| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Tongroach, S Sanguanrungsirikul, B Tantisira, P Kunlua. Angiotensin II-induced depression of Purkinje cell firing and possible modulatory action on GABA responses. Neuroscience research. vol 1. issue 5. 1985-08-26. PMID:6152637. |
angiotensin ii-induced depression of purkinje cell firing and possible modulatory action on gaba responses. |
1985-08-26 |
2023-08-12 |
rat |
| P Tongroach, S Sanguanrungsirikul, B Tantisira, P Kunlua. Angiotensin II-induced depression of Purkinje cell firing and possible modulatory action on GABA responses. Neuroscience research. vol 1. issue 5. 1985-08-26. PMID:6152637. |
both aii-induced depression of cell firing and the aii-induced enhancement of gaba depression were antagonized by a specific gaba antagonist, bicuculline methochloride. |
1985-08-26 |
2023-08-12 |
rat |
| S H Williams, A Constanti, D A Brow. Muscarinic depression of evoked surface-negative field potentials recorded from guinea-pig olfactory cortex in vitro. Neuroscience letters. vol 56. issue 3. 1985-08-23. PMID:2862610. |
this depression was blocked by atropine and pirenzepine, but not d-tubocurarine or by antagonists active at gamma-aminobutyric acid or adenosine receptors. |
1985-08-23 |
2023-08-11 |
Not clear |
| L Steel, C N Scholfiel. gamma-Aminobutyric acid partly mediates the pentobarbitone depression of synaptic excitation in the guinea-pig olfactory cortex in vitro. Neuroscience letters. vol 56. issue 1. 1985-08-12. PMID:2989734. |
gamma-aminobutyric acid partly mediates the pentobarbitone depression of synaptic excitation in the guinea-pig olfactory cortex in vitro. |
1985-08-12 |
2023-08-11 |
Not clear |
| L Steel, C N Scholfiel. gamma-Aminobutyric acid partly mediates the pentobarbitone depression of synaptic excitation in the guinea-pig olfactory cortex in vitro. Neuroscience letters. vol 56. issue 1. 1985-08-12. PMID:2989734. |
a study has been made to elucidate the possible role of gamma-aminobutyric acid (gaba) in this depression by testing pentobarbitone in the presence of high concentrations of the gaba blockers, i.e. |
1985-08-12 |
2023-08-11 |
Not clear |
| S Tanganelli, C Bianchi, L Bean. The modulation of cortical acetylcholine release by GABA, GABA-like drugs and benzodiazepines in freely moving guinea-pigs. Neuropharmacology. vol 24. issue 4. 1985-07-09. PMID:2860590. |
prevented the behavioural activation and the increased release of ach by gaba, unmasked the depression due to subthreshold doses of diazepam (i.c.v., 7-70 nmol) and reversed the stimulation induced by muscimol into sedation and reduced the outflow of ach. |
1985-07-09 |
2023-08-11 |
Not clear |
| J Z Xiang, C J Huan. Respiratory depression produced by injection of GABA into the fourth ventricle of the rabbit. Acta Academiae Medicinae Wuhan = Wu-han i hsueh yuan hsueh pao. vol 5. issue 1. 1985-07-09. PMID:4000586. |
respiratory depression produced by injection of gaba into the fourth ventricle of the rabbit. |
1985-07-09 |
2023-08-11 |
rabbit |
| G Bartholin. GABA receptor agonists: pharmacological spectrum and therapeutic actions. Medicinal research reviews. vol 5. issue 1. 1985-04-29. PMID:2984490. |
the fact that: (a) gaba receptor agonists and tricyclic antidepressants affect noradrenergic and serotonergic transmission differently; and (b) tricyclic antidepressants alter gaba-related parameters challenges the classical monoamine hypothesis of depression and suggests that gaba-mediated mechanisms play a role in mood disorders. |
1985-04-29 |
2023-08-11 |
human |
| A Pilc, K G Lloy. Chronic antidepressants and GABA "B" receptors: a GABA hypothesis of antidepressant drug action. Life sciences. vol 35. issue 21. 1984-12-19. PMID:6092815. |
these data suggest that gaba "b" receptors may be involved in the mechanism of action of antidepressant drugs and provide a link between gabaergic and monoaminergic hypotheses of depression. |
1984-12-19 |
2023-08-12 |
rat |
| J M Lakoski, D W Gallager, G K Aghajania. Histamine-induced depression of serotoninergic dorsal raphe neurons: antagonism by cimetidine, a reevaluation. European journal of pharmacology. vol 103. issue 1-2. 1984-11-20. PMID:6148254. |
microiontophoretic application of the histamine h2-receptor antagonist cimetidine selectively attenuated the histamine-induced, but not the gamma-aminobutyric acid (gaba)-induced, depression of serotoninergic cells recorded in the dorsal raphe nucleus of the rat. |
1984-11-20 |
2023-08-12 |
rat |
| W W Morgan, K A Pfei. Depression of cerebellar cGMP by barbiturates. Relationship to locomotor activity. Neuropharmacology. vol 23. issue 7A. 1984-10-19. PMID:6089023. |
collectively, these data suggest that the effects of the barbiturates on cgmp in the cerebellum are not exclusively or predominantly the result of a drug-related depression of locomotor activity and may be, at least partially, mediated via a barbiturate-induced potentiation of a gaba receptor-mediated mechanism. |
1984-10-19 |
2023-08-12 |
rat |
| G Bartholin. Experimental basis for the antidepressant action of the GABA receptor agonist progabide. Neuroscience letters. vol 47. issue 3. 1984-10-15. PMID:6089056. |
the different modes of action of gaba receptor agonists and tricyclics, as well as alterations of gaba-related parameters by tricyclics, challenge the classical monoaminergic hypothesis of depression and suggest that gaba-mediated mechanisms play a role in this disorder. |
1984-10-15 |
2023-08-12 |
Not clear |
| C E Stansfeld, D I Walli. Generation of an unusual depolarizing response in rabbit primary afferent neurones in the absence of divalent cations. The Journal of physiology. vol 352. 1984-09-19. PMID:6086912. |
depression of gaba responses in ca/mg-free medium could be entirely attributed to the absence of mg, mn being able to substitute for mg. x responses were generated only after equilibration for 1 h with ca/mg-free medium. |
1984-09-19 |
2023-08-12 |
rabbit |
| F Petty, A D Sherma. Plasma GABA levels in psychiatric illness. Journal of affective disorders. vol 6. issue 2. 1984-07-13. PMID:6233345. |
patients with unipolar depression who received a dexamethasone suppression test had no correlation between nonsuppression of cortisol secretion and plasma levels of gaba. |
1984-07-13 |
2023-08-12 |
Not clear |
| J Hedner, T Hedner, P Wessberg, J Jonaso. An analysis of the mechanism by which gamma-aminobutyric acid depresses ventilation in the rat. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 56. issue 4. 1984-07-11. PMID:6725063. |
the depression was due to changes in both respiratory frequency (f) and tidal volume (vt) after gaba, whereas aoaa decreased only f. intracerebroventricular gaba decreased inspiratory drive (vt/ti; intrapulmonary pressure at 100 ms) but did not change the bulbopontine setting of inspiratory duration (ti). |
1984-07-11 |
2023-08-12 |
rat |
| J Hedner, T Hedner, P Wessberg, J Jonaso. An analysis of the mechanism by which gamma-aminobutyric acid depresses ventilation in the rat. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 56. issue 4. 1984-07-11. PMID:6725063. |
the ventilatory depression induced by gaba was reversed by the gaba antagonist bicuculline. |
1984-07-11 |
2023-08-12 |
rat |
| J Hedne. Neuropharmacological aspects of central respiratory regulation. An experimental study in the rat. Acta physiologica Scandinavica. Supplementum. vol 524. 1984-06-18. PMID:6202094. |
an increase in endogenous gaba levels induced by the gaba transaminase inhibitor aoaa blunted the respiratory response to co2 and induced a ventilatory depression similar to that seen after exogenous gaba. |
1984-06-18 |
2023-08-12 |
rat |
| G G Collins, G A Probett, J Anson, N J McLaughli. Excitatory and inhibitory effects of noradrenaline on synaptic transmission in the rat olfactory cortex slice. Brain research. vol 294. issue 2. 1984-05-24. PMID:6322921. |
at higher concentrations of noradrenaline, the increased levels of excitatory transmitters release sufficient endogenous gaba (and possibly adenosine) to cause an overall depression of transmission. |
1984-05-24 |
2023-08-12 |
rat |
| T G Waldrop, F L Eldridge, D E Millhor. Inhibition of breathing after stimulation of muscle is mediated by endogenous opiates and GABA. Respiration physiology. vol 54. issue 2. 1984-03-22. PMID:6665335. |
the post-stimulatory depression of breathing was greatly attenuated in cats pretreated with an opiate antagonist (naloxone) and did not occur in animals pretreated with a gaba antagonist (bicuculline). |
1984-03-22 |
2023-08-12 |
Not clear |
| T G Waldrop, F L Eldridge, D E Millhor. Inhibition of breathing after stimulation of muscle is mediated by endogenous opiates and GABA. Respiration physiology. vol 54. issue 2. 1984-03-22. PMID:6665335. |
we conclude that endogenous opiates and possibly gaba, but not serotonin, dopamine or norepinephrine, are involved in the neural mechanism responsible for the prolonged depression of breathing. |
1984-03-22 |
2023-08-12 |
Not clear |