| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R D Allan, R H Evans, G A Johnsto. gamma-Aminobutyric acid agonists: an in vitro comparison between depression of spinal synaptic activity and depolarization of spinal root fibres in the rat. British journal of pharmacology. vol 70. issue 4. 1981-05-21. PMID:6258682. |
1 relative molar potencies, of a range of gamma-aminobutyrate (gaba)-related agonists, for depolarization of isolated spinal roots have been compared with their potencies for depression of spontaneous synaptic activity, recorded in ventral roots of hemisected spinal cord preparations from 3 to 9-day-old rats. |
1981-05-21 |
2023-08-12 |
rat |
| J Hedner, J Jonason, D Lundber. Respiratory effects of gamma-hydroxybutyric acid in anesthetized rats. Journal of neural transmission. vol 49. issue 3. 1981-03-17. PMID:6778955. |
picrotoxin (0.25, 0.5 or 1.0 mg/kg intravenously), a presumed gaba antagonist did not significantly change the respiratory pattern when given alone but clearly antagonized the ghba-induced respiratory depression. |
1981-03-17 |
2023-08-12 |
rat |
| A Hotchkiss, J W Gib. Blockade of methamphetamine-induced depression of tyrosine hydroxylase by GABA transaminase inhibitors. European journal of pharmacology. vol 66. issue 2-3. 1981-02-24. PMID:6108224. |
blockade of methamphetamine-induced depression of tyrosine hydroxylase by gaba transaminase inhibitors. |
1981-02-24 |
2023-08-12 |
rat |
| G Wennergren, B Ober. Cardiovascular effects elicited from the ventral surface of medulla oblongata in the cat. Pflugers Archiv : European journal of physiology. vol 387. issue 2. 1981-01-29. PMID:7191982. |
topical application of gaba or glycine on these structures resulted in blood pressure fall, bradycardia, vasodilatation in the kidney and the skeletal muscles and also depression of respiration. |
1981-01-29 |
2023-08-12 |
cat |
| H M Geller, B J Hoffer, D A Taylo. Electrophysiological actions of benzodiazepines. Federation proceedings. vol 39. issue 12. 1980-12-16. PMID:6252064. |
the studies summarized here indicate that this depression of excitability by benzodiazepines is a result of an increase in gamma-aminobutyric acid (gaba) mediated inhibition. |
1980-12-16 |
2023-08-12 |
Not clear |
| D L Gruol, J L Barker, T G Smit. Naloxone antagonism of GABA-evoked membrane polarizations in cultured mouse spinal cord neurons. Brain research. vol 198. issue 2. 1980-11-25. PMID:6250670. |
when naloxone was co-iontophoresed with the amino acids a depression of the gaba response resulted. |
1980-11-25 |
2023-08-12 |
mouse |
| D L Gruol, J L Barker, T G Smit. Naloxone antagonism of GABA-evoked membrane polarizations in cultured mouse spinal cord neurons. Brain research. vol 198. issue 2. 1980-11-25. PMID:6250670. |
the naloxone depression of the gaba response did not appear to involve opiate receptors since (+)-naloxone, the inactive isomer, equally depressed the gaba response. |
1980-11-25 |
2023-08-12 |
mouse |
| A Smiałowski, M Smiałowska, K Reichenberg, B Byrska, J Vetulan. Motor depression and head twitches induced by IP injection of GABA. Psychopharmacology. vol 69. issue 3. 1980-11-25. PMID:6774371. |
motor depression and head twitches induced by ip injection of gaba. |
1980-11-25 |
2023-08-12 |
mouse |
| V V Markovich, R U Ostrovskay. Cortical inhibition processes and the anticonvulsant action of benzodiazepine derivatives. Neuroscience and behavioral physiology. vol 10. issue 3. 1980-11-20. PMID:6106168. |
clear correlation was shown between the degree of protective action of the various benzodiazepine derivatives against convulsions due to the gaba deficiency and their ability to induce depression of the test response. |
1980-11-20 |
2023-08-12 |
Not clear |
| R U Ostrovskaia, G M Molodavki. [Participation of GABA-ergic structures in producing the effects of haloperidol]. Biulleten' eksperimental'noi biologii i meditsiny. vol 89. issue 3. 1980-09-23. PMID:6248144. |
in doses of 0.3--0.5 mg/kg producing a tranquilizing effect, haloperidol exerts a protective action in convulsions induced by bicuculline blocking of the gaba receptors and enhances the depression of the testing response during recovery cycle of the rat sensorimotor cortex primary response. |
1980-09-23 |
2023-08-12 |
mouse |
| H C Moises, D J Woodwar. Potentiation of GABA inhibitory action in cerebrllum by locus coeruleus stimulation. Brain research. vol 182. issue 2. 1980-05-14. PMID:7357389. |
locus coeruleus stimulation at current intensities which alone elicited no direct depression of purkinje cell spontaneous discharge potentiated the inhibition produced by gaba. |
1980-05-14 |
2023-08-12 |
Not clear |
| H C Moises, D J Woodwar. Potentiation of GABA inhibitory action in cerebrllum by locus coeruleus stimulation. Brain research. vol 182. issue 2. 1980-05-14. PMID:7357389. |
repetitive activation of the classic non-adrenergic cerebellar afferents did not enhance the gaba response, despite causing a direct depression in spontaneous rate. |
1980-05-14 |
2023-08-12 |
Not clear |
| D R Curtis, D Lodge, H McLenna. The excitation and depression of spinal neurones by ibotenic acid. The Journal of physiology. vol 291. 1979-11-29. PMID:480204. |
the depression of neuronal excitability produced by gaba, taurine, isoguvacine or 3-aminopropane sulphonate, ejected for periods of 5--6 min, recovered rapidly. |
1979-11-29 |
2023-08-11 |
Not clear |
| C J Pycock, R W Horto. Dopamine-dependent hyperactivity in the rat following manipulation of GABA mechanisms in the region of the nucleus accumbens. Journal of neural transmission. vol 45. issue 1. 1979-10-26. PMID:112217. |
blockade of gaba uptake systems with cis-1, 3-aminocyclohexane carboxylic acid (achc), nipecotic acid or beta-alanine within the region of the nucleus accumbens produced dose-related depression of dopamine-dependent hyperactivity in both models. |
1979-10-26 |
2023-08-11 |
rat |
| C J Pycock, R W Horto. Dopamine-dependent hyperactivity in the rat following manipulation of GABA mechanisms in the region of the nucleus accumbens. Journal of neural transmission. vol 45. issue 1. 1979-10-26. PMID:112217. |
gaba uptake blockade (nipecotic acid) significantly enhanced the gaba-mediated depression of hyperactivity induced by bilateral injection of dopamine into the nucleus accumbens. |
1979-10-26 |
2023-08-11 |
rat |
| C J Pycock, R W Horto. Dopamine-dependent hyperactivity in the rat following manipulation of GABA mechanisms in the region of the nucleus accumbens. Journal of neural transmission. vol 45. issue 1. 1979-10-26. PMID:112217. |
although open to criticisms of not being able to distinguish between true gaba effects and the results of non-specific neuronal depression the hyperactivity model underlines the potency of the gaba uptake blocking compounds and their possible potential for future clinical use. |
1979-10-26 |
2023-08-11 |
rat |
| J R Toleikis, L Wang, L L Boyarsk. Effects of excitatory and inhibitory amino acids on phasic respiratory neurons. Journal of neuroscience research. vol 4. issue 3. 1979-10-24. PMID:38345. |
in this case, however, the dosage of gaba required to produce a given depression was significantly less than the required dosage of glycine. |
1979-10-24 |
2023-08-11 |
Not clear |
| J A DiMicco, K Gale, B Hamilton, R A Gilli. GABA receptor control of parasympathetic outflow to heart: characterization and brainstem localization. Science (New York, N.Y.). vol 204. issue 4397. 1979-09-01. PMID:451556. |
blockade of gamma-aminobutyric acid (gaba) receptor function by direct microinjection of the gaba receptor antagonist bicuculline into the nucleus ambiguus of the brainstem produced a marked, dose-related depression of heart rate and blood pressure which was mediated by the vagus nerve. |
1979-09-01 |
2023-08-11 |
Not clear |
| P Gloor, A Pellegrini, G K Kostopoulo. Effects of changes in cortical excitability upon the epileptic bursts in generalized penicillin epilepsy of the cat. Electroencephalography and clinical neurophysiology. vol 46. issue 3. 1979-06-26. PMID:85521. |
in cats exhibiting the eeg signs of feline generalized penicillin epilepsy cortical excitability was decreased by hypoxia, by the topical application to the cortex of kcl (inducing spreading depression), barbiturates, gaba, amp or noradrenaline. |
1979-06-26 |
2023-08-11 |
cat |
| M A Lynch, B E Leonar. Changes in brain gamma-aminobutyric acid concentrations following acute and chronic amphetamine administration and during post amphetamine depression. Biochemical pharmacology. vol 27. issue 14. 1978-12-20. PMID:568471. |
changes in brain gamma-aminobutyric acid concentrations following acute and chronic amphetamine administration and during post amphetamine depression. |
1978-12-20 |
2023-08-11 |
Not clear |