:38942607. |
down syndrome (ds) is a common genetic disorder characterized by an extra copy of chromosome 21, leading to dysregulation of various metabolic pathways. |
2024-06-28 |
2024-07-01 |
mouse |
| Tessa K Kolstad, Lourdes M DelRosso, Mary Anne Tablizo, Manisha Witmans, Yeilim Cho, Michelle Sobremonte-Kin. Sleep-Disordered Breathing and Associated Comorbidities among Preschool-Aged Children with Down Syndrome. Children (Basel, Switzerland). vol 11. issue 6. 2024-06-27. PMID:38929231. |
children with down syndrome (ds) are at high risk of sleep-disordered breathing (sdb). |
2024-06-27 |
2024-06-29 |
Not clear |
| Xin Wang, Qian Yang, Xueyan Zhou, C Dirk Keene, Alexey G Ryazanov, Tao M. Suppression of eEF2 phosphorylation alleviates synaptic failure and cognitive deficits in mouse models of Down syndrome. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-06-27. PMID:38934363. |
cognitive impairment is a core feature of down syndrome (ds), and the underlying neurobiological mechanisms remain unclear. |
2024-06-27 |
2024-06-29 |
mouse |
| Blake Foxworthy, Chen Dai, Elizabeth C Davis, Ana C Xavier, Julienne Brackett, David Dickens, Alissa Kahn, Isaac Martinez, Archana Sharma, Carla Schwalm, Jessica Foley, Jennifer Wilkes, Smita Bhatia, Jennifer M Levine, Emily E Johnston, Julie A Wolfso. COVID-19 infection in children, adolescents, and young adults with Down syndrome and hematologic malignancies. Pediatric blood & cancer. vol 71. issue 8. 2024-06-26. PMID:38804869. |
children, adolescents, and young adults (cayas) with down syndrome (ds) and hematologic malignancies are particularly vulnerable to infections and related complications. |
2024-06-26 |
2024-06-29 |
Not clear |
| Lila Sari, Risti Saptarini Primarti, Arlette Suzy Setiawa. Navigating Treatment Refusal: Behaviour Guidance for Down Syndrome Oral Health Management. Case reports in dentistry. vol 2024. 2024-06-26. PMID:38919976. |
this case report explores these challenges within the context of a 9-year-old boy with down syndrome (ds) facing dental treatment refusal. |
2024-06-26 |
2024-06-29 |
Not clear |
| Kathryn S Marcus, Danielle R Larrow, Kevin S Gipson, Christopher J Hartnic. Optimizing Inspire Hypoglossal Nerve Stimulator Settings in Pediatric Obstructive Sleep Apnea. The Laryngoscope. 2024-06-26. PMID:38922916. |
hypoglossal nerve stimulation (hgns) is an effective therapy for carefully selected pediatric patients with down syndrome (ds) and obstructive sleep apnea (osa), but optimization of device settings has been focused on stimulation settings. |
2024-06-26 |
2024-06-29 |
Not clear |
| Su Morris, Emily K Farran, Katie A Gilligan-Le. Exploring relative strengths in people with Down syndrome: Spatial thinking and its role in mathematics. Journal of experimental child psychology. vol 246. 2024-06-25. PMID:38917683. |
however, a lack of information on mathematical development and spatial-mathematical associations in people with down syndrome (ds) hinders the translation of these interventions. |
2024-06-25 |
2024-06-29 |
human |
| Kentaro Nakashima, Takashi Imai, Akira Shiraishi, Ryoko Unose, Hironori Goto, Yusaku Nagatomo, Kanako Kojima-Ishii, Yuichi Mushimoto, Kei Nishiyama, Kenichiro Yamamura, Hazumu Nagata, Masataka Ishimura, Koichi Kusuhara, Yuhki Koga, Yasunari Sakai, Shouichi Ohg. The immunoreactive signature of monocyte-derived dendritic cells from patients with Down syndrome. Clinical and experimental immunology. 2024-06-25. PMID:38916251. |
the clinical spectrum of down syndrome (ds) ranges from congenital malformations to premature aging and early-onset senescence. |
2024-06-25 |
2024-06-27 |
Not clear |
| Saba Jafarpour, Abhik K Banerjee, Mellad M Khoshnood, Benjamin N Vogel, Natalie K Boyd, Lina Nguyen, Rebecca Partridge, Stephanie L Santoro, Grace Y Gombolay, Kristen S Fisher, Diego Real de Asua, Maria Carmen Del Ortega, Cathy Franklin, Michael S Rafii, Jonathan D Santor. De novo variants in immune regulatory genes in Down syndrome regression disorder. Journal of neurology. 2024-06-22. PMID:38909119. |
down syndrome regression disorder (dsrd) is a rare and poorly understood disorder of the central nervous system, characterized by acute or subacute neuropsychiatric symptoms in previously healthy individuals with down syndrome (ds). |
2024-06-22 |
2024-06-25 |
Not clear |
| Monique Maria Melo Mouchrek, Mayra Moura Franco, Leslie Alves da Silva, Kerry Alynne Campos Martins, Sueli Ismael Oliveira da Conceição, Ana Paula Silva de Azevedo Dos Santos, Vandílson Pinheiro Rodrigues, Cecilia Cláudia Costa Ribeiro, Bruno Braga Benatt. Cytokine levels in the gingival crevicular fluid and their association with periodontal status of down syndrome patients: a cross-sectional study. Clinical oral investigations. vol 28. issue 7. 2024-06-21. PMID:38907162. |
to evaluate cytokine levels of interleukin (il)-1β, il-4, il-6, il-17a, tumor necrosis factor (tnf)-α, and interferon (ifn)-γ in the gingival crevicular fluid (gcf) of periodontal sites in individuals with down syndrome (ds) and analyze their relationship with clinical periodontal parameters. |
2024-06-21 |
2024-06-24 |
Not clear |
| Egambaram Senthilvel, Kahir Jawad, Alessandra M Gearhart, Janki R Naidugari, Karim El-Kers. Adenotonsillectomy outcomes in children with down syndrome and obstructive sleep apnea: a single center study. Sleep & breathing = Schlaf & Atmung. 2024-06-19. PMID:38896208. |
this study aimed to evaluate polysomnographic (psg) outcomes of tonsillectomy and adenoidectomy (t&a) in children with down syndrome (ds) and osa, and the difference in psg outcomes of t&a between children with ds and age- and gender-matched normally developing (non-ds) children. |
2024-06-19 |
2024-06-21 |
Not clear |
| Nadia Echcharii, Nabila Chekhlabi, Nezha Din. Cardiac Pre-tamponade Secondary to Generalized Myxedema Due to Neglected Hashimoto's Thyroiditis in a Child With Down Syndrome. Cureus. vol 16. issue 5. 2024-06-17. PMID:38883046. |
down syndrome (ds) is the most common chromosomal disorder in live-born infants, often associated with intellectual disability and various medical conditions, including thyroid dysfunction. |
2024-06-17 |
2024-06-19 |
Not clear |
| Jr-Jiun Liou, Jerry Lou, Jamie Nakagiri, William Yong, Christy L Hom, Eric W Doran, Minodora Totoiu, Ira Lott, Mark Mapstone, David B Keator, Adam M Brickman, Sierra Wright, Brittany Nelson, Florence Lai, Laura Xicota, Lam-Ha T Dang, Jinghang Li, Tales Santini, Joseph M Mettenburg, Milos D Ikonomovic, Julia Kofler, Tamer Ibrahim, Elizabeth Hea. A Neuropathology Case Report of a Woman with Down Syndrome who Remained Cognitively Stable. medRxiv : the preprint server for health sciences. 2024-06-17. PMID:38883742. |
in this neuropathology case report, we present findings from an individual with down syndrome (ds) who remained cognitively stable despite alzheimer's disease (ad) neuropathology. |
2024-06-17 |
2024-06-19 |
human |