| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Pokorski, P E Paulev, M Szereda-Przestaszewsk. Endogenous benzodiazepine system and regulation of respiration in the cat. Respiration physiology. vol 97. issue 1. 1994-10-18. PMID:8091023. |
the respiratory depression was neither related to chemical drive nor to the gaba receptor complex, for it was sustained after antagonism of gaba with picrotoxin and bicuculline. |
1994-10-18 |
2023-08-12 |
cat |
| H R Olpe, M W Steinmann, K Greiner, M F Pozz. Contribution of presynaptic GABA-B receptors to paired-pulse depression of GABA-responses in the hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 349. issue 5. 1994-09-19. PMID:8065460. |
these findings indicate that the drug increases the gaba content in the synaptic cleft leading to a facilitation of paired-pulse depression. |
1994-09-19 |
2023-08-12 |
Not clear |
| E K Syvälaht. Biological aspects of depression. Acta psychiatrica Scandinavica. Supplementum. vol 377. 1994-09-06. PMID:7914394. |
studies related to monoamine (noradrenaline, serotonin or 5-ht, dopamine) metabolism have assumed a major role in biochemical research into depression; this research now also includes studies on other central neurotransmitters such as gaba and glutamic acid, and neuropeptides like somatostatin and corticotropin-releasing factor (crf). |
1994-09-06 |
2023-08-12 |
Not clear |
| C H Davies, G L Collingridg. The physiological regulation of synaptic inhibition by GABAB autoreceptors in rat hippocampus. The Journal of physiology. vol 472. 1994-05-03. PMID:8145143. |
the gamma-aminobutyric acid (gaba)b receptor antagonists phaclofen (0.4-2 mm), 2-hydroxy-saclofen (0.02-0.4 mm) and 3-aminopropyl(diethoxymethyl)phosphinic acid (cgp 35348; 0.01-1 mm) reduced or abolished, in a concentration-dependent and reversible manner, both the late phase of the ipsc (ipscb) and paired-pulse depression of the early phase of the ipsc (ipsca). |
1994-05-03 |
2023-08-12 |
rat |
| B G Schreurs, D L Alko. Rabbit cerebellar slice analysis of long-term depression and its role in classical conditioning. Brain research. vol 631. issue 2. 1994-04-21. PMID:8131052. |
based on intradendritic purkinje cell recordings obtained from rabbit cerebellar slices, we report that stimulation of climbing fibers and then parallel fibers in the presence of the gaba antagonist, bicuculline, produced significant depression of parallel fiber excitatory post synaptic potential (epsp) amplitude that continued to increase for at least 20 min after stimulation. |
1994-04-21 |
2023-08-12 |
rabbit |
| B G Schreurs, D L Alko. Rabbit cerebellar slice analysis of long-term depression and its role in classical conditioning. Brain research. vol 631. issue 2. 1994-04-21. PMID:8131052. |
however, application of the same stimulation protocol without gaba antagonists produced a brief depression of parallel fiber epsps that disappeared within minutes. |
1994-04-21 |
2023-08-12 |
rabbit |
| F Pett. Plasma concentrations of gamma-aminobutyric acid (GABA) and mood disorders: a blood test for manic depressive disease? Clinical chemistry. vol 40. issue 2. 1994-03-24. PMID:8313610. |
gamma-aminobutyric acid (gaba), an inhibitory neurotransmitter that serves about one-third of brain neurons, is involved in the development of depression and in the treatment of depression and mania with pharmacological therapy. |
1994-03-24 |
2023-08-12 |
Not clear |
| F Pett. Plasma concentrations of gamma-aminobutyric acid (GABA) and mood disorders: a blood test for manic depressive disease? Clinical chemistry. vol 40. issue 2. 1994-03-24. PMID:8313610. |
these low concentrations of gaba appear to persist after recovery from depression and are not increased by treatments that improve depressive symptoms. |
1994-03-24 |
2023-08-12 |
Not clear |
| G Lacey, P Berthelot, C Vaccher, N Flouquet, M P Vaccher, M Debaert, D R Curti. Thienyl-GABA derivatives as specific baclofen agonists in the rat and cat spinal cord in vivo. Neuroscience letters. vol 159. issue 1-2. 1994-01-25. PMID:8264980. |
the depression of the amplitude of extracellularly recorded monosynaptic excitatory field potentials in the lumbar spinal cord of pentobarbitone anaesthetised rats and cats by three thienyl derivatives of gaba: 4-amino-3-(2-thienyl)-butanoic acid; 4-amino-3-(2-thienyl-5-methyl)-butanoic acid and 4-amino-3-(2-thienyl-5-chloro)-butanoic acid was reversibly blocked by the (-)-baclofen antagonist 3-aminopropyl-diethoxymethyl-phosphinic acid (cgp 35348). |
1994-01-25 |
2023-08-12 |
rat |
| F Petty, J Steinberg, G L Kramer, M Fulton, F G Moelle. Desipramine does not alter plasma GABA in patients with major depression. Journal of affective disorders. vol 29. issue 1. 1994-01-13. PMID:8254144. |
desipramine does not alter plasma gaba in patients with major depression. |
1994-01-13 |
2023-08-12 |
Not clear |
| F Petty, J Steinberg, G L Kramer, M Fulton, F G Moelle. Desipramine does not alter plasma GABA in patients with major depression. Journal of affective disorders. vol 29. issue 1. 1994-01-13. PMID:8254144. |
low plasma gaba is a biological marker for depression in a subset of patients tested. |
1994-01-13 |
2023-08-12 |
Not clear |
| F Petty, J Steinberg, G L Kramer, M Fulton, F G Moelle. Desipramine does not alter plasma GABA in patients with major depression. Journal of affective disorders. vol 29. issue 1. 1994-01-13. PMID:8254144. |
we here report that plasma gaba remained stable after 4 weeks of treatment with desipramine in patients with major depression. |
1994-01-13 |
2023-08-12 |
Not clear |
| F Petty, J Steinberg, G L Kramer, M Fulton, F G Moelle. Desipramine does not alter plasma GABA in patients with major depression. Journal of affective disorders. vol 29. issue 1. 1994-01-13. PMID:8254144. |
since the levels of plasma gaba did not change with time, nor with clinical improvement, plasma gaba is not a state marker of depression. |
1994-01-13 |
2023-08-12 |
Not clear |
| G E Nilsson, P L Lut. Role of GABA in hypoxia tolerance, metabolic depression and hibernation--possible links to neurotransmitter evolution. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. vol 105. issue 3. 1993-11-26. PMID:7900957. |
role of gaba in hypoxia tolerance, metabolic depression and hibernation--possible links to neurotransmitter evolution. |
1993-11-26 |
2023-08-12 |
Not clear |
| K O'Flynn, T G Dina. Baclofen-induced growth hormone release in major depression: relationship to dexamethasone suppression test result. The American journal of psychiatry. vol 150. issue 11. 1993-11-16. PMID:8214184. |
these findings may indicate lower than normal responsivity of type b gamma-aminobutyric acid (gaba-b) receptors in depression and a relationship between gaba-b receptor abnormality and dysfunction of the hypothalamic-pituitary-adrenal axis. |
1993-11-16 |
2023-08-12 |
human |
| J E Warnick, S B Deshpande, Q Z Yang, S Das Gupt. Biphasic action of sarin on monosynaptic reflex in the neonatal rat spinal cord in vitro. Archives of toxicology. vol 67. issue 5. 1993-10-05. PMID:8368939. |
thus it is speculated that sarin at lower concentrations blocks gaba transmission, producing facilitation, and at higher concentrations activates the muscarinic receptors producing depression of msr. |
1993-10-05 |
2023-08-12 |
rat |
| M A Castro-Alamancos, I Torres-Alema. Long-term depression of glutamate-induced gamma-aminobutyric acid release in cerebellum by insulin-like growth factor I. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 15. 1993-09-07. PMID:8346260. |
these findings indicate that igf-i produces a long-lasting depression of gaba release by purkinje cells in response to glutamate. |
1993-09-07 |
2023-08-12 |
Not clear |
| T Coccini, S M Candura, L Manzo, L G Costa, M Tonin. Interaction of the neurotoxic pesticides ivermectin and lindane with the enteric GABAA receptor-ionophore complex in the guinea-pig. European journal of pharmacology. vol 248. issue 1. 1993-09-01. PMID:7687958. |
like picrotoxinin, lindane (10, 30 microm) caused a dose-related shift to the right of the concentration-response curve to gaba, 3-aps and ivermectin with depression of the maximum response. |
1993-09-01 |
2023-08-12 |
Not clear |
| L Guo, H Chai, Y Xie, X Li. [Observation of paired-pulse depression in CA1 region of hippocampal slices from coriaria lactone-kindled rats]. Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao. vol 23. issue 4. 1993-07-07. PMID:1304544. |
paired-pulse depression (ppd) technique was used to investigate the potency of recurrent synaptic inhibition mediated by gaba in area ca1 of 54 hippocampal slices from coriaria lactone (cl)-kindled and control rats. |
1993-07-07 |
2023-08-11 |
rat |
| L S Benard. GABAA receptor-mediated mechanisms contribute to frequency-dependent depression of IPSPs in the hippocampus. Brain research. vol 607. issue 1-2. 1993-06-03. PMID:8386977. |
depression of the slow ipsp appears to arise from at least two components: (1) a masking of the slow hyperpolarization resulting from an apparent increase in the depolarizing gaba response due to chloride accumulation; and (2) a novel process involving gabaa receptors, perhaps mediated through presynaptic inhibition. |
1993-06-03 |
2023-08-12 |
Not clear |