| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liping Xuan, Zhiyun Zhao, Xu Jia, Yanan Hou, Tiange Wang, Mian Li, Jieli Lu, Yu Xu, Yuhong Chen, Lu Qi, Weiqing Wang, Yufang Bi, Min X. Type 2 diabetes is causally associated with depression: a Mendelian randomization analysis. Frontiers of medicine. vol 12. issue 6. 2019-04-25. PMID:30446878. |
overall, the mr analyses provide evidence inferring a potential causal relationship between t2d and depression. |
2019-04-25 |
2023-08-13 |
human |
| Marie Krøll Knudsen, Jamie Near, Anne Bastholm Blicher, Poul Videbech, Jakob Udby Bliche. Magnetic resonance (MR) spectroscopic measurement of γ-aminobutyric acid (GABA) in major depression before and after electroconvulsive therapy. Acta neuropsychiatrica. vol 31. issue 1. 2019-04-17. PMID:30079857. |
magnetic resonance (mr) spectroscopic measurement of γ-aminobutyric acid (gaba) in major depression before and after electroconvulsive therapy. |
2019-04-17 |
2023-08-13 |
Not clear |
| Lavinia Maria Hogea, Laura Alexandra Nussbaum, Daniela Veronica Chiriac, LuminiŢa Ştefania Ageu, Nicoleta Ioana Andreescu, Mirela Loredana Grigoraş, Roxana Folescu, Ana Cristina Bredicean, Maria Puiu, Elena Cecilia Ildikó Roşca, Mihaela Adriana Simu, Codrina Mihaela Leva. Integrative clinico-biological, pharmacogenetic, neuroimagistic, neuroendocrinological and psychological correlations in depressive and anxiety disorders. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 58. issue 3. 2018-08-07. PMID:29250653. |
the efficacy of the chosen therapy in correlation with the pharmacogenetic testing was evaluated through the mean change in the cdrs (children's depression rating scale) total scores, in the cgi-s÷i (clinical global impression - severity÷improvement), cgas (children's global assessment scale) and through the change of the relevant neurobiological markers and mr spectroscopy metabolites. |
2018-08-07 |
2023-08-13 |
human |
| Li Juan Zheng, Gui Fen Yang, Xin Yuan Zhang, Yun Fei Wang, Ya Liu, Gang Zheng, Guang Ming Lu, Long Jiang Zhang, Ying Ha. Altered amygdala and hippocampus effective connectivity in mild cognitive impairment patients with depression: a resting-state functional MR imaging study with granger causality analysis. Oncotarget. vol 8. issue 15. 2018-03-05. PMID:28212570. |
altered amygdala and hippocampus effective connectivity in mild cognitive impairment patients with depression: a resting-state functional mr imaging study with granger causality analysis. |
2018-03-05 |
2023-08-13 |
Not clear |
| E R de Kloet, C Otte, R Kumsta, L Kok, M H J Hillegers, H Hasselmann, D Kliegel, M Joël. Stress and Depression: a Crucial Role of the Mineralocorticoid Receptor. Journal of neuroendocrinology. vol 28. issue 8. 2018-01-12. PMID:26970338. |
mr haplotype 2 (ca) is a gain of function variant that protects females against depression by association with an optimistic, resilient phenotype. |
2018-01-12 |
2023-08-13 |
Not clear |
| E R de Kloet, C Otte, R Kumsta, L Kok, M H J Hillegers, H Hasselmann, D Kliegel, M Joël. Stress and Depression: a Crucial Role of the Mineralocorticoid Receptor. Journal of neuroendocrinology. vol 28. issue 8. 2018-01-12. PMID:26970338. |
limbic mr is down-regulated by chronic stress and during depression but induced by antidepressants. |
2018-01-12 |
2023-08-13 |
Not clear |
| E R de Kloet, C Otte, R Kumsta, L Kok, M H J Hillegers, H Hasselmann, D Kliegel, M Joël. Stress and Depression: a Crucial Role of the Mineralocorticoid Receptor. Journal of neuroendocrinology. vol 28. issue 8. 2018-01-12. PMID:26970338. |
activation of mr therefore may offer a target for alleviating depression and cognitive dysfunction. |
2018-01-12 |
2023-08-13 |
Not clear |
| Benedetta Bigio, Aleksander A Mathé, Vasco C Sousa, Danielle Zelli, Per Svenningsson, Bruce S McEwen, Carla Nasc. Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 28. 2017-11-27. PMID:27354525. |
rna sequencing of the ventral dentate gyrus, a mood-regulatory region, identified metabolic factors as key markers predisposing to depression (insulin receptors insr, glucose transporters glut-4 and glut-12, and the regulator of appetite cartpt) and to lac responsiveness (leptin receptors lepr, metabotropic glutamate receptors-2 mglu2, neuropeptide-y npy, and mineralocorticoid receptors mr). |
2017-11-27 |
2023-08-13 |
human |
| David J DeWit, David DuBois, Gizem Erdem, Simon Larose, Ellen L Lipma. The Role of Program-Supported Mentoring Relationships in Promoting Youth Mental Health, Behavioral and Developmental Outcomes. Prevention science : the official journal of the Society for Prevention Research. vol 17. issue 5. 2017-10-23. PMID:27194480. |
structural equation model results at 18 months revealed that mentored youths, especially those in mr lasting 12 or more months (continuous or dissolved), reported significantly fewer behavioral problems and fewer symptoms of depression and social anxiety than did non-mentored youths. |
2017-10-23 |
2023-08-13 |
Not clear |
| Maria-Christina Zennaro, Fabio Fernandes-Ros. 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor mutations. The Journal of endocrinology. vol 234. issue 1. 2017-09-05. PMID:28348114. |
in addition to rare variants, frequent functional single nucleotide polymorphisms of the mr are associated with salt sensitivity, blood pressure, stress response and depression in the general population. |
2017-09-05 |
2023-08-13 |
Not clear |
| Ying Wang, Shuming Zhong, Yanbin Jia, Yao Sun, Bing Wang, Tao Liu, Jiyang Pan, Li Huan. Disrupted Resting-State Functional Connectivity in Nonmedicated Bipolar Disorder. Radiology. vol 280. issue 2. 2017-05-17. PMID:26909649. |
thirty-seven patients with nonmedicated bd ii depression and 37 healthy control participants underwent resting-state functional magnetic resonance (mr) imaging. |
2017-05-17 |
2023-08-13 |
human |
| Jiao Chen, Zhen-Zhen Wang, Shuai Zhang, Wei Zuo, Nai-Hong Che. Does mineralocorticoid receptor play a vital role in the development of depressive disorder? Life sciences. vol 152. 2017-02-07. PMID:27015790. |
an increasing number of studies, in recent years, indicate that abnormal function of mr is also a crucial component of the pathophysiology of depression. |
2017-02-07 |
2023-08-13 |
Not clear |
| Jiao Chen, Zhen-Zhen Wang, Shuai Zhang, Wei Zuo, Nai-Hong Che. Does mineralocorticoid receptor play a vital role in the development of depressive disorder? Life sciences. vol 152. 2017-02-07. PMID:27015790. |
all of which will provide more information about mr in depression. |
2017-02-07 |
2023-08-13 |
Not clear |
| Jiao Chen, Zhen-Zhen Wang, Shuai Zhang, Wei Zuo, Nai-Hong Che. Does mineralocorticoid receptor play a vital role in the development of depressive disorder? Life sciences. vol 152. 2017-02-07. PMID:27015790. |
thus, this review summarizes the role of mr in the hpa axis dysregulation, inflammation, decreased neurogenesis and stress-related behaviors in depression. |
2017-02-07 |
2023-08-13 |
Not clear |
| Iacopo Gesmundo, Tania Villanova, Eleonora Gargantini, Emanuela Arvat, Ezio Ghigo, Riccarda Granat. The Mineralocorticoid Agonist Fludrocortisone Promotes Survival and Proliferation of Adult Hippocampal Progenitors. Frontiers in endocrinology. vol 7. 2016-07-06. PMID:27379018. |
by contrast, mineralocorticoid receptor (mr) signaling is associated with neuronal survival in the dentate gyrus of the hippocampus, and impairment of hippocampal mr has been linked to pathological conditions, such as depression or neurodegenerative disorders. |
2016-07-06 |
2023-08-13 |
rat |
| Juliane Fleischer, Katja Wingenfeld, Linn K Kuehl, Kim Hinkelmann, Stefan Roepke, Christian Ott. Does fludrocortisone influence autobiographical memory retrieval? A study in patients with major depression, patients with borderline personality disorder and healthy controls. Stress (Amsterdam, Netherlands). vol 18. issue 6. 2016-06-17. PMID:26457343. |
there is evidence that stimulation of mineralocorticoid receptors (mr) enhances memory in healthy subjects and in patients with major depression (mdd). |
2016-06-17 |
2023-08-13 |
human |
| Christian Otte, Katja Wingenfeld, Linn K Kuehl, Steffen Richter, Francesca Regen, Dominique Piber, Kim Hinkelman. Cognitive function in older adults with major depression: Effects of mineralocorticoid receptor stimulation. Journal of psychiatric research. vol 69. 2016-06-07. PMID:26343603. |
therefore, diminished mr function could contribute to impaired cognition in older adults with depression and might be a promising target for pharmacological intervention. |
2016-06-07 |
2023-08-13 |
human |
| Christian Otte, Katja Wingenfeld, Linn K Kuehl, Steffen Richter, Francesca Regen, Dominique Piber, Kim Hinkelman. Cognitive function in older adults with major depression: Effects of mineralocorticoid receptor stimulation. Journal of psychiatric research. vol 69. 2016-06-07. PMID:26343603. |
our data suggest that -in contrast to younger depressed patients-older adults with depression do not benefit from mr stimulation but deteriorate in cognitive function. |
2016-06-07 |
2023-08-13 |
human |
| Mario Francisco Juruena, Cristiane Von Werne Baes, Itiana Castro Menezes, Frederico Guilherme Graef. Early life stress in depressive patients: role of glucocorticoid and mineralocorticoid receptors and of hypothalamic-pituitary-adrenal axis activity. Current pharmaceutical design. vol 21. issue 11. 2016-05-19. PMID:25564387. |
while most studies have consistently demonstrated that gr function is impaired in major depression (reduced gr-mediated feedback in hpa axis), data about the mr role in depression are still limited and contr oversial. |
2016-05-19 |
2023-08-13 |
Not clear |
| Yan-li Huang, Xue-bing Liang, Li-qi Qian, Chuan Cai, Jun Guo, Chao Gao, Jian-hua Guan, Guo-ping Zha. Effects of Kaixin Powder on melatonin receptor expression and (125)I-Mel binding affinity in a rat model of depression. Chinese journal of integrative medicine. vol 21. issue 7. 2016-04-12. PMID:25159863. |
to explore the effects of kaixin powder (, kxp) on melatonin receptor (mr) expression and (125)i-mel binding affinity in a depression rat model. |
2016-04-12 |
2023-08-13 |
rat |