| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M Billar. Taurine in deep cerebellar nuclei of the rat. In vivo comparison to GABA inhibitory effect. Brain research. vol 514. issue 1. 1990-07-31. PMID:2357522. |
both tau and gaba produced a dose-dependent depression of the firing rate. |
1990-07-31 |
2023-08-11 |
rat |
| D I Kerr, J Ong, R H Prage. Antagonism of GABAB-receptor-mediated responses in the guinea-pig isolated ileum and vas deferens by phosphono-analogues of GABA. British journal of pharmacology. vol 99. issue 2. 1990-05-30. PMID:2158379. |
the phosphono-analogues of gamma-aminobutyric acid (gaba), 4-amino-butylphosphonic acid (4-abpa), 3-amino-2-(4-chlorophenyl)-propylphosphonic acid (phaclofen) and 3-amino-2-cyclohexylpropyl-phosphonic acid, each antagonized the gaba- and baclofen-induced gabab-receptor-mediated depression of twitch responses to transmural stimulation in the guinea-pig isolated ileum, in a concentration-dependent, reversible and surmountable manner (apparent pa2 = 4.0 +/- 0.1, 4 +/- 0.2 and 3.7 +/- 0.2 respectively, compared with 3.9 +/- 0.1 for delta-aminovaleric acid). |
1990-05-30 |
2023-08-11 |
Not clear |
| D I Kerr, J Ong, R H Prage. Antagonism of GABAB-receptor-mediated responses in the guinea-pig isolated ileum and vas deferens by phosphono-analogues of GABA. British journal of pharmacology. vol 99. issue 2. 1990-05-30. PMID:2158379. |
by contrast, 3-amino-propylphosphonic acid (3-appa) behaved as a partial agonist, itself partly depressing ileal twitch contractions in a manner sensitive to 4-abpa and phaclofen, as well as antagonizing the depression of the ileal twitch by gaba and baclofen (apparent pa2 = 4.0 +/- 0.2). |
1990-05-30 |
2023-08-11 |
Not clear |
| b' M J Sheardown, J Drejer, L H Jensen, C E Stidsen, T Honor\\xc3\\xa. A potent antagonist of the strychnine insensitive glycine receptor has anticonvulsant properties. European journal of pharmacology. vol 174. issue 2-3. 1990-05-02. PMID:2560979.' |
mnqx potently antagonized n-methyl-d-aspartate (nmda)-evoked release of [3h]gaba from cultured cortical neurones, nmda evoked spreading depression and nmda depolarizations in the rat neo-cortex. |
1990-05-02 |
2023-08-11 |
mouse |
| M Del Tacca, C Blandizzi, M C Bernardin. Central GABAA excitatory and GABAB inhibitory receptors regulate gastric acid secretion in rats. European journal of pharmacology. vol 177. issue 3. 1990-04-26. PMID:2155808. |
overall, our results suggest the presence of two central gaba pathways which mediate opposite effects: (a) a bicuculline-sensitive gabaa-receptor, the stimulation of which increases acid secretion under pharmacological depression of central vagal tone (anaesthetized rats); (b) a phaclofen-sensitive gabab-receptor, the activation of which decreases vagally stimulated acid secretion (pylorus-ligated rats). |
1990-04-26 |
2023-08-11 |
rat |
| S Liske, A Li, M E Morri. Effects of ketamine on GABA-evoked excitability of peripheral nerve. Experimental brain research. vol 79. issue 1. 1990-04-25. PMID:2311696. |
0.1 and 10 microm ketamine, concentrations which by themselves had small or no effect, produced a dose-dependent depression of the large increases in excitability which are induced by activation of gaba receptors. |
1990-04-25 |
2023-08-11 |
Not clear |
| S Liske, A Li, M E Morri. Effects of ketamine on GABA-evoked excitability of peripheral nerve. Experimental brain research. vol 79. issue 1. 1990-04-25. PMID:2311696. |
in the presence of ketamine gaba concentration-response curves of the dorsal root fibers showed depression of the maximal response, while those of the ventral root fibers were shifted to the right. |
1990-04-25 |
2023-08-11 |
Not clear |
| K A Cunningham, J M Lakosk. The interaction of cocaine with serotonin dorsal raphe neurons. Single-unit extracellular recording studies. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 1. 1990-04-05. PMID:2137698. |
the putative 5-ht1a autoreceptor antagonist spiperone reversed the cocaine-induced depression of firing rate in 64% of 5-ht neurons tested whereas receptor antagonists for dopamine d2 (haloperidol), 5-ht2 (ketanserin), gamma-aminobutyric acid (picrotoxin) and 5-ht1/beta-adrenergic (propranolol) were ineffective. |
1990-04-05 |
2023-08-11 |
rat |
| R A Deisz, D A Princ. Frequency-dependent depression of inhibition in guinea-pig neocortex in vitro by GABAB receptor feed-back on GABA release. The Journal of physiology. vol 412. 1990-01-29. PMID:2557431. |
frequency-dependent depression of inhibition in guinea-pig neocortex in vitro by gabab receptor feed-back on gaba release. |
1990-01-29 |
2023-08-11 |
Not clear |
| R A Deisz, D A Princ. Frequency-dependent depression of inhibition in guinea-pig neocortex in vitro by GABAB receptor feed-back on GABA release. The Journal of physiology. vol 412. 1990-01-29. PMID:2557431. |
we attempted to test the possibility of a feedback depression of gaba on subsequent release. |
1990-01-29 |
2023-08-11 |
Not clear |
| Y De Koninck, J L Henr. Bombesin, neuromedin B and neuromedin C selectively depress superficial dorsal horn neurones in the cat spinal cord. Brain research. vol 498. issue 1. 1989-11-08. PMID:2790461. |
naloxone, bicuculline and caffeine failed to block the depression by bombesin, suggesting that the effect of the peptide may be direct and not through the indirect activation of an inhibitory system mediated by opioids, by gamma-aminobutyric acid (gaba) or by purines, respectively. |
1989-11-08 |
2023-08-11 |
cat |
| S K Long, R H Evans, F Krijze. Effects of depressant amino acids and antagonists on an in vitro spinal cord preparation from the adult rat. Neuropharmacology. vol 28. issue 7. 1989-09-11. PMID:2761679. |
gamma-aminobutanoate (gaba), glycine and taurine (0.5-5 mm) produced dose-dependent depression of spontaneous paroxysmal activity generated in mg2+ -free medium. |
1989-09-11 |
2023-08-11 |
rat |
| R C Drugan, A L Morrow, R Weizman, A Weizman, S I Deutsch, J N Crawley, S M Pau. Stress-induced behavioral depression in the rat is associated with a decrease in GABA receptor-mediated chloride ion flux and brain benzodiazepine receptor occupancy. Brain research. vol 487. issue 1. 1989-08-31. PMID:2546650. |
stress-induced behavioral depression in the rat is associated with a decrease in gaba receptor-mediated chloride ion flux and brain benzodiazepine receptor occupancy. |
1989-08-31 |
2023-08-11 |
rat |
| R C Drugan, A L Morrow, R Weizman, A Weizman, S I Deutsch, J N Crawley, S M Pau. Stress-induced behavioral depression in the rat is associated with a decrease in GABA receptor-mediated chloride ion flux and brain benzodiazepine receptor occupancy. Brain research. vol 487. issue 1. 1989-08-31. PMID:2546650. |
these data suggest that the development of stress-induced behavioral depression may be associated with a decrease in gaba receptor-mediated chloride channel function. |
1989-08-31 |
2023-08-11 |
rat |
| K G Lloyd, B Zivkovic, B Scatton, P L Morselli, G Bartholin. The gabaergic hypothesis of depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 13. issue 3-4. 1989-08-21. PMID:2664889. |
gabab receptors are decreased in the frontal cortex in two rodent behavioral models of depression and gaba release is reported diminished in the hippocampus. |
1989-08-21 |
2023-08-11 |
rat |
| W D Lust, A B Wheaton, G Feussner, J Passonnea. Metabolism in the hamster brain during hibernation and arousal. Brain research. vol 489. issue 1. 1989-08-21. PMID:2743144. |
the brains of hibernators were biochemically characterized by (1) a high concentration of energy reserves including glycogen, glucose, adenosine triphosphate, and p-creatine, (2) significantly elevated levels of lactate and gaba, and (3) near depletion of cyclic guanosine monophosphate with only a moderate depression of cyclic adenosine monophosphate. |
1989-08-21 |
2023-08-11 |
Not clear |
| M Lisa, E Marmo, J H Wible, J A DiMicc. Injection of muscimol into posterior hypothalamus blocks stress-induced tachycardia. The American journal of physiology. vol 257. issue 1 Pt 2. 1989-08-16. PMID:2750964. |
microinjection of muscimol (10 ng; 88 pmol) at the same posterior hypothalamic site in which gaba blockade causes cardiovascular changes similar to those seen in stress produced a modest depression of cardiovascular function in unstressed animals (-28 +/- 5 beats/min and -6 +/- 3 mmhg). |
1989-08-16 |
2023-08-11 |
rat |
| S C Gilman, J S Colton, A J Dutk. Pressure-dependent changes in the release of GABA by cerebrocortical synaptosomes. Undersea biomedical research. vol 16. issue 3. 1989-08-01. PMID:2741257. |
the mean depression in gamma-aminobutyric acid release during the first minute was an average of 15% at 19 ata, 28% at 37 ata, 38% at 50 ata, and 54% at 62 ata when compared to a 1 ata control. |
1989-08-01 |
2023-08-11 |
Not clear |
| J Kamei, M Ogawa, Y Kasuy. Effects of GABA antagonists on the pentobarbital-induced depression of respiration and cough in rats. Pharmacology, biochemistry, and behavior. vol 32. issue 1. 1989-07-17. PMID:2543992. |
effects of gaba antagonists on the pentobarbital-induced depression of respiration and cough in rats. |
1989-07-17 |
2023-08-11 |
rat |
| J Kamei, M Ogawa, Y Kasuy. Effects of GABA antagonists on the pentobarbital-induced depression of respiration and cough in rats. Pharmacology, biochemistry, and behavior. vol 32. issue 1. 1989-07-17. PMID:2543992. |
in order to determine the possible involvement of gaba-ergic mechanisms in the modulation of the cough reflex, the effects of gaba antagonists on the pentobarbital-induced depression of respiration and cough were examined in a comparative study in rats. |
1989-07-17 |
2023-08-11 |
rat |