| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E R de Kloet, C Otte, R Kumsta, L Kok, M H J Hillegers, H Hasselmann, D Kliegel, M Joël. Stress and Depression: a Crucial Role of the Mineralocorticoid Receptor. Journal of neuroendocrinology. vol 28. issue 8. 2018-01-12. PMID:26970338. |
activation of mr therefore may offer a target for alleviating depression and cognitive dysfunction. |
2018-01-12 |
2023-08-13 |
Not clear |
| Benedetta Bigio, Aleksander A Mathé, Vasco C Sousa, Danielle Zelli, Per Svenningsson, Bruce S McEwen, Carla Nasc. Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 28. 2017-11-27. PMID:27354525. |
rna sequencing of the ventral dentate gyrus, a mood-regulatory region, identified metabolic factors as key markers predisposing to depression (insulin receptors insr, glucose transporters glut-4 and glut-12, and the regulator of appetite cartpt) and to lac responsiveness (leptin receptors lepr, metabotropic glutamate receptors-2 mglu2, neuropeptide-y npy, and mineralocorticoid receptors mr). |
2017-11-27 |
2023-08-13 |
human |
| David J DeWit, David DuBois, Gizem Erdem, Simon Larose, Ellen L Lipma. The Role of Program-Supported Mentoring Relationships in Promoting Youth Mental Health, Behavioral and Developmental Outcomes. Prevention science : the official journal of the Society for Prevention Research. vol 17. issue 5. 2017-10-23. PMID:27194480. |
structural equation model results at 18 months revealed that mentored youths, especially those in mr lasting 12 or more months (continuous or dissolved), reported significantly fewer behavioral problems and fewer symptoms of depression and social anxiety than did non-mentored youths. |
2017-10-23 |
2023-08-13 |
Not clear |
| Maria-Christina Zennaro, Fabio Fernandes-Ros. 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor mutations. The Journal of endocrinology. vol 234. issue 1. 2017-09-05. PMID:28348114. |
in addition to rare variants, frequent functional single nucleotide polymorphisms of the mr are associated with salt sensitivity, blood pressure, stress response and depression in the general population. |
2017-09-05 |
2023-08-13 |
Not clear |
| Ying Wang, Shuming Zhong, Yanbin Jia, Yao Sun, Bing Wang, Tao Liu, Jiyang Pan, Li Huan. Disrupted Resting-State Functional Connectivity in Nonmedicated Bipolar Disorder. Radiology. vol 280. issue 2. 2017-05-17. PMID:26909649. |
thirty-seven patients with nonmedicated bd ii depression and 37 healthy control participants underwent resting-state functional magnetic resonance (mr) imaging. |
2017-05-17 |
2023-08-13 |
human |
| Jiao Chen, Zhen-Zhen Wang, Shuai Zhang, Wei Zuo, Nai-Hong Che. Does mineralocorticoid receptor play a vital role in the development of depressive disorder? Life sciences. vol 152. 2017-02-07. PMID:27015790. |
an increasing number of studies, in recent years, indicate that abnormal function of mr is also a crucial component of the pathophysiology of depression. |
2017-02-07 |
2023-08-13 |
Not clear |
| Jiao Chen, Zhen-Zhen Wang, Shuai Zhang, Wei Zuo, Nai-Hong Che. Does mineralocorticoid receptor play a vital role in the development of depressive disorder? Life sciences. vol 152. 2017-02-07. PMID:27015790. |
thus, this review summarizes the role of mr in the hpa axis dysregulation, inflammation, decreased neurogenesis and stress-related behaviors in depression. |
2017-02-07 |
2023-08-13 |
Not clear |
| Jiao Chen, Zhen-Zhen Wang, Shuai Zhang, Wei Zuo, Nai-Hong Che. Does mineralocorticoid receptor play a vital role in the development of depressive disorder? Life sciences. vol 152. 2017-02-07. PMID:27015790. |
all of which will provide more information about mr in depression. |
2017-02-07 |
2023-08-13 |
Not clear |
| Iacopo Gesmundo, Tania Villanova, Eleonora Gargantini, Emanuela Arvat, Ezio Ghigo, Riccarda Granat. The Mineralocorticoid Agonist Fludrocortisone Promotes Survival and Proliferation of Adult Hippocampal Progenitors. Frontiers in endocrinology. vol 7. 2016-07-06. PMID:27379018. |
by contrast, mineralocorticoid receptor (mr) signaling is associated with neuronal survival in the dentate gyrus of the hippocampus, and impairment of hippocampal mr has been linked to pathological conditions, such as depression or neurodegenerative disorders. |
2016-07-06 |
2023-08-13 |
rat |
| Juliane Fleischer, Katja Wingenfeld, Linn K Kuehl, Kim Hinkelmann, Stefan Roepke, Christian Ott. Does fludrocortisone influence autobiographical memory retrieval? A study in patients with major depression, patients with borderline personality disorder and healthy controls. Stress (Amsterdam, Netherlands). vol 18. issue 6. 2016-06-17. PMID:26457343. |
there is evidence that stimulation of mineralocorticoid receptors (mr) enhances memory in healthy subjects and in patients with major depression (mdd). |
2016-06-17 |
2023-08-13 |
human |
| Christian Otte, Katja Wingenfeld, Linn K Kuehl, Steffen Richter, Francesca Regen, Dominique Piber, Kim Hinkelman. Cognitive function in older adults with major depression: Effects of mineralocorticoid receptor stimulation. Journal of psychiatric research. vol 69. 2016-06-07. PMID:26343603. |
therefore, diminished mr function could contribute to impaired cognition in older adults with depression and might be a promising target for pharmacological intervention. |
2016-06-07 |
2023-08-13 |
human |
| Christian Otte, Katja Wingenfeld, Linn K Kuehl, Steffen Richter, Francesca Regen, Dominique Piber, Kim Hinkelman. Cognitive function in older adults with major depression: Effects of mineralocorticoid receptor stimulation. Journal of psychiatric research. vol 69. 2016-06-07. PMID:26343603. |
our data suggest that -in contrast to younger depressed patients-older adults with depression do not benefit from mr stimulation but deteriorate in cognitive function. |
2016-06-07 |
2023-08-13 |
human |
| Mario Francisco Juruena, Cristiane Von Werne Baes, Itiana Castro Menezes, Frederico Guilherme Graef. Early life stress in depressive patients: role of glucocorticoid and mineralocorticoid receptors and of hypothalamic-pituitary-adrenal axis activity. Current pharmaceutical design. vol 21. issue 11. 2016-05-19. PMID:25564387. |
while most studies have consistently demonstrated that gr function is impaired in major depression (reduced gr-mediated feedback in hpa axis), data about the mr role in depression are still limited and contr oversial. |
2016-05-19 |
2023-08-13 |
Not clear |
| Yan-li Huang, Xue-bing Liang, Li-qi Qian, Chuan Cai, Jun Guo, Chao Gao, Jian-hua Guan, Guo-ping Zha. Effects of Kaixin Powder on melatonin receptor expression and (125)I-Mel binding affinity in a rat model of depression. Chinese journal of integrative medicine. vol 21. issue 7. 2016-04-12. PMID:25159863. |
to explore the effects of kaixin powder (, kxp) on melatonin receptor (mr) expression and (125)i-mel binding affinity in a depression rat model. |
2016-04-12 |
2023-08-13 |
rat |
| Christiaan H Vinkers, Marian Joëls, Yuri Milaneschi, Lotte Gerritsen, René S Kahn, Brenda W J H Penninx, Marco P M Bok. Mineralocorticoid receptor haplotypes sex-dependently moderate depression susceptibility following childhood maltreatment. Psychoneuroendocrinology. vol 54. 2016-02-25. PMID:25686805. |
to investigate the hypothesis that the mr sex-dependently influences the relation between childhood maltreatment and depression, we investigated three common and functional mr haplotypes (ga, ca, and cg haplotype, based on rs5522 and rs2070951) in a population-based cohort (n = 665) and an independent clinical cohort from the netherlands study of depression and anxiety (nesda) (n = 1639). |
2016-02-25 |
2023-08-13 |
Not clear |
| Christiaan H Vinkers, Marian Joëls, Yuri Milaneschi, Lotte Gerritsen, René S Kahn, Brenda W J H Penninx, Marco P M Bok. Mineralocorticoid receptor haplotypes sex-dependently moderate depression susceptibility following childhood maltreatment. Psychoneuroendocrinology. vol 54. 2016-02-25. PMID:25686805. |
these sex-dependent effects of mr on depression susceptibility following childhood maltreatment are relevant in light of the increased prevalence of mood disorders in women and point to a sex-specific role of mr in the etiology of depression following childhood maltreatment. |
2016-02-25 |
2023-08-13 |
Not clear |
| Matthias Büttner, Daniela Jezova, Brandon Greene, Carsten Konrad, Tilo Kircher, Harald Murc. Target-based biomarker selection - Mineralocorticoid receptor-related biomarkers and treatment outcome in major depression. Journal of psychiatric research. vol 66-67. 2016-02-25. PMID:25959615. |
aldosterone and mineralocorticoid receptor (mr)-function have been related to depression. |
2016-02-25 |
2023-08-13 |
Not clear |
| Freija ter Heegde, Roel H De Rijk, Christiaan H Vinker. The brain mineralocorticoid receptor and stress resilience. Psychoneuroendocrinology. vol 52. 2016-01-29. PMID:25459896. |
second, individuals with a relatively low mr functionality may possess an increased stress susceptibility for depression. |
2016-01-29 |
2023-08-13 |
Not clear |
| D A Hamstra, E R de Kloet, A M van Hemert, R H de Rijk, A J W Van der Doe. Mineralocorticoid receptor haplotype, oral contraceptives and emotional information processing. Neuroscience. vol 286. 2015-09-14. PMID:25497375. |
female carriers of mineralocorticoid receptor (mr) haplotype 2 have been shown to be more optimistic and less vulnerable to depression. |
2015-09-14 |
2023-08-13 |
Not clear |
| Afsaneh Nikjooy, Nader Maroufi, Ismaeil Ebrahimi Takamjani, Homayoun Hadizdeh Kharazi, Bahar Mahjoubi, Rasoul Azizi, Hamid Haghan. MR defecography: a diagnostic test for the evaluation of pelvic floor motion in patients with dyssynergic defecation after biofeedback therapy. Medical journal of the Islamic Republic of Iran. vol 29. 2015-06-02. PMID:26034741. |
we clinically evaluated the effects of biofeedback therapy on the pelvic floor motion indices through magnetic resonance (mr) defecography, quality of life and depression in patients with dyssynergic defecation. |
2015-06-02 |
2023-08-13 |
Not clear |