| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M Lakoski, G K Aghajania. Effects of histamine, H1- and H2-receptor antagonists on the activity of serotonergic neurons in the dorsal raphe nucleus. The Journal of pharmacology and experimental therapeutics. vol 227. issue 2. 1983-12-17. PMID:6138428. |
application of histamine at low iontophoretic currents (1-5 na) produced a rapid depression of the firing of all serotonergic neurons tested. |
1983-12-17 |
2023-08-12 |
rat |
| L J Siever, T W Uhde, D C Jimerson, M S Kafka, C R Lake, S Targum, D L Murph. Clinical studies of monoamine receptors in the affective disorders and receptor changes with antidepressant treatment. Progress in neuro-psychopharmacology & biological psychiatry. vol 7. issue 2-3. 1983-10-28. PMID:6310694. |
the prolactin increase in response to fenfluramine is less in depressed patients compared to controls suggesting decreased functional activity of the serotonergic system in depression. |
1983-10-28 |
2023-08-12 |
Not clear |
| A Gratto. Time course analysis of para-chlorophenylalanine induced suppression of self-stimulation behavior. Pharmacology, biochemistry, and behavior. vol 17. issue 4. 1983-02-25. PMID:6217466. |
the hypothesis of a serotonergic basis of reward rests partly on data showing that serotonin (5-ht) depletion by para-chlorophenylalanine (p-cpa) causes depression of self-stimulation (ss) rates. |
1983-02-25 |
2023-08-12 |
Not clear |
| R D Kaplan, J J Man. Altered platelet serotonin uptake kinetics in schizophrenia and depression. Life sciences. vol 31. issue 6. 1982-12-21. PMID:7132568. |
this alteration, if present in central serotonergic neurons, may play a role in the etiology and pathogenesis of depression and schizophrenia. |
1982-12-21 |
2023-08-12 |
Not clear |
| L R Meyerson, L P Wennogle, M S Abel, J Coupet, A S Lippa, C E Rauh, B Bee. Human brain receptor alterations in suicide victims. Pharmacology, biochemistry, and behavior. vol 17. issue 1. 1982-12-02. PMID:6289359. |
the attendant roles of serotonergic and muscarinic-cholinergic processes in the psychobiology of suicide and depression are addressed. |
1982-12-02 |
2023-08-12 |
human |
| C Bakhit, J W Gib. Methamphetamine-induced depression of tryptophan hydroxylase: recovery following acute treatment. European journal of pharmacology. vol 76. issue 2-3. 1982-05-21. PMID:6120843. |
the depression was observed in several serotonergic nerve terminal regions of the rat brain and spinal cord. |
1982-05-21 |
2023-08-12 |
rat |
| J N Ghia, R A Mueller, G H Duncan, D S Scott, W Ma. Serotonergic activity in man as a function of pain, pain mechanisms, and depression. Anesthesia and analgesia. vol 60. issue 12. 1982-02-25. PMID:6172060. |
serotonergic activity in man as a function of pain, pain mechanisms, and depression. |
1982-02-25 |
2023-08-12 |
Not clear |
| R Takahashi, T Tateishi, H Yoshida, H Nagayama, K H Tachik. Serotonin metabolism of animal model of depression. Advances in experimental medicine and biology. vol 133. 1982-02-12. PMID:6172020. |
all results presented here would indicate that serotonin plays an important role in animal behavior such as locomotor depression and that, taking into consideration the effects of antidepressants on 5-ht receptor activity as well as recent biochemical findings of human depression, some forms of human depression could be induced by a cerebral serotonergic receptor hyperactivity contrary to a conventional theory of serotonin deficiency in the synaptic cleft in the brain. |
1982-02-12 |
2023-08-12 |
human |
| M H Aprison, J N Hingtge. Hypersensitive serotonergic receptors: a new hypothesis for one subgroup of unipolar depression derived from an animal model. Advances in experimental medicine and biology. vol 133. 1982-02-12. PMID:6976074. |
hypersensitive serotonergic receptors: a new hypothesis for one subgroup of unipolar depression derived from an animal model. |
1982-02-12 |
2023-08-12 |
Not clear |
| V Bhargava, A Salamy, S Sha. Role of serotonin in the nicotine-induced depression of the brainstem auditory evoked response. Pharmacology, biochemistry, and behavior. vol 15. issue 4. 1981-12-22. PMID:6457306. |
we have examined the role of serotonergic and/or dopaminergic mechanism in the mediation of the nicotine-induced depression of brainstem auditory evoked responses (baer) to auditory stimuli. |
1981-12-22 |
2023-08-12 |
Not clear |
| V Bhargava, A Salamy, S Sha. Role of serotonin in the nicotine-induced depression of the brainstem auditory evoked response. Pharmacology, biochemistry, and behavior. vol 15. issue 4. 1981-12-22. PMID:6457306. |
these data thus suggest a role for serotonergic mechanisms in the mediation of nicotine-induced depression of the brainstem auditory pathway. |
1981-12-22 |
2023-08-12 |
Not clear |
| M E Trulson, J Heym, B L Jacob. Dissociations between the effects of hallucinogenic drugs on behavior and raphe unit activity in freely moving cats. Brain research. vol 215. issue 1-2. 1981-10-14. PMID:6114779. |
the hypothesis that the action of hallucinogenic drugs is mediated by a depression of the activity of brain serotonergic (raphe) neurons was tested by examining the behavioral effects of several hallucinogenic drugs while concurrently monitoring the activity of raphe neurons in freely moving cats. |
1981-10-14 |
2023-08-12 |
Not clear |
| R E Chapin, G R Breese, R A Muelle. Antagonism of ethanol-induced decrease in LH by para-chlorophenylalanine: lack of correlation with altered serotonergic mechanisms. Pharmacology, biochemistry, and behavior. vol 14. issue 3. 1981-07-23. PMID:6453351. |
since ethanol may interact with central serotonergic (5ht) neurons, and since 5ht systems have been found to play a role in modulating lh release, we examined the possible role of central serotonergic neurons in the ethanol-induced depression of lh. |
1981-07-23 |
2023-08-12 |
Not clear |
| R E Chapin, G R Breese, R A Muelle. Antagonism of ethanol-induced decrease in LH by para-chlorophenylalanine: lack of correlation with altered serotonergic mechanisms. Pharmacology, biochemistry, and behavior. vol 14. issue 3. 1981-07-23. PMID:6453351. |
x 3 days before ethanol) produced similar reductions in hypothalamic 5ht but did not block the ethanol effect, and because electrolytic lesions of the median raphe nucleus were also ineffective in preventing the post-ethanol depression of lh, we conclude that activation of serotonergic systems does not play a major role in the ethanol induced depression of lh. |
1981-07-23 |
2023-08-12 |
Not clear |
| A A Borbély, H U Neuhaus, I Toble. Effect of p-chlorophenylalanine and tryptophan on sleep, EEG and motor activity in the rat. Behavioural brain research. vol 2. issue 1. 1981-07-20. PMID:6452888. |
the experiments show that the depression of sws and rems, and the hyperactivity 1-2 days after pcpa administration, are a consequence of the reduced 5-ht level, whereas the involvement of serotonergic mechanisms in the initial sedative phase and in the recovery phase is less clear. |
1981-07-20 |
2023-08-12 |
rat |
| H Nagayama, J N Hingtgen, M H Apriso. Pre- and postsynaptic serotonergic manipulations in an animal model of depression. Pharmacology, biochemistry, and behavior. vol 13. issue 4. 1981-01-29. PMID:6968915. |
pre- and postsynaptic serotonergic manipulations in an animal model of depression. |
1981-01-29 |
2023-08-12 |
human |
| A Coppen, K Woo. Adrenergic and serotonergic mechanisms in depression and their response to amitriptyline. Ciba Foundation symposium. issue 74. 1980-11-24. PMID:261682. |
adrenergic and serotonergic mechanisms in depression and their response to amitriptyline. |
1980-11-24 |
2023-08-11 |
Not clear |
| A Coppen, K M Woo. Peripheral serotonergic and adrenergic responses in depression. Acta psychiatrica Scandinavica. Supplementum. vol 280. 1980-10-24. PMID:6931476. |
peripheral serotonergic and adrenergic responses in depression. |
1980-10-24 |
2023-08-12 |
Not clear |
| H Francès, Y Lecrubier, A J Puech, P Simo. Evidence for the role of noradrenaline in some effects of quipazine. Psychopharmacology. vol 67. issue 3. 1980-08-25. PMID:6770410. |
quipazine, in addition to its well-known serotonergic effects, seems to have beta-adrenergic properties which should be kept in mind when this drug is used as a pharmacological tool and which suggest that the beta-adrenergic system is implied in depression. |
1980-08-25 |
2023-08-12 |
mouse |
| D B Lundberg, R A Mueller, G R Brees. An evaluation of the mechanism by which serotonergic activation depresses respiration. The Journal of pharmacology and experimental therapeutics. vol 212. issue 3. 1980-05-23. PMID:6965719. |
the present investigation attempted to determine if the previously reported depression of respiration by serotonergic agonists was a result of peripheral or central nervous system drug effects. |
1980-05-23 |
2023-08-12 |
rat |