| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew Merckling, Sima Vazquez, Bridget Nolan, Galadu Subah, Michael Fortunato, Alan Stein, Harsdadkumar Patel, David Asprinio, John Wainwright, Merritt Kinon, Chirag Gandhi, Fawaz Al-Muft. Atlantoaxial subluxation and Down syndrome: A cross-sectional analysis. Journal of craniovertebral junction & spine. vol 15. issue 2. 2024-07-03. PMID:38957770. |
a higher prevalence of aas within the down syndrome (ds) population has been well-established. |
2024-07-03 |
2024-07-06 |
Not clear |
| Angela L Rachubinski, Elizabeth Wallace, Emily Gurnee, Belinda A Enriquez Estrada, Kayleigh R Worek, Keith P Smith, Paula Araya, Katherine A Waugh, Ross E Granrath, Eleanor Britton, Hannah R Lyford, Micah G Donovan, Neetha Paul Eduthan, Amanda A Hill, Barry Martin, Kelly D Sullivan, Lina Patel, Deborah J Fidler, Matthew D Galbraith, Cory A Dunnick, David A Norris, Joaquin M Espinos. JAK inhibition decreases the autoimmune burden in Down syndrome. medRxiv : the preprint server for health sciences. 2024-07-01. PMID:38946973. |
individuals with down syndrome (ds), the genetic condition caused by trisomy 21 (t21), display clear signs of immune dysregulation, including high rates of autoimmune disorders and severe complications from infections. |
2024-07-01 |
2024-07-03 |
human |
| Sophia Krasny, Cynthia Yan, Sigan L Hartley, Ben L Handen, Julie K Wisch, Anna H Boehrwinkle, Beau M Ances, Michael S Rafi. Assessing amyloid PET positivity and cognitive function in Down syndrome to guide clinical trials targeting amyloid. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-06-28. PMID:38940611. |
trisomy 21, or down syndrome (ds), predisposes individuals to early-onset alzheimer's disease (ad). |
2024-06-28 |
2024-06-30 |
Not clear |
| Sebastiano Giallongo, Jessica Ferrigno, Rosario Caltabiano, Giuseppe Broggi, Amer M Alanazi, Alfio Distefano, Emanuela Tropea, Antonella Tramutola, Marzia Perluigi, Giovanni Li Volti, Eugenio Barone, Ignazio Alberto Barbagall. Aging exacerbates oxidative stress and liver fibrosis in an animal model of Down Syndrome. Aging. vol 16. 2024-06-28. PMID:38942607. |
down syndrome (ds) is a common genetic disorder characterized by an extra copy of chromosome 21, leading to dysregulation of various metabolic pathways. |
2024-06-28 |
2024-07-01 |
mouse |
| Tessa K Kolstad, Lourdes M DelRosso, Mary Anne Tablizo, Manisha Witmans, Yeilim Cho, Michelle Sobremonte-Kin. Sleep-Disordered Breathing and Associated Comorbidities among Preschool-Aged Children with Down Syndrome. Children (Basel, Switzerland). vol 11. issue 6. 2024-06-27. PMID:38929231. |
children with down syndrome (ds) are at high risk of sleep-disordered breathing (sdb). |
2024-06-27 |
2024-06-29 |
Not clear |
| Xin Wang, Qian Yang, Xueyan Zhou, C Dirk Keene, Alexey G Ryazanov, Tao M. Suppression of eEF2 phosphorylation alleviates synaptic failure and cognitive deficits in mouse models of Down syndrome. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-06-27. PMID:38934363. |
cognitive impairment is a core feature of down syndrome (ds), and the underlying neurobiological mechanisms remain unclear. |
2024-06-27 |
2024-06-29 |
mouse |
| Blake Foxworthy, Chen Dai, Elizabeth C Davis, Ana C Xavier, Julienne Brackett, David Dickens, Alissa Kahn, Isaac Martinez, Archana Sharma, Carla Schwalm, Jessica Foley, Jennifer Wilkes, Smita Bhatia, Jennifer M Levine, Emily E Johnston, Julie A Wolfso. COVID-19 infection in children, adolescents, and young adults with Down syndrome and hematologic malignancies. Pediatric blood & cancer. vol 71. issue 8. 2024-06-26. PMID:38804869. |
children, adolescents, and young adults (cayas) with down syndrome (ds) and hematologic malignancies are particularly vulnerable to infections and related complications. |
2024-06-26 |
2024-06-29 |
Not clear |
| Lila Sari, Risti Saptarini Primarti, Arlette Suzy Setiawa. Navigating Treatment Refusal: Behaviour Guidance for Down Syndrome Oral Health Management. Case reports in dentistry. vol 2024. 2024-06-26. PMID:38919976. |
this case report explores these challenges within the context of a 9-year-old boy with down syndrome (ds) facing dental treatment refusal. |
2024-06-26 |
2024-06-29 |
Not clear |
| Kathryn S Marcus, Danielle R Larrow, Kevin S Gipson, Christopher J Hartnic. Optimizing Inspire Hypoglossal Nerve Stimulator Settings in Pediatric Obstructive Sleep Apnea. The Laryngoscope. 2024-06-26. PMID:38922916. |
hypoglossal nerve stimulation (hgns) is an effective therapy for carefully selected pediatric patients with down syndrome (ds) and obstructive sleep apnea (osa), but optimization of device settings has been focused on stimulation settings. |
2024-06-26 |
2024-06-29 |
Not clear |
| Su Morris, Emily K Farran, Katie A Gilligan-Le. Exploring relative strengths in people with Down syndrome: Spatial thinking and its role in mathematics. Journal of experimental child psychology. vol 246. 2024-06-25. PMID:38917683. |
however, a lack of information on mathematical development and spatial-mathematical associations in people with down syndrome (ds) hinders the translation of these interventions. |
2024-06-25 |
2024-06-29 |
human |
| Kentaro Nakashima, Takashi Imai, Akira Shiraishi, Ryoko Unose, Hironori Goto, Yusaku Nagatomo, Kanako Kojima-Ishii, Yuichi Mushimoto, Kei Nishiyama, Kenichiro Yamamura, Hazumu Nagata, Masataka Ishimura, Koichi Kusuhara, Yuhki Koga, Yasunari Sakai, Shouichi Ohg. The immunoreactive signature of monocyte-derived dendritic cells from patients with Down syndrome. Clinical and experimental immunology. 2024-06-25. PMID:38916251. |
the clinical spectrum of down syndrome (ds) ranges from congenital malformations to premature aging and early-onset senescence. |
2024-06-25 |
2024-06-27 |
Not clear |
| Saba Jafarpour, Abhik K Banerjee, Mellad M Khoshnood, Benjamin N Vogel, Natalie K Boyd, Lina Nguyen, Rebecca Partridge, Stephanie L Santoro, Grace Y Gombolay, Kristen S Fisher, Diego Real de Asua, Maria Carmen Del Ortega, Cathy Franklin, Michael S Rafii, Jonathan D Santor. De novo variants in immune regulatory genes in Down syndrome regression disorder. Journal of neurology. 2024-06-22. PMID:38909119. |
down syndrome regression disorder (dsrd) is a rare and poorly understood disorder of the central nervous system, characterized by acute or subacute neuropsychiatric symptoms in previously healthy individuals with down syndrome (ds). |
2024-06-22 |
2024-06-25 |
Not clear |
| Monique Maria Melo Mouchrek, Mayra Moura Franco, Leslie Alves da Silva, Kerry Alynne Campos Martins, Sueli Ismael Oliveira da Conceição, Ana Paula Silva de Azevedo Dos Santos, Vandílson Pinheiro Rodrigues, Cecilia Cláudia Costa Ribeiro, Bruno Braga Benatt. Cytokine levels in the gingival crevicular fluid and their association with periodontal status of down syndrome patients: a cross-sectional study. Clinical oral investigations. vol 28. issue 7. 2024-06-21. PMID:38907162. |
to evaluate cytokine levels of interleukin (il)-1β, il-4, il-6, il-17a, tumor necrosis factor (tnf)-α, and interferon (ifn)-γ in the gingival crevicular fluid (gcf) of periodontal sites in individuals with down syndrome (ds) and analyze their relationship with clinical periodontal parameters. |
2024-06-21 |
2024-06-24 |
Not clear |
| Egambaram Senthilvel, Kahir Jawad, Alessandra M Gearhart, Janki R Naidugari, Karim El-Kers. Adenotonsillectomy outcomes in children with down syndrome and obstructive sleep apnea: a single center study. Sleep & breathing = Schlaf & Atmung. 2024-06-19. PMID:38896208. |
this study aimed to evaluate polysomnographic (psg) outcomes of tonsillectomy and adenoidectomy (t&a) in children with down syndrome (ds) and osa, and the difference in psg outcomes of t&a between children with ds and age- and gender-matched normally developing (non-ds) children. |
2024-06-19 |
2024-06-21 |
Not clear |
| Nadia Echcharii, Nabila Chekhlabi, Nezha Din. Cardiac Pre-tamponade Secondary to Generalized Myxedema Due to Neglected Hashimoto's Thyroiditis in a Child With Down Syndrome. Cureus. vol 16. issue 5. 2024-06-17. PMID:38883046. |
down syndrome (ds) is the most common chromosomal disorder in live-born infants, often associated with intellectual disability and various medical conditions, including thyroid dysfunction. |
2024-06-17 |
2024-06-19 |
Not clear |
| Jr-Jiun Liou, Jerry Lou, Jamie Nakagiri, William Yong, Christy L Hom, Eric W Doran, Minodora Totoiu, Ira Lott, Mark Mapstone, David B Keator, Adam M Brickman, Sierra Wright, Brittany Nelson, Florence Lai, Laura Xicota, Lam-Ha T Dang, Jinghang Li, Tales Santini, Joseph M Mettenburg, Milos D Ikonomovic, Julia Kofler, Tamer Ibrahim, Elizabeth Hea. A Neuropathology Case Report of a Woman with Down Syndrome who Remained Cognitively Stable. medRxiv : the preprint server for health sciences. 2024-06-17. PMID:38883742. |
in this neuropathology case report, we present findings from an individual with down syndrome (ds) who remained cognitively stable despite alzheimer's disease (ad) neuropathology. |
2024-06-17 |
2024-06-19 |
human |
| Shivum Desai, Ivy Y Chen, Christy Hom, Eric Doran, Dana D Nguyen, Ruth M Benca, Ira T Lott, Bryce A Mande. Insomnia Symptoms Are Associated with Measures of Functional Deterioration and Dementia Status in Adults with Down Syndrome at High Risk for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2024-06-14. PMID:38875029. |
while obstructive sleep apnea (osa) and insomnia symptoms in neurotypical populations are associated with alzheimer's disease (ad), their association with dementia in adults with down syndrome (ds) remains less clear, even though these symptoms are prevalent and treatable in ds. |
2024-06-14 |
2024-06-17 |
Not clear |
| Ujjayini Ghosh, Eric Tse, Hyunjun Yang, Marie Shi, Christoffer D Caro, Feng Wang, Gregory E Merz, Stanley B Prusiner, Daniel R Southworth, Carlo Condell. Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold. Acta neuropathologica communications. vol 12. issue 1. 2024-06-13. PMID:38867338. |
down syndrome (ds) is a common genetic condition caused by trisomy of chromosome 21. |
2024-06-13 |
2024-06-15 |
Not clear |
| Prakhar Bansal, Erin C Banda, Heather R Glatt-Deeley, Christopher E Stoddard, Jeremy W Linsley, Neha Arora, Cécile Deleschaux, Darcy T Ahern, Yuvabharath Kondaveeti, Rachael E Massey, Michael Nicouleau, Shijie Wang, Miguel Sabariego-Navarro, Mara Dierssen, Steven Finkbeiner, Stefan F Pinte. A dynamic in vitro model of Down syndrome neurogenesis with trisomy 21 gene dosage correction. Science advances. vol 10. issue 23. 2024-06-07. PMID:38848354. |
excess gene dosage from chromosome 21 (chr21) causes down syndrome (ds), spanning developmental and acute phenotypes in terminal cell types. |
2024-06-07 |
2024-06-10 |
human |
| Joan Lorente-Piera, Raquel Manrique-Huarte, Manuel Manrique, Francisco Javier Cervera-Pa. Clinical profile, otologic, and auditory outcomes in patients with Down syndrome. Acta otorrinolaringologica espanola. 2024-06-06. PMID:38823774. |
even though the incidence has decreased in recent years, down syndrome (ds) remains the most common chromosomal disorder today. |
2024-06-06 |
2024-06-10 |
Not clear |