| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mengyang Chu, Shengxian Shen, Zhenlai Zhu, Zhiguo Li, Yaxing Bai, Jingyi Ma, Junfeng Hao, Lei Wang, Meng Fu, Erle Dang, Gang Wang, Shuai Sha. Association of psoriasis with depression, anxiety, and suicidality: A bidirectional two-sample Mendelian randomization study. The Journal of dermatology. 2023-09-12. PMID:37697936. |
to investigate the cause-effect relationships between psoriasis and mental disorders including depression, anxiety, and suicidality, we conducted a bidirectional two-sample mendelian randomization (mr) study utilizing summary statistics from the most comprehensive genome-wide association studies of psoriasis (n = 306 123), broad depression (n = 500 199), major depressive disorder (n = 173 005), anxiety (n = 17 310), and suicide attempts (n = 50 264). |
2023-09-12 |
2023-10-07 |
Not clear |
| Mengyang Chu, Shengxian Shen, Zhenlai Zhu, Zhiguo Li, Yaxing Bai, Jingyi Ma, Junfeng Hao, Lei Wang, Meng Fu, Erle Dang, Gang Wang, Shuai Sha. Association of psoriasis with depression, anxiety, and suicidality: A bidirectional two-sample Mendelian randomization study. The Journal of dermatology. 2023-09-12. PMID:37697936. |
using the random-effects inverse-variance weighted method as primary method, the forward mr analyses indicated that psoriasis was significantly associated with higher odds of broad depression (odds ratio [or] 1.030, 95% confidence interval [ci] 1.010-1.051, p = 0.003) and suggestively associated with an increased risk of major depressive disorder (or 1.054, 95% ci 1.002-1.109, p = 0.040), but not with the risk of anxiety (p = 0.160) or suicide attempts (p = 0.648). |
2023-09-12 |
2023-10-07 |
Not clear |
| Mengyang Chu, Shengxian Shen, Zhenlai Zhu, Zhiguo Li, Yaxing Bai, Jingyi Ma, Junfeng Hao, Lei Wang, Meng Fu, Erle Dang, Gang Wang, Shuai Sha. Association of psoriasis with depression, anxiety, and suicidality: A bidirectional two-sample Mendelian randomization study. The Journal of dermatology. 2023-09-12. PMID:37697936. |
in reverse mr analyses, significant causal impact of broad depression (or 1.363, 95% ci 1.103-1.684, p = 0.004) and major depressive disorder (or 1.890, 95% ci 1.285-2.781, p = 0.001), but not anxiety (p = 0.787) and suicide attempts (p = 0.961) on psoriasis risk was observed. |
2023-09-12 |
2023-10-07 |
Not clear |
| Mengyang Chu, Shengxian Shen, Zhenlai Zhu, Zhiguo Li, Yaxing Bai, Jingyi Ma, Junfeng Hao, Lei Wang, Meng Fu, Erle Dang, Gang Wang, Shuai Sha. Association of psoriasis with depression, anxiety, and suicidality: A bidirectional two-sample Mendelian randomization study. The Journal of dermatology. 2023-09-12. PMID:37697936. |
in conclusion, this mr study indicates a bidirectional causal relationship between psoriasis and depression that was previously unrecognized, which highlights the significance of screening for depression in psoriasis patients and initiating appropriate interventions. |
2023-09-12 |
2023-10-07 |
Not clear |
| Haohao Zhu, Yifan Sun, Shuaiyi Guo, Qin Zhou, Ying Jiang, Yuan Shen, Zhenhe Zhou, Zhiqiang Du, Hongliang Zho. Causal relationship between sex hormone-binding globulin and major depression: A Mendelian randomization study. Acta psychiatrica Scandinavica. 2023-09-08. PMID:37681458. |
this study aimed to explore the causal relationship between sex hormone-binding globulin (shbg) and major depression using two-sample mendelian randomization (mr) studies. |
2023-09-08 |
2023-10-07 |
Not clear |
| Kristin Klaeske, Constantin Schreiber, Sandra Eifert, Tillmann Dieterlen, Khalil Jawad, Diyar Saeed, Sandra Semmig-Könze, Anna Lassia Meyer, Michael Andrew Borger, Maja-Theresa Dieterle. Health status analysis is comparable in HM3 patients with different preoperative grades of mitral regurgitation. Journal of patient-reported outcomes. vol 7. issue 1. 2023-08-24. PMID:37615830. |
we investigated different parameters of health status including exercise capacity, anxiety and depression after lvad implantation in patients with different preoperative grades of mitral regurgitation (mr). |
2023-08-24 |
2023-09-07 |
Not clear |
| Ni Sang, Bo-Han Li, Meng-Yao Zhang, Meng Wei, Ruo-Xuan Fang, Wen-Jing Liu, Li-E Huang, Jing Zhang, Guo-Cui W. Bidirectional causal relationship between depression and frailty: a univariate and multivariate Mendelian randomisation study. Age and ageing. vol 52. issue 7. 2023-07-02. PMID:37392400. |
therefore, this study used a bidirectional two-sample mendelian randomisation (mr) study to investigate the causal relationship between depression and frailty. |
2023-07-02 |
2023-08-14 |
Not clear |
| Mengyu Pan, James M Roe, Ron Nudel, Andrew J Schork, Olena Iakunchykova, Anders M Fjell, Kristine B Walhovd, Thomas Werge, Chi-Hua Chen, Michael E Benros, Yunpeng Wan. Circulating S100B levels at birth and risk of six major neuropsychiatric or neurological disorders: a two-sample Mendelian Randomization Study. Translational psychiatry. vol 13. issue 1. 2023-05-24. PMID:37225692. |
we applied two-sample mendelian randomization (mr) on the association statistics from genome-wide association studies (gwas) for circulating s100b levels measured 5-7 days after birth (the ipsych sample) and in an older adult sample (mean age, 72.5 years; the lothian sample), upon those derived from major depression disorder (mdd), schizophrenia (scz), bipolar disorder (bip), autism spectral disorder (asd), alzheimer's disease (ad), and parkinson's disease (pd). |
2023-05-24 |
2023-08-14 |
Not clear |
| Ole-Jørgen Bekkevold, Jan Kristian Damås, Ben Michael Brumpton, Bjørn Olav Åsvol. The causal role of C-reactive protein and interleukin-6 on anxiety and depression symptoms and life satisfaction: Mendelian randomisation analyses in the HUNT study. Psychological medicine. 2023-05-22. PMID:37217205. |
a recent mendelian randomisation (mr) study suggested that crp may decrease and il-6 may increase anxiety and depression symptoms. |
2023-05-22 |
2023-08-14 |
Not clear |
| Xixian Ruan, Jie Chen, Yuhao Sun, Yao Zhang, Jianhui Zhao, Xiaoyan Wang, Xue Li, Shuai Yuan, Susanna C Larsso. Depression and 24 gastrointestinal diseases: a Mendelian randomization study. Translational psychiatry. vol 13. issue 1. 2023-05-04. PMID:37142593. |
we conducted mendelian randomization (mr) analyses to systematically explore the associations of depression with 24 gastrointestinal diseases. |
2023-05-04 |
2023-08-14 |
Not clear |
| Xixian Ruan, Jie Chen, Yuhao Sun, Yao Zhang, Jianhui Zhao, Xiaoyan Wang, Xue Li, Shuai Yuan, Susanna C Larsso. Depression and 24 gastrointestinal diseases: a Mendelian randomization study. Translational psychiatry. vol 13. issue 1. 2023-05-04. PMID:37142593. |
this mr study suggests that depression may play a causal role in many gastrointestinal diseases. |
2023-05-04 |
2023-08-14 |
Not clear |
| Jiayue-Clara Jiang, Chenwen Hu, Andrew M McIntosh, Sonia Sha. Investigating the potential anti-depressive mechanisms of statins: a transcriptomic and Mendelian randomization analysis. Translational psychiatry. vol 13. issue 1. 2023-04-04. PMID:37015906. |
mr analysis did not identify any significant associations between statin exposure and depression risk or symptoms after multiple testing correction. |
2023-04-04 |
2023-08-14 |
human |
| Xianjie Wan, Jiale Xie, Mingyi Yang, Hui Yu, Weikun Hou, Ke Xu, Jiachen Wang, Peng X. Does Having Rheumatoid Arthritis Increase the Dose of Depression Medications? A Mendelian Randomization Study. Journal of clinical medicine. vol 12. issue 4. 2023-02-25. PMID:36835939. |
therefore, in this study, we used two-sample mendelian randomization (mr) to explore whether ra increases the dose of depression medications and gain a more comprehensive understanding of the relationship between ra and depression. |
2023-02-25 |
2023-08-14 |
Not clear |
| Lingsi Zeng, Honggang Lv, Xubo Wang, Ranran Xue, Cong Zhou, Xia Liu, Hao Y. Causal effects of fatty acids on depression: Mendelian randomization study. Frontiers in nutrition. vol 9. 2022-12-23. PMID:36562041. |
we aimed to investigate the potential causal relationship between fa [saturated fatty acids (sfa), mono-unsaturated fatty acids (mufa), and polyunsaturated fatty acids (pufa)] and the risk of depression using mendelian randomization (mr) analysis. |
2022-12-23 |
2023-08-14 |
Not clear |
| Harald Murck, Lisa Lehr, Daniela Jezov. A viewpoint on aldosterone and BMI related brain morphology in relation to treatment outcome in patients with major depression. Journal of neuroendocrinology. 2022-12-21. PMID:36539978. |
this review focuses on the importance of the adrenocortical stress hormone aldosterone, which is released by adrenocorticotropic hormone and angiotensin, and the mineralocorticoid receptor (mr) in depression. |
2022-12-21 |
2023-08-14 |
human |
| Christian Adolf, Harald Murck, Anna-Lina Sarkis, Holger Schneider, Daniel A Heinrich, Tracy Ann Williams, Martin Reincke, Heike Künze. Differential central regulatory mineralocorticoidreceptor systems for anxiety and depression - Could KCNJ5 be an interesting target for further investigations in major depression? Journal of psychiatric research. vol 156. 2022-10-15. PMID:36242946. |
the mineralocorticoid receptor (mr) is suggested to play a role in the pathophysiology of depression and anxiety. |
2022-10-15 |
2023-08-14 |
Not clear |
| Christian Adolf, Harald Murck, Anna-Lina Sarkis, Holger Schneider, Daniel A Heinrich, Tracy Ann Williams, Martin Reincke, Heike Künze. Differential central regulatory mineralocorticoidreceptor systems for anxiety and depression - Could KCNJ5 be an interesting target for further investigations in major depression? Journal of psychiatric research. vol 156. 2022-10-15. PMID:36242946. |
main support comes from studies in patients with primary aldosteronism (pa) which suggested different central pathways for depression and anxiety mediated via the mr and gender differences. |
2022-10-15 |
2023-08-14 |
Not clear |
| Christian Adolf, Harald Murck, Anna-Lina Sarkis, Holger Schneider, Daniel A Heinrich, Tracy Ann Williams, Martin Reincke, Heike Künze. Differential central regulatory mineralocorticoidreceptor systems for anxiety and depression - Could KCNJ5 be an interesting target for further investigations in major depression? Journal of psychiatric research. vol 156. 2022-10-15. PMID:36242946. |
we investigated 118 patients with pa over 3 years using self-rating questionnaires for anxiety (gad-7) and depression (phqd) at baseline and once a year under specific treatment with adrenalectomy (adx; n = 48) or a mr antagonist (mra; n = 70). |
2022-10-15 |
2023-08-14 |
Not clear |
| Christian Adolf, Harald Murck, Anna-Lina Sarkis, Holger Schneider, Daniel A Heinrich, Tracy Ann Williams, Martin Reincke, Heike Künze. Differential central regulatory mineralocorticoidreceptor systems for anxiety and depression - Could KCNJ5 be an interesting target for further investigations in major depression? Journal of psychiatric research. vol 156. 2022-10-15. PMID:36242946. |
these data support a differentiated regulation of depression and anxiety by the mr. |
2022-10-15 |
2023-08-14 |
Not clear |
| Evangelos Handakas, Yiwen Xu, Alexa Blair Segal, Maria Carmen Huerta, Kirsty Bowman, Laura D Howe, Franco Sassi, Oliver Robinso. Molecular mediators of the association between child obesity and mental health. Frontiers in genetics. vol 13. 2022-09-19. PMID:36118877. |
two-sample mendelian randomization (mr) analyses were additionally applied to test causal associations of metabolites with depression in independent adult samples. |
2022-09-19 |
2023-08-14 |
Not clear |