| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' J Drejer, M Sheardown, E O Nielsen, T Honor\\xc3\\xa. Glycine reverses the effect of HA-966 on NMDA responses in cultured rat cortical neurons and in chick retina. Neuroscience letters. vol 98. issue 3. 1989-07-10. PMID:2657505.' |
the effects of glycine on nmda antagonism by a series of excitatory amino acid antagonists were tested in two functional in vitro models: nmda induced [3h]gaba release from cultured mouse cortical neurons and nmda evoked spreading depression in chick retina. |
1989-07-10 |
2023-08-11 |
mouse |
| G M Nicholson, I Spence, G A Johnsto. Depolarizing actions of convulsant barbiturates on isolated rat dorsal root ganglion cells. Neuroscience letters. vol 93. issue 2-3. 1989-05-16. PMID:3241657. |
only the convulsant barbiturates (+)-dmbb and cheb produced a concentration-dependent depression in the responses to gamma-aminobutyric acid (gaba). |
1989-05-16 |
2023-08-11 |
rat |
| Y S Guo, J C Thompson, P Sing. Effect of gamma-aminobutyric acid on bombesin-evoked release of somatostatin and gastrin from isolated rat stomach. Regulatory peptides. vol 24. issue 2. 1989-04-19. PMID:2564210. |
infusion of gaba (1-1000 nm) caused a depression of sli release induced by bbs (10 nm) in a dose-dependent fashion. |
1989-04-19 |
2023-08-11 |
rat |
| P Bielik, J Pavláse. The extrasynaptic effect of gamma-aminobutyric acid and pentobarbital and the influence of temperature on the response of parallel fibres of the frog cerebellum in vitro. Physiologia Bohemoslovaca. vol 37. issue 6. 1989-04-11. PMID:2976508. |
at t = 13 degrees c, depression of direct responses was significant only in superfusion with gaba (10(-6) and 10(-3) mol.l-1) and not in superfusion with pb (10(-6) and 10(3-) mol.l-1). |
1989-04-11 |
2023-08-11 |
Not clear |
| J Kapur, J L Stringer, E W Lothma. Evidence that repetitive seizures in the hippocampus cause a lasting reduction of GABAergic inhibition. Journal of neurophysiology. vol 61. issue 2. 1989-04-06. PMID:2918363. |
the gaba agonist muscimol and the benzodiazepine diazepam enhanced paired-pulse depression whereas the gaba antagonist bicuculline decreased it. |
1989-04-06 |
2023-08-11 |
rat |
| P S Rodrigues, A P Guimarães, F A de Azeredo, H Martins-Ferreir. Involvement of GABA and ACh in retinal spreading depression: effects of "low calcium-high magnesium" solutions. Experimental brain research. vol 73. issue 3. 1989-03-29. PMID:3224675. |
involvement of gaba and ach in retinal spreading depression: effects of "low calcium-high magnesium" solutions. |
1989-03-29 |
2023-08-11 |
chicken |
| S C Cheetham, M R Crompton, C L Katona, S J Parker, R W Horto. Brain GABAA/benzodiazepine binding sites and glutamic acid decarboxylase activity in depressed suicide victims. Brain research. vol 460. issue 1. 1989-03-23. PMID:2851368. |
we have investigated the involvement of gamma-aminobutyric acid (gaba) in depression by quantitating benzodiazepine (bz) binding sites, the ability of gaba to stimulate bz binding and glutamic acid decarboxylase activity in frontal and temporal cortex obtained at postmortem examination from 21 suicide victims and 21 age- and sex-matched controls. |
1989-03-23 |
2023-08-11 |
human |
| J Ong, D I Kerr, G A Johnsto. Alfaxalone potentiates and mimics GABA-induced contractile responses in the guinea-pig isolated ileum. British journal of pharmacology. vol 95. issue 1. 1989-03-23. PMID:3219474. |
picrotoxinin (10 microm) induced a non-parallel rightward shift of the gaba concentration-response curve, with a 50% depression of the maximum response to gaba. |
1989-03-23 |
2023-08-11 |
human |
| J Ong, D I Kerr, G A Johnsto. Alfaxalone potentiates and mimics GABA-induced contractile responses in the guinea-pig isolated ileum. British journal of pharmacology. vol 95. issue 1. 1989-03-23. PMID:3219474. |
alfaxalone (100 nm) potentiated the responses to gaba in the presence of picrotoxinin (10 microm) over the gaba concentration-range of 10-100 microm, causing a leftward shift of the concentration-response curve, but without affecting the depression of the maximum response by picrotoxinin. |
1989-03-23 |
2023-08-11 |
human |
| b' T Tursk\\xc3\\xb. Pyritinol inhibition of the GABA and benzodiazepine receptor. Physiologia Bohemoslovaca. vol 37. issue 5. 1989-03-22. PMID:2851848.' |
depression of the affinities of gaba and the associated benzodiazepine receptor, together with inhibition of gaba synthesis, in the presence of pyritinol indicate that diminished activity of the gaba system in the brain might be related to the activating effect of pyritinol. |
1989-03-22 |
2023-08-11 |
Not clear |
| A Fernández Teruel, F Boix, R M Escorihuela, P Yáñez, A Tobeñ. Sodium valproate reduces immobility in the behavioral 'despair' test in rats. European journal of pharmacology. vol 152. issue 1-2. 1989-02-23. PMID:3145207. |
the data agree with previous findings from several animal models of depression of an antidepressant-like activity of gaba mimetics or agents which stimulate gabaergic function. |
1989-02-23 |
2023-08-11 |
rat |
| D R Stevens, J P Gallagher, P Shinnick-Gallaghe. In vitro studies of the role of gamma-aminobutyric acid in inhibition in the lateral septum of the rat. Synapse (New York, N.Y.). vol 1. issue 2. 1989-02-21. PMID:3505368. |
treatment with bicuculline or picrotoxin results in depression of biphasic gaba responses that appears selective for the depolarizing portion of the potential. |
1989-02-21 |
2023-08-11 |
rat |
| J N Nobrega, J Snow, L M Dixon, D V Coscin. Graded increases in brain GABA: differential effects on feeding and other behaviours in rats. Behavioural brain research. vol 31. issue 2. 1989-02-02. PMID:2849456. |
elevations of brain gamma-aminobutyric acid (gaba) induced by inhibitors of gaba transaminase (gaba-t) are known to induce a number of functional effects including depression of food intake. |
1989-02-02 |
2023-08-11 |
rat |
| F Zinebi, L Fagni, M Hugo. Decrease of recurrent and feed-forward inhibitions under high pressure of helium in rat hippocampal slices. European journal of pharmacology. vol 153. issue 2-3. 1988-12-21. PMID:2903060. |
however, the depression of synaptic and antidromic field potentials induced by perfusion of gaba or muscimol were not significantly affected by pressure. |
1988-12-21 |
2023-08-11 |
rat |
| K Kawasaki, A Matsushita, M Satoh, H Takag. The lateral vestibular nucleus is a site for the depressant action of benzodiazepines on the crossed extensor reflex. Brain research. vol 461. issue 2. 1988-12-21. PMID:3141001. |
depressant actions on neuronal activity in the lvn produced by both diazepam and flurazepam were clearly antagonized by intravenously administered ro 15-1788, while it failed to reverse the depression produced by gaba. |
1988-12-21 |
2023-08-11 |
rat |
| A Lev-Tov, D E Meyers, R E Burk. Activation of type B gamma-aminobutyric acid receptors in the intact mammalian spinal cord mimics the effects of reduced presynaptic Ca2+ influx. Proceedings of the National Academy of Sciences of the United States of America. vol 85. issue 14. 1988-08-24. PMID:2839843. |
intracellular recordings from mammalian spinal motoneurons in vivo show that the type b gamma-aminobutyric acid receptor agonist, l-(-)-baclofen, when administered systemically to pentobarbital-anesthetized or decerebrate unanesthetized cats decreases the amplitude of monosynaptic group ia excitatory postsynaptic potentials (epsps), markedly increases tetanic and posttetanic potentiation, and reduces or abolishes synaptic depression during high-frequency synaptic activation and in the posttetanic period. |
1988-08-24 |
2023-08-11 |
Not clear |
| M W Salter, J L Henr. Purine-induced depression of dorsal horn neurons in the cat spinal cord: enhancement by tachykinins. Neuroscience. vol 23. issue 3. 1988-04-05. PMID:2449638. |
on the other hand, depression induced by gaba was unaffected by physalaemin in every case (n = 8); in 4 of these cases gaba was tested on units for which purine-induced depression was enhanced by physalaemin. |
1988-04-05 |
2023-08-11 |
cat |
| M Ariyoshi, T Akas. Voltage-clamp studies of the inhibition of gamma-aminobutyric acid response by glucocorticoids in bullfrog primary afferent neurons. Brain research. vol 435. issue 1-2. 1988-03-10. PMID:3501326. |
the depression of the gaba current is neither due to a blockage of open channels nor a facilitation of the desensitization of gaba receptors. |
1988-03-10 |
2023-08-11 |
Not clear |
| J Ong, D I Kerr, G A Johnsto. Cortisol: a potent biphasic modulator at GABAA-receptor complexes in the guinea pig isolated ileum. Neuroscience letters. vol 82. issue 1. 1988-02-17. PMID:2827068. |
there was a sinistral shift of the gaba dose-response curve in the presence of 10 pm cortisol, with a significant potentiation of the gaba-induced contractions over the lower dose range of gaba (3-30 microm), whereas 100 nm cortisol caused a non-parallel dextral shift of the gaba dose-response curve, with a depression of the maximum gaba response indicative of non-competitive antagonism. |
1988-02-17 |
2023-08-11 |
Not clear |
| M W Salter, J L Henr. Evidence that adenosine mediates the depression of spinal dorsal horn neurons induced by peripheral vibration in the cat. Neuroscience. vol 22. issue 2. 1987-12-17. PMID:3670602. |
these findings suggest that vibration-induced depression of these units occurs without involvement of bicuculline-sensitive gaba receptors, strychnine-sensitive glycine receptors and naloxone-sensitive opiate receptors. |
1987-12-17 |
2023-08-11 |
cat |