| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rui Weng, Sensen Shen, Casey Burton, Li Yang, Honggang Nie, Yonglu Tian, Yu Bai, Huwei Li. Lipidomic profiling of tryptophan hydroxylase 2 knockout mice reveals novel lipid biomarkers associated with serotonin deficiency. Analytical and bioanalytical chemistry. vol 408. issue 11. 2016-12-13. PMID:26780709. |
consequently, serotonin deficiency is involved in a wide variety of neurodegenerative diseases, including alzheimer's disease, parkinson's disease, schizophrenia, and depression. |
2016-12-13 |
2023-08-13 |
mouse |
| Justine M Kent, Ella Daly, Iva Kezic, Rosanne Lane, Pilar Lim, Heidi De Smedt, Peter De Boer, Luc Van Nueten, Wayne C Drevets, Marc Ceuster. Efficacy and safety of an adjunctive mGlu2 receptor positive allosteric modulator to a SSRI/SNRI in anxious depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 67. 2016-12-13. PMID:26804646. |
eligible patients (18-64 years) had a dsm-iv diagnosis of mdd, hamilton depression rating scale-17 (hdrs17) score of ≥ 18, hdrs17 anxiety/somatization factor score of ≥ 7, and an insufficient response to current treatment with a selective serotonin reuptake inhibitor or serotonin-norepinephrine reuptake inhibitor. |
2016-12-13 |
2023-08-13 |
Not clear |
| Debbie Tallon, Nicola Wiles, John Campbell, Carolyn Chew-Graham, Chris Dickens, Una Macleod, Tim J Peters, Glyn Lewis, Ian M Anderson, Simon Gilbody, William Hollingworth, Simon Davies, David Kessle. Mirtazapine added to selective serotonin reuptake inhibitors for treatment-resistant depression in primary care (MIR trial): study protocol for a randomised controlled trial. Trials. vol 17. 2016-12-13. PMID:26842107. |
mirtazapine added to selective serotonin reuptake inhibitors for treatment-resistant depression in primary care (mir trial): study protocol for a randomised controlled trial. |
2016-12-13 |
2023-08-13 |
Not clear |
| Debbie Tallon, Nicola Wiles, John Campbell, Carolyn Chew-Graham, Chris Dickens, Una Macleod, Tim J Peters, Glyn Lewis, Ian M Anderson, Simon Gilbody, William Hollingworth, Simon Davies, David Kessle. Mirtazapine added to selective serotonin reuptake inhibitors for treatment-resistant depression in primary care (MIR trial): study protocol for a randomised controlled trial. Trials. vol 17. 2016-12-13. PMID:26842107. |
this paper describes the protocol for a randomised controlled trial (mir) to investigate the extent to which the addition of the antidepressant mirtazapine is effective in reducing the symptoms of depression compared with placebo in patients who are still depressed after they have been treated with a selective serotonin reuptake inhibitor (ssri) or serotonin and noradrenaline reuptake inhibitor (snri) for at least 6 weeks in primary care. |
2016-12-13 |
2023-08-13 |
Not clear |
| V Kiryanova, S J Meunier, H A Vecchiarelli, M N Hill, R H Dyc. Effects of maternal stress and perinatal fluoxetine exposure on behavioral outcomes of adult male offspring. Neuroscience. vol 320. 2016-12-13. PMID:26872999. |
in pregnant women, fluoxetine (flx) is the most widely prescribed selective serotonin reuptake inhibitor (ssri) used for the treatment of depression. |
2016-12-13 |
2023-08-13 |
mouse |
| Chao Dong, Ji-chun Zhang, Wei Yao, Qian Ren, Chun Yang, Min Ma, Mei Han, Ryo Saito, Kenji Hashimot. Effects of escitalopram, R-citalopram, and reboxetine on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration. Pharmacology, biochemistry, and behavior. vol 144. 2016-12-13. PMID:26892759. |
the purpose of this study is to examine whether the selective serotonin reuptake inhibitor (ssri) escitalopram, its inactive enantiomer r-citalopram, and selective noradrenaline reuptake inhibitor (nri) reboxetine, show anti-inflammatory and antidepressant effects in an inflammation-induced model of depression. |
2016-12-13 |
2023-08-13 |
mouse |
| Tone Kristine Hermansen, Espen Røysamb, Else-Marie Augusti, Annika Melinde. Behavior and inhibitory control in children with prenatal exposure to antidepressants and medically untreated depression. Psychopharmacology. vol 233. issue 8. 2016-12-13. PMID:26924747. |
the present study investigates child development following prenatal exposure to maternal use of selective serotonin reuptake inhibitors (ssris; n = 28), versus prenatal exposure to medically untreated depression (n = 42), and no exposure (n = 33). |
2016-12-13 |
2023-08-13 |
Not clear |
| Alexandrine Robert, Tiphaine Monsinjon, Jean-Paul Delbecque, Stéphanie Olivier, Agnès Poret, Frank Le Foll, Fabrice Durand, Thomas Knigg. Neuroendocrine disruption in the shore crab Carcinus maenas: Effects of serotonin and fluoxetine on chh- and mih-gene expression, glycaemia and ecdysteroid levels. Aquatic toxicology (Amsterdam, Netherlands). vol 175. 2016-12-13. PMID:27060239. |
selective serotonin reuptake inhibitors (ssris), such as fluoxetine, are commonly used in human medication to ease depression by affecting serotonin levels. |
2016-12-13 |
2023-08-13 |
human |
| A Ferrés-Coy, M Galofré, F Pilar-Cuéllar, R Vidal, V Paz, E Ruiz-Bronchal, L Campa, Á Pazos, J R Caso, J C Leza, G Alvarado, A Montefeltro, E M Valdizán, F Artigas, A Bortolozz. Therapeutic antidepressant potential of a conjugated siRNA silencing the serotonin transporter after intranasal administration. Molecular psychiatry. vol 21. issue 3. 2016-11-14. PMID:26100539. |
major depression brings about a heavy socio-economic burden worldwide due to its high prevalence and the low efficacy of antidepressant drugs, mostly inhibiting the serotonin transporter (sert). |
2016-11-14 |
2023-08-13 |
mouse |
| W Y Guo, Z H Zhang, J L Mu, D Liu, L Zhao, Z Y Yao, J G Son. Relationship between 5-HTTLPR polymorphism and post-stroke depression. Genetics and molecular research : GMR. vol 15. issue 1. 2016-11-11. PMID:26909988. |
the serotonin transporter-linked polymorphic region (5-httlpr) has been examined as a factor associated with depression and other mental disorders. |
2016-11-11 |
2023-08-13 |
Not clear |
| Mi Youn Cha, Hae Sook Hon. [Effect and Path Analysis of Laughter Therapy on Serotonin, Depression and Quality of Life in Middle-aged Women]. Journal of Korean Academy of Nursing. vol 45. issue 2. 2016-11-10. PMID:25947184. |
[effect and path analysis of laughter therapy on serotonin, depression and quality of life in middle-aged women]. |
2016-11-10 |
2023-08-13 |
Not clear |
| Mi Youn Cha, Hae Sook Hon. [Effect and Path Analysis of Laughter Therapy on Serotonin, Depression and Quality of Life in Middle-aged Women]. Journal of Korean Academy of Nursing. vol 45. issue 2. 2016-11-10. PMID:25947184. |
this study was done to examine how laughter therapy impacts serotonin levels, qol and depression in middle-aged women and to perform a path analysis for verification of the effects. |
2016-11-10 |
2023-08-13 |
Not clear |
| Wahid Zada, Sara Zeeshan, Huma Aslam Bhatti, Wajahat Mahmood, Khalid Rauf, Ghulam Abba. Cinnamomum cassia: an implication of serotonin reuptake inhibition in animal models of depression. Natural product research. vol 30. issue 10. 2016-11-09. PMID:26134381. |
cinnamomum cassia: an implication of serotonin reuptake inhibition in animal models of depression. |
2016-11-09 |
2023-08-13 |
Not clear |
| Rui Zhao, Shoubao Wang, Zhonglin Huang, Li Zhang, Xiuying Yang, Xiaoyu Bai, Dan Zhou, Zhizhen Qin, Guanhua D. Lipopolysaccharide-induced serotonin transporter up-regulation involves PKG-I and p38MAPK activation partially through A3 adenosine receptor. Bioscience trends. vol 9. issue 6. 2016-11-04. PMID:26781794. |
serotonin transporter (sert) is a critical determinant of synaptic serotonin (5-hydroxytryptamine, 5-ht) inactivation which plays a critical role in the pathology of depression and other mood disorders. |
2016-11-04 |
2023-08-13 |
Not clear |
| A J M Loonen, S A Ivanov. Circuits regulating pleasure and happiness in major depression. Medical hypotheses. vol 87. 2016-10-31. PMID:26826634. |
the introduction of selective serotonin reuptake inhibitors has gradually changed the borders of the major depression disease class. |
2016-10-31 |
2023-08-13 |
Not clear |
| Nina M Molenaar, Marlies E Brouwer, Claudi L H Bockting, Gouke J Bonsel, Christine N van der Veere, Hanneke W Torij, Witte J G Hoogendijk, Johannes J Duvekot, Huibert Burger, Mijke P Lambregtse-van den Ber. Stop or go? Preventive cognitive therapy with guided tapering of antidepressants during pregnancy: study protocol of a pragmatic multicentre non-inferiority randomized controlled trial. BMC psychiatry. vol 16. 2016-10-31. PMID:26993629. |
approximately 6.2 % of women in the usa and 3.7 % of women in the uk, use selective serotonin reuptake inhibitors (ssris) during their pregnancies because of depression and/or anxiety. |
2016-10-31 |
2023-08-13 |
Not clear |
| Shi-jing Huang, Xian-hui Zhang, Yan-yun Wang, Ju-hua Pan, Han-ming Cui, Su-ping Fang, Wei Wu, Jun Zheng, Duo-jiao Li, Ge Ba. Effects of Kaixin Jieyu Decoction () on behavior, monoamine neurotransmitter levels, and serotonin receptor subtype expression in the brain of a rat depression model. Chinese journal of integrative medicine. vol 20. issue 4. 2016-10-24. PMID:24567255. |
to determine the mechanisms underlying the anti-depressant effects of kaixin jieyu decoction (, kjd) by investigating the effects of kjd on behavior, monoamine neurotransmitter levels, and serotonin (5-ht) receptor subtype expression in the brain in a rat model of depression. |
2016-10-24 |
2023-08-12 |
rat |
| Mikko Joensuu, Pasi Ahola, Paul Knekt, Olavi Lindfors, Pirjo Saarinen, Tommi Tolmunen, Minna Valkonen-Korhonen, Ritva Vanninen, Tuija Jääskeläinen, Esa Virtala, Jyrki Kuikka, Jari Tiihonen, Johannes Lehtone. Baseline symptom severity predicts serotonin transporter change during psychotherapy in patients with major depression. Psychiatry and clinical neurosciences. vol 70. issue 1. 2016-10-24. PMID:26311446. |
baseline symptom severity predicts serotonin transporter change during psychotherapy in patients with major depression. |
2016-10-24 |
2023-08-13 |
Not clear |
| Mikko Joensuu, Pasi Ahola, Paul Knekt, Olavi Lindfors, Pirjo Saarinen, Tommi Tolmunen, Minna Valkonen-Korhonen, Ritva Vanninen, Tuija Jääskeläinen, Esa Virtala, Jyrki Kuikka, Jari Tiihonen, Johannes Lehtone. Baseline symptom severity predicts serotonin transporter change during psychotherapy in patients with major depression. Psychiatry and clinical neurosciences. vol 70. issue 1. 2016-10-24. PMID:26311446. |
the role of the serotonin transporter (sert) in the pathophysiology of depression is unclear and only a few follow-up studies exist. |
2016-10-24 |
2023-08-13 |
Not clear |
| Nastaran Kordjazy, Arya Haj-Mirzaian, Shayan Amiri, Sattar Ostadhadi, Hossein Amini-Khoei, Ahmad Reza Dehpou. Involvement of N-methyl-d-aspartate receptors in the antidepressant-like effect of 5-hydroxytryptamine 3 antagonists in mouse forced swimming test and tail suspension test. Pharmacology, biochemistry, and behavior. vol 141. 2016-10-19. PMID:26604075. |
recent evidence indicates that 5-hydroxytryptamine 3 (5-ht3) antagonists such as ondansetron and tropisetron exert positive behavioral effects in animal models of depression. |
2016-10-19 |
2023-08-13 |
mouse |