| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Y Meltzer, R C Aror. Platelet markers of suicidality. Annals of the New York Academy of Sciences. vol 487. 1987-05-01. PMID:3471162. |
six serotonergic measures in blood platelets, km and vmax of serotonin (5-ht) uptake, kd and bmax of 3h-imipramine binding, 5-ht content, and mao activity, were measured in depressed and other psychiatric patients and related to hamilton depression scale suicide ratings. |
1987-05-01 |
2023-08-11 |
Not clear |
| R W Fulle. Pharmacologic properties of serotonergic agents and antidepressant drugs. The Journal of clinical psychiatry. vol 48 Suppl. 1987-04-17. PMID:3493240. |
selective drugs for modulating serotonergic function will facilitate understanding of the role of serotonin and of specific subtypes of serotonin receptors in depression. |
1987-04-17 |
2023-08-11 |
Not clear |
| L J Siever, E F Coccaro, E Benjamin, K Rubinstein, K L Davi. Adrenergic and serotonergic receptor responsiveness in depression. Ciba Foundation symposium. vol 123. 1987-04-08. PMID:3816411. |
adrenergic and serotonergic receptor responsiveness in depression. |
1987-04-08 |
2023-08-11 |
Not clear |
| L J Siever, E F Coccaro, E Benjamin, K Rubinstein, K L Davi. Adrenergic and serotonergic receptor responsiveness in depression. Ciba Foundation symposium. vol 123. 1987-04-08. PMID:3816411. |
these and related findings are discussed in terms of a possible contributory role of the serotonergic system in depression. |
1987-04-08 |
2023-08-11 |
Not clear |
| R C Arora, H Y Meltze. Effect of subchronic treatment with imipramine, chlorpromazine and the combination on 3H-imipramine binding in rat blood platelets and frontal cortex. Life sciences. vol 39. issue 24. 1987-02-12. PMID:3796194. |
these results, together with previous evidence that the combination has a synergistic effect on down regulation of brain serotonin-2 (5-ht2) receptors, suggest that changes in serotonergic neurotransmission may be relevant to the enhanced efficacy of the combination of tricyclic antidepressants and neuroleptics, compared to either type of drug alone, in the treatment of delusional depression. |
1987-02-12 |
2023-08-11 |
rat |
| H Nagayama, J Akiyoshi, M Tob. Action of chronically administered antidepressants on the serotonergic postsynapse in a model of depression. Pharmacology, biochemistry, and behavior. vol 25. issue 4. 1987-01-13. PMID:3491369. |
action of chronically administered antidepressants on the serotonergic postsynapse in a model of depression. |
1987-01-13 |
2023-08-11 |
human |
| J A Severson, J O Marcusson, H H Osterburg, C E Finch, B Winbla. Elevated density of [3H]imipramine binding in aged human brain. Journal of neurochemistry. vol 45. issue 5. 1985-11-18. PMID:2413170. |
the increase in brain antidepressant binding sites is discussed in relationship to other indices of brain serotonergic function in aging and to the relationship of [3h]imipramine binding and depression. |
1985-11-18 |
2023-08-11 |
mouse |
| V L Perri. Clinical pharmacokinetics of ergotamine in migraine and cluster headache. Clinical pharmacokinetics. vol 10. issue 4. 1985-10-31. PMID:3899452. |
the mode of action of ergotamine in migraine may be by means of selective arterial vasoconstriction on certain cranial vessel beds or, alternatively, by depression of central serotonergic neurons mediating pain transmission or circulatory regulation. |
1985-10-31 |
2023-08-11 |
human |
| J N Hingtgen, R W Fuller, N R Mason, M H Apriso. Blockade of a 5-hydroxytryptophan-induced animal model of depression with a potent and selective 5-HT2 receptor antagonist (LY53857). Biological psychiatry. vol 20. issue 6. 1985-07-08. PMID:3873259. |
these data suggest that the 5-htp-induced depression is mediated by serotonergic mechanisms involving 5-ht2 receptors, as ly53857 is a selective antagonist of these receptors. |
1985-07-08 |
2023-08-11 |
rat |
| G Bartholin. GABA receptor agonists: pharmacological spectrum and therapeutic actions. Medicinal research reviews. vol 5. issue 1. 1985-04-29. PMID:2984490. |
the fact that: (a) gaba receptor agonists and tricyclic antidepressants affect noradrenergic and serotonergic transmission differently; and (b) tricyclic antidepressants alter gaba-related parameters challenges the classical monoamine hypothesis of depression and suggests that gaba-mediated mechanisms play a role in mood disorders. |
1985-04-29 |
2023-08-11 |
human |
| C L Bowden, S H Koslow, I Hanin, J W Maas, J M Davis, E Robin. Effects of amitriptyline and imipramine on brain amine neurotransmitter metabolites in cerebrospinal fluid. Clinical pharmacology and therapeutics. vol 37. issue 3. 1985-04-10. PMID:2578912. |
results provide conclusive evidence of the effects of ami and imi on noradrenergic and serotonergic (but not dopaminergic) systems in patients with depression. |
1985-04-10 |
2023-08-11 |
human |
| J N Hingtgen, H C Hendrie, M H Apriso. Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression. Pharmacology, biochemistry, and behavior. vol 20. issue 3. 1984-05-24. PMID:6608737. |
postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression. |
1984-05-24 |
2023-08-12 |
rat |
| L J Siever, D L Murphy, S Slater, E de la Vega, S Lippe. Plasma prolactin changes following fenfluramine in depressed patients compared to controls: an evaluation of central serotonergic responsivity in depression. Life sciences. vol 34. issue 11. 1984-04-26. PMID:6700367. |
plasma prolactin changes following fenfluramine in depressed patients compared to controls: an evaluation of central serotonergic responsivity in depression. |
1984-04-26 |
2023-08-12 |
Not clear |
| H Y Meltzer, B Umberkoman-Wiita, A Robertson, B J Tricou, M Lowy, R Perlin. Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. I. Enhanced response in depression and mania. Archives of general psychiatry. vol 41. issue 4. 1984-04-24. PMID:6608335. |
these results are consistent with the hypothesis that decreased serotonergic activity, which would be expected to produce increased 5-ht receptor sensitivity, may be present in both depression and mania. |
1984-04-24 |
2023-08-12 |
Not clear |
| G R Heninger, D S Charney, D E Sternber. Serotonergic function in depression. Prolactin response to intravenous tryptophan in depressed patients and healthy subjects. Archives of general psychiatry. vol 41. issue 4. 1984-04-24. PMID:6703856. |
serotonergic function in depression. |
1984-04-24 |
2023-08-12 |
human |
| G R Heninger, D S Charney, D E Sternber. Serotonergic function in depression. Prolactin response to intravenous tryptophan in depressed patients and healthy subjects. Archives of general psychiatry. vol 41. issue 4. 1984-04-24. PMID:6703856. |
the data provide strong support for a possible serotonergic abnormality in depression. |
1984-04-24 |
2023-08-12 |
human |
| O Plaisant, M Leboyer, Q Debray, Y Pelicie. [The concept of serotonergic depression]. Annales de medecine interne. vol 134. issue 8. 1984-03-21. PMID:6198949. |
[the concept of serotonergic depression]. |
1984-03-21 |
2023-08-12 |
Not clear |
| C de Montign. Electroconvulsive shock treatments enhance responsiveness of forebrain neurons to serotonin. The Journal of pharmacology and experimental therapeutics. vol 228. issue 1. 1984-02-29. PMID:6319668. |
inasmuch as long-term tricyclic antidepressant drug administration has been shown to produce a similar sensitization to serotonin, the present results suggest that enhancement of serotonergic neurotransmission might mediate the therapeutic effect of both types of treatment in major depression. |
1984-02-29 |
2023-08-12 |
rat |
| A Cardona, P Rudomi. Activation of brainstem serotoninergic pathways decreases homosynaptic depression of monosynaptic responses of frog spinal motoneurons. Brain research. vol 280. issue 2. 1984-02-14. PMID:6652498. |
these observations show that the magnitude of the homosynaptic depression of monosynaptic responses of motoneurons can be controlled by descending serotonergic mechanisms. |
1984-02-14 |
2023-08-12 |
Not clear |
| H Y Meltzer, B Uberkoman-Wiita, A Robertson, B J Tricou, M Low. Enhanced serum cortisol response to 5-hydroxytryptophan in depression and mania. Life sciences. vol 33. issue 25. 1984-01-26. PMID:6645813. |
in view of evidence for decreased brain serotonergic activity in depression and perhaps mania, the results suggest at least some serotonin receptors may be supersensitive in some patients with affective disorders. |
1984-01-26 |
2023-08-12 |
Not clear |