| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marcello Ms Nico, Silvia V Lourenç. Obsessive-compulsive behaviour related cutaneous ulcers: two cases with therapeutic considerations. International wound journal. vol 13. issue 5. 2017-07-11. PMID:25585672. |
obsessive-compulsive-related cutaneous disease is better treated with serotonin reuptake inhibitor antidepressants in higher dosages than those used to treat depression. |
2017-07-11 |
2023-08-13 |
Not clear |
| C D Pandya, N Hoda, A Crider, D Peter, A Kutiyanawalla, S Kumar, A O Ahmed, G Turecki, C M Hernandez, A V Terry, A Pilla. Transglutaminase 2 overexpression induces depressive-like behavior and impaired TrkB signaling in mice. Molecular psychiatry. vol 22. issue 5. 2017-06-29. PMID:27620841. |
serotonin (5-hydroxytryptamine, 5-ht) and brain-derived neurotrophic factor (bdnf) are two signaling molecules that have important regulatory roles in the development and plasticity of neural circuits that are known to be altered in depression. |
2017-06-29 |
2023-08-13 |
mouse |
| Yaa-Hui Dong, Katsiaryna Bykov, Niteesh K Choudhry, Macarius M Donneyong, Krista F Huybrechts, Raisa Levin, Sebastian Schneeweiss, Joshua J Gagn. Clinical Outcomes of Concomitant Use of Warfarin and Selective Serotonin Reuptake Inhibitors: A Multidatabase Observational Cohort Study. Journal of clinical psychopharmacology. vol 37. issue 2. 2017-06-26. PMID:28129313. |
patients treated with warfarin are often coprescribed selective serotonin reuptake inhibitors (ssris) for coexisting depression. |
2017-06-26 |
2023-08-13 |
Not clear |
| Chun-Sing Lam, George Lim Tipoe, Johnny Kong-Ching Wong, Moussa B H Youdim, Man-Lung Fun. M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus. PloS one. vol 11. issue 11. 2017-06-23. PMID:27870896. |
our results suggest that m30 is neuroprotective against cort-induced depression targeting elevated mao activities that cause oxidative stress and neuroinflammation, resulting in ido-1 activation, serotonin deficiency and neurodegeneration. |
2017-06-23 |
2023-08-13 |
rat |
| Jonathan Savit. Role of Kynurenine Metabolism Pathway Activation in Major Depressive Disorders. Current topics in behavioral neurosciences. vol 31. 2017-06-20. PMID:27221627. |
initially, activation of the kynurenine pathway was believed to precipitate depressive symptoms by depleting brain serotonin, however, the weight of the evidence now suggests that an imbalance between neurotoxic and neuroprotective metabolites may be the principal driver of depression; conceivably via its effects on glutamatergic neurotransmission. |
2017-06-20 |
2023-08-13 |
Not clear |
| Chang Xu, Xin-Ming Ma, Hui-Bin Chen, Meng-He Zhou, Hui Qiao, Shu-Cheng A. Orbitofrontal cortex 5-HT2A receptor mediates chronic stress-induced depressive-like behaviors and alterations of spine density and Kalirin7. Neuropharmacology. vol 109. 2017-06-19. PMID:26921771. |
although the serotonin (5-ht) 2a receptor, which is abundant in the ofc, has been implicated in depression, the underlying mechanisms in the development of stress-induced depression remain unclear. |
2017-06-19 |
2023-08-13 |
rat |
| Chang Xu, Xin-Ming Ma, Hui-Bin Chen, Meng-He Zhou, Hui Qiao, Shu-Cheng A. Orbitofrontal cortex 5-HT2A receptor mediates chronic stress-induced depressive-like behaviors and alterations of spine density and Kalirin7. Neuropharmacology. vol 109. 2017-06-19. PMID:26921771. |
the aim of this study was to investigate the role of orbitofrontal 5-ht and 5-ht2a receptors in depressive-like behaviors and their associations with kal7 and dendritic spines using chronic unpredictable mild stress (cums), an established animal model of depression. |
2017-06-19 |
2023-08-13 |
rat |
| Hsin-Yi Chen, Cheng-Li Lin, Shih-Wei Lai, Chia-Hung Ka. Association of Selective Serotonin Reuptake Inhibitor Use and Acute Angle-Closure Glaucoma. The Journal of clinical psychiatry. vol 77. issue 6. 2017-06-09. PMID:27135704. |
selective serotonin reuptake inhibitors (ssris) are the most widely used antidepressant medications for treating patients with depression; however, ocular complication has been noted occasionally. |
2017-06-09 |
2023-08-13 |
Not clear |
| M Y Liu, L J Zhang, M C Li. [Effect of ginsenoside pre-treatment on 5-hydroxytryptamine system in SD rats with myocardial infarction and depression]. Zhonghua nei ke za zhi. vol 55. issue 9. 2017-06-08. PMID:27586978. |
[effect of ginsenoside pre-treatment on 5-hydroxytryptamine system in sd rats with myocardial infarction and depression]. |
2017-06-08 |
2023-08-13 |
rat |
| M Y Liu, L J Zhang, M C Li. [Effect of ginsenoside pre-treatment on 5-hydroxytryptamine system in SD rats with myocardial infarction and depression]. Zhonghua nei ke za zhi. vol 55. issue 9. 2017-06-08. PMID:27586978. |
to evaluate the effect of ginsenoside pre-treatment on serotonin (5-hydroxytryptamine, 5-ht), 5-ht2a receptor (5-ht2ar), and 5-ht transporter (serotonin transporter, sert) in serum, platelet lysate and brain tissue homogenates in sd rats with myocardial infarction (mi) or depression. |
2017-06-08 |
2023-08-13 |
rat |
| Harris R Lieberman, Sanjiv Agarwal, Victor L Fulgon. Tryptophan Intake in the US Adult Population Is Not Related to Liver or Kidney Function but Is Associated with Depression and Sleep Outcomes. The Journal of nutrition. vol 146. issue 12. 2017-06-06. PMID:27934652. |
tryptophan metabolites, such as serotonin and melatonin, are thought to participate in the regulation of mood and sleep and tryptophan is used to treat insomnia, sleep apnea, and depression. |
2017-06-06 |
2023-08-13 |
Not clear |
| Marie-Laure Rives, Jonathan A Javitch, Alan D Wickende. Potentiating SLC transporter activity: Emerging drug discovery opportunities. Biochemical pharmacology. vol 135. 2017-06-01. PMID:28214518. |
although long under-explored, slc transporters are an emerging drug target class and the molecular target of several approved inhibitor drugs, such as selective serotonin reuptake inhibitors (ssris) for depression and sodium/glucose co-transporter (sglt2) inhibitors for diabetes. |
2017-06-01 |
2023-08-13 |
human |
| M Würtz, M Schmidt, E L Grove, E Horváth-Puhó, C F Christiansen, H T Sørense. Preadmission use of selective serotonin reuptake inhibitors and short-term mortality in diabetic patients hospitalized due to stroke. Journal of internal medicine. vol 280. issue 4. 2017-05-31. PMID:27138221. |
moreover, diabetic patients are at increased risk of depression and therefore likely to use selective serotonin reuptake inhibitors (ssris). |
2017-05-31 |
2023-08-13 |
Not clear |
| Leah C Susser, Stephanie A Sansone, Alison D Herman. Selective serotonin reuptake inhibitors for depression in pregnancy. American journal of obstetrics and gynecology. vol 215. issue 6. 2017-05-31. PMID:27430585. |
selective serotonin reuptake inhibitors for depression in pregnancy. |
2017-05-31 |
2023-08-13 |
Not clear |
| Leah C Susser, Stephanie A Sansone, Alison D Herman. Selective serotonin reuptake inhibitors for depression in pregnancy. American journal of obstetrics and gynecology. vol 215. issue 6. 2017-05-31. PMID:27430585. |
this review discusses the risks and benefits of selective serotonin reuptake inhibitor treatment in pregnancy within the context of perinatal depression. |
2017-05-31 |
2023-08-13 |
Not clear |
| Leah C Susser, Stephanie A Sansone, Alison D Herman. Selective serotonin reuptake inhibitors for depression in pregnancy. American journal of obstetrics and gynecology. vol 215. issue 6. 2017-05-31. PMID:27430585. |
whereas selective serotonin reuptake inhibitors may be associated with certain risks, the absolute risks are low and may be outweighed by the risks of untreated depression for many women and their offspring. |
2017-05-31 |
2023-08-13 |
Not clear |
| Meysam Amidfar, Yong-Ku Kim, Lejla Colic, Mohammad Arbabi, Gholamhossein Mobaraki, Gholamreza Hassanzadeh, Martin Walte. Increased levels of 5HT2A receptor mRNA expression in peripheral blood mononuclear cells of patients with major depression: correlations with severity and duration of illness. Nordic journal of psychiatry. vol 71. issue 4. 2017-05-26. PMID:28125323. |
neuroimaging, immunologic, and pharmacologic studies have emphasized the role of 5-ht2a and 5-ht3a serotonin receptors in the pathophysiology of major depression. |
2017-05-26 |
2023-08-13 |
Not clear |
| Katsiaryna Bykov, Sebastian Schneeweiss, Macarius M Donneyong, Yaa-Hui Dong, Niteesh K Choudhry, Joshua J Gagn. Impact of an Interaction Between Clopidogrel and Selective Serotonin Reuptake Inhibitors. The American journal of cardiology. vol 119. issue 4. 2017-05-24. PMID:27939386. |
patients receiving clopidogrel are often treated with selective serotonin reuptake inhibitors (ssris) for co-existing depression. |
2017-05-24 |
2023-08-13 |
Not clear |
| K Kaminska, Z Rogo. The antidepressant- and anxiolytic-like effects following co-treatment with escitalopram and risperidone in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 67. issue 3. 2017-05-09. PMID:27512008. |
several clinical reports have documented a beneficial effect of the addition of a low dose of risperidone to the ongoing treatment with antidepressants, in particular selective serotonin reuptake inhibitors (ssri), in the treatment of drug-resistant depression and treatment-resistant anxiety disorders. |
2017-05-09 |
2023-08-13 |
rat |
| Brenda Mc Mahon, Sofie B Andersen, Martin K Madsen, Liv V Hjordt, Ida Hageman, Henrik Dam, Claus Svarer, Sofi da Cunha-Bang, William Baaré, Jacob Madsen, Lis Hasholt, Klaus Holst, Vibe G Frokjaer, Gitte M Knudse. Seasonal difference in brain serotonin transporter binding predicts symptom severity in patients with seasonal affective disorder. Brain : a journal of neurology. vol 139. issue Pt 5. 2017-05-08. PMID:26994750. |
in the patients with seasonal affective disorder, the seasonal change in serotonin transporter binding was positively associated with change in depressive symptom severity, as indexed by hamilton rating scale for depression - seasonal affective disorder version scores (p = 0.01). |
2017-05-08 |
2023-08-13 |
human |