| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simon A Lowe, James J L Hodge, Maria M Usowic. A third copy of the Down syndrome cell adhesion molecule (Dscam) causes synaptic and locomotor dysfunction in Drosophila. Neurobiology of disease. vol 110. 2019-09-06. PMID:29196216. |
down syndrome (ds) is caused by triplication of chromosome 21 (hsa21). |
2019-09-06 |
2023-08-13 |
drosophila_melanogaster |
| b' Susana Garc\\xc3\\xada-Cerro, Ver\\xc3\\xb3nica Vidal, Sara Lantigua, Maria Teresa Berciano, Miguel Lafarga, Pedro Ramos-Cabrer, Daniel Padro, Noem\\xc3\\xad Rueda, Carmen Mart\\xc3\\xadnez-Cu\\xc3\\xa. Cerebellar alterations in a model of Down syndrome: The role of the Dyrk1A gene. Neurobiology of disease. vol 110. 2019-09-06. PMID:29221819.' |
down syndrome (ds) is characterized by a marked reduction in the size of the brain and cerebellum. |
2019-09-06 |
2023-08-13 |
mouse |
| Larisa V Lysenko, Jeesun Kim, Francisco Madamba, Anna A Tyrtyshnaia, Aarti Ruparelia, Alexander M Kleschevniko. Developmental excitatory-to-inhibitory GABA polarity switch is delayed in Ts65Dn mice, a genetic model of Down syndrome. Neurobiology of disease. vol 115. 2019-09-06. PMID:29550538. |
down syndrome (ds) is the most frequent genetic cause of developmental abnormalities leading to intellectual disability. |
2019-09-06 |
2023-08-13 |
mouse |
| Gurjinder Kaur, Sebastien A Gauthier, Rocio Perez-Gonzalez, Monika Pawlik, Amol Bikram Singh, Benjamin Cosby, Panaiyur S Mohan, John F Smiley, Efrat Lev. Cystatin C prevents neuronal loss and behavioral deficits via the endosomal pathway in a mouse model of down syndrome. Neurobiology of disease. vol 120. 2019-09-06. PMID:30176349. |
we investigated whether cysc protects from trisomy-induced pathologies in a mouse model of down syndrome (ds), the most common cause of developmental cognitive and behavioral impairments in humans. |
2019-09-06 |
2023-08-13 |
mouse |
| Roberto Latina, Virginia Di Maglie, Alessandro Sili, Daniela D'Angelo, Anna Rita Marucci, Biagio Di Ettore, Laura Scozz. [Pain assessment in Down Syndrome patients: a narrative review of the literature]. Professioni infermieristiche. vol 71. issue 4. 2019-09-05. PMID:30980706. |
the paper provides a description of available measurement tools which are able to adequately assess acute chronic pain in down syndrome (ds) patients, regardless of their age and cognitive impairment. |
2019-09-05 |
2023-08-13 |
Not clear |
| Carla L Pennella, Jorge G Rossi, Edgardo M Baialardo, Cristina N Alonso, Myriam R Guitter, Cristian G Sánchez La Rosa, Natalia C Millán, Elizabeth M Alfaro, Pedro A Zubizarreta, María S Felic. Acute lymphoblastic leukemia in children with Down syndrome: Comparative analysis versus patients without Down syndrome. Archivos argentinos de pediatria. vol 116. issue 4. 2019-09-04. PMID:30016023. |
children with down syndrome (ds) more commonly have acute lymphoblastic leukemia (all) and a lower survival rate than those without down syndrome (wds). |
2019-09-04 |
2023-08-13 |
Not clear |
| Elyse C Page, Susan L Heatley, David T Yeung, Paul Q Thomas, Deborah L Whit. Precision medicine approaches may be the future for CRLF2 rearranged Down Syndrome Acute Lymphoblastic Leukaemia patients. Cancer letters. vol 432. 2019-09-03. PMID:29879498. |
children with down syndrome (ds) have a predisposition to developing crlf2 rearranged-all which is observed in 60% of ds-all patients. |
2019-09-03 |
2023-08-13 |
Not clear |
| Andre Strydom, Amanda Heslegrave, Carla M Startin, Kin Y Mok, John Hardy, Jurgen Groet, Dean Nizetic, Henrik Zetterber. Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome. Alzheimer's research & therapy. vol 10. issue 1. 2019-08-27. PMID:29631614. |
down syndrome (ds) may be considered a genetic form of alzheimer's disease (ad) due to universal development of ad neuropathology, but diagnosis and treatment trials are hampered by a lack of reliable blood biomarkers. |
2019-08-27 |
2023-08-13 |
Not clear |
| Miguel Galeote, Elena Checa, Eugenia Sebastián, Mª Auxiliadora Robles-Bell. The acquisition of different classes of words in Spanish children with Down syndrome. Journal of communication disorders. vol 75. 2019-08-26. PMID:30016759. |
the primary aim of this study was to analyze the acquisition of different classes of words in spanish-speaking children with down syndrome (ds), with special emphasis on nouns and verbs. |
2019-08-26 |
2023-08-13 |
Not clear |
| Rui Zheng, Weiqing Zhang, Baoguo Chen, Zhiying Shen, Aifen Li. [Clinical and laboratory analysis of a neonate with Down syndrome and a novel GATA1 gene mutation]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 36. issue 4. 2019-08-20. PMID:30950017. |
to analyze the clinical and molecular biological characteristics of a neonate with myeloid proliferation related to down syndrome (ds). |
2019-08-20 |
2023-08-13 |
Not clear |
| Lilian Chrystiane Giannasi, Marignês T S Dutra, Vera L S Tenguan, Gabriela P Mancilha, Gabriela R C Silva, Elaine Fillietaz-Bacigalupo, Daniel B da Silva, Fabiano Politti, Sergio R Nacif, Ezequiel F de Oliveira, João C da Rocha, Carolina T Rocha, Mateus M Romero, Claudia S de Oliveira, Luis V F de Oliveira, Sigmar de Mello Rode, Cristiane Yumi Koga-Ito, Jose B O Amorim, Miguel A C Salgado, Mônica F Gome. Evaluation of the masticatory muscle function, physiological sleep variables, and salivary parameters after electromechanical therapeutic approaches in adult patients with Down syndrome: a randomized controlled clinical trial. Trials. vol 20. issue 1. 2019-08-19. PMID:30975204. |
there are many comorbidities associated with down syndrome (ds), including obstructive sleep apnea (osa) and masticatory muscle alteration. |
2019-08-19 |
2023-08-13 |
Not clear |
| Alessandro Salvi, Marika Vezzoli, Sara Busatto, Lucia Paolini, Teresa Faranda, Edoardo Abeni, Maria Caracausi, Francesca Antonaros, Allison Piovesan, Chiara Locatelli, Guido Cocchi, Gualtiero Alvisi, Giuseppina De Petro, Doris Ricotta, Paolo Bergese, Annalisa Radeghier. Analysis of a nanoparticle‑enriched fraction of plasma reveals miRNA candidates for Down syndrome pathogenesis. International journal of molecular medicine. vol 43. issue 6. 2019-08-19. PMID:31017260. |
down syndrome (ds) is caused by the presence of part or all of a third copy of chromosome 21. |
2019-08-19 |
2023-08-13 |
human |
| Federica Trucco, Michelle Chatwin, Thomas Semple, Mark Rosenthal, Andrew Bush, Hui-Leng Ta. Sleep disordered breathing and ventilatory support in children with Down syndrome. Pediatric pulmonology. vol 53. issue 10. 2019-08-16. PMID:29992744. |
obstructive sleep apnoea (osas) in children with down syndrome (ds) is now well recognized, but other forms of sleep disordered breathing (sdb) in this population are less well described. |
2019-08-16 |
2023-08-13 |
Not clear |
| Toru Imagi, Tomonaga Matsushita, Miyuki Matsushita, Yukako Yae, Takaoki Yokochi, Go Kawano, Yukihiro Akita, Keizo Ohbu, Toyojiro Matsuish. Brain stem infarction in a 6-year-old boy with Down syndrome. Brain & development. vol 41. issue 6. 2019-08-14. PMID:30857880. |
infarct locations in children with arterial ischemic stroke have primarily been reported to be lobar or in the basal ganglia, and those in patients with down syndrome (ds) and antiphospholipid syndrome (aps) are typically wide and multiple. |
2019-08-14 |
2023-08-13 |
Not clear |
| Patrick J Lao, Ben L Handen, Tobey J Betthauser, Karly A Cody, Annie D Cohen, Dana L Tudorascu, Charles K Stone, Julie C Price, Sterling C Johnson, William E Klunk, Bradley T Christia. Imaging neurodegeneration in Down syndrome: brain templates for amyloid burden and tissue segmentation. Brain imaging and behavior. vol 13. issue 2. 2019-08-12. PMID:29752653. |
the focus of alzheimer's disease (ad) neuroimaging research has shifted towards an investigation of the earliest stages of ad pathogenesis, which manifests in every young adult with down syndrome (ds; trisomy 21) resulting from a deterministic genetic predisposition to amyloid precursor protein overproduction. |
2019-08-12 |
2023-08-13 |
Not clear |
| Oscar G W Wong, Claire L Y Cheung, Philip P C Ip, Hextan Y S Ngan, Annie N Y Cheun. Amyloid Precursor Protein Overexpression in Down Syndrome Trophoblast Reduces Cell Invasiveness and Interferes with Syncytialization. The American journal of pathology. vol 188. issue 10. 2019-08-12. PMID:30031727. |
the placentas of down syndrome (ds) pregnancies exhibit morphologic and functional abnormalities. |
2019-08-12 |
2023-08-13 |
Not clear |
| Gustavo Wandresen, Fernanda Sgarbi, Renato Nisihar. Management of contraceptives and menstrual complaints in patients with Down syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 35. issue 2. 2019-08-12. PMID:30324830. |
enhanced health care for patients with down syndrome (ds) results in improved overall quality of life and longer life expectancy. |
2019-08-12 |
2023-08-13 |
Not clear |
| Tatiana Dias de Carvalho, Thais Massetti, Talita Dias da Silva, Tânia Brusque Crocetta, Regiani Guarnieri, Luiz Carlos Marques Vanderlei, Carlos Bandeira de Mello Monteiro, David M Garner, Celso Ferreir. Heart rate variability in individuals with Down syndrome - A systematic review and meta-analysis. Autonomic neuroscience : basic & clinical. vol 213. 2019-08-08. PMID:30005737. |
down syndrome (ds) results in many changes, including dysfunction in cardiac autonomic modulation. |
2019-08-08 |
2023-08-13 |
Not clear |
| Gillian R Diercks, Carissa Wentland, Donald Keamy, Thomas Bernard Kinane, Brian Skotko, Vanessa de Guzman, Ellen Grealish, John Dobrowski, Ryan Soose, Christopher J Hartnic. Hypoglossal Nerve Stimulation in Adolescents With Down Syndrome and Obstructive Sleep Apnea. JAMA otolaryngology-- head & neck surgery. vol 144. issue 1. 2019-08-05. PMID:29098288. |
obstructive sleep apnea (osa) affects up to 60% of children with down syndrome (ds) and may persist in half of patients after adenotonsillectomy. |
2019-08-05 |
2023-08-13 |
Not clear |
| Gabriele Cipriani, Sabrina Danti, Cecilia Carlesi, Mario Di Fiorin. Aging With Down Syndrome: The Dual Diagnosis: Alzheimer's Disease and Down Syndrome. American journal of Alzheimer's disease and other dementias. vol 33. issue 4. 2019-07-31. PMID:29504408. |
people with down syndrome (ds) enjoy a longer life expectancy now than they ever have before and are therefore at greater risk of developing conditions associated with aging, including dementia. |
2019-07-31 |
2023-08-13 |
Not clear |