| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Evangelos Handakas, Yiwen Xu, Alexa Blair Segal, Maria Carmen Huerta, Kirsty Bowman, Laura D Howe, Franco Sassi, Oliver Robinso. Molecular mediators of the association between child obesity and mental health. Frontiers in genetics. vol 13. 2022-09-19. PMID:36118877. |
in mr analysis, one unit increase in tyrosine was associated with 0.13 higher log odds of depression ( |
2022-09-19 |
2023-08-14 |
Not clear |
| Bastian Bruns, Ricarda Daub, Thomas Schmitz, Maria Hamze-Sinno, Sebastian Spaich, Matthias Dewenter, Chrysovalandis Schwale, Peter Gass, Miriam Vogt, Hugo Katus, Wolfgang Herzog, Hans-Christoph Friederich, Norbert Frey, Jobst-Hendrik Schultz, Johannes Back. Forebrain corticosteroid receptors promote post-myocardial infarction depression and mortality. Basic research in cardiology. vol 117. issue 1. 2022-09-06. PMID:36068417. |
impaired central mineralocorticoid (mr) and glucocorticoid receptor (gr) equilibrium has been suggested as a key mechanism in the pathogenesis of human depression. |
2022-09-06 |
2023-08-14 |
mouse |
| D Galan, B I Perry, V Warrier, C C Davidson, O Stupart, D Easton, G M Khandaker, G K Murra. Applying Mendelian randomization to appraise causality in relationships between smoking, depression and inflammation. Scientific reports. vol 12. issue 1. 2022-09-03. PMID:36057695. |
we performed inverse variance weighted mendelian randomization (mr) analyses using recently published summary-level gwas data for lifetime smoking index, crp levels, and depression. |
2022-09-03 |
2023-08-14 |
Not clear |
| E Wu, Jun-Tao Ni, Tian Xie, Lin Ta. Noncausal effects of genetic predicted depression and colorectal cancer risk: A Mendelian randomization study. Medicine. vol 101. issue 34. 2022-08-31. PMID:36042675. |
this study aimed to evaluate the potential causal association between genetic variants related to depression and the risk of crc using mendelian randomization (mr). |
2022-08-31 |
2023-08-14 |
Not clear |
| E Wu, Jun-Tao Ni, Tian Xie, Lin Ta. Noncausal effects of genetic predicted depression and colorectal cancer risk: A Mendelian randomization study. Medicine. vol 101. issue 34. 2022-08-31. PMID:36042675. |
two-sample mr analysis using summary data was performed to examine whether depression was causally associated with crc risk. |
2022-08-31 |
2023-08-14 |
Not clear |
| E Wu, Jun-Tao Ni, Tian Xie, Lin Ta. Noncausal effects of genetic predicted depression and colorectal cancer risk: A Mendelian randomization study. Medicine. vol 101. issue 34. 2022-08-31. PMID:36042675. |
based on the results of mr using inverse-variance weighted method, we found that genetically determined major depressive disorder (odds ratio = 1.06, 95% confidence interval = 0.77-1.45) or major depression (odds ratio = 0.77, 95% confidence interval = 0.57-1.04) did not causally increase crc risk. |
2022-08-31 |
2023-08-14 |
Not clear |
| E Wu, Jun-Tao Ni, Tian Xie, Lin Ta. Noncausal effects of genetic predicted depression and colorectal cancer risk: A Mendelian randomization study. Medicine. vol 101. issue 34. 2022-08-31. PMID:36042675. |
the two-sample mr analysis showed that depression is not causally associated with crc risk. |
2022-08-31 |
2023-08-14 |
Not clear |
| Jiahao Zhu, Nini Wang, Houpu Liu, Han Jiang, Bingyue Cai, Dingwan Chen, Yingjun L. Multisite chronic pain as a causal risk factor for coronary artery disease: findings from Mendelian randomization. Pain. 2022-08-02. PMID:35916731. |
we then conducted mr mediation analyses to establish whether body mass index (bmi), smoking, and depression causally mediate any association. |
2022-08-02 |
2023-08-14 |
Not clear |
| Jiahao Zhu, Nini Wang, Houpu Liu, Han Jiang, Bingyue Cai, Dingwan Chen, Yingjun L. Multisite chronic pain as a causal risk factor for coronary artery disease: findings from Mendelian randomization. Pain. 2022-08-02. PMID:35916731. |
in multivariable mr analyses, the excess risk of coronary artery disease was attenuated after adjusting for bmi (or 1.43, 95% ci 1.05 to 1.93), smoking (or 1.49, 95% ci 1.11 to 2.00), depression (or 1.44, 95% ci 1.03 to 2.01), and three risk factors combined (or 1.34, 95% ci 0.88 to 2.05). |
2022-08-02 |
2023-08-14 |
Not clear |
| Shi Yao, Meng Zhang, Shan-Shan Dong, Jia-Hao Wang, Kun Zhang, Jing Guo, Yan Guo, Tie-Lin Yan. Bidirectional two-sample Mendelian randomization analysis identifies causal associations between relative carbohydrate intake and depression. Nature human behaviour. 2022-07-19. PMID:35851841. |
mr evidence suggested a causal relationship between higher relative carbohydrate intake and lower depression risk (odds ratio, 0.42 for depression per one-standard-deviation increment in relative carbohydrate intake; 95% confidence interval, 0.28 to 0.62; p = 1.49 × 10 |
2022-07-19 |
2023-08-14 |
Not clear |
| Frances M K Williams, Elizaveta E Elgaeva, Maxim B Freidin, Olga O Zaytseva, Yurii S Aulchenko, Yakov A Tsepilov, Pradeep Sur. Causal effects of psychosocial factors on chronic back pain: a bidirectional Mendelian randomisation study. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 2022-06-06. PMID:35662366. |
we conducted a bi-directional mendelian randomisation (mr) study to examine the causal effects of risk factors (education, smoking, alcohol consumption, physical activity, sleep and depression) on cbp and the causal effect of cbp on the same risk factors. |
2022-06-06 |
2023-08-14 |
Not clear |
| Michela Michielli, Brian Cohe. Cortisol Receptor Sensitivity as a Risk Factor for Depression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560510. |
analysis of the data yielded no significant correlation between snps relating to gr or mr and depression as scored by the beck depression inventory (bdi). |
2022-05-13 |
2023-08-13 |
Not clear |
| Ji-Yu Zhao, Jing Yan, Hong-Yang Wang, Qing-Qing Liu, Tian-Sheng Zhang, Chong-Yao Ha. [Effect of wheat-grain moxibustion on the expression of 5-HT and cortisol in the serum, and MR and GR in the hippocampus in rats with hypothyroidism complicated with depression]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 42. issue 5. 2022-05-11. PMID:35543943. |
[effect of wheat-grain moxibustion on the expression of 5-ht and cortisol in the serum, and mr and gr in the hippocampus in rats with hypothyroidism complicated with depression]. |
2022-05-11 |
2023-08-13 |
rat |
| Ji-Yu Zhao, Jing Yan, Hong-Yang Wang, Qing-Qing Liu, Tian-Sheng Zhang, Chong-Yao Ha. [Effect of wheat-grain moxibustion on the expression of 5-HT and cortisol in the serum, and MR and GR in the hippocampus in rats with hypothyroidism complicated with depression]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 42. issue 5. 2022-05-11. PMID:35543943. |
to observe the effect of wheat-grain moxibustion on behavior, 5-hydroxytryptamine (5-ht) and cortisol in the serum, mineralocorticoid receptor (mr) and glucocorticoid receptor (gr) in the hippocampus in rats with hypothyroidism complicated with depression, and to explore the possible mechanism of wheat-grain moxibustion on improving depression in rats with hypothyroidism. |
2022-05-11 |
2023-08-13 |
rat |
| Desmond Campbell, Michael James Green, Neil Davies, Evangelia Demou, Laura D Howe, Sean Harrison, Daniel J Smith, David M Howard, Andrew M McIntosh, Marcus Munafò, Srinivasa Vittal Katikiredd. Effects of depression on employment and social outcomes: a Mendelian randomisation study. Journal of epidemiology and community health. 2022-03-23. PMID:35318279. |
we used mendelian randomisation (mr) to investigate whether depression affects employment and related outcomes in the uk biobank dataset. |
2022-03-23 |
2023-08-13 |
Not clear |
| Yue-Ting Deng, Ya-Nan Ou, Bang-Sheng Wu, Yu-Xiang Yang, Yan Jiang, Yu-Yuan Huang, Yi Liu, Lan Tan, Qiang Dong, John Suckling, Fei Li, Jin-Tai Y. Identifying causal genes for depression via integration of the proteome and transcriptome from brain and blood. Molecular psychiatry. 2022-03-17. PMID:35296807. |
addressing this, we aimed to highlight potentially causal genes by systematically integrating the brain and blood protein and expression quantitative trait loci (qtl) data with a depression gwas dataset via a statistical framework including mendelian randomization (mr), bayesian colocalization, and steiger filtering analysis. |
2022-03-17 |
2023-08-13 |
Not clear |
| Min Zhang, Jing Chen, Zhiqun Yin, Lanbing Wang, Lihua Pen. The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study. Translational psychiatry. vol 11. issue 1. 2021-12-14. PMID:34903730. |
we performed a bidirectional two-sample mendelian randomization (mr) study using summary-level data from the most comprehensive genome-wide association studies (gwas) of depression (n = 2,113,907), mets (n = 291,107), waist circumference (n = 462,166), hypertension (n = 463,010) fasting blood glucose (fbg, n = 281,416), triglycerides (n = 441,016), high-density lipoprotein cholesterol (hdl-c, n = 403,943). |
2021-12-14 |
2023-08-13 |
Not clear |
| Francesco Casanova, Jessica O'Loughlin, Susan Martin, Robin N Beaumont, Andrew R Wood, Edward R Watkins, Rachel M Freathy, Saskia P Hagenaars, Timothy M Frayling, Hanieh Yaghootkar, Jess Tyrrel. Higher adiposity and mental health: causal inference using Mendelian randomization. Human molecular genetics. vol 30. issue 24. 2021-12-08. PMID:34270736. |
two-sample mr provided evidence that a genetically determined one standard deviation (1-sd) higher bmi (4.6 kg/m2) was associated with higher odds of current depression [or: 1.50, 95%ci: 1.15, 1.95] and lower well-being [ß: -0.15, 95%ci: -0.26, -0.04]. |
2021-12-08 |
2023-08-13 |
human |
| Tiffany C Ho, Lucinda M Sisk, Artenisa Kulla, Giana I Teresi, Melissa M Hansen, Hua Wu, Ian H Gotli. Sex differences in myelin content of white matter tracts in adolescents with depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 13. 2021-11-22. PMID:34215842. |
here, we used multimodal mr imaging to characterize myelin, indexed by r1, in white matter tracts previously associated with depression and compare 48 adolescents with lifetime depression (45 with current depression, 3 remitted) and 35 healthy controls in r1. |
2021-11-22 |
2023-08-13 |
Not clear |
| Ryan Arathimos, Amy Ronaldson, Laurence J Howe, Chiara Fabbri, Saskia Hagenaars, Matthew Hotopf, Fiona Gaughran, Cathryn M Lewis, Alexandru Drega. Vitamin D and the risk of treatment-resistant and atypical depression: A Mendelian randomization study. Translational psychiatry. vol 11. issue 1. 2021-11-09. PMID:34737282. |
our comprehensive investigations indicated some evidence of an association between vitamin d and trd/ad observationally, but little evidence of association when using prs and mr, mirroring findings of genetic studies of vitamin d on broad depression phenotypes. |
2021-11-09 |
2023-08-13 |
Not clear |