| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N G Bowery, A Dra. Reversal of the action of amino acid antagonists by barbiturates and other hypnotic drugs. British journal of pharmacology. vol 63. issue 1. 1978-07-15. PMID:206305. |
on most occasions a slight potentiation occurred in responses to low concentrations of gaba (below 10 mum) coupled with a depression in the responses to concentrations of gaba greater than 10 mum.4 superfusion with pb in the presence of bic reversed the depression in the response to gaba produced by bic. |
1978-07-15 |
2023-08-11 |
rat |
| N G Bowery, A Dra. Reversal of the action of amino acid antagonists by barbiturates and other hypnotic drugs. British journal of pharmacology. vol 63. issue 1. 1978-07-15. PMID:206305. |
by contrast the effect of pb lasted only 15-30 min after its removal.9 chlordiazepoxide (30 mum) applied in the absence of bic did not affect the response to gaba but did reduce the depression produced by the subsequent application of bic even though the chlordiazepoxide had been removed 40 min earlier.10 in the rat brain stem in vivo pb, applied iontophoretically in amounts which neither decreased the spontaneous neuronal firing rate nor affected the response to gaba or glycine, reversed the gaba antagonism induced by iontophoretic application of bic (in all 23 neurones tested). |
1978-07-15 |
2023-08-11 |
rat |
| D A Brown, A Constant. Interaction of pentobarbitone and gamma-aminobutyric acid on mammalian sympathetic ganglion cells. British journal of pharmacology. vol 63. issue 1. 1978-07-15. PMID:647160. |
pentobarbitone (100 micrometer) strikingly enhanced the conductance increases produced by gaba and 3-aminopropanesulphonic acid, and reversed the depression of gaba-evoked responses by bicuculline. |
1978-07-15 |
2023-08-11 |
rat |
| R C Frederickson, M Neuss, S L Morzorati, W J McBrid. A comparison of the inhibitory effects of taurine and GABA on identified Purkinje cells and other neurons in the cerebellar cortex of the rat. Brain research. vol 145. issue 1. 1978-06-28. PMID:205321. |
both taurine and gaba produced a dose-dependent depression of spike frequency of cerebellar neurons. |
1978-06-28 |
2023-08-11 |
rat |
| R D Moone. GABA-mediated control of transient signals in the inner retina. Brain research. vol 145. issue 1. 1978-06-28. PMID:305812. |
depression produced by gaba was antagonized by picrotoxin or bicuculline; while glycine-produced depression was selectively antagonized by strychnine. |
1978-06-28 |
2023-08-11 |
Not clear |
| R L Macdonald, J L Barke. Specific antagonism of GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons: a common mode of convulsant action. Neurology. vol 28. issue 4. 1978-05-24. PMID:565020. |
bath application of all four convulsants produced paroxysmal depolarizing events in the neurons; iontophoresis of the four convulsants selectively depressed responses produced by iontophoresis of the putative inhibitory transmitter gaba, and effected this depression without altering either inhibitory responses to beta-alanine or glycine, or excitation mediated by glutamate. |
1978-05-24 |
2023-08-11 |
Not clear |
| V V Markovich, R U Ostrovskai. [Inhibitory processes in the cerebral cortex and the anticonvulsive action of benzodiazepine derivatives]. Biulleten' eksperimental'noi biologii i meditsiny. vol 84. issue 10. 1977-12-29. PMID:21007. |
the threshold doses of the drugs inducing the depression of the test response and of ed50, preventing the development of convulsions, caused by gaba deficiency or by gaba-ergic receptor block, were compared; a correlation between the mentioned effects was demonstrated. |
1977-12-29 |
2023-08-11 |
Not clear |
| K Krnjević, E Puil, R Werma. Bicuculline, benzyl penicillin, and inhibitory amino acids in the spinal cord of the cat. Canadian journal of physiology and pharmacology. vol 55. issue 3. 1977-09-29. PMID:884620. |
with approximately equal iontophoretic currents of gamma-aminobutyric acid (gaba) and bmc, there is an almost equal chance of observing no change, a potentiation, or a depression of the gaba-evoked conductance increase. |
1977-09-29 |
2023-08-11 |
cat |
| K Krnjević, E Puil, R Werma. Bicuculline, benzyl penicillin, and inhibitory amino acids in the spinal cord of the cat. Canadian journal of physiology and pharmacology. vol 55. issue 3. 1977-09-29. PMID:884620. |
this may be due to depression of gaba uptake by bmc, which would also account for its potentiating action at lower relative doses. |
1977-09-29 |
2023-08-11 |
cat |
| T Kimura, H Imamura, K Hashimot. Facilitatory and inhibitory effects of gamma-aminobutyric acid on ganglionic transmission in the sympathetic cardiac nerves of the dog. The Journal of pharmacology and experimental therapeutics. vol 202. issue 2. 1977-09-22. PMID:196068. |
these results clearly demonstrated dual effects of gaba on ganglionic transmission, i.e., facilitation in small doses and depression in large doses. |
1977-09-22 |
2023-08-11 |
dog |
| T Kimura, H Imamura, K Hashimot. Facilitatory and inhibitory effects of gamma-aminobutyric acid on ganglionic transmission in the sympathetic cardiac nerves of the dog. The Journal of pharmacology and experimental therapeutics. vol 202. issue 2. 1977-09-22. PMID:196068. |
the depression caused by large doses of gaba was markedly reduced by picrotoxin, 1 mg/kg, while the facilitation remained unaffected. |
1977-09-22 |
2023-08-11 |
dog |
| W A Corrigall, S M Crain, M B Bornstei. Electrophysiological studies of fetal mouse olifactory bulb explants during development of synaptic functions in culture. Journal of neurobiology. vol 7. issue 6. 1977-02-16. PMID:1003199. |
in addition, the selective and reversible depression of these slow wave potentials by gaba (1-5 x 10(-4)m), but not by glycine (up to 3 x 10(-3)m), indicates a gaba-ergic component in the inhibitory network. |
1977-02-16 |
2023-08-11 |
mouse |
| W B Levy, J W Haycock, C W Cotma. Stimulation-dependent depression of readily releasable neurotransmitter pools in brain. Brain research. vol 115. issue 2. 1977-01-03. PMID:788858. |
neither initial gaba release nor the subsequent depression of release was affected by variations in the labelling duration. |
1977-01-03 |
2023-08-11 |
Not clear |
| W B Levy, J W Haycock, C W Cotma. Stimulation-dependent depression of readily releasable neurotransmitter pools in brain. Brain research. vol 115. issue 2. 1977-01-03. PMID:788858. |
stimulation-dependent depression of labelled gaba and norepinephrine release was demonstrated from both cerebral cortex and cerebellum synaptosomal preparations. |
1977-01-03 |
2023-08-11 |
Not clear |
| A Dray, T J Gonye, N R Oakle. Caudate stimulation and substantia nigra activity in the rat. The Journal of physiology. vol 259. issue 3. 1976-10-20. PMID:8637. |
electrophoretic bicuculline methochloride (bmc) consistently reduced gaba but not glycine depression of substantia nigra neurones. |
1976-10-20 |
2023-08-11 |
rat |
| A Dray, T J Gonye, N R Oakle. Caudate stimulation and substantia nigra activity in the rat. The Journal of physiology. vol 259. issue 3. 1976-10-20. PMID:8637. |
electrophoretic strychnine consistently reduced glycine but not gaba depression of substantia nigra neurones, and did not modify caudate evoked inhibition of these neurones or the accompanying field potential. |
1976-10-20 |
2023-08-11 |
rat |
| W Haefely, A Kulcsár, H Möhler, L Pieri, P Polc, R Schaffne. Possible involvement of GABA in the central actions of benzodiazepines. Advances in biochemical psychopharmacology. issue 14. 1976-01-17. PMID:242199. |
the effects of several benzodiazepines on a variety of nervous activities known or presumed to depend on gaba are presented and compared with those of agents that deplete or increase the level of endogenous gaba: antagonism of various convulsant agents in mice, enhancement of presynaptic inhibition in the spinal cord and the cuneate nucleus of cats, decrease of the spontaneous firing rate of cerebellar purkinje cells in cats and rats, antagonism of bicuculine-induced depression of the strio-nigral-evoked potential in the cat, potentiation of haloperidol-induced catalepsy in rats, gaba-mimetic actions on drug-induced pgo-waves in cats and on eserine-induced circling in guinea pigs. |
1976-01-17 |
2023-08-11 |
rat |
| Y Kudo, N Abe, S Goto, H Fukud. The chloride-dependent depression by GABA in the frog spinal cord. European journal of pharmacology. vol 32. issue 02. 1975-11-07. PMID:1080113. |
the chloride-dependent depression by gaba in the frog spinal cord. |
1975-11-07 |
2023-08-11 |
Not clear |
| E A Brunner, S C Cheng, M L Berma. Effects of anesthesia on intermediary metabolism. Annual review of medicine. vol 26. 1975-09-22. PMID:167650. |
major inhalational anesthetics cause inhibition in the electron transport chain in the region of complex i resulting in decreased oxygen utilization, inhibition of metabolism of nad-linked substrates, but not of succinate, inhibition of mitochondrial calcium uptake, and depression of synaptic transmission because of postulated changes in ach sensitivity or gaba inhibition. |
1975-09-22 |
2023-08-11 |
Not clear |
| J A Bell, E G Anderso. Dissociation between amino-oxyacetic acid-induced depression of spinal reflexes and the rise in cord GABA levels. Neuropharmacology. vol 13. issue 9. 1975-02-06. PMID:4154420. |
dissociation between amino-oxyacetic acid-induced depression of spinal reflexes and the rise in cord gaba levels. |
1975-02-06 |
2023-08-11 |
Not clear |