| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Siegfried Kasper, Bruce S McEwe. Neurobiological and clinical effects of the antidepressant tianeptine. CNS drugs. vol 22. issue 1. 2008-02-25. PMID:18072812. |
impairment of neuroplasticity in the hippocampus, amygdala and cortex is hypothesized to be the mechanism by which cognitive function, learning, memory and emotions are altered in depression. |
2008-02-25 |
2023-08-12 |
Not clear |
| Siegfried Kasper, Bruce S McEwe. Neurobiological and clinical effects of the antidepressant tianeptine. CNS drugs. vol 22. issue 1. 2008-02-25. PMID:18072812. |
structural changes in the hippocampus that have been proposed to be associated with depression include dendritic atrophy, reduced levels of cerebral metabolites, decreased adult neurogenesis (generation of new nerve cells) and reduced volume. |
2008-02-25 |
2023-08-12 |
Not clear |
| Vanja Duric, Kenneth E McCarso. Neurokinin-1 (NK-1) receptor and brain-derived neurotrophic factor (BDNF) gene expression is differentially modulated in the rat spinal dorsal horn and hippocampus during inflammatory pain. Molecular pain. vol 3. 2008-02-21. PMID:17974009. |
an opposite effect was observed in the hippocampus, where cfa down-regulated nk-1 receptor and bdnf gene expression, phenomena previously observed in immobilization models of stress and depression. |
2008-02-21 |
2023-08-12 |
rat |
| A Zeller, F Crestani, I Camenisch, T Iwasato, S Itohara, J M Fritschy, U Rudolp. Cortical glutamatergic neurons mediate the motor sedative action of diazepam. Molecular pharmacology. vol 73. issue 2. 2008-02-19. PMID:17965197. |
forebrain-specific alpha1(-/-) mice showed enhanced diazepam-induced motor depression and increased expression of the alpha2 and alpha3 subunits in the neocortex and hippocampus, in comparison with their pseudo-wild-type littermates. |
2008-02-19 |
2023-08-12 |
mouse |
| Christiaan B Brink, Brian H Harvey, Linda Bran. Tianeptine: a novel atypical antidepressant that may provide new insights into the biomolecular basis of depression. Recent patents on CNS drug discovery. vol 1. issue 1. 2008-02-15. PMID:18221189. |
in reliable animal models of depression tianeptine has been shown to prevent neurodegeneration and decreases in hippocampal volume in response to chronic stress. |
2008-02-15 |
2023-08-12 |
Not clear |
| Li-Min Wu, Hui Han, Qu-Nan Wang, Hai-Long Hou, Hui Tong, Xue-Bo Yan, Jiang-Ning Zho. Mifepristone repairs region-dependent alteration of synapsin I in hippocampus in rat model of depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 12. 2008-02-14. PMID:17392736. |
mifepristone repairs region-dependent alteration of synapsin i in hippocampus in rat model of depression. |
2008-02-14 |
2023-08-12 |
rat |
| Li-Min Wu, Hui Han, Qu-Nan Wang, Hai-Long Hou, Hui Tong, Xue-Bo Yan, Jiang-Ning Zho. Mifepristone repairs region-dependent alteration of synapsin I in hippocampus in rat model of depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 12. 2008-02-14. PMID:17392736. |
depression is associated with hippocampal plasticity, for which increased excitatory amino acid (eaa) release in ca3 induced by chronic stress is responsible, and glucocorticoids have a permissive role and act synergistically with eaas in producing neuronal damage. |
2008-02-14 |
2023-08-12 |
rat |
| Li-Min Wu, Hui Han, Qu-Nan Wang, Hai-Long Hou, Hui Tong, Xue-Bo Yan, Jiang-Ning Zho. Mifepristone repairs region-dependent alteration of synapsin I in hippocampus in rat model of depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 12. 2008-02-14. PMID:17392736. |
in the present study, we observed both the expression of hippocampal synapsin i and depression-associated behavior in a rat model of depression induced by chronic unpredictable mild stress (cums). |
2008-02-14 |
2023-08-12 |
rat |
| Jennifer A Ronesi, Kimberly M Hube. Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 2. 2008-02-08. PMID:18184796. |
group i metabotropic glutamate receptors (mglurs) induce a form of long-term synaptic depression (mglur-ltd) in area ca1 of the hippocampus that requires rapid protein synthesis. |
2008-02-08 |
2023-08-12 |
mouse |
| Ja Wook Koo, Ronald S Duma. IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 2. 2008-02-06. PMID:18178625. |
stress decreases neurogenesis in the adult hippocampus, and blockade of this effect is required for the actions of antidepressants in behavioral models of depression. |
2008-02-06 |
2023-08-12 |
mouse |
| Duncan G MacGregor, Andrew P Mallon, Alan L Harvey, Louise Young, Hugh G Nimmo, Trevor W Ston. Group S8A serine proteases, including a novel enzyme cadeprin, induce long-lasting, metabotropic glutamate receptor-dependent synaptic depression in rat hippocampal slices. The European journal of neuroscience. vol 26. issue 7. 2008-01-29. PMID:17897396. |
group s8a serine proteases, including a novel enzyme cadeprin, induce long-lasting, metabotropic glutamate receptor-dependent synaptic depression in rat hippocampal slices. |
2008-01-29 |
2023-08-12 |
rat |
| Qiong Liu, Jin Yu, Wen-Li Mi, Qi-Liang Mao-Ying, Ru Yang, Yan-Qing Wang, Gen-Cheng W. Electroacupuncture attenuates the decrease of hippocampal progenitor cell proliferation in the adult rats exposed to chronic unpredictable stress. Life sciences. vol 81. issue 21-22. 2008-01-09. PMID:17976657. |
the present study was designed to investigate whether electroacupuncture (ea) was beneficial to extenuate the behavioral deficit in a rat model of depression induced by chronic unpredictable stress (cus) and to observe the effect of ea on progenitor cell proliferation in the dentate gyrus (dg) of hippocampus. |
2008-01-09 |
2023-08-12 |
rat |
| Qiong Liu, Jin Yu, Wen-Li Mi, Qi-Liang Mao-Ying, Ru Yang, Yan-Qing Wang, Gen-Cheng W. Electroacupuncture attenuates the decrease of hippocampal progenitor cell proliferation in the adult rats exposed to chronic unpredictable stress. Life sciences. vol 81. issue 21-22. 2008-01-09. PMID:17976657. |
moreover, as shown by 5-bromo-2-deoxyuridine (brdu) labeling immunohistochemistry, hippocampal progenitor cell proliferation was decreased in the dg of depression model rats. |
2008-01-09 |
2023-08-12 |
rat |
| Qiong Liu, Jin Yu, Wen-Li Mi, Qi-Liang Mao-Ying, Ru Yang, Yan-Qing Wang, Gen-Cheng W. Electroacupuncture attenuates the decrease of hippocampal progenitor cell proliferation in the adult rats exposed to chronic unpredictable stress. Life sciences. vol 81. issue 21-22. 2008-01-09. PMID:17976657. |
the study demonstrated a potential antidepressant-like effect of ea treatment on cus induced depression model rats, which might be mediated by up-regulating the hippocampal progenitor cell proliferation. |
2008-01-09 |
2023-08-12 |
rat |
| Jerome J Maller, Z Jeff Daskalakis, Paul B Fitzgeral. Hippocampal volumetrics in depression: the importance of the posterior tail. Hippocampus. vol 17. issue 11. 2008-01-08. PMID:17604352. |
hippocampal volumetrics in depression: the importance of the posterior tail. |
2008-01-08 |
2023-08-12 |
human |
| Jerome J Maller, Z Jeff Daskalakis, Paul B Fitzgeral. Hippocampal volumetrics in depression: the importance of the posterior tail. Hippocampus. vol 17. issue 11. 2008-01-08. PMID:17604352. |
studies of patients with major depression disorder (mdd) have revealed reduced hippocampal volumes, but findings have been inconsistent due to sample and measurement differences. |
2008-01-08 |
2023-08-12 |
human |
| Jerome J Maller, Z Jeff Daskalakis, Paul B Fitzgeral. Hippocampal volumetrics in depression: the importance of the posterior tail. Hippocampus. vol 17. issue 11. 2008-01-08. PMID:17604352. |
the findings of this study indicate that (1) mdd results in reduced hippocampal volume, particularly in the tail section, (2) region of interest (roi) estimation protocols and sample characteristics may help explain volumetric differences between previous mdd studies, and (3) specific roi atrophy in treatment-resistant depression is influenced by sex. |
2008-01-08 |
2023-08-12 |
human |
| Daniel Kondziella, Silje Alvestad, Arne Vaaler, Ursula Sonnewal. Which clinical and experimental data link temporal lobe epilepsy with depression? Journal of neurochemistry. vol 103. issue 6. 2008-01-08. PMID:17887964. |
last, but not least, in temporal lobe epilepsy and depression astrocytes play a role that reaches far beyond their involvement in hippocampal sclerosis and ultimately, therapeutic regulation of glial-neuronal interactions may be a target for future research. |
2008-01-08 |
2023-08-12 |
Not clear |
| Jana K Shirey, Zixiu Xiang, Darren Orton, Ashley E Brady, Kari A Johnson, Richard Williams, Jennifer E Ayala, Alice L Rodriguez, Jürgen Wess, David Weaver, Colleen M Niswender, P Jeffrey Con. An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nature chemical biology. vol 4. issue 1. 2008-01-08. PMID:18059262. |
whole-cell patch clamp recordings revealed that selective potentiation of m4 with vu10010 increases carbachol-induced depression of transmission at excitatory but not inhibitory synapses in the hippocampus. |
2008-01-08 |
2023-08-12 |
mouse |
| Amar Sahay, Rene He. Adult hippocampal neurogenesis in depression. Nature neuroscience. vol 10. issue 9. 2008-01-04. PMID:17726477. |
adult hippocampal neurogenesis in depression. |
2008-01-04 |
2023-08-12 |
Not clear |