| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vishal Bali, Satabdi Chatterjee, Ryan M Carnahan, Hua Chen, Michael L Johnson, Rajender R Aparas. Risk of Dementia Among Elderly Nursing Home Patients Using Paroxetine and Other Selective Serotonin Reuptake Inhibitors. Psychiatric services (Washington, D.C.). vol 66. issue 12. 2016-09-21. PMID:26234334. |
selective serotonin reuptake inhibitors (ssris) are the first line of treatment for depression. |
2016-09-21 |
2023-08-13 |
Not clear |
| Melissa J Maguire, Cerian F Jackson, Anthony G Marson, Sarah J Nola. Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP). The Cochrane database of systematic reviews. vol 7. 2016-09-21. PMID:27434597. |
preventative strategies for sudep include reducing the occurrence of gtcs by timely referral for presurgical evaluation in people with lesional epilepsy and advice on lifestyle measures; detecting cardiorespiratory distress through clinical observation and seizure, respiratory, and heart rate monitoring devices; preventing airway obstruction through nocturnal supervision and safety pillows; reducing central hypoventilation through physical stimulation and enhancing serotonergic mechanisms of respiratory regulation using selective serotonin reuptake inhibitors (ssris); reducing adenosine and endogenous opioid-induced brain and brainstem depression. |
2016-09-21 |
2023-08-13 |
Not clear |
| Achikam Haim, Christopher Albin-Brooks, Morgan Sherer, Emily Mills, Benedetta Leune. The effects of gestational stress and Selective Serotonin reuptake inhibitor antidepressant treatment on structural plasticity in the postpartum brain--A translational model for postpartum depression. Hormones and behavior. vol 77. 2016-09-15. PMID:25997412. |
the effects of gestational stress and selective serotonin reuptake inhibitor antidepressant treatment on structural plasticity in the postpartum brain--a translational model for postpartum depression. |
2016-09-15 |
2023-08-13 |
rat |
| Noam Gordon, Gadi Goelma. Understanding alterations in serotonin connectivity in a rat model of depression within the monoamine-deficiency and the hippocampal-neurogenesis frameworks. Behavioural brain research. vol 296. 2016-09-15. PMID:26367472. |
understanding alterations in serotonin connectivity in a rat model of depression within the monoamine-deficiency and the hippocampal-neurogenesis frameworks. |
2016-09-15 |
2023-08-13 |
rat |
| Gisela H Maia, Joana I Soares, Pedro A Andrade, Juliana F Leite, Liliana L Luz, José P Andrade, Nikolai V Lukoyano. Altered taste preference and loss of limbic-projecting serotonergic neurons in the dorsal raphe nucleus of chronically epileptic rats. Behavioural brain research. vol 297. 2016-09-15. PMID:26456522. |
interestingly, epilepsy-related loss of 5-ht neurons (approximately 35%) was observed only in the interfascicular part of the dr complex, which is known to innervate brain regions involved in depression. |
2016-09-15 |
2023-08-13 |
rat |
| Irene Gracia-Rubio, Maria Moscoso-Castro, Oscar J Pozo, Josep Marcos, Roser Nadal, Olga Valverd. Maternal separation induces neuroinflammation and long-lasting emotional alterations in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 65. 2016-09-14. PMID:26382758. |
emotional alterations like depression result in reduced serotonin availability and enhanced kynurenine metabolism through the action of indoleamine 2, 3-dioxygenase in response to neuroinflammatory factors. |
2016-09-14 |
2023-08-13 |
mouse |
| Tia Sternat, Martin A Katzma. Neurobiology of hedonic tone: the relationship between treatment-resistant depression, attention-deficit hyperactivity disorder, and substance abuse. Neuropsychiatric disease and treatment. vol 12. 2016-09-07. PMID:27601909. |
dysfunction of these circuits has also been implicated in the relative ineffectiveness of selective serotonin reuptake inhibitors used to treat anxiety and depression in patients with low hedonic tone. |
2016-09-07 |
2023-08-13 |
Not clear |
| Mehdi Sayyah, Kaveh Eslami, Shabnam AlaiShehni, Leila Kout. Cognitive Function before and during Treatment with Selective Serotonin Reuptake Inhibitors in Patients with Depression or Obsessive-Compulsive Disorder. Psychiatry journal. vol 2016. 2016-09-06. PMID:27597949. |
cognitive function before and during treatment with selective serotonin reuptake inhibitors in patients with depression or obsessive-compulsive disorder. |
2016-09-06 |
2023-08-13 |
Not clear |
| Haitao Wang, Rémi Quirion, Peter J Little, Yufang Cheng, Zhong-Ping Feng, Hong-Shuo Sun, Jiangping Xu, Wenhua Zhen. Forkhead box O transcription factors as possible mediators in the development of major depression. Neuropharmacology. vol 99. 2016-08-30. PMID:26279492. |
furthermore, foxos could be regulated by serotonin and norepinephrine receptor signaling as well as the hypothalamic-pituitary-adrenal axis, all of which are involved in the pathogenesis of depression. |
2016-08-30 |
2023-08-13 |
Not clear |
| Jacob Andersen, Lucy Kate Ladefoged, Danyang Wang, Trine N Bjerre Kristensen, Benny Bang-Andersen, Anders S Kristensen, Birgit Schiøtt, Kristian Strømgaar. Binding of the multimodal antidepressant drug vortioxetine to the human serotonin transporter. ACS chemical neuroscience. vol 6. issue 11. 2016-08-30. PMID:26389667. |
selective inhibitors of the human serotonin transporter (hsert) have been first-line treatment against depression for several decades. |
2016-08-30 |
2023-08-13 |
human |
| Robert Schwamborn, Eric Brown, Jana Haas. Elevation of cortical serotonin transporter activity upon peripheral immune challenge is regulated independently of p38 mitogen-activated protein kinase activation and transporter phosphorylation. Journal of neurochemistry. vol 137. issue 3. 2016-08-30. PMID:26924154. |
the serotonin transporter (sert) is responsible for high-affinity serotonin (5-ht) uptake from extracellular fluid and is a prominent pharmacological target in the treatment of depression. |
2016-08-30 |
2023-08-13 |
rat |
| Elizabeth Hitchner, Doug Morrison, Phoebe Liao, Allyson Rosen, Wei Zho. Genetic Polymorphisms Influence Cognition in Patients Undergoing Carotid Interventions. The International journal of angiology : official publication of the International College of Angiology, Inc. vol 25. issue 3. 2016-08-30. PMID:27574384. |
after correcting for age and genetic polymorphisms in bdnf and serotonin transporter (5-htt), apoe 4 allele was associated with depression (p= 0.044) and showed a trend with baseline cognitive impairment (p= 0.10). |
2016-08-30 |
2023-08-13 |
Not clear |
| C L Bethea, A P Redd. Ovarian steroids regulate gene expression related to DNA repair and neurodegenerative diseases in serotonin neurons of macaques. Molecular psychiatry. vol 20. issue 12. 2016-08-29. PMID:25600110. |
serotonin dysfunction is frequently found in the different etiologies of depression. |
2016-08-29 |
2023-08-13 |
monkey |
| K-W Lee, L Westin, J Kim, J C Chang, Y-S Oh, B Amreen, J Gresack, M Flajolet, D Kim, A Aperia, Y Kim, P Greengar. Alteration by p11 of mGluR5 localization regulates depression-like behaviors. Molecular psychiatry. vol 20. issue 12. 2016-08-29. PMID:26370144. |
the protein s100a10 (p11) was identified as a regulator of serotonin receptors, and it has been implicated in the etiology of depression and in mediating the antidepressant actions of selective serotonin reuptake inhibitors. |
2016-08-29 |
2023-08-13 |
mouse |
| Yue Zhang, Shan-shan Qu, Ji-ping Zhang, Ya-ling Sun, Wei-lu Liu, Ling Xie, Yong Huang, Jun-qi Che. Rapid Onset of the Effects of Combined Selective Serotonin Reuptake Inhibitors and Electroacupuncture on Primary Depression: A Meta-Analysis. Journal of alternative and complementary medicine (New York, N.Y.). vol 22. issue 1. 2016-08-29. PMID:26655087. |
rapid onset of the effects of combined selective serotonin reuptake inhibitors and electroacupuncture on primary depression: a meta-analysis. |
2016-08-29 |
2023-08-13 |
Not clear |
| Yue Zhang, Shan-shan Qu, Ji-ping Zhang, Ya-ling Sun, Wei-lu Liu, Ling Xie, Yong Huang, Jun-qi Che. Rapid Onset of the Effects of Combined Selective Serotonin Reuptake Inhibitors and Electroacupuncture on Primary Depression: A Meta-Analysis. Journal of alternative and complementary medicine (New York, N.Y.). vol 22. issue 1. 2016-08-29. PMID:26655087. |
to evaluate the efficacy and safety of combined selective serotonin reuptake inhibitors (ssris) and electroacupuncture therapies for the early treatment of primary depression. |
2016-08-29 |
2023-08-13 |
Not clear |
| Timo Siepmann, Ana Isabel Penzlin, Jessica Kepplinger, Ben Min-Woo Illigens, Kerstin Weidner, Heinz Reichmann, Kristian Barlin. Selective serotonin reuptake inhibitors to improve outcome in acute ischemic stroke: possible mechanisms and clinical evidence. Brain and behavior. vol 5. issue 10. 2016-08-23. PMID:26516608. |
several clinical studies have indicated that selective serotonin reuptake inhibitors (ssris) administered in patients after acute ischemic stroke can improve clinical recovery independently of depression. |
2016-08-23 |
2023-08-13 |
Not clear |
| Mehmet M Can, Gamze Guler, Ekrem Guler, Olcay Ozveren, Burak Turan, James J DiNicolantinio, Nodar Kipshidze, Victor Serebruan. Enhanced platelet reactivity in pediatric depression: an observational study. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. vol 26. issue 7. 2016-08-22. PMID:25688456. |
however, beyond pure assessment of platelet activity, other elements including serotonin content and cell receptor changes in pediatric depression should be elucidated before randomized trial(s) can be justified. |
2016-08-22 |
2023-08-13 |
human |
| Hyung-Mun Yun, Kyung-Ran Park, Eun-Cheol Kim, Sanghyeon Kim, Jin Tae Hon. Serotonin 6 receptor controls Alzheimer's disease and depression. Oncotarget. vol 6. issue 29. 2016-08-22. PMID:26449188. |
serotonin 6 receptor controls alzheimer's disease and depression. |
2016-08-22 |
2023-08-13 |
mouse |
| Hyung-Mun Yun, Kyung-Ran Park, Eun-Cheol Kim, Sanghyeon Kim, Jin Tae Hon. Serotonin 6 receptor controls Alzheimer's disease and depression. Oncotarget. vol 6. issue 29. 2016-08-22. PMID:26449188. |
serotonin 6 receptor (5-ht6r) has caused much interest for potential roles in ad and depression. |
2016-08-22 |
2023-08-13 |
mouse |