| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Desmond Campbell, Michael James Green, Neil Davies, Evangelia Demou, Laura D Howe, Sean Harrison, Daniel J Smith, David M Howard, Andrew M McIntosh, Marcus Munafò, Srinivasa Vittal Katikiredd. Effects of depression on employment and social outcomes: a Mendelian randomisation study. Journal of epidemiology and community health. 2022-03-23. PMID:35318279. |
we used mendelian randomisation (mr) to investigate whether depression affects employment and related outcomes in the uk biobank dataset. |
2022-03-23 |
2023-08-13 |
Not clear |
| Yue-Ting Deng, Ya-Nan Ou, Bang-Sheng Wu, Yu-Xiang Yang, Yan Jiang, Yu-Yuan Huang, Yi Liu, Lan Tan, Qiang Dong, John Suckling, Fei Li, Jin-Tai Y. Identifying causal genes for depression via integration of the proteome and transcriptome from brain and blood. Molecular psychiatry. 2022-03-17. PMID:35296807. |
addressing this, we aimed to highlight potentially causal genes by systematically integrating the brain and blood protein and expression quantitative trait loci (qtl) data with a depression gwas dataset via a statistical framework including mendelian randomization (mr), bayesian colocalization, and steiger filtering analysis. |
2022-03-17 |
2023-08-13 |
Not clear |
| Min Zhang, Jing Chen, Zhiqun Yin, Lanbing Wang, Lihua Pen. The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study. Translational psychiatry. vol 11. issue 1. 2021-12-14. PMID:34903730. |
we performed a bidirectional two-sample mendelian randomization (mr) study using summary-level data from the most comprehensive genome-wide association studies (gwas) of depression (n = 2,113,907), mets (n = 291,107), waist circumference (n = 462,166), hypertension (n = 463,010) fasting blood glucose (fbg, n = 281,416), triglycerides (n = 441,016), high-density lipoprotein cholesterol (hdl-c, n = 403,943). |
2021-12-14 |
2023-08-13 |
Not clear |
| Francesco Casanova, Jessica O'Loughlin, Susan Martin, Robin N Beaumont, Andrew R Wood, Edward R Watkins, Rachel M Freathy, Saskia P Hagenaars, Timothy M Frayling, Hanieh Yaghootkar, Jess Tyrrel. Higher adiposity and mental health: causal inference using Mendelian randomization. Human molecular genetics. vol 30. issue 24. 2021-12-08. PMID:34270736. |
two-sample mr provided evidence that a genetically determined one standard deviation (1-sd) higher bmi (4.6 kg/m2) was associated with higher odds of current depression [or: 1.50, 95%ci: 1.15, 1.95] and lower well-being [ß: -0.15, 95%ci: -0.26, -0.04]. |
2021-12-08 |
2023-08-13 |
human |
| Tiffany C Ho, Lucinda M Sisk, Artenisa Kulla, Giana I Teresi, Melissa M Hansen, Hua Wu, Ian H Gotli. Sex differences in myelin content of white matter tracts in adolescents with depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 13. 2021-11-22. PMID:34215842. |
here, we used multimodal mr imaging to characterize myelin, indexed by r1, in white matter tracts previously associated with depression and compare 48 adolescents with lifetime depression (45 with current depression, 3 remitted) and 35 healthy controls in r1. |
2021-11-22 |
2023-08-13 |
Not clear |
| Ryan Arathimos, Amy Ronaldson, Laurence J Howe, Chiara Fabbri, Saskia Hagenaars, Matthew Hotopf, Fiona Gaughran, Cathryn M Lewis, Alexandru Drega. Vitamin D and the risk of treatment-resistant and atypical depression: A Mendelian randomization study. Translational psychiatry. vol 11. issue 1. 2021-11-09. PMID:34737282. |
our comprehensive investigations indicated some evidence of an association between vitamin d and trd/ad observationally, but little evidence of association when using prs and mr, mirroring findings of genetic studies of vitamin d on broad depression phenotypes. |
2021-11-09 |
2023-08-13 |
Not clear |
| Jiao Luo, Zhongwei Xu, Raymond Noordam, Diana van Heemst, Ruifang Li-Ga. Depression and Inflammatory Bowel Disease: A Bidirectional two-sample Mendelian Randomization Study. Journal of Crohn's & colitis. 2021-11-05. PMID:34739073. |
we investigated the association between depression and ibd by using bidirectional two-sample mendelian randomization (mr). |
2021-11-05 |
2023-08-13 |
Not clear |
| Weihui Zhang, Elizabeth Vásquez, Anda Botoseneanu, Recai Yuce. Metabolic Risk and Depression among Elderly Mexican Americans: The Roles of Nativity Status. Ethnicity & disease. vol 31. issue 2. 2021-10-26. PMID:33883865. |
to evaluate the relationship between metabolic risk (mr) and depression in a sample of older mexican americans and examine whether the association differs by age at migration. |
2021-10-26 |
2023-08-13 |
Not clear |
| Kate E M Godfrey, Suresh D Muthukumaraswamy, Cathy M Stinear, Nicholas Hoe. Effect of rTMS on GABA and glutamate levels in treatment-resistant depression: An MR spectroscopy study. Psychiatry research. Neuroimaging. vol 317. 2021-10-25. PMID:34479176. |
effect of rtms on gaba and glutamate levels in treatment-resistant depression: an mr spectroscopy study. |
2021-10-25 |
2023-08-13 |
Not clear |
| Stefanie Binzer, Xia Jiang, Jan Hillert, Ali Manouchehrini. Depression and multiple sclerosis: A bidirectional Mendelian randomisation study. Multiple sclerosis (Houndmills, Basingstoke, England). vol 27. issue 11. 2021-10-21. PMID:33605804. |
in this study, we examined a putative causal relationship between depression and ms using a bidirectional mendelian randomisation (mr) framework. |
2021-10-21 |
2023-08-13 |
Not clear |
| Balwinder Singh, John D Port, Jennifer L Vande Voort, Brandon J Coombes, Jennifer R Geske, Ian R Lanza, Robert J Morgan, Mark A Fry. A preliminary study of the association of increased anterior cingulate gamma-aminobutyric acid with remission of depression after ketamine administration. Psychiatry research. vol 301. 2021-10-14. PMID:33933839. |
seven patients with treatment-resistant depression enrolled in an open-label, feasibility trial of a single iv 40-min ketamine infusion during a functional mr spectroscopy (fmrs) scan utilizing a novel frequency adjusting mega-press sequence. |
2021-10-14 |
2023-08-13 |
Not clear |
| Shaoqiang Han, Ruiping Zheng, Shuying Li, Liang Liu, Caihong Wang, Yu Jiang, Mengmeng Wen, Bingqian Zhou, Yarui Wei, Jianyue Pang, Hengfen Li, Yong Zhang, Yuan Chen, Jingliang Chen. Progressive brain structural abnormality in depression assessed with MR imaging by using causal network analysis. Psychological medicine. 2021-09-29. PMID:34583785. |
progressive brain structural abnormality in depression assessed with mr imaging by using causal network analysis. |
2021-09-29 |
2023-08-13 |
Not clear |
| Anwar Mulugeta, Amanda Lumsden, Elina Hyppöne. Relationship between Serum 25(OH)D and Depression: Causal Evidence from a Bi-Directional Mendelian Randomization Study. Nutrients. vol 13. issue 1. 2021-09-07. PMID:33396887. |
we examined the causality and direction of the relationship between 25-hydroxyvitamin d (25(oh)d) and depression in bi-directional mendelian randomization (mr) analyses using information from up to 307,618 white british participants from the uk biobank and summary results from the sunlight ( |
2021-09-07 |
2023-08-13 |
human |
| Xiong Chen, Jianqiu Kong, Xiayao Diao, Jiahao Cai, Junjiong Zheng, Weibin Xie, Haide Qin, Jian Huang, Tianxin Li. Depression and prostate cancer risk: A Mendelian randomization study. Cancer medicine. vol 9. issue 23. 2021-07-21. PMID:33027558. |
we aimed to assess the causal effect of depression on pca using the two-sample mendelian randomization (mr) method. |
2021-07-21 |
2023-08-13 |
Not clear |
| Bhedita J Seewoo, Lauren A Hennessy, Kirk W Feindel, Sarah J Etherington, Paul E Croarkin, Jennifer Rodge. Validation of Chronic Restraint Stress Model in Young Adult Rats for the Study of Depression Using Longitudinal Multimodal MR Imaging. eNeuro. vol 7. issue 4. 2021-06-18. PMID:32669346. |
validation of chronic restraint stress model in young adult rats for the study of depression using longitudinal multimodal mr imaging. |
2021-06-18 |
2023-08-13 |
human |
| Harald Murck, Christian Adolf, Anna Schneider, Lena Schlageter, Daniel Heinrich, Katrin Ritzel, Lisa Sturm, Marcus Quinkler, Felix Beuschlein, Martin Reincke, Heike Künze. Differential effects of reduced mineralocorticoid receptor activation by unilateral adrenalectomy vs mineralocorticoid antagonist treatment in patients with primary aldosteronism - Implications for depression and anxiety. Journal of psychiatric research. vol 137. 2021-05-20. PMID:33761426. |
these data suggest different mechanistic pathways for depression and anxiety mediated via the mr. for treatment of depression a reduction of aldosterone levels might be relevant at cns locations specific for aldosterone, whereas mra targets mr more broadly, including areas, where cortisol is the main ligand. |
2021-05-20 |
2023-08-13 |
Not clear |
| Harald Murck, Christian Adolf, Anna Schneider, Lena Schlageter, Daniel Heinrich, Katrin Ritzel, Lisa Sturm, Marcus Quinkler, Felix Beuschlein, Martin Reincke, Heike Künze. Differential effects of reduced mineralocorticoid receptor activation by unilateral adrenalectomy vs mineralocorticoid antagonist treatment in patients with primary aldosteronism - Implications for depression and anxiety. Journal of psychiatric research. vol 137. 2021-05-20. PMID:33761426. |
the mineralocorticoid receptor (mr) and its ligand aldosterone have been found to play a major role in the pathophysiology of depression. |
2021-05-20 |
2023-08-13 |
Not clear |
| J K van Niekerk, M Middeldorp, L L Guan, M A Steel. Preweaning to postweaning rumen papillae structural growth, ruminal fermentation characteristics, and acute-phase proteins in calves. Journal of dairy science. vol 104. issue 3. 2021-04-14. PMID:33455747. |
further, the observed prolonged ruminal ph depression suggests that dietary rumen adaptation after weaning can take several weeks in calves with a high mr feeding rate preweaning. |
2021-04-14 |
2023-08-13 |
Not clear |
| Sylvain Giroud, Caroline Habold, Roberto F Nespolo, Carlos Mejías, Jérémy Terrien, Samantha M Logan, Robert H Henning, Kenneth B Store. The Torpid State: Recent Advances in Metabolic Adaptations and Protective Mechanisms Frontiers in physiology. vol 11. 2021-02-10. PMID:33551846. |
this notably includes the endocrine changes involved in fat- and food-storing hibernating species, explaining biomedical implications of mr depression. |
2021-02-10 |
2023-08-13 |
Not clear |
| Koji Shinoda, Takuya Matsushita, Yuri Nakamura, Katsuhisa Masaki, Shiori Sakai, Haruka Nomiyama, Osamu Togao, Akio Hiwatashi, Masaaki Niino, Noriko Isobe, Jun-Ichi Kir. Contribution of cortical lesions to cognitive impairment in Japanese patients with multiple sclerosis. Scientific reports. vol 10. issue 1. 2020-12-16. PMID:32251297. |
however, the contribution of cls to cognitive impairment remains unclear in asian ms. sixty-one prospectively enrolled ms patients underwent three-dimensional double inversion recovery mr imaging, the brief repeatable battery of neuropsychological tests (brb-n), the apathy scale (as), the fatigue questionnaire (fq), and the hospital anxiety and depression scale (hads) within a 1-week period. |
2020-12-16 |
2023-08-13 |
Not clear |