| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Khadeeja Khan, Abul Kalam Najmi, Mohd Akhta. A Natural Phenolic Compound Quercetin Showed the Usefulness by Targeting Inflammatory, Oxidative Stress Markers and Augment 5-HT Levels in One of the Animal Models of Depression in Mice. Drug research. vol 69. issue 7. 2019-12-16. PMID:30296804. |
a natural phenolic compound quercetin showed the usefulness by targeting inflammatory, oxidative stress markers and augment 5-ht levels in one of the animal models of depression in mice. |
2019-12-16 |
2023-08-13 |
mouse |
| Khadeeja Khan, Abul Kalam Najmi, Mohd Akhta. A Natural Phenolic Compound Quercetin Showed the Usefulness by Targeting Inflammatory, Oxidative Stress Markers and Augment 5-HT Levels in One of the Animal Models of Depression in Mice. Drug research. vol 69. issue 7. 2019-12-16. PMID:30296804. |
in the present study quercetin was studied for its role in inflammation, oxidative stress markers and 5-ht levels in unpredictable chronic mild stress (ucms) animal model of depression. |
2019-12-16 |
2023-08-13 |
mouse |
| Miłosz Gołyszny, Ewa Obuchowic. Are neuropeptides relevant for the mechanism of action of SSRIs? Neuropeptides. vol 75. 2019-12-16. PMID:30824124. |
selective serotonin reuptake inhibitors (ssris) are drugs of first choice in the therapy of moderate to severe depression and anxiety disorders. |
2019-12-16 |
2023-08-13 |
Not clear |
| Ulla Knorr, Jasmine Melissa Madsen, Lars Vedel Kessin. The effect of selective serotonin reuptake inhibitors in healthy subjects revisited: A systematic review of the literature. Experimental and clinical psychopharmacology. vol 27. issue 5. 2019-12-06. PMID:30869982. |
selective serotonin reuptake inhibitors (ssris) are the first-line drugs in the treatment of depression. |
2019-12-06 |
2023-08-13 |
human |
| Caleb J Browne, Andrew R Abela, Duong Chu, Zhaoxia Li, Xiaodong Ji, Evelyn K Lambe, Paul J Fletche. Dorsal raphe serotonin neurons inhibit operant responding for reward via inputs to the ventral tegmental area but not the nucleus accumbens: evidence from studies combining optogenetic stimulation and serotonin reuptake inhibition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 4. 2019-11-25. PMID:30420603. |
these studies support an oppositional interaction between 5-ht and da systems in controlling motivation and goal-directed behavior, and have important implications for the development and refinement of treatment strategies for psychiatric disorders such as depression and addiction. |
2019-11-25 |
2023-08-13 |
mouse |
| Marona-Lewicka, Nichol. The Effect of Selective Serotonin Releasing Agents in the Chronic Mild Stress Model of Depression in Rats. Stress (Amsterdam, Netherlands). vol 2. issue 2. 2019-11-20. PMID:9787258. |
the effect of selective serotonin releasing agents in the chronic mild stress model of depression in rats. |
2019-11-20 |
2023-08-12 |
rat |
| Marona-Lewicka, Nichol. The Effect of Selective Serotonin Releasing Agents in the Chronic Mild Stress Model of Depression in Rats. Stress (Amsterdam, Netherlands). vol 2. issue 2. 2019-11-20. PMID:9787258. |
in single-bottle tests, chronic treatment with the selective 5-ht releasers, mmai (5 mg/kg, 2 x day) or mta (p-methylthioamphetamine; 5 mg/kg, 2 x day), reversed the deficit in rewarded behavior (anhedonia) measured as a decrease in the consumption of 1% sucrose solution in the chronic mild stress model of depression in rats. |
2019-11-20 |
2023-08-12 |
rat |
| A. Tazi, M. Farh, M. Moumni, F. Hakko. Potentiation of behavioural effects of a calcium channel antagonist, nifedipine, by ipsapirone. Behavioural pharmacology. vol 3. issue 3. 2019-11-20. PMID:11224126. |
the synergistic effect between the 5-ht(1a) agonist ipsapirone and the calcium channel antagonist, nifedipine, was studied in animal models of anxiety and depression. |
2019-11-20 |
2023-08-12 |
Not clear |
| Kumatoshi Ishihara, Taku Amano, Hiroshi Hayakawa, Shigeto Yamawaki, Masashi Sas. Enhancement of serotonin(1A) receptor function following repeated electroconvulsive shock in young rat hippocampal neurons in vitro. The international journal of neuropsychopharmacology. vol 2. issue 2. 2019-11-20. PMID:11281976. |
this supports the hypothesis that enhanced 5-ht(1a) receptor function, at least in part, contributes to the effectiveness of ecs treatment for depression directly and/or indirectly. |
2019-11-20 |
2023-08-12 |
rat |
| Klaus-Peter Lesch, Rainald Mössne. Knockout Corner: 5-HT(1A) receptor inactivation: anxiety or depression as a murine experience. The international journal of neuropsychopharmacology. vol 2. issue 4. 2019-11-20. PMID:11285149. |
knockout corner: 5-ht(1a) receptor inactivation: anxiety or depression as a murine experience. |
2019-11-20 |
2023-08-12 |
mouse |
| Klaus-Peter Lesch, Rainald Mössne. Knockout Corner: 5-HT(1A) receptor inactivation: anxiety or depression as a murine experience. The international journal of neuropsychopharmacology. vol 2. issue 4. 2019-11-20. PMID:11285149. |
5-ht(1a) receptors play a critical role in the pathophysiology of anxiety and depression as well as in the mode of action of anxiolytic and antidepressant drugs. |
2019-11-20 |
2023-08-12 |
mouse |
| Dirk van West, Michael Mae. Activation of the inflammatory response system: A new look at the etiopathogenesis of major depression. Neuro endocrinology letters. vol 20. issue 1-2. 2019-11-20. PMID:11473226. |
the reciprocal relationships between irs activation and hypothalamic-pituitary-adrenal (hpa)-axis hyperactivity, alterations in hp thyroid (hpt)-axis function and the availability of tryptophan to the brain led us to hypothesize that these neuroendocrine changes in depression are indicators of irs activation and that a combined dysregulation of the irs, the turnover of serotonin (5-ht) and the hpa-axis is an integral component of depression. |
2019-11-20 |
2023-08-12 |
Not clear |
| H. Bras, E. Jankowska, B. Noga, B. Skoo. Comparison of Effects of Various Types of NA and 5-HT Agonists on Transmission from Group II Muscle Afferents in the Cat. The European journal of neuroscience. vol 2. issue 12. 2019-11-20. PMID:12106064. |
the results suggest that this depression may involve different membrane receptors at different locations, primarily alpha2 adrenoceptors in the intermediate zone/ventral horn and 5-ht1a serotonin receptors in the dorsal horn. |
2019-11-20 |
2023-08-12 |
cat |
| Andreas Conca, Edgar Swoboda, Peter König, Stefan Koppi, Wolfgang Beraus, Arno Künz, Heinz Fritzsche, Peter Weis. Clinical impacts of single transcranial magnetic stimulation (sTMS) as an add-on therapy in severely depressed patients under SSRI treatment. Human psychopharmacology. vol 15. issue 6. 2019-11-20. PMID:12404305. |
in our 4 week study of stms, 12 patients affected by severe non-psychotic major depression (dsm-iii-r) were enrolled and put on standardized combined antidepressant medication with the serotonin re-uptake inhibitor citalopram, and the serotonin modulating drug, trazodone. |
2019-11-20 |
2023-08-12 |
Not clear |
| Johan A. Den Boer, Fokko J. Bosker, Bernhard R. Slaa. Serotonergic drugs in the treatment of depressive and anxiety disorders. Human psychopharmacology. vol 15. issue 5. 2019-11-20. PMID:12404310. |
5-ht(1a) agonists have been used extensively for the treatment of depression and gad but evidence of their efficacy in other anxiety disorders is equivocal. |
2019-11-20 |
2023-08-12 |
Not clear |
| John F. Cryan, Brian E. Leonar. 5-HT1A and beyond: the role of serotonin and its receptors in depression and the antidepressant response. Human psychopharmacology. vol 15. issue 2. 2019-11-20. PMID:12404340. |
5-ht1a and beyond: the role of serotonin and its receptors in depression and the antidepressant response. |
2019-11-20 |
2023-08-12 |
human |
| John F. Cryan, Brian E. Leonar. 5-HT1A and beyond: the role of serotonin and its receptors in depression and the antidepressant response. Human psychopharmacology. vol 15. issue 2. 2019-11-20. PMID:12404340. |
since its discovery 50 years ago, the role of the indoleamine 5-ht (5-hydroxytryptamine; serotonin) in the pathogenesis of depression and in the mechanism of action of antidepressant drugs has been the subject of considerable research. |
2019-11-20 |
2023-08-12 |
human |
| John F. Cryan, Brian E. Leonar. 5-HT1A and beyond: the role of serotonin and its receptors in depression and the antidepressant response. Human psychopharmacology. vol 15. issue 2. 2019-11-20. PMID:12404340. |
this classification has led to the development of selective compounds that have aided in the efforts of dissecting the complex role of 5-ht in depression and in mediating the antidepressant response. |
2019-11-20 |
2023-08-12 |
human |
| John F. Cryan, Brian E. Leonar. 5-HT1A and beyond: the role of serotonin and its receptors in depression and the antidepressant response. Human psychopharmacology. vol 15. issue 2. 2019-11-20. PMID:12404340. |
in addition, a number of postsynaptic 5-ht receptors have been shown to be dysfunctional in depression and are also potential targets for a number of antidepressants. |
2019-11-20 |
2023-08-12 |
human |
| I. Hindmarc. Expanding the horizons of depression: beyond the monoamine hypothesis. Human psychopharmacology. vol 16. issue 3. 2019-11-20. PMID:12404573. |
the monoamine hypothesis has dominated our understanding of depression and of pharmacological approaches to its management and it has produced several generations of antidepressant agents, ranging from the monoamine oxidase inhibitors (maois), through tricyclics (tcas) and selective serotonin reuptake inhibitors (ssris), to the recently introduced selective noradrenaline reuptake inhibitor (nari), reboxetine. |
2019-11-20 |
2023-08-12 |
human |