| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Silvia R S Ouakinin, David P Barreira, Carlos J Goi. Depression and Obesity: Integrating the Role of Stress, Neuroendocrine Dysfunction and Inflammatory Pathways. Frontiers in endocrinology. vol 9. 2019-11-20. PMID:30108549. |
literature on depression and obesity describes the relevance of the hypothalamic pituitary adrenal axis dysfunction, sympathetic nervous system (sns) activation, and inflammatory processes as well as the interaction of genetic and environmental factors. |
2019-11-20 |
2023-08-13 |
Not clear |
| TimothyG Dina. Novel approaches to the treatment of depression by modulating the hypothalamic - pituitary - adrenal axis. Human psychopharmacology. vol 16. issue 1. 2019-11-20. PMID:12404603. |
novel approaches to the treatment of depression by modulating the hypothalamic - pituitary - adrenal axis. |
2019-11-20 |
2023-08-12 |
Not clear |
| TimothyG Dina. Novel approaches to the treatment of depression by modulating the hypothalamic - pituitary - adrenal axis. Human psychopharmacology. vol 16. issue 1. 2019-11-20. PMID:12404603. |
many patients with major depression show evidence of over-activation of the hypothalamic - pituitary - adrenal axis (hpa), as evidenced by hypercortisolism and adrenal hyperplasia. |
2019-11-20 |
2023-08-12 |
Not clear |
| Marilisa Citton, Giovanni Viel, Francesca Torresan, Gian Paolo Rossi, Maurizio Iacobon. Effect of unilateral adrenalectomy on the quality of life of patients with lateralized primary aldosteronism. BMC surgery. vol 18. issue Suppl 1. 2019-07-02. PMID:31074381. |
the aim of the study was to assess the impact of surgery on health-related qol and depression status of patients suffering from pa, comparing the results with a control group of patients undergoing surgery for non-secreting adrenal tumors. |
2019-07-02 |
2023-08-13 |
Not clear |
| Leslie Alejandra Ramírez, Elsy Arlene Pérez-Padilla, Francisco García-Oscos, Humberto Salgado, Marco Atzori, Juan Carlos Pined. A new theory of depression based on the serotonin/kynurenine relationship and the hypothalamicpituitary- adrenal axis Biomedica : revista del Instituto Nacional de Salud. vol 38. issue 3. 2019-04-16. PMID:30335249. |
a new theory of depression based on the serotonin/kynurenine relationship and the hypothalamicpituitary- adrenal axis the serotonergic and immunological hypothesis of depression proposes that certain types of excessive stress distort the relationship between the activities of the innate immune and central nervous systems, so that the stress caused by an infection, or excessive psychological stress, activate toll-like receptors such as the tlr-4, the transcription factor nf-kb, the inflammasome nlrp3, as well as the secretion of interleukin-1 beta (il-1β), interleukin-6 (il-6) and other factors of the innate immune response, causing first, the general symptoms of the disease which appear with any infection, but also those characteristic of depressive illness such as dysphoria and anhedonia.the evidence indicates that, if the stimulus persists or recurs within 24 hours, the indole-2, 3-dioxygenase enzyme (ido) of the kynurenine metabolic pathway, which increases the synthesis of quinolinic acid, is activated with an associated reduction of serotonin synthesis. |
2019-04-16 |
2023-08-13 |
Not clear |
| Rebecca Lipschutz, Johanna Bick, Victoria Nguyen, Maria Lee, Lin Leng, Elena Grigorenko, Richard Bucala, Linda C Mayes, Michael J Crowle. Macrophage migration inhibitory factor (MIF) gene is associated with adolescents' cortisol reactivity and anxiety. Psychoneuroendocrinology. vol 95. 2019-04-10. PMID:29870971. |
macrophage migration inhibitory factor (mif) is a pleiotropic cytokine involved in inflammatory signaling and hypothalamus pituitary adrenal (hpa) axis stress-response, and has recently been identified as a candidate biomarker for depression and anxiety risk. |
2019-04-10 |
2023-08-13 |
Not clear |
| Gemma Lewis, Konstantinos Ioannidis, Anne-Laura van Harmelen, Sharon Neufeld, Jan Stochl, Glyn Lewis, Peter B Jones, Ian Goodye. The association between pubertal status and depressive symptoms and diagnoses in adolescent females: A population-based cohort study. PloS one. vol 13. issue 6. 2019-01-02. PMID:29912985. |
we tested the hypothesis that stage of breast development in female adolescents, controlled largely by increased estradiol, would be more strongly associated with depression than pubic hair development which occurs in both males and females, and is controlled by adrenal androgens. |
2019-01-02 |
2023-08-13 |
Not clear |
| Elizabeth T Nguyen, Jody L Caldwell, Joshua Streicher, Valentina Ghisays, Nikolaus J Balmer, Christina M Estrada, Matia B Solomo. Differential effects of imipramine and CORT118335 (Glucocorticoid receptor modulator/mineralocorticoid receptor antagonist) on brain-endocrine stress responses and depression-like behavior in female rats. Behavioural brain research. vol 336. 2018-06-01. PMID:28866130. |
depression is commonly associated with hypothalamic-pituitary adrenal (hpa) axis dysfunction that primarily manifests as aberrant glucocorticoid secretion. |
2018-06-01 |
2023-08-13 |
rat |
| Asher Orno. Neurobehavioral risks of SSRIs in pregnancy: Comparing human and animal data. Reproductive toxicology (Elmsford, N.Y.). vol 72. 2018-05-14. PMID:28495514. |
depression seems to be associated with up regulation of hypothalamic pituitary adrenal (hpa) axis and prenatal ssris also seem to affect the hpa axis in animals and man, but the possible long-term outcome has yet to be established. |
2018-05-14 |
2023-08-13 |
human |
| Sara Jenkins-Jones, Lotta Parviainen, John Porter, Mike Withe, Martin J Whitaker, Sarah E Holden, Christopher Li Morgan, Craig J Currie, Richard J M Ros. Poor compliance and increased mortality, depression and healthcare costs in patients with congenital adrenal hyperplasia. European journal of endocrinology. vol 178. issue 4. 2018-03-30. PMID:29371334. |
poor compliance and increased mortality, depression and healthcare costs in patients with congenital adrenal hyperplasia. |
2018-03-30 |
2023-08-13 |
Not clear |
| Sara Jenkins-Jones, Lotta Parviainen, John Porter, Mike Withe, Martin J Whitaker, Sarah E Holden, Christopher Li Morgan, Craig J Currie, Richard J M Ros. Poor compliance and increased mortality, depression and healthcare costs in patients with congenital adrenal hyperplasia. European journal of endocrinology. vol 178. issue 4. 2018-03-30. PMID:29371334. |
to evaluate the risks of depression and all-cause mortality, healthcare utilisation costs and treatment adherence in congenital adrenal hyperplasia (cah) in the united kingdom. |
2018-03-30 |
2023-08-13 |
Not clear |
| Elizabeth C Braithwaite, Susannah E Murphy, Paul G Ramchandan. Effects of prenatal depressive symptoms on maternal and infant cortisol reactivity. Archives of women's mental health. vol 19. issue 4. 2018-02-05. PMID:26940835. |
prenatal depression is associated with adverse offspring outcomes, and the prevailing mechanistic theory to account for mood-associated effects implicates alterations of the maternal and foetal hypothalamic-pituitary adrenal (hpa) axes. |
2018-02-05 |
2023-08-13 |
Not clear |
| George Anderson, Cathy Vaillancourt, Michael Maes, Russel J Reite. Breastfeeding and the gut-brain axis: is there a role for melatonin? Biomolecular concepts. vol 8. issue 3-4. 2018-01-31. PMID:28723608. |
the biological underpinnings of depression include increased levels of pro-inflammatory cytokines, oxidative stress, kynurenine pathway activity and dysregulation of the hypothalamic-pituitary adrenal axis, all of which can decrease melatonergic pathway activity. |
2018-01-31 |
2023-08-13 |
Not clear |
| Michael H Smolensky, Ramon C Hermida, Alain Reinberg, Linda Sackett-Lundeen, Francesco Portalupp. Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention. Chronobiology international. vol 33. issue 8. 2018-01-10. PMID:27308960. |
a surprisingly large number of medical conditions involve cd: adrenal insufficiency; nocturia; sleep-time non-dipping and rising blood pressure 24 h patterns (nocturnal hypertension); delayed sleep phase syndrome, non-24 h sleep/wake disorder; recurrent hypersomnia; sw intolerance; delirium; peptic ulcer disease; kidney failure; depression; mania; bipolar disorder; parkinson's disease; smith-magenis syndrome; fatal familial insomnia syndrome; autism spectrum disorder; asthma; byssinosis; cancers; hand, foot and mouth disease; post-operative state; and icu outcome. |
2018-01-10 |
2023-08-13 |
human |
| Lisa A Martin, Alison G Porter, Vincent A Pelligrini, Peter F Schnatz, Xuezhi Jiang, Nicole Kleinstreuer, Janet E Hall, Sarah Verbiest, Jill Olmstead, Ryan Fair, Alberto Falorni, Luca Persani, Aleksandar Rajkovic, Khanjan Mehta, Lawrence M Nelso. A design thinking approach to primary ovarian insufficiency. Panminerva medica. vol 59. issue 1. 2017-07-13. PMID:27827529. |
there may be significant morbidity due to: 1) depression and anxiety related to the loss of reproductive hormones and infertility; 2) associated autoimmune adrenal insufficiency or hypothyroidism; and 3) reduced bone mineral density and increased risk of cardiovascular disease related to estrogen deficiency. |
2017-07-13 |
2023-08-13 |
Not clear |
| Xiaoling Jiang, Wen Zhong, Haiyan An, Mingyu Fu, Yuanyuan Chen, Zhenggang Zhang, Zhongju Xia. Attenuated DHEA and DHEA-S response to acute psychosocial stress in individuals with depressive disorders. Journal of affective disorders. vol 215. 2017-07-03. PMID:28319688. |
in recent years, a relationship between depression and basal dehydroepiandrosterone (dhea) and dehydroepiandrosterone sulfate (dhea-s) levels has frequently been suggested, but responses of these adrenal steroids to psychosocial stress have not been examined in individuals with depressive disorders. |
2017-07-03 |
2023-08-13 |
Not clear |
| Kazuyoshi Kitaoka, Shiyori Kawata, Tomohiro Yoshida, Fumiya Kadoriku, Mitsuo Kitamur. Exposure to an Extremely-Low-Frequency Magnetic Field Stimulates Adrenal Steroidogenesis via Inhibition of Phosphodiesterase Activity in a Mouse Adrenal Cell Line. PloS one. vol 11. issue 4. 2017-04-05. PMID:27100201. |
the mechanism underlying elf-mf-induced depression is considered to involve adrenal steroidogenesis, which is triggered by elf-mf exposure. |
2017-04-05 |
2023-08-13 |
mouse |
| M F Rubin de Celis, M F R de Celis, S R Bornstein, A Androutsellis-Theotokis, C L Andoniadou, J Licinio, M-L Wong, M Ehrhart-Bornstei. The effects of stress on brain and adrenal stem cells. Molecular psychiatry. vol 21. issue 5. 2017-01-10. PMID:26809844. |
high levels of glucocorticoids produced by the adrenal cortex of the stressed subject reduce neurogenesis, which contributes to the development of depression. |
2017-01-10 |
2023-08-13 |
human |
| Magda M Santana, Joana Rosmaninho-Salgado, Vera Cortez, Frederico C Pereira, Manuella P Kaster, Célia A Aveleira, Marisa Ferreira, Ana Rita Álvaro, Cláudia Cavada. Impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 10. 2016-07-12. PMID:26187454. |
impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress. |
2016-07-12 |
2023-08-13 |
mouse |
| Rivka Ben Dor, Christine E Marx, Lawrence J Shampine, David R Rubinow, Peter J Schmid. DHEA metabolism to the neurosteroid androsterone: a possible mechanism of DHEA's antidepressant action. Psychopharmacology. vol 232. issue 18. 2016-03-17. PMID:26105109. |
in a previous study, the adrenal androgen dhea, a precursor of the neurosteroid androsterone, produced antidepressant and libido-enhancing effects in patients with midlife depression. |
2016-03-17 |
2023-08-13 |
Not clear |