| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cara J Westmark, Pamela R Westmark, James S Malte. MPEP reduces seizure severity in Fmr-1 KO mice over expressing human Abeta. International journal of clinical and experimental pathology. vol 3. issue 1. 2010-03-02. PMID:19918329. |
these data suggest that abeta contributes to seizure incidence and may be an appropriate therapeutic target to lessen seizure pathology in fxs, alzheimer's disease (ad) and down syndrome (ds) patients. |
2010-03-02 |
2023-08-12 |
mouse |
| Beatrijs L P Bloemers, A Marceline van Furth, Michel E Weijerman, Reinoud J B J Gemke, Chantal J M Broers, Jan L L Kimpen, Louis Bon. High incidence of recurrent wheeze in children with down syndrome with and without previous respiratory syncytial virus lower respiratory tract infection. The Pediatric infectious disease journal. vol 29. issue 1. 2010-02-26. PMID:19907362. |
in a recent study, we found a high incidence (9.9%) of hospitalization for rsv-induced lrti among children with down syndrome (ds), indicating ds as a new risk factor for rsv-induced lrti. |
2010-02-26 |
2023-08-12 |
Not clear |
| Anindita Roy, Irene Roberts, Alice Norton, Paresh Vya. Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis. British journal of haematology. vol 147. issue 1. 2010-02-22. PMID:19594743. |
children with down syndrome (ds) have a marked increase in susceptibility to acute megakaryoblastic leukaemia (ds-amkl) and the closely linked neonatal preleukaemic syndrome, transient myeloproliferative disorder (ds-tmd). |
2010-02-22 |
2023-08-12 |
human |
| Yan Wang, Lei Gao, Sze-Wah Tse, Athena Andreadi. Heterogeneous nuclear ribonucleoprotein E3 modestly activates splicing of tau exon 10 via its proximal downstream intron, a hotspot for frontotemporal dementia mutations. Gene. vol 451. issue 1-2. 2010-02-17. PMID:19914360. |
tauopathies include alzheimer's disease (ad), frontotemporal dementia with parkinsonism (ftdp) and the early-onset dementia observed in down syndrome (ds; trisomy 21). |
2010-02-17 |
2023-08-12 |
Not clear |
| Patricia Lopes Pereira, Laetitia Magnol, Ignasi Sahún, Véronique Brault, Arnaud Duchon, Paola Prandini, Agnès Gruart, Jean-Charles Bizot, Bernadette Chadefaux-Vekemans, Samuel Deutsch, Fabrice Trovero, José María Delgado-García, Stylianos E Antonarakis, Mara Dierssen, Yann Heraul. A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome. Human molecular genetics. vol 18. issue 24. 2010-02-12. PMID:19783846. |
mental retardation in down syndrome (ds), the most frequent trisomy in humans, varies from moderate to severe. |
2010-02-12 |
2023-08-12 |
mouse |
| Satoshi Ieiri, Mayumi Higashi, Risa Teshiba, Isamu Saeki, Genshiro Esumi, Junko Akiyoshi, Takanori Nakatsuji, Tomoaki Taguch. Clinical features of Hirschsprung's disease associated with Down syndrome: a 30-year retrospective nationwide survey in Japan. Journal of pediatric surgery. vol 44. issue 12. 2010-02-12. PMID:20006024. |
to identify the clinical features in diagnosis and treatment of hirschsprung's disease (hd) associated with down syndrome (ds), the authors retrospectively analyzed data for patients with ds from the past 3 nationwide surveys in japan. |
2010-02-12 |
2023-08-12 |
Not clear |
| Ana Carolina de Campos, Nelci Adriana Cicuto Ferreira Rocha, Geert J P Savelsberg. Development of reaching and grasping skills in infants with Down syndrome. Research in developmental disabilities. vol 31. issue 1. 2010-01-27. PMID:19713074. |
seven infants with down syndrome (ds) and seven infants with typical development were assessed at the ages of 4, 5 and 6 months. |
2010-01-27 |
2023-08-12 |
Not clear |
| Giovanni Neri, John M Opit. Down syndrome: comments and reflections on the 50th anniversary of Lejeune's discovery. American journal of medical genetics. Part A. vol 149A. issue 12. 2010-01-27. PMID:19921741. |
over the past some 160 years, the study of down syndrome (ds) went from early efforts of differentiating it from cretinism (séguin) to its establishment as a specific nosologic category of mental deficiency (down) and subsequent attempts to infer its cause. |
2010-01-27 |
2023-08-12 |
mouse |
| Futoshi Suizu, Yosuke Hiramuki, Fumihiko Okumura, Mami Matsuda, Akiko J Okumura, Noriyuki Hirata, Masumi Narita, Takashi Kohno, Jun Yokota, Miyuki Bohgaki, Chikashi Obuse, Shigetsugu Hatakeyama, Toshiyuki Obata, Masayuki Noguch. The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Developmental cell. vol 17. issue 6. 2010-01-27. PMID:20059950. |
ttc3 contains a canonical ring finger motif, a pair of tetratricopeptide motifs, a putative akt phosphorylation site, and nuclear localization signals, and is encoded by a gene within the down syndrome (ds) critical region on chromosome 21. |
2010-01-27 |
2023-08-12 |
human |
| Donald E Kuhn, Gerard J Nuovo, Alvin V Terry, Mickey M Martin, Geraldine E Malana, Sarah E Sansom, Adam P Pleister, Wayne D Beck, Elizabeth Head, David S Feldman, Terry S Elto. Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains. The Journal of biological chemistry. vol 285. issue 2. 2010-01-26. PMID:19897480. |
down syndrome (ds), or trisomy 21, is the most common genetic cause of cognitive impairment and congenital heart defects in the human population. |
2010-01-26 |
2023-08-12 |
mouse |
| Ozlem Akinci, Ercan Mihci, Sukran Tacoy, Firat Kardelen, Ibrahim Keser, Mutay Asla. Neutrophil oxidative metabolism in Down syndrome patients with congenital heart defects. Environmental and molecular mutagenesis. vol 51. issue 1. 2010-01-25. PMID:19593803. |
down syndrome (ds) occurs when an individual has three, rather than two, copies of the 21st chromosome. |
2010-01-25 |
2023-08-12 |
cat |
| Robert J McGrath, David J Laflamme, Amy P Schwartz, Michelle Stransky, John B Moeschle. Access to genetic counseling for children with autism, Down syndrome, and intellectual disabilities. Pediatrics. vol 124 Suppl 4. 2010-01-22. PMID:19948611. |
we examined the need for genetic counseling services (gcs) for families of children with autism spectrum disorder (asd), down syndrome (ds), and/or mental retardation (mr) and factors that influence the receipt of needed gcs for those children relative to other children with special health care needs (cshcn). |
2010-01-22 |
2023-08-12 |
Not clear |
| Renato M Nisihara, Shirley R R Utiyama, Nanci P Oliveira, Iara J Messias-Reaso. Mannan-binding lectin deficiency increases the risk of recurrent infections in children with Down's syndrome. Human immunology. vol 71. issue 1. 2010-01-21. PMID:19804807. |
down syndrome (ds) is the most frequent cause of intellectual disability worldwide. |
2010-01-21 |
2023-08-12 |
Not clear |
| Karen T Chang, Kyung-Tai Mi. Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 40. 2010-01-15. PMID:19805187. |
at the neuronal level of down syndrome (ds) brains, there are evidences of altered shape, number, and density of synapses, as well as aberrant endocytosis associated with accumulation of enlarged endosomes, suggesting that proteins involved in synaptic vesicle recycling may play key roles in ds neurons. |
2010-01-15 |
2023-08-12 |
human |
| Regiane Luz Carvalho, Gil Lúcio Almeid. The effect of vibration on postural response of Down syndrome individuals on the seesaw. Research in developmental disabilities. vol 30. issue 6. 2010-01-14. PMID:19394195. |
in order to better understand the role of proprioception in postural adjustments on unstable surfaces, we analyzed the effect of vibration on the pattern of muscle activity and joint displacements (ankle, knee and hip) of eight intellectually normal participants (control group-cg) and eight individuals with down syndrome (ds) while balancing on seesaws of different heights. |
2010-01-14 |
2023-08-12 |
human |
| Johan Simons, Inge Dedroo. Body awareness in children with mental retardation. Research in developmental disabilities. vol 30. issue 6. 2010-01-14. PMID:19577426. |
twenty-nine of the children with mental retardation were diagnosed as down syndrome (ds). |
2010-01-14 |
2023-08-12 |
Not clear |
| Varaprasad Kolla, Paul Jenö, Suzette Moes, Sevgi Tercanli, Olav Lapaire, Mahesh Choolani, Sinuhe Hah. Quantitative proteomics analysis of maternal plasma in Down syndrome pregnancies using isobaric tagging reagent (iTRAQ). Journal of biomedicine & biotechnology. vol 2010. 2010-01-13. PMID:19902006. |
currently no specific biomarkers exist for the screening of pregnancies at risk for down syndrome (ds). |
2010-01-13 |
2023-08-12 |
Not clear |
| Bruna Marques Bononi, Maria José Carvalho Sant'Anna, André Chao Vasconcellos de Oliveira, Tadeu Silveira Renattini, Carla Franchi Pinto, Maria Lúcia Passarelli, Veronica Coates, Hatim A Oma. Sexuality and persons with Down syndrome. A study from Brazil. International journal of adolescent medicine and health. vol 21. issue 3. 2010-01-13. PMID:20014635. |
in recent years, important gains and changes have been observed in the life of teenagers with down syndrome (ds) with increased inclusion into society. |
2010-01-13 |
2023-08-12 |
Not clear |
| Debarati Ghosh, Swagata Sinha, Anindita Chatterjee, Krishnadas Nandagopa. A study of GluK1 kainate receptor polymorphisms in Down syndrome reveals allelic non-disjunction at 1173(C/T). Disease markers. vol 27. issue 2. 2010-01-12. PMID:19893199. |
mechanisms underlying down syndrome (ds)-related mental retardation (mr) remain poorly understood. |
2010-01-12 |
2023-08-12 |
Not clear |
| Carol F Lippa, Andrea L Rosso, Lauren D Stutzbach, Manuela Neumann, Virginia M-Y Lee, John Q Trojanowsk. Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome. Archives of neurology. vol 66. issue 12. 2010-01-12. PMID:20008652. |
to assess the transactive response dna-binding protein 43 (tdp-43) burden in familial forms of alzheimer disease (fad) and down syndrome (ds) to determine whether tdp-43 inclusions are also present. |
2010-01-12 |
2023-08-12 |
Not clear |